{"id":"https://openalex.org/W4324147635","doi":"https://doi.org/10.3389/fphar.2023.1114410","title":"Efficacy of Perilla frutescens (L.) Britton var. frutescens extract on mild knee joint pain: A randomized controlled trial","display_name":"Efficacy of Perilla frutescens (L.) Britton var. frutescens extract on mild knee joint pain: A randomized controlled trial","publication_year":2023,"publication_date":"2023-03-14","ids":{"openalex":"https://openalex.org/W4324147635","doi":"https://doi.org/10.3389/fphar.2023.1114410","pmid":"https://pubmed.ncbi.nlm.nih.gov/36998613","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10043449"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2023.1114410","doi":"https://doi.org/10.3389/fphar.2023.1114410","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2023.1114410","pdf_url":null,"source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fphar.2023.1114410","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049197800","display_name":"NamHoon Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119522612","display_name":"Daejeon University","ror":"https://ror.org/02eqchk86","country_code":"KR","type":"education","lineage":["https://openalex.org/I119522612"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"NamHoon Kim","raw_affiliation_strings":["Department of Korean Rehabilitation Medicine, College of Korean Medicine, Daejeon University, Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Korean Rehabilitation Medicine, College of Korean Medicine, Daejeon University, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I119522612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029161176","display_name":"Si Yeon Kim","orcid":"https://orcid.org/0000-0002-3467-3444","observed_orcids":["https://orcid.org/0000-0002-3467-3444","https://orcid.org/0000-0002-5939-429X","https://orcid.org/0009-0000-5443-6422"]},"institutions":[{"id":"https://openalex.org/I119522612","display_name":"Daejeon University","ror":"https://ror.org/02eqchk86","country_code":"KR","type":"education","lineage":["https://openalex.org/I119522612"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Si-Yeon Kim","raw_affiliation_strings":["Clinical Trial Center, Daejeon Korean Medicine Hospital of Daejeon University, Daejeon, Republic of Korea","Department of Korean Rehabilitation Medicine, College of Korean Medicine, Daejeon University, Daejeon, Republic of Korea","SFC Bio Co., Ltd, Cheonan-si, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trial Center, Daejeon Korean Medicine Hospital of Daejeon University, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I119522612"]},{"raw_affiliation_string":"Department of Korean Rehabilitation Medicine, College of Korean Medicine, Daejeon University, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I119522612"]},{"raw_affiliation_string":"SFC Bio Co., Ltd, Cheonan-si, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100452154","display_name":"Sangwoo Kim","orcid":"https://orcid.org/0000-0001-5356-0827","observed_orcids":["https://orcid.org/0000-0001-5356-0827","https://orcid.org/0009-0009-8380-631X"]},"institutions":[{"id":"https://openalex.org/I119522612","display_name":"Daejeon University","ror":"https://ror.org/02eqchk86","country_code":"KR","type":"education","lineage":["https://openalex.org/I119522612"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sang-Woo Kim","raw_affiliation_strings":["Clinical Trial Center, Daejeon Korean Medicine Hospital of Daejeon University, Daejeon, Republic of Korea","Department of Korean Rehabilitation Medicine, College of Korean Medicine, Daejeon University, Daejeon, Republic of Korea","SFC Bio Co., Ltd, Cheonan-si, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trial Center, Daejeon Korean Medicine Hospital of Daejeon University, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I119522612"]},{"raw_affiliation_string":"Department of Korean Rehabilitation Medicine, College of Korean Medicine, Daejeon University, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I119522612"]},{"raw_affiliation_string":"SFC Bio Co., Ltd, Cheonan-si, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jung Min Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119522612","display_name":"Daejeon University","ror":"https://ror.org/02eqchk86","country_code":"KR","type":"education","lineage":["https://openalex.org/I119522612"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jung Min Lee","raw_affiliation_strings":["Department of Korean Rehabilitation Medicine, College of Korean Medicine, Daejeon University, Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Korean Rehabilitation Medicine, College of Korean Medicine, Daejeon University, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I119522612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040372679","display_name":"Sung Kyu Kim","orcid":"https://orcid.org/0000-0002-0062-9373","observed_orcids":["https://orcid.org/0000-0002-0062-9373","https://orcid.org/0009-0007-6390-9763"]},"institutions":[{"id":"https://openalex.org/I119522612","display_name":"Daejeon University","ror":"https://ror.org/02eqchk86","country_code":"KR","type":"education","lineage":["https://openalex.org/I119522612"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sung-Kyu