{"id":"https://openalex.org/W4323967459","doi":"https://doi.org/10.1177/17562848231155987","title":"Pursuing neutrophils: systematic scoping review on blood-based biomarkers as predictors of treatment outcomes in inflammatory bowel disease","display_name":"Pursuing neutrophils: systematic scoping review on blood-based biomarkers as predictors of treatment outcomes in inflammatory bowel disease","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4323967459","doi":"https://doi.org/10.1177/17562848231155987","pmid":"https://pubmed.ncbi.nlm.nih.gov/36923488","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10009059"},"language":"en","primary_location":{"id":"doi:10.1177/17562848231155987","doi":"https://doi.org/10.1177/17562848231155987","is_oa":true,"landing_page_url":"https://doi.org/10.1177/17562848231155987","pdf_url":null,"source":{"id":"https://openalex.org/S23481971","display_name":"Therapeutic Advances in Gastroenterology","issn_l":"1756-283X","issn":["1756-283X","1756-2848"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Advances in Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1177/17562848231155987","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045428922","display_name":"Diogo Magalh\u00e3es","orcid":"https://orcid.org/0000-0002-0800-9136","observed_orcids":["https://orcid.org/0000-0002-0800-9136"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Diogo Magalhaes","raw_affiliation_strings":["Department of Biomedicine, Unit of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine, Unit of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Porto, Portugal","institution_ids":["https://openalex.org/I182534213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042884495","display_name":"Laurent Peyrin\u2010Biroulet","orcid":"https://orcid.org/0000-0003-2536-6618","observed_orcids":["https://orcid.org/0000-0003-2536-6618"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210100260","display_name":"Centre Hospitalier R\u00e9gional et Universitaire de Nancy","ror":"https://ror.org/016ncsr12","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100260"]},{"id":"https://openalex.org/I4387152275","display_name":"Nutrition-G\u00e9n\u00e9tique et Exposition aux Risques Environnementaux","ror":"https://ror.org/053d03003","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4387152275","https://openalex.org/I90183372"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laurent Peyrin-Biroulet","raw_affiliation_strings":["Department of Gastroenterology and Inserm NGERE U1256, University Hospital of Nancy, University of Lorraine, Vandoeuvre-l\u00e8s-Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Inserm NGERE U1256, University Hospital of Nancy, University of Lorraine, Vandoeuvre-l\u00e8s-Nancy, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210100260","https://openalex.org/I4387152275","https://openalex.org/I90183372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038543325","display_name":"Mar\u00eda Manuela Estevinho","orcid":"https://orcid.org/0000-0001-7171-0139","observed_orcids":["https://orcid.org/0000-0001-7171-0139"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210141686","display_name":"Centro Hospitalar de Vila Nova de Gaia","ror":"https://ror.org/042jpy919","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210141686"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Maria Manuela Estevinho","raw_affiliation_strings":["Department of Biomedicine, Unit of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Porto, Portugal","Department of Gastroenterology, Vila Nova de Gaia/Espinho Hospital Center, Vila Nova de Gaia, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine, Unit of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Porto, Portugal","institution_ids":["https://openalex.org/I182534213"]},{"raw_affiliation_string":"Department of Gastroenterology, Vila Nova de Gaia/Espinho Hospital Center, Vila Nova de Gaia, Portugal","institution_ids":["https://openalex.org/I4210141686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047563454","display_name":"Silvio Danese","orcid":"https://orcid.org/0000-0001-7341-1351","observed_orcids":["https://orcid.org/0000-0001-7341-1351"]},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvio Danese","raw_affiliation_strings":["Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy","IBD center, Humanitas Research Hospital, IRCCS, Rozzano, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy","institution_ids":["https://openalex.org/I1339471597"]},{"raw_affiliation_string":"IBD