{"id":"https://openalex.org/W4324045895","doi":"https://doi.org/10.21203/rs.3.rs-2664226/v1","title":"Efficacy and Safety of Phaseolus angularis L for. as Anti- aging Therapy in Healthy Skin","display_name":"Efficacy and Safety of Phaseolus angularis L for. as Anti- aging Therapy in Healthy Skin","publication_year":2023,"publication_date":"2023-03-13","ids":{"openalex":"https://openalex.org/W4324045895","doi":"https://doi.org/10.21203/rs.3.rs-2664226/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-2664226/v1","doi":"https://doi.org/10.21203/rs.3.rs-2664226/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-2664226/v1","pdf_url":"https://www.researchsquare.com/article/rs-2664226/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-2664226/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012537283","display_name":"Sarang Oh","orcid":"https://orcid.org/0000-0002-7818-0529","observed_orcids":["https://orcid.org/0000-0002-7818-0529"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarang Oh","raw_affiliation_strings":["Snowwhitefactory Co., Ltd","University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Snowwhitefactory Co., Ltd","institution_ids":[]},{"raw_affiliation_string":"University","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053649576","display_name":"Jeehaeng Jeong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeehaeng Jeong","raw_affiliation_strings":["Snowwhitefactory Co., Ltd","University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Snowwhitefactory Co., Ltd","institution_ids":[]},{"raw_affiliation_string":"University","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084328314","display_name":"Xiangji Jin","orcid":"https://orcid.org/0009-0006-4168-0403","observed_orcids":["https://orcid.org/0009-0006-4168-0403"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Xiangji Jin","raw_affiliation_strings":["Kyung Hee University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyung Hee University","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060080786","display_name":"Myeongju Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Myeongju Kim","raw_affiliation_strings":["Kyung Hee University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyung Hee University","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080921078","display_name":"Sheng Zheng","orcid":"https://orcid.org/0000-0003-3398-4627","observed_orcids":["https://orcid.org/0000-0003-3398-4627"]},"institutions":[{"id":"https://openalex.org/I4210107562","display_name":"Semyung University","ror":"https://ror.org/01d100w34","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210107562"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Shengdao Zheng","raw_affiliation_strings":["Snowwhitefactory Co., Ltd","Semyung University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Snowwhitefactory Co., Ltd","institution_ids":[]},{"raw_affiliation_string":"Semyung University","institution_ids":["https://openalex.org/I4210107562"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100616254","display_name":"Yong\u2010Min Kim","orcid":"https://orcid.org/0000-0002-3064-9412","observed_orcids":["https://orcid.org/0000-0002-3064-9412"]},"institutions":[{"id":"https://openalex.org/I4210107562","display_name":"Semyung University","ror":"https://ror.org/01d100w34","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210107562"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yong-Min Kim","raw_affiliation_strings":["Semyung University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Semyung University","institution_ids":["https://openalex.org/I4210107562"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043673106","display_name":"Tae\u2010Hoo Yi","orcid":"https://orcid.org/0000-0001-9369-6542","observed_orcids":["https://orcid.org/0000-0001-9369-6542"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Tae-Hoo Yi","raw_affiliation_strings":["Kyung Hee University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyung Hee University","institution_ids":["https://openalex.org/I35928602"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5043673106"],"corresponding_institution_ids":["https://openalex.org/I35928602"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11322","display_name":"Facial Rejuvenation and Surgery Techniques","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phaseolus-angularis","display_name":"Phaseolus angularis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/anti-aging-treatment","display_name":"anti-aging therapy","score":0.7680000066757202},{"id":"https://openalex.org/keywords/photoaging","display_name":"photoaging","score":0.8429999947547913},{"id":"https://openalex.org/keywords/wrinkle-improvement","display_name":"wrinkle improvement","score":0.6499999761581421},{"id":"https://openalex.org/keywords/skin-roughness","display_name":"skin roughness","score":0.7689999938011169},{"id":"https://openalex.org/keywords/topical-cream","display_name":"topical cream","score":0.6349999904632568},{"id":"https://openalex.org/keywords/natural-cosmetics","display_name":"natural cosmetics","score":0.6389999985694885},{"id":"https://openalex.org/keywords/uvb-protection","display_name":"UVB protection","score":0.6940000057220459},{"id":"https://openalex.org/keywords/hacat-cells","display_name":"HaCaT keratinocytes","score":0.8140000104904175}],"concepts":[{"id":"https://openalex.org/C2777872592","wikidata":"https://www.wikidata.org/wiki/Q349185","display_name":"Wrinkle","level":2,"score":0.9315005540847778},{"id":"https://openalex.org/C2776960578","wikidata":"https://www.wikidata.org/wiki/Q3705873","display_name":"Photoaging","level":2,"score":0.9071224927902222},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6703720688819885},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6312003135681152},{"id":"https://openalex.org/C2909910311","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Skin