{"id":"https://openalex.org/W4324130320","doi":null,"title":"Clinical characteristics and survival analysis of class I pulmonary arterial hypertension.","display_name":"Clinical characteristics and survival analysis of class I pulmonary arterial hypertension.","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4324130320","pmid":"https://pubmed.ncbi.nlm.nih.gov/36915738","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10006787"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10006787","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10006787","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10006787/pdf/ajtr0015-1476.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10006787/pdf/ajtr0015-1476.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111726562","display_name":"Lu Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lu Zheng","raw_affiliation_strings":["Department of Cardiology, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450000, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450000, Henan, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115602279","display_name":"Yingying Yang","orcid":"https://orcid.org/0000-0003-2919-9853","observed_orcids":["https://orcid.org/0000-0003-2919-9853","https://orcid.org/0000-0002-7719-0397"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingying Yang","raw_affiliation_strings":["Department of Cardiology, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450000, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450000, Henan, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101630045","display_name":"Wenlong Zhao","orcid":"https://orcid.org/0000-0002-6019-5132","observed_orcids":["https://orcid.org/0000-0002-6019-5132","https://orcid.org/0000-0002-6002-7091","https://orcid.org/0000-0003-2133-7895"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenlong Zhao","raw_affiliation_strings":["Department of Cardiology, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450000, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450000, Henan, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020159246","display_name":"Haibo Yang","orcid":"https://orcid.org/0000-0003-0386-5336","observed_orcids":["https://orcid.org/0000-0003-0386-5336"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haibo Yang","raw_affiliation_strings":["Department of Cardiology, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450000, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450000, Henan, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073355485","display_name":"Hanqiang Zhan","orcid":"https://orcid.org/0009-0008-9099-1202","observed_orcids":["https://orcid.org/0009-0008-9099-1202"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hanqiang Zhan","raw_affiliation_strings":["Medical Record Management Department, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450000, Henan China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Record Management Department, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450000, Henan China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112993267","display_name":"Yintao Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yintao Zhao","raw_affiliation_strings":["Department of Cardiology, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450000, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450000, Henan, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085680442","display_name":"Rong Jiang","orcid":"https://orcid.org/0000-0003-4062-5550","observed_orcids":["https://orcid.org/0000-0003-4062-5550"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210127126","display_name":"Shanghai Pulmonary Hospital","ror":"https://ror.org/033nbnf69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127126"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rong Jiang","raw_affiliation_strings":["Department of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, School of Medicine, Tongji University Shanghai 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, School of Medicine, Tongji University Shanghai 200433, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.339,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.54740536,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"15","issue":"2","first_page":"1476","last_page":"1484"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12199","display_name":"Vascular Anomalies and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulmonary-arterial-hypertension","display_name":"pulmonary arterial hypertension","score":0.9739999771118164},{"id":"https://openalex.org/keywords/connective-tissue-disease-associated-pulmonary-arterial-hypertension","display_name":"connective tissue disease-associated pulmonary arterial hypertension","score":0.9490000009536743},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.4790000021457672},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.7599999904632568},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.8270000219345093},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8100000023841858},{"id":"https://openalex.org/keywords/right-heart-catheterization","display_name":"right heart catheterization","score":0.8240000009536743},{"id":"https://openalex.org/keywords/echocardiography","display_name":"echocardiography","score":0.828000009059906},{"id":"https://openalex.org/keywords/multidisciplinary-care","display_name":"multidisciplinary