center, Humanitas Research Hospital, IRCCS, Rozzano, Milan, Italy","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052535018","display_name":"Fernando Magro","orcid":"https://orcid.org/0000-0003-2634-9668","observed_orcids":["https://orcid.org/0000-0003-2634-9668"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I3018176973","display_name":"Hospital de S\u00e3o Jo\u00e3o","ror":"https://ror.org/04qsnc772","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I3018176973"]},{"id":"https://openalex.org/I4210137384","display_name":"Centre for Health Technology and Services Research","ror":"https://ror.org/0434vme59","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4210137384"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Fernando Magro","raw_affiliation_strings":["Center for Health Technology and Services Research (CINTESIS), Porto, Portugal","Department of Biomedicine, Unit of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Rua Dr. Pl\u00e1cido Costa, 3, Porto, 4200-450, Portugal","Department of Gastroenterology, S\u00e3o Jo\u00e3o Hospital University Centre, Porto, Portugal","Portuguese Inflammatory Bowel Disease group (GEDII)","Unidade de Farmacologia Cl\u00ednica, S\u00e3o Jo\u00e3o Hospital University Centre, Porto, Portugal"],"raw_orcid":"https://orcid.org/0000-0003-2634-9668","affiliations":[{"raw_affiliation_string":"Center for Health Technology and Services Research (CINTESIS), Porto, Portugal","institution_ids":["https://openalex.org/I4210137384"]},{"raw_affiliation_string":"Department of Biomedicine, Unit of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Rua Dr. Pl\u00e1cido Costa, 3, Porto, 4200-450, Portugal","institution_ids":["https://openalex.org/I182534213"]},{"raw_affiliation_string":"Department of Gastroenterology, S\u00e3o Jo\u00e3o Hospital University Centre, Porto, Portugal","institution_ids":["https://openalex.org/I3018176973"]},{"raw_affiliation_string":"Portuguese Inflammatory Bowel Disease group (GEDII)","institution_ids":[]},{"raw_affiliation_string":"Unidade de Farmacologia Cl\u00ednica, S\u00e3o Jo\u00e3o Hospital University Centre, Porto, Portugal","institution_ids":["https://openalex.org/I3018176973"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5052535018"],"corresponding_institution_ids":["https://openalex.org/I182534213","https://openalex.org/I3018176973","https://openalex.org/I4210137384"],"apc_list":{"value":2300,"currency":"USD","value_usd":2300},"apc_paid":{"value":2300,"currency":"USD","value_usd":2300},"fwci":0.5381,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.49908088,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"16","issue":null,"first_page":"17562848231155987","last_page":"17562848231155987"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.9760000109672546},{"id":"https://openalex.org/keywords/blood-based-biomarkers","display_name":"blood-based biomarkers","score":0.9649999737739563},{"id":"https://openalex.org/keywords/treatment-outcome-prediction","display_name":"treatment outcome prediction","score":0.9399999976158142},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.9900000095367432},{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":1.0},{"id":"https://openalex.org/keywords/calprotectin","display_name":"calprotectin","score":0.8199999928474426},{"id":"https://openalex.org/keywords/oncostatin-m","display_name":"oncostatin M","score":0.972000002861023},{"id":"https://openalex.org/keywords/neutrophil-elastase","display_name":"neutrophil elastase","score":0.8629999756813049},{"id":"https://openalex.org/keywords/trem-1","display_name":"TREM-1","score":0.8550000190734863},{"id":"https://openalex.org/keywords/neutrophil-extracellular-traps","display_name":"neutrophil extracellular traps","score":0.6570000052452087},{"id":"https://openalex.org/keywords/s100a12","display_name":"S100A12","score":0.8479999899864197},{"id":"https://openalex.org/keywords/neutrophil-gelatinase-associated-lipocalin","display_name":"neutrophil gelatinase-associated lipocalin","score":0.8429999947547913},{"id":"https://openalex.org/keywords/ll-37","display_name":"LL-37","score":0.8309999704360962},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.4950000047683716}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8674370050430298},{"id":"https://openalex.org/C2778292693","wikidata":"https://www.wikidata.org/wiki/Q22328664","display_name":"Calprotectin","level":4,"score":0.8396486043930054},{"id":"https://openalex.org/C2776317360","wikidata":"https://www.wikidata.org/wiki/Q14905648","display_name":"Neutrophil