{"id":"https://openalex.org/W4322770122","doi":"https://doi.org/10.1158/1538-7445.sabcs22-p3-03-13","title":"Abstract P3-03-13: Long-term heart failure risk of trastuzumab with or without anthracyclines in early stage breast cancer: A SEER-Medicare Database Analysis","display_name":"Abstract P3-03-13: Long-term heart failure risk of trastuzumab with or without anthracyclines in early stage breast cancer: A SEER-Medicare Database Analysis","publication_year":2023,"publication_date":"2023-03-01","ids":{"openalex":"https://openalex.org/W4322770122","doi":"https://doi.org/10.1158/1538-7445.sabcs22-p3-03-13"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.sabcs22-p3-03-13","doi":"https://doi.org/10.1158/1538-7445.sabcs22-p3-03-13","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.sabcs22-p3-03-13","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088539775","display_name":"Nicholas Patrick McAndrew","orcid":"https://orcid.org/0000-0002-6799-5204","observed_orcids":["https://orcid.org/0000-0002-6799-5204"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas P. McAndrew","raw_affiliation_strings":["1UCLA David Geffen School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UCLA David Geffen School of Medicine","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032479645","display_name":"Karissa Britten","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karissa Britten","raw_affiliation_strings":["2UCLA David Geffen School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2UCLA David Geffen School of Medicine","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100381768","display_name":"Xiaoyan Wang","orcid":"https://orcid.org/0000-0001-7406-5008","observed_orcids":["https://orcid.org/0000-0001-7406-5008","https://orcid.org/0009-0004-5381-9383"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoyan Wang","raw_affiliation_strings":["3UCLA David Geffen School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3UCLA David Geffen School of Medicine","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075120074","display_name":"Eric H. Yang","orcid":"https://orcid.org/0000-0003-4889-7454","observed_orcids":["https://orcid.org/0000-0003-4889-7454"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Yang","raw_affiliation_strings":["4UCLA David Geffen School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4UCLA David Geffen School of Medicine","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068059897","display_name":"Sara Alsterlind Hurvitz","orcid":"https://orcid.org/0000-0001-7808-7191","observed_orcids":["https://orcid.org/0000-0001-7808-7191"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara Hurvitz","raw_affiliation_strings":["5University of California, Los Angeles, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5University of California, Los Angeles, Los Angeles, California","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015491002","display_name":"Dennis J. Slamon","orcid":"https://orcid.org/0000-0002-6330-498X","observed_orcids":["https://orcid.org/0000-0002-6330-498X"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis Slamon","raw_affiliation_strings":["6UCLA David Geffen School of Medicine, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6UCLA David Geffen School of Medicine, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"83","issue":"5_Supplement","first_page":"P3","last_page":"03"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":0.9919999837875366},{"id":"https://openalex.org/keywords/anthracyclines","display_name":"anthracyclines","score":0.9589999914169312},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.8650000095367432},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.9570000171661377},{"id":"https://openalex.org/keywords/early-breast-cancer","display_name":"early breast cancer","score":0.9190000295639038},{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/long-term-risk","display_name":"long-term risk","score":0.6050000190734863},{"id":"https://openalex.org/keywords/chemotherapy-induced-cardiotoxicity","display_name":"chemotherapy-induced cardiotoxicity","score":0.6309999823570251},{"id":"https://openalex.org/keywords/her2-negative-breast-cancer","display_name":"HER2-negative breast