{"id":"https://openalex.org/W4323928429","doi":"https://doi.org/10.1096/fj.202202164r","title":"Long\u2010lived autoreactive memory CD4 + T cells mediate the sustained retinopathy in chronic autoimmune uveitis","display_name":"Long\u2010lived autoreactive memory CD4 + T cells mediate the sustained retinopathy in chronic autoimmune uveitis","publication_year":2023,"publication_date":"2023-03-11","ids":{"openalex":"https://openalex.org/W4323928429","doi":"https://doi.org/10.1096/fj.202202164r","pmid":"https://pubmed.ncbi.nlm.nih.gov/36906286","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10478160"},"language":"en","primary_location":{"id":"doi:10.1096/fj.202202164r","doi":"https://doi.org/10.1096/fj.202202164r","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fj.202202164r","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10478160/pdf/nihms-1927877.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027390524","display_name":"Nai\u2010Wen Fan","orcid":"https://orcid.org/0009-0006-3147-5043","observed_orcids":["https://orcid.org/0009-0006-3147-5043"]},"institutions":[{"id":"https://openalex.org/I1287163989","display_name":"Massachusetts Eye and Ear Infirmary","ror":"https://ror.org/04g3dn724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1287163989"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]},{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]}],"countries":["TW","US"],"is_corresponding":false,"raw_author_name":"Nai\u2010Wen Fan","raw_affiliation_strings":["Department of Ophthalmology, Harvard Medical School, Schepens Eye Research Institute of Massachusetts Eye and Ear, Boston, Massachusetts, USA","Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan","Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Hsinchu, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Harvard Medical School, Schepens Eye Research Institute of Massachusetts Eye and Ear, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1287163989","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Hsinchu, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112454448","display_name":"Qiurong Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1287163989","display_name":"Massachusetts Eye and Ear Infirmary","ror":"https://ror.org/04g3dn724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1287163989"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qiurong Zhu","raw_affiliation_strings":["Department of Ophthalmology, Harvard Medical School, Schepens Eye Research Institute of Massachusetts Eye and Ear, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Harvard Medical School, Schepens Eye Research Institute of Massachusetts Eye and Ear, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1287163989","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089201871","display_name":"Shudan Wang","orcid":"https://orcid.org/0000-0002-9292-0992","observed_orcids":["https://orcid.org/0000-0002-9292-0992"]},"institutions":[{"id":"https://openalex.org/I1287163989","display_name":"Massachusetts Eye and Ear Infirmary","ror":"https://ror.org/04g3dn724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1287163989"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shudan Wang","raw_affiliation_strings":["Department of Ophthalmology, Harvard Medical School, Schepens Eye Research Institute of Massachusetts Eye and Ear, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Harvard Medical School, Schepens Eye Research Institute of Massachusetts Eye and Ear, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1287163989","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000038582","display_name":"Gustavo Ortiz","orcid":"https://orcid.org/0000-0002-0186-6530","observed_orcids":["https://orcid.org/0000-0002-0186-6530"]},"institutions":[{"id":"https://openalex.org/I1287163989","display_name":"Massachusetts Eye and Ear Infirmary","ror":"https://ror.org/04g3dn724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1287163989"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gustavo Ortiz","raw_affiliation_strings":["Department of Ophthalmology, Harvard Medical School, Schepens Eye Research Institute of Massachusetts Eye and Ear, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Harvard Medical School, Schepens Eye Research Institute of Massachusetts Eye and Ear, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1287163989","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035711783","display_name":"Rachel M. Huckfeldt","orcid":"https://orcid.org/0000-0002-9220-2261","observed_orcids":["https://orcid.org/0000-0002-9220-2261"]},"institutions":[{"id":"https://openalex.org/I1287163989","display_name":"Massachusetts Eye and Ear Infirmary","ror":"https://ror.org/04g3dn724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1287163989"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel M. Huckfeldt","raw_affiliation_strings":["Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1287163989","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042050339","display_name":"Yihe Chen","orcid":"https://orcid.org/0000-0002-2336-6182","observed_orcids":["https://orcid.org/0000-0002-2336-6182","https://orcid.org/0009-0000-3571-8870"]},"institutions":[{"id":"https://openalex.org/I1287163989","display_name":"Massachusetts