{"id":"https://openalex.org/W4322720281","doi":"https://doi.org/10.1007/s00213-023-06336-4","title":"Intranasal administration of interleukin-4 ameliorates depression-like behavior and biochemical alterations in mouse submitted to the chronic unpredictable mild stress: modulation of neuroinflammation and oxidative stress","display_name":"Intranasal administration of interleukin-4 ameliorates depression-like behavior and biochemical alterations in mouse submitted to the chronic unpredictable mild stress: modulation of neuroinflammation and oxidative stress","publication_year":2023,"publication_date":"2023-03-01","ids":{"openalex":"https://openalex.org/W4322720281","doi":"https://doi.org/10.1007/s00213-023-06336-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/36856802"},"language":"en","primary_location":{"id":"doi:10.1007/s00213-023-06336-4","doi":"https://doi.org/10.1007/s00213-023-06336-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00213-023-06336-4","pdf_url":null,"source":{"id":"https://openalex.org/S80334769","display_name":"Psychopharmacology","issn_l":"0033-3158","issn":["0033-3158","1432-2072"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004907275","display_name":"Thiago \u00c2ngelo Smaniotto","orcid":"https://orcid.org/0000-0003-1600-1713","observed_orcids":["https://orcid.org/0000-0003-1600-1713"]},"institutions":[{"id":"https://openalex.org/I169248161","display_name":"Universidade Federal de Pelotas","ror":"https://ror.org/05msy9z54","country_code":"BR","type":"education","lineage":["https://openalex.org/I169248161"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Thiago \u00c2ngelo Smaniotto","raw_affiliation_strings":["Technology Development Center, Division of Biotechnology, Neurobiotechnology Research Group, Federal University of Pelotas, Pelotas, RS, 96010900, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technology Development Center, Division of Biotechnology, Neurobiotechnology Research Group, Federal University of Pelotas, Pelotas, RS, 96010900, Brazil","institution_ids":["https://openalex.org/I169248161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015910070","display_name":"Angela Maria Casaril","orcid":"https://orcid.org/0000-0003-4994-1891","observed_orcids":["https://orcid.org/0000-0003-4994-1891"]},"institutions":[{"id":"https://openalex.org/I169248161","display_name":"Universidade Federal de Pelotas","ror":"https://ror.org/05msy9z54","country_code":"BR","type":"education","lineage":["https://openalex.org/I169248161"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Angela Maria Casaril","raw_affiliation_strings":["Technology Development Center, Division of Biotechnology, Neurobiotechnology Research Group, Federal University of Pelotas, Pelotas, RS, 96010900, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technology Development Center, Division of Biotechnology, Neurobiotechnology Research Group, Federal University of Pelotas, Pelotas, RS, 96010900, Brazil","institution_ids":["https://openalex.org/I169248161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077833915","display_name":"Darling de Andrade Louren\u00e7o","orcid":"https://orcid.org/0000-0001-9890-6713","observed_orcids":["https://orcid.org/0000-0001-9890-6713"]},"institutions":[{"id":"https://openalex.org/I169248161","display_name":"Universidade Federal de Pelotas","ror":"https://ror.org/05msy9z54","country_code":"BR","type":"education","lineage":["https://openalex.org/I169248161"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Darling de Andrade Louren\u00e7o","raw_affiliation_strings":["Technology Development Center, Division of Biotechnology, Neurobiotechnology Research Group, Federal University of Pelotas, Pelotas, RS, 96010900, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technology Development Center, Division of Biotechnology, Neurobiotechnology Research Group, Federal University of Pelotas, Pelotas, RS, 96010900, Brazil","institution_ids":["https://openalex.org/I169248161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032983513","display_name":"Fernanda Severo Sabedra Sousa","orcid":"https://orcid.org/0000-0002-8396-6585","observed_orcids":["https://orcid.org/0000-0002-8396-6585"]},"institutions":[{"id":"https://openalex.org/I169248161","display_name":"Universidade Federal de Pelotas","ror":"https://ror.org/05msy9z54","country_code":"BR","type":"education","lineage":["https://openalex.org/I169248161"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fernanda S. Sousa","raw_affiliation_strings":["Technology Development Center, Division of Biotechnology, Cancer Biotechnology Laboratory, Federal University of Pelotas, Pelotas, RS, 96010900, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technology