care","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8979179859161377},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7526597380638123},{"id":"https://openalex.org/C2780940725","wikidata":"https://www.wikidata.org/wiki/Q206280","display_name":"Pulmonary artery","level":2,"score":0.7089236974716187},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.689347505569458},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.5897781848907471},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5715706944465637},{"id":"https://openalex.org/C58245268","wikidata":"https://www.wikidata.org/wiki/Q456026","display_name":"Vascular resistance","level":3,"score":0.5060479044914246},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.4783869981765747},{"id":"https://openalex.org/C2777385415","wikidata":"https://www.wikidata.org/wiki/Q1615191","display_name":"Cardiac catheterization","level":2,"score":0.4219251275062561}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:10006787","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10006787","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10006787/pdf/ajtr0015-1476.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},{"id":"pmid:36915738","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36915738","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10006787","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10006787","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10006787/pdf/ajtr0015-1476.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4324130320.pdf","grobid_xml":"https://content.openalex.org/works/W4324130320.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W2012452674","https://openalex.org/W2077788923","https://openalex.org/W2098416330","https://openalex.org/W2107011819","https://openalex.org/W2117339256","https://openalex.org/W2122425344","https://openalex.org/W2138287259","https://openalex.org/W2140319297","https://openalex.org/W2141262339","https://openalex.org/W2158891637","https://openalex.org/W2161370807","https://openalex.org/W2161450347","https://openalex.org/W2169001316","https://openalex.org/W2415292446","https://openalex.org/W2482228149","https://openalex.org/W2559213835","https://openalex.org/W2606323667","https://openalex.org/W2778632170","https://openalex.org/W2780121422","https://openalex.org/W2884726989","https://openalex.org/W2888447429","https://openalex.org/W2904180601","https://openalex.org/W2944603719","https://openalex.org/W3062049710","https://openalex.org/W3135288386","https://openalex.org/W3178237887","https://openalex.org/W3208579920"],"related_works":["https://openalex.org/W2122425344","https://openalex.org/W2049711423","https://openalex.org/W1993693229","https://openalex.org/W2415292446","https://openalex.org/W2169001316","https://openalex.org/W1980546043","https://openalex.org/W2408326697","https://openalex.org/W4322011887","https://openalex.org/W7214296877","https://openalex.org/W3034036591"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"analyze":[2],"the":[3,27,51,79,118,124,131,153,202,210],"clinical":[4,28],"data":[5,29],"and":[6,36,48,64,76,101,106,112,138,155,158,233],"prognosis":[7,77],"of":[8,41,53,58,78,117,126,146,160,173,178,193,212,230],"patients":[9,46,80,205,218],"with":[10,190],"World":[11],"Health":[12],"Organization":[13],"(WHO)":[14],"functional":[15],"class":[16,43,215],"I":[17,44,216],"pulmonary":[18,102],"arterial":[19],"hypertension":[20],"(PAH).":[21],"METHODS:":[22],"This":[23],"research":[24],"retrospectively":[25],"analyzed":[26],"(baseline,":[30],"laboratory":[31,108],"as":[32,34],"well":[33],"echocardiography":[35],"right":[37,98],"heart":[38],"catheterization":[39],"data)":[40],"63":[42],"PAH":[45,204,217],"diagnosed":[47,151],"treated":[49],"in":[50,92,152,219],"Department":[52],"Cardiology,":[54],"First":[55],"Affiliated":[56],"Hospital":[57],"Zhengzhou":[59],"University,":[60],"between":[61],"January":[62],"2021":[63],"June":[65],"2022.":[66],"The":[67,74,85,196],"mean":[68,171],"follow-up":[69,172],"time":[70],"was":[71,130,206],"10.7\u00b16.5":[72,174],"months.":[73],"treatment":[75],"were":[81,149,162],"analyzed.":[82],"RESULTS:":[83],"<0.05).":[84],"three":[86],"subgroups":[87],"showed":[88],"no":[89],"obvious":[90],"differences":[91],"echocardiographic":[93],"indexes":[94,109],"(right":[95],"atrial":[96],"size,":[97],"ventricular":[99],"size":[100],"artery":[103],"systolic":[104],"pressure)":[105],"related":[107],"(blood":[110],"routines":[111],"hepatorenal":[113],"function).":[114],"In":[115,209],"terms":[116],"targeted":[119,164,213],"drug":[120,165],"therapy":[121,129,141,166,232],"for":[122,167,200],"PAH,":[123],"proportion":[125,229],"dual-drug":[127],"combination":[128,140],"highest":[132],"(48.1%),":[133],"followed":[134],"by":[135],"monotherapy":[136],"(35%)":[137],"triple":[139],"(15.9%).":[142],"Nearly":[143],"half":[144],"(48.7%)":[145],"CTD-PAH":[147,188],"cases":[148],"first":[150],"Rheumatology":[154],"Immunology":[156],"Department,":[157],"all":[159,201],"them":[161],"given":[163],"PAH.":[168],"After":[169],"a":[170,176,222,227],"months,":[175],"total":[177],"8":[179],"endpoint":[180],"events":[181],"occurred,":[182],"including":[183],"3":[184],"deaths":[185],"due":[186],"to":[187],"complicated":[189],"serious":[191],"complications":[192],"other":[194],"organs.":[195],"1-year":[197],"survival":[198,225],"rate":[199],"included":[203],"95.2%.":[207],"CONCLUSIONS:":[208],"era":[211],"therapy,":[214],"China":[220],"have":[221],"high":[223,228],"early":[224],"rate,":[226],"combined":[231],"strong":[234],"multidisciplinary":[235],"attention.":[236]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-03-15T00:00:00"}