cancer","score":0.6100000143051147},{"id":"https://openalex.org/keywords/seer-medicare","display_name":"SEER-Medicare","score":0.6000000238418579},{"id":"https://openalex.org/keywords/risk-factors-for-heart-failure","display_name":"heart failure risk","score":0.6359999775886536},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.5799999833106995},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.8669999837875366},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8972926139831543},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5703621506690979},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5527674555778503},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5433616638183594},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5011060237884521},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.41794273257255554},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4164988100528717},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.39503276348114014},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3891989588737488},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.sabcs22-p3-03-13","doi":"https://doi.org/10.1158/1538-7445.sabcs22-p3-03-13","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.sabcs22-p3-03-13","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2597924473","https://openalex.org/W2209859982","https://openalex.org/W3088016615","https://openalex.org/W2105436256","https://openalex.org/W2915251242","https://openalex.org/W2613913247","https://openalex.org/W2255758241","https://openalex.org/W2403428300","https://openalex.org/W2206503387","https://openalex.org/W1520030457"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Cardiotoxicity":[2],"associated":[3,491,510,588,600],"with":[4,18,30,36,79,91,139,171,175,236,256,360,375,386,406,449,461,492,511,551,589,601,645,664,678,709],"use":[5,32,50,646],"of":[6,25,33,47,98,103,119,132,239,251,261,294,300,317,330,367,381,384,397,409,426,457,459,463,488,496,507,515,531,539,564,595,605,627,647,657,675,707,725],"trastuzumab":[7,708],"(T)":[8],"in":[9,15,51,56,65,76,82,153,198,244,266,278,311,378,391,411,428,472,549,582,617,633,651,713],"breast":[10,53,716],"cancer":[11,54],"has":[12],"been":[13],"assessed":[14],"multiple":[16],"studies":[17],"short-term":[19],"follow":[20,59,259,527],"up.":[21],"However,":[22],"long-term":[23,58,526,655],"risk":[24,462,495,514,538,563,594,604,706],"clinical":[26,658],"heart":[27,704],"failure":[28,705],"(CHF)":[29],"the":[31,45,66,83,133,154,157,168,233,245,267,303,400,529,537,568,583,618,634,654,726],"T,":[34,174],"either":[35,163],"or":[37,93,100,121,165,172,176,419,710],"without":[38,173,177,354,433,543,558,711],"anthracyclines":[39,712],"(A),":[40],"is":[41,62],"poorly":[42],"understood.":[43],"Since":[44],"approval":[46],"T":[48,120,144,268,291,314,324,353,359,418,432,448,489,534,542,557,574,586,619,635,648],"for":[49,128,242,399,444,477,579,609],"early-stage":[52],"(ESBC)":[55],"2006,":[57],"up":[60,260],"data":[61,642],"now":[63],"available":[64],"SEER-Medicare":[67,84,719],"database.":[68],"Methods:":[69],"We":[70],"performed":[71],"a":[72,101,227,237,257,407,493,561,590],"retrospective":[73],"cohort":[74],"study":[75],"patients":[77],"(pts)":[78],"ESBC":[80,140,652],"identified":[81,112,185,255],"database,":[85],"diagnosed":[86],"between":[87],"2005-2016,":[88],"excluding":[89],"pts":[90,138,253,287,342,350,356,412,429,550,554],"in-situ":[92],"metastatic":[94],"disease":[95,214],"at":[96,637],"time":[97],"diagnosis":[99],"history":[102],"CHF":[104,385,398,427,464,497,516,540,565],"prior":[105],"to":[106,150,313,341,349,533,547,567,625],"diagnosis.":[107],"Primary":[108,679],"exposure":[109,135,158,169,387],"variables":[110,136,159,388],"were":[111,160,224,254,284,631],"using":[113,186,226,232],"HCPCS":[114],"codes":[115,187],"and":[116,192,220,230,292,337,373,442,505,685],"included":[117,203],"receipt":[118,487,506],"A.":[122,146,576],"The":[123,179,394,424],"reference":[124],"baseline":[125,328,365,379,422,479,569],"population":[126,403,570,620,636],"used":[127,197],"univariate":[129],"logistic":[130,200],"regression":[131,201],"primary":[134,180],"was":[137,183,272,404,435,490,587],"who":[141,288,322,343,351,357,413,430,446,555,571],"received":[142,290,297,309,323,352,358,431,447,556,572],"neither":[143,573],