Development Center, Division of Biotechnology, Cancer Biotechnology Laboratory, Federal University of Pelotas, Pelotas, RS, 96010900, Brazil","institution_ids":["https://openalex.org/I169248161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032069387","display_name":"Fabiana K. Seixas","orcid":"https://orcid.org/0000-0003-4204-2500","observed_orcids":["https://orcid.org/0000-0003-4204-2500"]},"institutions":[{"id":"https://openalex.org/I169248161","display_name":"Universidade Federal de Pelotas","ror":"https://ror.org/05msy9z54","country_code":"BR","type":"education","lineage":["https://openalex.org/I169248161"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fabiana K. Seixas","raw_affiliation_strings":["Technology Development Center, Division of Biotechnology, Cancer Biotechnology Laboratory, Federal University of Pelotas, Pelotas, RS, 96010900, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technology Development Center, Division of Biotechnology, Cancer Biotechnology Laboratory, Federal University of Pelotas, Pelotas, RS, 96010900, Brazil","institution_ids":["https://openalex.org/I169248161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083960543","display_name":"Tiago Veiras Collares","orcid":"https://orcid.org/0000-0002-1535-3795","observed_orcids":["https://orcid.org/0000-0002-1535-3795"]},"institutions":[{"id":"https://openalex.org/I169248161","display_name":"Universidade Federal de Pelotas","ror":"https://ror.org/05msy9z54","country_code":"BR","type":"education","lineage":["https://openalex.org/I169248161"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Tiago Collares","raw_affiliation_strings":["Technology Development Center, Division of Biotechnology, Cancer Biotechnology Laboratory, Federal University of Pelotas, Pelotas, RS, 96010900, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technology Development Center, Division of Biotechnology, Cancer Biotechnology Laboratory, Federal University of Pelotas, Pelotas, RS, 96010900, Brazil","institution_ids":["https://openalex.org/I169248161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113839295","display_name":"Rafael Woloski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169248161","display_name":"Universidade Federal de Pelotas","ror":"https://ror.org/05msy9z54","country_code":"BR","type":"education","lineage":["https://openalex.org/I169248161"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rafael Woloski","raw_affiliation_strings":["Technology Development Center, Division of Biotechnology, Bioinformatics and Proteomics Laboratory, Federal University of Pelotas, Pelotas, RS, 96010900, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technology Development Center, Division of Biotechnology, Bioinformatics and Proteomics Laboratory, Federal University of Pelotas, Pelotas, RS, 96010900, Brazil","institution_ids":["https://openalex.org/I169248161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011748990","display_name":"Luciano da Silva Pinto","orcid":"https://orcid.org/0000-0001-8656-4031","observed_orcids":["https://orcid.org/0000-0001-8656-4031"]},"institutions":[{"id":"https://openalex.org/I169248161","display_name":"Universidade Federal de Pelotas","ror":"https://ror.org/05msy9z54","country_code":"BR","type":"education","lineage":["https://openalex.org/I169248161"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Luciano da Silva Pinto","raw_affiliation_strings":["Technology Development Center, Division of Biotechnology, Bioinformatics and Proteomics Laboratory, Federal University of Pelotas, Pelotas, RS, 96010900, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technology Development Center, Division of Biotechnology, Bioinformatics and Proteomics Laboratory, Federal University of Pelotas, Pelotas, RS, 96010900, Brazil","institution_ids":["https://openalex.org/I169248161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062042044","display_name":"Diego A.C. Alves","orcid":"https://orcid.org/0000-0002-1074-0294","observed_orcids":["https://orcid.org/0000-0002-1074-0294"]},"institutions":[{"id":"https://openalex.org/I169248161","display_name":"Universidade Federal de Pelotas","ror":"https://ror.org/05msy9z54","country_code":"BR","type":"education","lineage":["https://openalex.org/I169248161"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Diego Alves","raw_affiliation_strings":["Center of Chemical, Pharmaceutical and Food Sciences, Laboratory of Clean Organic Synthesis, Federal University of Pelotas, Pelotas, RS, 96010900, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Chemical, Pharmaceutical and Food Sciences, Laboratory of Clean Organic Synthesis, Federal University of