{"id":"https://openalex.org/W43233463","doi":null,"title":"[Efficacy of cetuximab in therapy of metastatic colorectal cancer: a system evaluation].","display_name":"[Efficacy of cetuximab in therapy of metastatic colorectal cancer: a system evaluation].","publication_year":2009,"publication_date":"2009-05-26","ids":{"openalex":"https://openalex.org/W43233463","mag":"43233463","pmid":"https://pubmed.ncbi.nlm.nih.gov/19671328"},"language":"zh","primary_location":{"id":"pmid:19671328","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19671328","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua yi xue za zhi","raw_type":"English Abstract"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103421685","display_name":"Sheng-huai Hou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17721919","display_name":"Shanxi Medical University","ror":"https://ror.org/0265d1010","country_code":"CN","type":"education","lineage":["https://openalex.org/I17721919"]},{"id":"https://openalex.org/I4210133678","display_name":"Second Hospital of Shanxi Medical University","ror":"https://ror.org/03tn5kh37","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133678"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sheng-huai Hou","raw_affiliation_strings":["Department of General Surgery, Second Clinical Medicine College of Shanxi Medical University, Taiyuan 030001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Second Clinical Medicine College of Shanxi Medical University, Taiyuan 030001, China","institution_ids":["https://openalex.org/I17721919","https://openalex.org/I4210133678"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100713958","display_name":"Xiaobo Liang","orcid":"https://orcid.org/0000-0002-0852-3987","observed_orcids":["https://orcid.org/0000-0002-0852-3987"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao-bo Liang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103190483","display_name":"Wenqi Bai","orcid":"https://orcid.org/0009-0001-9779-9095","observed_orcids":["https://orcid.org/0009-0001-9779-9095"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wen-qi Bai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061426227","display_name":"Jun Yang","orcid":"https://orcid.org/0000-0002-4233-3220","observed_orcids":["https://orcid.org/0000-0002-4233-3220"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112961896","display_name":"Dong Yan","orcid":"https://orcid.org/0000-0002-8221-1965","observed_orcids":["https://orcid.org/0000-0002-8221-1965"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dong Yan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110516399","display_name":"Xin Zhang","orcid":"https://orcid.org/0000-0001-6036-2685","observed_orcids":["https://orcid.org/0000-0001-6036-2685","https://orcid.org/0000-0003-0124-099X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xin Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100661627","display_name":"Lichun Wang","orcid":"https://orcid.org/0000-0002-9757-3256","observed_orcids":["https://orcid.org/0000-0002-9757-3256"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li-chun Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00524691,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"89","issue":"20","first_page":"1387","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cetuximab","display_name":"cetuximab","score":1.0},{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":1.0},{"id":"https://openalex.org/keywords/anti-egfr-therapy","display_name":"anti-EGFR therapy","score":0.828000009059906},{"id":"https://openalex.org/keywords/irinotecan","display_name":"irinotecan","score":0.9649999737739563},{"id":"https://openalex.org/keywords/oxaliplatin","display_name":"oxaliplatin","score":0.9309999942779541},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.921999990940094},{"id":"https://openalex.org/keywords/leucovorin","display_name":"leucovorin","score":0.8769999742507935},{"id":"https://openalex.org/keywords/kras-mutation-status","display_name":"KRAS mutation status","score":0.8309999704360962},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.968999981880188},{"id":"https://openalex.org/keywords/tumor-response-rate","display_name":"tumor response rate","score":0.8640000224113464},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9039999842643738},{"id":"https://openalex.org/keywords/second-line-treatment","display_name":"second-line