Aging","level":2,"score":0.45768988132476807},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.45590466260910034},{"id":"https://openalex.org/C19720800","wikidata":"https://www.wikidata.org/wiki/Q7722","display_name":"Morning","level":2,"score":0.4288186728954315},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2458634376525879},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12608256936073303},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-2664226/v1","doi":"https://doi.org/10.21203/rs.3.rs-2664226/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-2664226/v1","pdf_url":"https://www.researchsquare.com/article/rs-2664226/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-2664226/v1","doi":"https://doi.org/10.21203/rs.3.rs-2664226/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-2664226/v1","pdf_url":"https://www.researchsquare.com/article/rs-2664226/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G675260798","display_name":null,"funder_award_id":"S3160102","funder_id":"https://openalex.org/F4320327819","funder_display_name":"Ministry of SMEs and Startups"}],"funders":[{"id":"https://openalex.org/F4320327819","display_name":"Ministry of SMEs and Startups","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4324045895.pdf","grobid_xml":"https://content.openalex.org/works/W4324045895.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1727506032","https://openalex.org/W1988007485","https://openalex.org/W1994972521","https://openalex.org/W2031449464","https://openalex.org/W2039773944","https://openalex.org/W2056758965","https://openalex.org/W2063967757","https://openalex.org/W2071353897","https://openalex.org/W2071419221","https://openalex.org/W2112501841","https://openalex.org/W2121511326","https://openalex.org/W2134987073","https://openalex.org/W2149761207","https://openalex.org/W2154749879","https://openalex.org/W2170784637","https://openalex.org/W2206739480","https://openalex.org/W2281774277","https://openalex.org/W2409710963","https://openalex.org/W2531545899","https://openalex.org/W2574794987","https://openalex.org/W2800438504","https://openalex.org/W2801393350","https://openalex.org/W2910334608","https://openalex.org/W2979750773","https://openalex.org/W2981465012","https://openalex.org/W2991567342","https://openalex.org/W3007088350","https://openalex.org/W3093628151","https://openalex.org/W3110672704","https://openalex.org/W3111545648","https://openalex.org/W3115033946","https://openalex.org/W3116795213","https://openalex.org/W4308197795"],"related_works":["https://openalex.org/W4311958368","https://openalex.org/W4389628423","https://openalex.org/W4319035137","https://openalex.org/W2464079148","https://openalex.org/W7134073746","https://openalex.org/W4400158608","https://openalex.org/W4405662719","https://openalex.org/W7155557578","https://openalex.org/W12981099","https://openalex.org/W7213644765"],"abstract_inverted_index":{"Abstract":[0],"Skin":[1],"photoaging":[2,39],"is":[3,201],"caused":[4],"by":[5,126,172],"prolonged":[6],"exposure":[7],"to":[8,83,90,99,190],"ultraviolet":[9],"(UV)":[10],"radiation":[11],"from":[12],"sunlight.":[13],"UV-exposed":[14],"skin":[15,129],"appears":[16],"rough,":[17],"thick,":[18,117],"dry,":[19],"loose,":[20],"and":[21,24,96,109,131,150,168,175,206],"showsdeep":[22],"wrinkles,":[23],"thickening.":[25],"Our":[26,184],"previous":[27],"research":[28],"showed":[29,186],"that":[30,187],"a":[31,85,97,106,132,135,202,214],"Phaseolus":[32],"angularis":[33],"seed":[34],"extract":[35],"(PASE)":[36],"effectively":[37],"inhibits":[38],"through":[40],"UVB":[41],"protection":[42],"in":[43,53,71,116,156,221],"HaCaT":[44],"cells.":[45],"However,":[46],"its":[47],"efficacy":[48],"has":[49],"not":[50],"been":[51],"evaluated":[52],"clinical":[54],"trials":[55],"so":[56],"far.":[57],"In":[58,177,197],"this":[59],"single-centered,":[60],"randomized,":[61],"double-blind":[62],"study,":[63],"we":[64],"investigated":[65],"the":[66,91,100,122,137,157,160,222],"anti-aging":[67],"effect":[68],"of":[69,194],"PASE":[70,86,161,188,200],"eye":[72,93,102],"wrinkle":[73,94,103,195],"areas.":[74],"To":[75],"these":[76],"21":[77],"healthy":[78],"adult":[79],"women":[80],"aged":[81],"30":[82],"59,":[84],"cream":[87,162],"was":[88,124],"applied":[89],"right":[92],"area":[95,104],"placebo":[98],"left":[101],"twice":[105],"day":[107],"(morning":[108],"evening)":[110],"for":[111,217],"12":[112],"weeks.":[113],"The":[114],"change":[115],"deep":[118],"crease":[119],"wrinkles":[120],"around":[121],"eyes":[123],"confirmed":[125],"visual":[127],"evaluation,":[128],"measurements,":[130],"questionnaire.":[133],"As":[134],"result,":[136],"R1":[138],"(surface":[139],"roughness),":[140,143,146],"R2":[141],"(maximum":[142],"R3":[144],"(average":[145],"R4":[147],"(smoothness":[148],"depth),":[149],"R5":[151,169],"(arithmetic":[152],"mean":[153],"roughness)":[154],"values":[155],"group":[158],"using":[159],"all":[163],"decreased.":[164],"Particularly,":[165],"R1,":[166],"R4,":[167],"significantly":[170],"decreased":[171],"18.1%,":[173],"18.6%,":[174],"25.0%.":[176],"addition,":[178],"no":[179],"participants":[180],"reported":[181],"side":[182,209],"effects.":[183],"study":[185],"led":[189],"clinically":[191],"significant":[192],"levels":[193],"improvement.":[196],"conclusion,":[198],"as":[199],"natural":[203,218],"food,":[204],"safe,":[205],"with":[207],"few":[208],"effects,":[210],"it":[211],"can":[212],"be":[213],"good":[215],"resource":[216],"anti-wrinkle":[219],"cosmetics":[220],"future.":[223]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-03-14T00:00:00"}