elastase","level":3,"score":0.5909652709960938},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.5502800345420837},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5441071391105652},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5086796879768372},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.505657434463501},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.4943385124206543},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4161616265773773},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.36712539196014404},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.31326138973236084},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.25126373767852783},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1177/17562848231155987","doi":"https://doi.org/10.1177/17562848231155987","is_oa":true,"landing_page_url":"https://doi.org/10.1177/17562848231155987","pdf_url":null,"source":{"id":"https://openalex.org/S23481971","display_name":"Therapeutic Advances in Gastroenterology","issn_l":"1756-283X","issn":["1756-283X","1756-2848"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Advances in Gastroenterology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10009059","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10009059","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10009059/pdf/10.1177_17562848231155987.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therap Adv Gastroenterol","raw_type":"Text"},{"id":"pmid:36923488","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36923488","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic advances in gastroenterology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:47eeeb31cfd34315b732403bfd589160","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/47eeeb31cfd34315b732403bfd589160","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Therapeutic Advances in Gastroenterology, Vol 16 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1177/17562848231155987","doi":"https://doi.org/10.1177/17562848231155987","is_oa":true,"landing_page_url":"https://doi.org/10.1177/17562848231155987","pdf_url":null,"source":{"id":"https://openalex.org/S23481971","display_name":"Therapeutic Advances in Gastroenterology","issn_l":"1756-283X","issn":["1756-283X","1756-2848"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Advances in Gastroenterology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4323967459.pdf","grobid_xml":"https://content.openalex.org/works/W4323967459.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W65595218","https://openalex.org/W88943984","https://openalex.org/W1974217486","https://openalex.org/W1974838035","https://openalex.org/W1982304490","https://openalex.org/W2003737781","https://openalex.org/W2008345543","https://openalex.org/W2022798385","https://openalex.org/W2024798843","https://openalex.org/W2036552077","https://openalex.org/W2037249933","https://openalex.org/W2052776464","https://openalex.org/W2055213169","https://openalex.org/W2064557077","https://openalex.org/W2079733143","https://openalex.org/W2107274834","https://openalex.org/W2110299641","https://openalex.org/W2155178750","https://openalex.org/W2161374186","https://openalex.org/W2173095346","https://openalex.org/W2320552475","https://openalex.org/W2513920879","https://openalex.org/W2528453882","https://openalex.org/W2581785719","https://openalex.org/W2593085926","https://openalex.org/W2604780989","https://openalex.org/W2613759337","https://openalex.org/W2779922261","https://openalex.org/W2790434969","https://openalex.org/W2795429678","https://openalex.org/W2801876748","https://openalex.org/W2809294474","https://openalex.org/W2884572336","https://openalex.org/W2884826108","https://openalex.org/W2891378911","https://openalex.org/W2908458267","https://openalex.org/W2912129903","https://openalex.org/W2933639593","https://openalex.org/W2966314303","https://openalex.org/W2969248609","https://openalex.org/W2977922594","https://openalex.org/W2980725718","https://openalex.org/W2989747340","https://openalex.org/W2999084747","https://openalex.org/W3018216828","https://openalex.org/W3019058605","https://openalex.org/W3022073735","https://openalex.org/W3033854321","https://openalex.org/W3081902840","https://openalex.org/W3087517738","https://openalex.org/W3113400896","https://openalex.org/W3115410759","https://openalex.org/W3131805557","https://openalex.org/W