Kim","raw_affiliation_strings":["Clinical Trial Center, Daejeon Korean Medicine Hospital of Daejeon University, Daejeon, Republic of Korea","Department of Korean Rehabilitation Medicine, College of Korean Medicine, Daejeon University, Daejeon, Republic of Korea","SFC Bio Co., Ltd, Cheonan-si, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trial Center, Daejeon Korean Medicine Hospital of Daejeon University, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I119522612"]},{"raw_affiliation_string":"Department of Korean Rehabilitation Medicine, College of Korean Medicine, Daejeon University, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I119522612"]},{"raw_affiliation_string":"SFC Bio Co., Ltd, Cheonan-si, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045201385","display_name":"Mi-Houn Park","orcid":"https://orcid.org/0000-0003-4834-5668","observed_orcids":["https://orcid.org/0000-0003-4834-5668"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mi-Houn Park","raw_affiliation_strings":["SFC Bio Co., Ltd, Cheonan-si, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SFC Bio Co., Ltd, Cheonan-si, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100655392","display_name":"Ki-Hwan Kim","orcid":"https://orcid.org/0000-0002-2882-4816","observed_orcids":["https://orcid.org/0000-0002-2882-4816"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ki-Hwan Kim","raw_affiliation_strings":["SFC Bio Co., Ltd, Cheonan-si, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SFC Bio Co., Ltd, Cheonan-si, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056377585","display_name":"Minseok Oh","orcid":"https://orcid.org/0000-0003-4992-2527","observed_orcids":["https://orcid.org/0000-0003-4992-2527"]},"institutions":[{"id":"https://openalex.org/I119522612","display_name":"Daejeon University","ror":"https://ror.org/02eqchk86","country_code":"KR","type":"education","lineage":["https://openalex.org/I119522612"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Minseok Oh","raw_affiliation_strings":["Department of Korean Rehabilitation Medicine, College of Korean Medicine, Daejeon University, Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Korean Rehabilitation Medicine, College of Korean Medicine, Daejeon University, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I119522612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103126845","display_name":"Chang\u2010Gue Son","orcid":"https://orcid.org/0000-0003-4876-0167","observed_orcids":["https://orcid.org/0000-0003-4876-0167"]},"institutions":[{"id":"https://openalex.org/I119522612","display_name":"Daejeon University","ror":"https://ror.org/02eqchk86","country_code":"KR","type":"education","lineage":["https://openalex.org/I119522612"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chang-Gue Son","raw_affiliation_strings":["Institute of Bioscience and Integrative Medicine, Department of Korean Medicine, Daejeon University, Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioscience and Integrative Medicine, Department of Korean Medicine, Daejeon University, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I119522612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074926242","display_name":"In Chul Jung","orcid":"https://orcid.org/0000-0001-7245-4990","observed_orcids":["https://orcid.org/0000-0001-7245-4990"]},"institutions":[{"id":"https://openalex.org/I119522612","display_name":"Daejeon University","ror":"https://ror.org/02eqchk86","country_code":"KR","type":"education","lineage":["https://openalex.org/I119522612"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"In Chul Jung","raw_affiliation_strings":["Department of Oriental Neuropsychiatry, College of Korean Medicine, Daejeon University, Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oriental Neuropsychiatry, College of Korean Medicine, Daejeon University, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I119522612"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100398838","display_name":"Eunjung Lee","orcid":"https://orcid.org/0000-0002-8287-6131","observed_orcids":["https://orcid.org/0000-0002-8287-6131"]},"institutions":[{"id":"https://openalex.org/I119522612","display_name":"Daejeon University","ror":"https://ror.org/02eqchk86","country_code":"KR","type":"education","lineage":["https://openalex.org/I119522612"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Eun-Jung Lee","raw_affiliation_strings":["Department of Korean Rehabilitation Medicine, College of Korean Medicine, Daejeon University, Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Korean Rehabilitation Medicine, College of Korean Medicine, Daejeon University, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I119522612"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5074926242","https://openalex.org/A5100398838"],"corresponding_institution_ids":["https://openalex.org/I119522612"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":0.8331,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.69645243,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"14","issue":null,"first_page":"1114410","last_page":"1114410"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.8202999830245972,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.8202999830245972,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13335","display_name":"Pharmacological