Eye and Ear Infirmary","ror":"https://ror.org/04g3dn724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1287163989"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yihe Chen","raw_affiliation_strings":["Department of Ophthalmology, Harvard Medical School, Schepens Eye Research Institute of Massachusetts Eye and Ear, Boston, Massachusetts, USA"],"raw_orcid":"https://orcid.org/0000-0002-2336-6182","affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Harvard Medical School, Schepens Eye Research Institute of Massachusetts Eye and Ear, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1287163989","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5042050339"],"corresponding_institution_ids":["https://openalex.org/I1287163989","https://openalex.org/I136199984"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":null,"fwci":3.3701,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.9260862,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"37","issue":"4","first_page":"e22855","last_page":"e22855"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/memory-cd4-t-cells","display_name":"memory CD4+ T cells","score":0.8529999852180481},{"id":"https://openalex.org/keywords/autoreactive-t-cells","display_name":"autoreactive T cells","score":0.9259999990463257},{"id":"https://openalex.org/keywords/retinopathy","display_name":"retinopathy","score":0.7059999704360962},{"id":"https://openalex.org/keywords/il-15","display_name":"IL-15","score":0.628000020980835},{"id":"https://openalex.org/keywords/interleukin-7","display_name":"IL-7","score":0.8339999914169312},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":0.7620000243186951},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9660000205039978},{"id":"https://openalex.org/keywords/intraocular-inflammation","display_name":"intraocular inflammation","score":0.7210000157356262},{"id":"https://openalex.org/keywords/retinal-damage","display_name":"retinal damage","score":0.5609999895095825},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C2776194053","wikidata":"https://www.wikidata.org/wiki/Q280027","display_name":"Uveitis","level":2,"score":0.7479931116104126},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6413370370864868},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5837000608444214},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47018328309059143},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4346715211868286},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.41229814291000366},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3630291819572449}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012164","descriptor_name":"Retinal Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014605","descriptor_name":"Uveitis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1096/fj.202202164r","doi":"https://doi.org/10.1096/fj.202202164r","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fj.202202164r","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},{"id":"pmid:36906286","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36906286","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10478160","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10478160","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10478160/pdf/nihms-1927877.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"FASEB J","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10478160","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10478160","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10478160/pdf/nihms-1927877.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"FASEB J","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4616509172","display_name":null,"funder_award_id":"P30EY003790","funder_id":"https://openalex.org/F4320309699","funder_display_name":"Massachusetts Eye and Ear"},{"id":"https://openalex.org/G593431837","display_name":"Pathogenicity of memory Th17 cells in chronic autoimmune uveitis","funder_award_id":"R21EY031781","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G8341515271","display_name":null,"funder_award_id":"EY031781","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G9000913113","display_name":"Core Grant for Vision Research","funder_award_id":"P30EY003790","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320306080","display_name":"Foundation for the National Institutes of Health","ror":"https://ror.org/00k86s890"},{"id":"https://openalex.org/F4320309699","display_name":"Massachusetts Eye and Ear","ror":"https://ror.org/04g3dn724"},{"id":"https://openalex.org/F4320310048","display_name":"Massachusetts Lions Eye Research Fund","ror":"https://ror.org/05hffq650"},{"id":"https://openalex.org/F4320323275","display_name":"National Yang-Ming University","ror":"https://ror.org/009h5ks85"},{"id":"https://openalex.org/F4320327358","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4323928429.pdf","grobid_xml":"https://content.openalex.org/works/W4323928429.