therapy","score":0.6589999794960022},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.9580000042915344}],"concepts":[{"id":"https://openalex.org/C2779998722","wikidata":"https://www.wikidata.org/wiki/Q420296","display_name":"Cetuximab","level":4,"score":0.9533467292785645},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9022635221481323},{"id":"https://openalex.org/C2780259306","wikidata":"https://www.wikidata.org/wiki/Q412197","display_name":"Irinotecan","level":4,"score":0.8803441524505615},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7805655002593994},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6906238794326782},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6873539686203003},{"id":"https://openalex.org/C2780962732","wikidata":"https://www.wikidata.org/wiki/Q422327","display_name":"Oxaliplatin","level":4,"score":0.6312680244445801},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.598902702331543},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5577380061149597},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.48954591155052185},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4696691930294037},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4436712861061096},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068818","descriptor_name":"Cetuximab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:19671328","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19671328","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua yi xue za zhi","raw_type":"English Abstract"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2034038962","https://openalex.org/W2107467998","https://openalex.org/W2095201384","https://openalex.org/W2313360580","https://openalex.org/W2068751193","https://openalex.org/W814222516","https://openalex.org/W3028669915","https://openalex.org/W2374705172","https://openalex.org/W2074826639","https://openalex.org/W2413825706"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"assess":[2],"the":[3,9,50,63,71,77,116,213,226,233,259],"clinical":[4,24,44,81],"efficacy":[5,45,257],"of":[6,11,47,101,105,147,156,163,181,190,196,216,261,267,277],"cetuximab":[7,30,164,197],"in":[8,31,176,251,258],"treatment":[10],"individuals":[12],"with":[13,70,127,199,225,230,235,253],"metastatic":[14,33,129,172,205,262],"colorectal":[15,34,130,173,206,227,263],"cancer.":[16],"METHODS:":[17],"Literature":[18],"searches":[19],"were":[20,53,83,86],"performed":[21,58],"on":[22,27],"all":[23],"trails":[25],"reported":[26],"target-therapy":[28],"agent":[29],"treating":[32],"cancer":[35,131,174,207,228],"prior":[36],"to":[37,76,136,138,165,170],"August":[38],"2008.":[39],"The":[40,161,193],"basic":[41],"characteristics":[42],"and":[43,95,151,185,212,244,265],"data":[46,64,111],"trials":[48,69],"meeting":[49],"screening":[51],"criteria":[52],"extracted.":[54],"Date":[55],"analysis":[56],"was":[57,208,219],"by":[59,115],"RevMan":[60],"4.2":[61],"if":[62],"came":[65],"from":[66],"randomized":[67,88,107],"controlled":[68,89,93,108],"same":[72],"objective.":[73],"RESULTS:":[74],"According":[75],"selection":[78],"criteria,":[79],"22":[80],"studies":[82],"included.":[84],"There":[85],"8":[87,106],"trials,":[90,109],"1":[91],"non-randomized":[92],"trial":[94],"13":[96],"single":[97],"group":[98],"trials.":[99],"Because":[100],"different":[102],"study":[103],"objectives":[104],"no":[110],"could":[112,141,238],"be":[113],"analyzed":[114],"Meta-analysis":[117],"method.":[118],"Cetuximab":[119,250],"plus":[120],"irinotecan":[121,166],"as":[122,167,201],"second-line":[123],"therapy":[124,140,169,203,260],"for":[125,204,275],"patients":[126,234],"EGFR-expressing":[128],"who":[132],"had":[133],"previously":[134],"failed":[135],"respond":[137],"irinotecan-added":[139],"reach":[142],"a":[143,177,240,245],"tumor":[144,178],"response":[145,179,194,242,276],"rate":[146,180,195,243],"16.4%":[148],"-":[149,158,183,210,221],"23.0%,":[150],"median":[152,186,214],"overall":[153,187,217],"survival":[154,188,218],"duration":[155,189,215],"8.6":[157],"10.7":[159],"months.":[160,192,223],"addition":[162],"first-line":[168,202],"treat":[171],"resulted":[175],"42.0%":[182],"67.0%,":[184],"33.0":[191],"combined":[198],"oxaliplatin/5-FU/LV":[200],"46.0%":[209],"72.0%":[211],"28.2":[220],"30.0":[222],"Compared":[224],"population":[229],"mutant":[231],"KRAS,":[232],"wild-type":[236],"KRAS":[237,269],"obtain":[239],"higher":[241],"longer":[246],"progression-free":[247],"survival.":[248],"CONCLUSION:":[249],"combination":[252],"chemotherapy":[254],"has":[255],"promising":[256],"cancer,":[264],"status":[266],"gene":[268],"is":[270],"an":[271],"independent":[272],"predictive":[273],"marker":[274],"cetuximab.":[278]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}