Effects of Medicinal Plants","score":0.057100001722574234,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13828","display_name":"Natural Products and Biological Research","score":0.022600000724196434,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/perilla-frutescens","display_name":"Perilla frutescens","score":0.9810000061988831},{"id":"https://openalex.org/keywords/knee-pain","display_name":"knee pain","score":0.9580000042915344},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.8669999837875366},{"id":"https://openalex.org/keywords/knee-function","display_name":"knee function","score":0.7099999785423279},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.6240000128746033},{"id":"https://openalex.org/keywords/cartilage-oligomeric-matrix-protein","display_name":"cartilage oligomeric matrix protein","score":0.902999997138977},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9449999928474426},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9589999914169312},{"id":"https://openalex.org/keywords/erythrocyte-sedimentation-rate","display_name":"erythrocyte sedimentation rate","score":0.953000009059906},{"id":"https://openalex.org/keywords/neutrophil-to-lymphocyte-ratio","display_name":"neutrophil-to-lymphocyte ratio","score":0.828000009059906},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.640999972820282},{"id":"https://openalex.org/keywords/safety-and-tolerability","display_name":"safety and tolerability","score":0.6840000152587891},{"id":"https://openalex.org/keywords/womac","display_name":"WOMAC","score":0.859000027179718}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8747035264968872},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.8325531482696533},{"id":"https://openalex.org/C2779286237","wikidata":"https://www.wikidata.org/wiki/Q3569749","display_name":"WOMAC","level":4,"score":0.7964317798614502},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.7398771047592163},{"id":"https://openalex.org/C14184104","wikidata":"https://www.wikidata.org/wiki/Q1362526","display_name":"Visual analogue scale","level":2,"score":0.6853048205375671},{"id":"https://openalex.org/C2778143017","wikidata":"https://www.wikidata.org/wiki/Q111208","display_name":"Erythrocyte sedimentation rate","level":2,"score":0.6548339128494263},{"id":"https://openalex.org/C2779279471","wikidata":"https://www.wikidata.org/wiki/Q6421876","display_name":"Knee pain","level":4,"score":0.4720364809036255},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.45872682332992554},{"id":"https://openalex.org/C2776237595","wikidata":"https://www.wikidata.org/wiki/Q683498","display_name":"Joint pain","level":2,"score":0.4575253427028656},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.444964200258255},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4370560646057129},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07623231410980225},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fphar.2023.1114410","doi":"https://doi.org/10.3389/fphar.2023.1114410","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2023.1114410","pdf_url":null,"source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10043449","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10043449","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10043449/pdf/fphar-14-1114410.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmid:36998613","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36998613","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:61dae863f92c4651962ab10679e949f5","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/61dae863f92c4651962ab10679e949f5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 14 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2023.1114410","doi":"https://doi.org/10.3389/fphar.2023.1114410","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2023.1114410","pdf_url":null,"source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321207","display_name":"Daejeon University","ror":"https://ror.org/02eqchk86"},{"id":"https://openalex.org/F4320321681","display_name":"Ministry of Trade, Industry and Energy","ror":"https://ror.org/008nkqk13"},{"id":"https://openalex.org/F4320322064","display_name":"Korea Institute for Advancement of Technology","ror":"https://ror.org/015w1qa96"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4324147635.pdf","grobid_xml":"https://content.openalex.org/works/W4324147635.