Pelotas, Pelotas, RS, 96010900, Brazil","institution_ids":["https://openalex.org/I169248161"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067575787","display_name":"Lucielli Savegnago","orcid":"https://orcid.org/0000-0003-0494-5610","observed_orcids":["https://orcid.org/0000-0003-0494-5610"]},"institutions":[{"id":"https://openalex.org/I169248161","display_name":"Universidade Federal de Pelotas","ror":"https://ror.org/05msy9z54","country_code":"BR","type":"education","lineage":["https://openalex.org/I169248161"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Lucielli Savegnago","raw_affiliation_strings":["Center of Chemical, Pharmaceutical and Food Sciences, Laboratory of Clean Organic Synthesis, Federal University of Pelotas, Pelotas, RS, 96010900, Brazil. luciellisavegnago@yahoo.com.br","Technology Development Center, Division of Biotechnology, Neurobiotechnology Research Group, Federal University of Pelotas, Pelotas, RS, 96010900, Brazil. luciellisavegnago@yahoo.com.br","Center of Chemical, Pharmaceutical and Food Sciences, Laboratory of Clean Organic Synthesis, Federal University of Pelotas, Pelotas, RS, 96010900, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Chemical, Pharmaceutical and Food Sciences, Laboratory of Clean Organic Synthesis, Federal University of Pelotas, Pelotas, RS, 96010900, Brazil. luciellisavegnago@yahoo.com.br","institution_ids":["https://openalex.org/I169248161"]},{"raw_affiliation_string":"Technology Development Center, Division of Biotechnology, Neurobiotechnology Research Group, Federal University of Pelotas, Pelotas, RS, 96010900, Brazil. luciellisavegnago@yahoo.com.br","institution_ids":["https://openalex.org/I169248161"]},{"raw_affiliation_string":"Center of Chemical, Pharmaceutical and Food Sciences, Laboratory of Clean Organic Synthesis, Federal University of Pelotas, Pelotas, RS, 96010900, Brazil","institution_ids":["https://openalex.org/I169248161"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5067575787"],"corresponding_institution_ids":["https://openalex.org/I169248161"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":null,"fwci":1.6799,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.80992736,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"240","issue":"4","first_page":"935","last_page":"950"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.7148000001907349,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.7148000001907349,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.20280000567436218,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.07270000129938126,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":1.0},{"id":"https://openalex.org/keywords/intranasal-administration","display_name":"intranasal administration","score":0.765999972820282},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.7179999947547913},{"id":"https://openalex.org/keywords/chronic-unpredictable-mild-stress","display_name":"chronic unpredictable mild stress","score":0.9750000238418579},{"id":"https://openalex.org/keywords/depression-like-behavior","display_name":"depression-like behavior","score":0.8629999756813049},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9739999771118164},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":1.0},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.9419999718666077},{"id":"https://openalex.org/keywords/corticosterone","display_name":"corticosterone","score":0.9919999837875366},{"id":"https://openalex.org/keywords/adrenal-gland","display_name":"adrenal gland","score":0.7279999852180481},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"prefrontal cortex","score":0.8339999914169312},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":1.0},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.7950000166893005},{"id":"https://openalex.org/keywords/indoleamine-2-3-dioxygenase","display_name":"indoleamine 2,3-dioxygenase","score":0.902999997138977},{"id":"https://openalex.org/keywords/nf-kb","display_name":"NF-kB","score":0.7829999923706055},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.9700000286102295},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.7760000228881836},{"id":"https://openalex.org/keywords/antidepressant-effects","display_name":"antidepressant effects","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.7383637428283691},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6648208498954773},{"id":"https://openalex.org/C85663871","wikidata":"https://www.wikidata.org/wiki/Q6966562","display_name":"Nasal administration","level":2,"score":0.6376111507415771},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.628608226776123},{"id":"https://openalex.org/C136569192","wikidata":"https://www.wikidata.org/wiki/Q4880745","display_name":"Behavioural