"nor":[145,575],"For":[147],"multivariate":[148,199],"analyses,":[149],"avoid":[151],"co-linearity":[152],"final":[155,246],"model,":[156,585],"categorized":[161],"as":[162,315,339,465,467,482,484],"having":[164,167],"not":[166,345,415],"(i.e.":[170],"A).":[178],"outcome":[181],"variable":[182],"CHF,":[184,596],"428.0-9,":[188],"402.11,":[189],"402.91":[190],"(ICD9)":[191],"I50.0-9,":[193],"I110":[194],"(ICD10).":[195],"Covariates":[196],"(MLR)":[202],"hypertension":[204],"(HTN),":[205],"valve":[206,332,369],"disease,":[207,333,370],"hyperthyroidism,":[208,334,371],"diabetes":[209],"(DM),":[210],"emphysema,":[211,336,372],"coronary":[212],"artery":[213],"(CAD),":[215],"left":[216],"sided":[217],"radiation,":[218],"age,":[219],"race.":[221],"MLR":[222,468,584],"models":[223,469],"constructed":[225],"stepwise-up":[228],"approach":[229],"confirmed":[231],"stepwise-down":[234],"method":[235],"cutoff":[238],"p<":[240,503,522],"0.05":[241],"inclusion":[243],"model.":[247],"Results:":[248],"A":[249,310,361,420,434,450,508,532,544,559,598,650,718],"total":[250],"244,129":[252,402],"median":[258],"6.7":[262],"years":[263,265],"(7.7":[264],"cohort).":[269],"Median":[270],"age":[271],"68.":[273],"Other":[274],"demographics":[275],"are":[276,389,470,667],"listed":[277],"Table":[279,392,473,669,672,682],"1.":[280],"Of":[281,302],"these,":[282],"10,603":[283],"HER2-positive":[285],"(HER2+)":[286],"all":[289,293,478],"whom":[295],"also":[296,308],"some":[298],"form":[299],"chemotherapy.":[301],"HER2+":[304],"pts,":[305],"19.1%":[306,436,546],"(2,026)":[307],"addition":[312,530],"part":[316],"their":[318],"treatment":[319],"regimen.":[320],"Pts":[321],"had":[325,362,560],"significantly":[326,363,535],"higher":[327,364,632],"rates":[329,366],"HTN,":[331,368],"DM,":[335],"CAD":[338,374],"compared":[340,566],"did":[344,414],"receive":[346,416],"T.":[347],"Compared":[348],"A,":[355],"no":[376],"difference":[377],"rate":[380,396,408,425],"DM.":[382],"Risk":[383,674],"summarized":[390,471],"2.":[393],"overall":[395,593],"entire":[401],"21.3%":[405],"20.8%":[410],"any":[417],"(the":[421],"population).":[423],"(OR":[437,451,498,517],"0.90,":[438],"95%":[439,453,500,519],"CI":[440,454,501,520],"0.85-0.95),":[441],"29.0%":[443],"those":[445],"1.55,":[452],"1.41-1.71).":[455],"Associations":[456],"covariates":[458],"interest":[460],"well":[466,483],"3.":[474],"After":[475,577],"adjusting":[476,578],"cardiac":[480,615,628],"comorbidities":[481],"other":[485],"covariates,":[486],"reduced":[494],"0.74,":[499],"0.70-0.79,":[502],"0.001),":[504],"remained":[509,599],"an":[512,602],"increased":[513,536,603,614],"1.19,":[518],"1.15-1.24,":[521],"0.001).":[523],"Conclusions:":[524],"With":[525],"up,":[528],"over":[541],"(from":[545],"29.0%)":[548],"ESBC.":[552],"Additionally,":[553],"similar":[562,665],"potential":[580,613],"confounders":[581],"slightly":[591],"decreased":[592],"while":[597],"CHF.":[606],"Possible":[607],"explanations":[608],"these":[610,641],"findings":[611],"include":[612],"monitoring":[616],"which":[621,630],"may":[622],"have":[623],"led":[624],"optimization":[626],"comorbidities,":[629],"baseline.":[638],"Taken":[639],"together,":[640],"indicate":[643],"concern":[644],"plus":[649],"regarding":[653],"development":[656],"CHF;":[659],"especially":[660],"when":[661],"non-A":[662],"regimens":[663],"efficacy":[666],"available.":[668],"1:":[670],"Demographics":[671],"2:":[673],"Heart":[676],"Failure":[677],"Exposure":[680],"Variables":[681],"3:":[683],"Univariate":[684],"Multivariate":[686],"Analyses":[687],"Citation":[688],"Format:":[689],"Nicholas":[690],"P.":[691],"McAndrew,":[692],"Karissa":[693],"Britten,":[694],"Xiaoyan":[695],"Wang,":[696],"Eric":[697],"Yang,":[698],"Sara":[699],"Hurvitz,":[700],"Dennis":[701],"Slamon.":[702],"Long-term":[703],"early":[714],"stage":[715],"cancer:":[717],"Database":[720],"Analysis":[721],"[abstract].":[722],"In:":[723],"Proceedings":[724],"2022":[727,733],"San":[728,736],"Antonio":[729],"Breast":[730],"Cancer":[731,742],"Symposium;":[732],"Dec":[734],"6-10;":[735],"Antonio,":[737],"TX.":[738],"Philadelphia":[739],"(PA):":[740],"AACR;":[741],"Res":[743],"2023;83(5":[744],"Suppl):Abstract":[745],"nr":[746],"P3-03-13.":[747]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2023-03-03T00:00:00"}