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1507500705","https://openalex.org/W1539208316","https://openalex.org/W1974654019","https://openalex.org/W1989145179","https://openalex.org/W1999381311","https://openalex.org/W2010286207","https://openalex.org/W2026960752","https://openalex.org/W2029351075","https://openalex.org/W2029353932","https://openalex.org/W2032249326","https://openalex.org/W2032624822","https://openalex.org/W2047684720","https://openalex.org/W2056469914","https://openalex.org/W2058147305","https://openalex.org/W2058506370","https://openalex.org/W2061464305","https://openalex.org/W2072500831","https://openalex.org/W2072619434","https://openalex.org/W2083537240","https://openalex.org/W2084225430","https://openalex.org/W2087139148","https://openalex.org/W2100457319","https://openalex.org/W2105539667","https://openalex.org/W2112870271","https://openalex.org/W2145606620","https://openalex.org/W2153831122","https://openalex.org/W2160839431","https://openalex.org/W2160963242","https://openalex.org/W2171648444","https://openalex.org/W2190378646","https://openalex.org/W2215739393","https://openalex.org/W2529441609","https://openalex.org/W2561383208","https://openalex.org/W2580048677","https://openalex.org/W2607429716","https://openalex.org/W2738338726","https://openalex.org/W2739509001","https://openalex.org/W2745407817","https://openalex.org/W2799331758","https://openalex.org/W2806764939","https://openalex.org/W2863653928","https://openalex.org/W2887230286","https://openalex.org/W2894438391","https://openalex.org/W2903826746","https://openalex.org/W2953076229","https://openalex.org/W2970916347","https://openalex.org/W2991614664","https://openalex.org/W2994092353","https://openalex.org/W3032154118","https://openalex.org/W3047503730","https://openalex.org/W3107012386","https://openalex.org/W3114528238","https://openalex.org/W3129103580","https://openalex.org/W3133854280","https://openalex.org/W3144412344","https://openalex.org/W4210666384","https://openalex.org/W4221008329","https://openalex.org/W4238122685"],"related_works":["https://openalex.org/W2527137999","https://openalex.org/W2122999655","https://openalex.org/W4415649451","https://openalex.org/W2611433168","https://openalex.org/W3042733099","https://openalex.org/W4392095727","https://openalex.org/W4323067230","https://openalex.org/W2415539887","https://openalex.org/W2086170145","https://openalex.org/W4410248774"],"abstract_inverted_index":{"Objectives:":[0],"This":[1],"study":[2],"aimed":[3],"to":[4,197,254],"evaluate":[5],"the":[6,16,63,93,107,116,163,181,193,198,228,241,257],"clinical":[7,41],"efficacy":[8],"and":[9,21,50,65,97,100,109,128,135,167,175,183,213,233,252,275,288],"safety":[10,144,293],"of":[11,18,92,262],"PE":[12],"extracts":[13],"developed":[14],"for":[15,87,230],"purpose":[17],"relieving":[19],"pain":[20,49,274],"improving":[22,276],"knee":[23,31,47,272,277,285],"joint":[24,32,48,273,278,286],"function":[25,279],"on":[26],"semi-healthy":[27],"people":[28,282],"with":[29,46,67,283],"mild":[30,284],"pain.":[33],"Methods:":[34],"A":[35],"randomized,":[36],"double-blind,":[37],"two-arm,":[38],"single-center,":[39],"placebo-controlled":[40],"trial":[42,164],"was":[43,146,265],"conducted.":[44],"Individuals":[45],"a":[51,78,84,143],"visual":[52],"analogue":[53],"scale":[54],"(VAS)":[55],"score":[56,96],"<":[57,211,225],"50":[58],"mm":[59],"were":[60,70,73,112,139,159,178,189,238,249,290],"included":[61],"in":[62,180,192,240,270,280],"study,":[64],"participants":[66,150],"radiological":[68],"arthritis":[69],"excluded.":[71],"Participants":[72],"administered":[74],"either":[75],"PFE":[76,108,182,194,263],"or":[77],"placebo":[79,110,168,184,199,269],"capsule":[80],"(700":[81],"mg,":[82],"twice":[83],"day)":[85],"orally":[86],"eight":[88,171],"weeks.":[89],"The":[90,186],"comparisons":[91],"changed":[94,187],"VAS":[95,174,208],"Western":[98],"Ontario":[99],"McMaster":[101],"Universities":[102],"Osteoarthritis":[103],"(WOMAC)":[104],"scores":[105,177,188,209,223],"between":[106],"groups":[111],"primary":[113],"outcomes,":[114],"while":[115],"five":[117,242],"inflammation-related":[118,243],"laboratory":[119,244],"tests":[120],"including":[121,227],"cartilage":[122],"oligomeric":[123],"matrix":[124],"protein,":[125,134],"cyclooxygenase-2,":[126],"neutrophil":[127],"lymphocyte":[129],"ratio,":[130],"high":[131],"sensitive":[132],"C-reactive":[133],"erythrocyte":[136],"sedimentation":[137],"rate":[138],"secondary":[140],"outcomes.":[141],"Also,":[142],"assessment":[145],"done.":[147],"Results:":[148],"Eighty":[149],"(mean":[151],"age,":[152],"38.4":[153],"\u00b1":[154,202,206,215,219],"14.0,":[155],"male:":[156],"female,":[157],"28:52)":[158],"enrolled;":[160],"75":[161],"completed":[162],"(PFE":[165],"36":[166],"39).":[169],"After":[170],"weeks,":[172],"both":[173],"WOMAC":[176,222],"reduced":[179],"groups.":[185],"significantly":[190],"higher":[191],"group":[195],"compared":[196],"group:":[200],"19.6":[201],"10.9":[203],"vs.":[204,217],"6.8":[205],"10.5;":[207],"(p":[210,224],"0.001),":[212],"20.5":[214],"14.7":[216],"9.3":[218],"16.5;":[220],"total":[221],"0.01)":[226],"sub-scores":[229],"pain,":[231,287],"stiffness,":[232],"functions.":[234],"No":[235],"significant":[236],"changes":[237],"reported":[239],"parameters.":[245],"All":[246],"adverse":[247],"events":[248],"considered":[250],"minor":[251],"unlikely":[253],"result":[255],"from":[256],"intervention.":[258],"Conclusion:":[259],"Eight":[260],"weeks":[261],"intake":[264],"more":[266],"effective":[267],"than":[268],"reducing":[271],"sub-healthy":[281],"there":[289],"no":[291],"major":[292],"concerns.":[294],"Clinical":[295],"Trial":[296],"Registration:":[297],"https://cris.nih.go.kr/cris/search/detailSearch.do?search_lang=E&focus=reset_12&search_page=M&pageSize=10&page=undefined&seq=23101&status=5&seq_group=19745":[298],",":[299],"identifier":[300],"CRIS:":[301],"KCT0007219":[302]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-03-15T00:00:00"}