despair test","level":4,"score":0.6084716320037842},{"id":"https://openalex.org/C2781001258","wikidata":"https://www.wikidata.org/wiki/Q7676084","display_name":"Tail suspension test","level":5,"score":0.600325882434845},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5692257881164551},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.5429333448410034},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.48730456829071045},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47709164023399353},{"id":"https://openalex.org/C2780352252","wikidata":"https://www.wikidata.org/wiki/Q422543","display_name":"Corticosterone","level":3,"score":0.45278993248939514},{"id":"https://openalex.org/C2778654844","wikidata":"https://www.wikidata.org/wiki/Q3305232","display_name":"Chronic stress","level":2,"score":0.43887585401535034},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.36823663115501404},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3458932638168335},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2858763337135315},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.20757952332496643},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.19329234957695007},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1345568597316742}],"mesh":[{"descriptor_ui":"D000090862","descriptor_name":"Neuroinflammatory Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000281","descriptor_name":"Administration, Intranasal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s00213-023-06336-4","doi":"https://doi.org/10.1007/s00213-023-06336-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00213-023-06336-4","pdf_url":null,"source":{"id":"https://openalex.org/S80334769","display_name":"Psychopharmacology","issn_l":"0033-3158","issn":["0033-3158","1432-2072"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology","raw_type":"journal-article"},{"id":"pmid:36856802","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36856802","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320322502","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","ror":"https://ror.org/05k49za97"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W42627113","https://openalex.org/W136985941","https://openalex.org/W191793640","https://openalex.org/W1519638308","https://openalex.org/W1750541493","https://openalex.org/W1750690213","https://openalex.org/W1775749144","https://openalex.org/W1929282196","https://openalex.org/W1965164425","https://openalex.org/W1967364478","https://openalex.org/W1973251492","https://openalex.org/W1980374662","https://openalex.org/W1983099697","https://openalex.org/W1983310681","https://openalex.org/W2003982930","https://openalex.org/W2004456745","https://openalex.org/W2005594217","https://openalex.org/W2007636259","https://openalex.org/W2011362026","https://openalex.org/W2031045752","https://openalex.org/W2050508296","https://openalex.org/W2054252070","https://openalex.org/W2054668663","https://openalex.org/W2055747883","https://openalex.org/W2056151767","https://openalex.org/W2079040386","https://openalex.org/W2083048709","https://openalex.org/W2092395511","https://openalex.org/W2093663264","https://openalex.org/W2110729320","https://openalex.org/W2111387452","https://openalex.org/W2125286001","https://openalex.org/W2134287314","https://openalex.org/W2149671708","https://openalex.org/W2154516741","https://openalex.org/W2160933319","https://openalex.org/W2170899083","https://openalex.org/W2194350630","https://openalex.org/W2237598232","https://openalex.org/W2495910804","https://openalex.org/W2595322359","https://openalex.org/W2766569620","https://openalex.org/W2788048790","https://openalex.org/W2788475922","https://openalex.org/W2790171761","https://openalex.org/W2804884324","https://openalex.org/W2891373107","https://openalex.org/W2892958757","https://openalex.org/W2894122996","https://openalex.org/W2898327765","https://openalex.org/W2925103155","https://openalex.org/W2943751833","https://openalex.org/W2963540498","https://openalex.org/W2982430136","https://openalex.org/W2994886340","https://openalex.org/W3122042396","https://openalex.org/W3151144641","https://openalex.org/W4200361159","https://openalex.org/W4296816736"],"related_works":["https://openalex.org/W7038734469","https://openalex.org/W4293425577","https://openalex.org/W3001664724","https://openalex.org/W4361256034","https://openalex.org/W2893590951","https://openalex.org/W4410382727","https://openalex.org/W2792716312","https://openalex.org/W4309387983","https://openalex.org/W2912959584","https://openalex.org/W1499662792"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-03-03T00:00:00"}