3134346695","https://openalex.org/W3170116140","https://openalex.org/W3173062350","https://openalex.org/W3197827253","https://openalex.org/W3208419348","https://openalex.org/W3214011159","https://openalex.org/W4200442660","https://openalex.org/W4205838617","https://openalex.org/W4206389187","https://openalex.org/W4207014846","https://openalex.org/W4207041686","https://openalex.org/W4210846631","https://openalex.org/W4220670683","https://openalex.org/W4225102312","https://openalex.org/W4225526007","https://openalex.org/W4287010289"],"related_works":["https://openalex.org/W6887758794","https://openalex.org/W7203634793","https://openalex.org/W4400610472","https://openalex.org/W7155986643","https://openalex.org/W7156697428","https://openalex.org/W4411342681","https://openalex.org/W7168149338","https://openalex.org/W7066027224","https://openalex.org/W2049657114","https://openalex.org/W4214812325"],"abstract_inverted_index":{"Background:":[0],"Long-term":[1],"management":[2],"of":[3,13,47,75,82,111,247,271],"inflammatory":[4],"bowel":[5],"diseases":[6],"(IBD)":[7],"is":[8,19],"challenging":[9],"and":[10,63,78,98,145,155,180,199,213,257],"the":[11,30,41,45,109,223,238,244,248],"identification":[12],"reliable":[14],"predictors":[15],"for":[16,95,206,222],"treatment":[17,53,117],"outcomes":[18,54,118],"an":[20],"unmet":[21],"need.":[22],"Neutrophil-related":[23],"biomarkers":[24,50,139,166,190],"have":[25,35],"been":[26],"mainly":[27],"studied":[28],"in":[29,55,70,132,237],"feces,":[31],"but":[32],"blood":[33,251],"analyses":[34],"inherent":[36],"advantages.":[37],"Objective:":[38],"To":[39],"review":[40],"recent":[42],"learnings":[43],"on":[44,184,267],"ability":[46,219],"blood-based":[48,105],"neutrophil-expressed":[49,252],"to":[51,91,242],"predict":[52],"IBD.":[56],"Design:":[57],"Systematic":[58,96],"scoping":[59],"review.":[60],"Data":[61],"sources":[62],"methods:":[64],"We":[65],"performed":[66],"a":[67,227,272],"literature":[68],"search":[69],"Pubmed,":[71],"EMBASE,":[72],"SCOPUS,":[73],"Web":[74],"Science,":[76],"ScienceDirect,":[77],"Cochrane":[79],"Central":[80],"Register":[81],"Controlled":[83],"Trials":[84],"from":[85,140],"inception":[86],"until":[87],"May":[88],"2022":[89],"according":[90],"Preferred":[92],"Reporting":[93],"Items":[94],"reviews":[97],"Meta-Analyses":[99],"guidelines.":[100],"All":[101],"human":[102,207],"studies":[103,127],"associating":[104],"neutrophil-related":[106],"compounds":[107],"with":[108],"prediction":[110],"disease":[112,153],"progression,":[113],"complication":[114],"onset,":[115],"or":[116,134],"were":[119,128,147,161,167,204],"included.":[120,162],"Results:":[121],"From":[122],"1032":[123],"retrieved":[124],"entries,":[125],"34":[126],"selected,":[129],"32":[130],"published":[131],"2013":[133],"later.":[135],"In":[136,149],"all,":[137],"17":[138],"granules,":[141],"cytoplasm,":[142],"plasmatic":[143],"membrane,":[144],"plasma":[146],"explored.":[148],"total,":[150],"1850":[151],"Crohn's":[152],"(CD)":[154],"1122":[156],"ulcerative":[157],"colitis":[158],"non-duplicated":[159],"patients":[160],"The":[163],"most":[164],"mentioned":[165],"nCD64,":[168,197,255],"serum":[169],"calprotectin":[170,177],"(SC),":[171],"oncostatin":[172],"M":[173],"(OSM),":[174],"neutrophil":[175,208,214,228],"elastase-generated":[176],"fragment":[178],"(CPa9-HNE),":[179],"triggering":[181],"receptor":[182],"expressed":[183],"myeloid":[185],"cells":[186],"1":[187],"(TREM1).":[188],"Six":[189],"showed":[191],"promising":[192],"results:":[193],"OSM,":[194],"SC,":[195],"eNAMPT,":[196],"TREM1,":[198,256],"CPa9-HNE.":[200,258],"Variable":[201],"positive":[202],"signals":[203],"found":[205,221],"peptide":[209],"1-3,":[210],"LL-37,":[211],"S100A12,":[212],"gelatinase-associated":[215],"lipocalin.":[216],"No":[217],"predictive":[218],"was":[220],"remaining":[224],"markers.":[225],"Sharing":[226],"compartment":[229],"did":[230],"not":[231],"indicate":[232],"similar":[233],"behavior.":[234],"Conclusion:":[235],"Advances":[236],"last":[239],"decade":[240],"began":[241],"unveil":[243],"untapped":[245],"potential":[246],"readily":[249],"accessible":[250],"biomarkers,":[253],"especially":[254],"Current":[259],"evidence":[260],"suggests":[261],"that":[262],"future":[263],"research":[264],"should":[265],"focus":[266],"well-defined":[268],"subpopulations":[269],"instead":[270],"one-size-fits-all":[273],"biomarker.":[274],"Registration:":[275],"https://osf.io/kes9a.":[276]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-03-13T00:00:00"}