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W1516263086","https://openalex.org/W1553247507","https://openalex.org/W1928412993","https://openalex.org/W1965411838","https://openalex.org/W1978021965","https://openalex.org/W1980661152","https://openalex.org/W1980973795","https://openalex.org/W1981651463","https://openalex.org/W1991754241","https://openalex.org/W1991766753","https://openalex.org/W1995391551","https://openalex.org/W2001282809","https://openalex.org/W2010234200","https://openalex.org/W2011435677","https://openalex.org/W2017893786","https://openalex.org/W2026620460","https://openalex.org/W2037269612","https://openalex.org/W2038374656","https://openalex.org/W2043198160","https://openalex.org/W2059141867","https://openalex.org/W2061217789","https://openalex.org/W2066560916","https://openalex.org/W2077486579","https://openalex.org/W2077982842","https://openalex.org/W2078781365","https://openalex.org/W2082983272","https://openalex.org/W2093945135","https://openalex.org/W2094412198","https://openalex.org/W2095433065","https://openalex.org/W2103119361","https://openalex.org/W2104040734","https://openalex.org/W2111888415","https://openalex.org/W2112901522","https://openalex.org/W2113847305","https://openalex.org/W2126193607","https://openalex.org/W2131420789","https://openalex.org/W2135358480","https://openalex.org/W2147167907","https://openalex.org/W2150117087","https://openalex.org/W2151960040","https://openalex.org/W2155426437","https://openalex.org/W2170955899","https://openalex.org/W2274830109","https://openalex.org/W2405712190","https://openalex.org/W2419271990","https://openalex.org/W2550388627","https://openalex.org/W2565267802","https://openalex.org/W2621829859","https://openalex.org/W2719999682","https://openalex.org/W2731662468","https://openalex.org/W2762484263","https://openalex.org/W2787256597","https://openalex.org/W2788070661","https://openalex.org/W3011626148","https://openalex.org/W3012538686","https://openalex.org/W3025403854","https://openalex.org/W3041092590","https://openalex.org/W3043321092","https://openalex.org/W3088144672","https://openalex.org/W3130512165","https://openalex.org/W3167106377","https://openalex.org/W3174780254","https://openalex.org/W4200305939","https://openalex.org/W4206128862","https://openalex.org/W4231196213","https://openalex.org/W4233096244"],"related_works":["https://openalex.org/W7204782419","https://openalex.org/W2147167907","https://openalex.org/W3191649747","https://openalex.org/W3088144672","https://openalex.org/W2323701555","https://openalex.org/W4410091650","https://openalex.org/W1004991340","https://openalex.org/W2124026373","https://openalex.org/W7164560915","https://openalex.org/W4413408801"],"abstract_inverted_index":{"Abstract":[0],"Chronic":[1],"uveitis":[2,27,204],"comprises":[3],"heterogeneous":[4],"clinical":[5],"entities":[6],"characterized":[7],"by":[8,20],"sustained":[9],"and":[10,37,106,125,148,157,166,197],"recurrent":[11],"intraocular":[12,76,186],"inflammation":[13,77],"that":[14,189],"is":[15,28],"believed":[16],"to":[17,129,145,163],"be":[18,194],"driven":[19],"autoimmune":[21,86,115],"responses.":[22],"The":[23],"management":[24],"of":[25,34,50,59,84,114,142,177],"chronic":[26,75,85,185,203],"challenging":[29],"with":[30],"the":[31,38,48,56,60,70,146,151,173],"limited":[32],"availability":[33],"efficacious":[35],"treatments,":[36],"underlying":[39,74],"mechanisms":[40,73],"mediating":[41],"disease":[42,61],"chronicity":[43],"remain":[44],"poorly":[45],"understood":[46],"as":[47],"majority":[49],"experimental":[51],"data":[52,171],"are":[53,140],"derived":[54],"from":[55],"acute":[57],"phase":[58],"(the":[62],"first":[63],"2\u20133":[64],"weeks":[65],"post\u2010induction).":[66],"Herein,":[67],"we":[68],"investigated":[69],"key":[71],"cellular":[72],"using":[78],"our":[79,170],"recently":[80],"established":[81],"murine":[82],"model":[83],"uveitis.":[87,116],"We":[88],"demonstrate":[89],"unique":[90],"long\u2010lived":[91],"CD44":[92],"hi":[93],"IL\u20107R":[94],"+":[95,97,99,180],"IL\u201015R":[96],"CD4":[98,179],"memory":[100,118,178,190],"T":[101,119,138,181,191],"cells":[102,120,139,182,192],"in":[103,127,133,150,183,205],"both":[104,155],"retina":[105,147],"secondary":[107],"lymphoid":[108],"organs":[109],"after":[110],"3":[111],"months":[112],"postinduction":[113],"These":[117],"functionally":[121],"exhibit":[122],"antigen\u2010specific":[123],"proliferation":[124],"activation":[126],"response":[128],"retinal":[130,164],"peptide":[131],"stimulation":[132],"vitro.":[134],"Critically,":[135],"these":[136],"effector\u2010memory":[137],"capable":[141],"effectively":[143],"trafficking":[144],"accumulating":[149],"local":[152],"tissues":[153],"secreting":[154],"IL\u201017":[156],"IFN\u2010\u03b3":[158],"upon":[159],"adoptively":[160],"transferred,":[161],"leading":[162],"structural":[165],"functional":[167],"damage.":[168],"Thus,":[169],"reveal":[172],"critical":[174],"uveitogenic":[175],"functions":[176],"sustaining":[184],"inflammation,":[187],"suggesting":[188],"can":[193],"a":[195],"novel":[196],"promising":[198],"therapeutic":[199],"target":[200],"for":[201],"treating":[202],"future":[206],"translational":[207],"studies.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-03-12T00:00:00"}