{"id":"https://openalex.org/W4322698246","doi":"https://doi.org/10.1530/acta.0.0650371","title":"AMINES AND MOUSE THYROID ACTIVITY:","display_name":"AMINES AND MOUSE THYROID ACTIVITY:","publication_year":1970,"publication_date":"1970-10-01","ids":{"openalex":"https://openalex.org/W4322698246","doi":"https://doi.org/10.1530/acta.0.0650371","mag":"2056400699","pmid":"https://pubmed.ncbi.nlm.nih.gov/4097031"},"language":"en","primary_location":{"id":"doi:10.1530/acta.0.0650371","doi":"https://doi.org/10.1530/acta.0.0650371","is_oa":false,"landing_page_url":"https://doi.org/10.1530/acta.0.0650371","pdf_url":null,"source":{"id":"https://openalex.org/S4210218062","display_name":"European Journal of Endocrinology","issn_l":"0804-4643","issn":["0804-4643","1479-683X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Endocrinologica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109282871","display_name":"Arne Melander","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Arne Melander","raw_affiliation_strings":["Department of Pharmacology, University of Lund, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Lund, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109282871"],"corresponding_institution_ids":["https://openalex.org/I187531555"],"apc_list":{"value":3798,"currency":"EUR","value_usd":4292},"apc_paid":null,"fwci":2.7264,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.90027811,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"65","issue":"2","first_page":"371","last_page":"384"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyroid-hormone-secretion","display_name":"thyroid hormone secretion","score":0.9179999828338623},{"id":"https://openalex.org/keywords/epinephrine","display_name":"epinephrine","score":0.4099999964237213},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.996999979019165},{"id":"https://openalex.org/keywords/isoproterenol","display_name":"isoproterenol","score":0.9110000133514404},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.7319999933242798},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tryptamine","display_name":"tryptamine","score":0.9800000190734863},{"id":"https://openalex.org/keywords/tyramine","display_name":"tyramine","score":1.0},{"id":"https://openalex.org/keywords/alpha-adrenergic-receptors","display_name":"alpha-adrenergic receptors","score":0.847000002861023},{"id":"https://openalex.org/keywords/beta-adrenergic-receptors","display_name":"beta-adrenergic receptors","score":0.9980000257492065},{"id":"https://openalex.org/keywords/phenoxybenzamine","display_name":"phenoxybenzamine","score":0.8740000128746033},{"id":"https://openalex.org/keywords/propranolol","display_name":"propranolol","score":0.8930000066757202},{"id":"https://openalex.org/keywords/phentolamine","display_name":"phentolamine","score":0.9139999747276306},{"id":"https://openalex.org/keywords/theophylline","display_name":"theophylline","score":0.8989999890327454},{"id":"https://openalex.org/keywords/adenylate-cyclase","display_name":"adenylate cyclase","score":0.9120000004768372},{"id":"https://openalex.org/keywords/hypophysectomy","display_name":"hypophysectomy","score":0.7950000166893005}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8839112520217896},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8656893968582153},{"id":"https://openalex.org/C2778151854","wikidata":"https://www.wikidata.org/wiki/Q423364","display_name":"Propranolol","level":2,"score":0.7623642683029175},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7304192781448364},{"id":"https://openalex.org/C2780253649","wikidata":"https://www.wikidata.org/wiki/Q420360","display_name":"Phentolamine","level":3,"score":0.7212472558021545},{"id":"https://openalex.org/C2780668150","wikidata":"https://www.wikidata.org/wiki/Q419824","display_name":"Phenoxybenzamine","level":3,"score":0.6991918087005615},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.6531476378440857},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5232683420181274},{"id":"https://openalex.org/C2776090920","wikidata":"https://www.wikidata.org/wiki/Q415550","display_name":"Isoprenaline","level":3,"score":0.48917821049690247},{"id":"https://openalex.org/C158453852","wikidata":"https://www.wikidata.org/wiki/Q4684738","display_name":"Adrenergic","level":3,"score":0.44216668605804443},{"id":"https://openalex.org/C2780948584","wikidata":"https://www.wikidata.org/wiki/Q251347","display_name":"Haloperidol","level":3,"score":0.42038044333457947},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.4159943163394928},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15484833717346191},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.13645917177200317},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.09162524342536926}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004837","descriptor_name":"Epinephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007016","descriptor_name":"Hypophysectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007455","descriptor_name":"Iodine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007456","descriptor_name":"Iodine Isotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007545","descriptor_name":"Isoproterenol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010643","descriptor_name":"Phenoxybenzamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013806","descriptor_name":"Theophylline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013960","descriptor_name":"Thyroid Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013963","descriptor_name":"Thyroid Hormones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D014363","descriptor_name":"Tryptamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014439","descriptor_name":"Tyramine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1530/acta.0.0650371","doi":"https://doi.org/10.1530/acta.0.0650371","is_oa":false,"landing_page_url":"https://doi.org/10.1530/acta.0.0650371","pdf_url":null,"source":{"id":"https://openalex.org/S4210218062","display_name":"European Journal of Endocrinology","issn_l":"0804-4643","issn":["0804-4643","1479-683X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Endocrinologica","raw_type":"journal-article"},{"id":"pmid:4097031","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4097031","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta endocrinologica","raw_type":"Journal Article"},{"id":"mag:2056400699","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4097031","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2056400699","https://openalex.org/W2031912672","https://openalex.org/W2070326884","https://openalex.org/W2395541158","https://openalex.org/W2004391765","https://openalex.org/W2029665662","https://openalex.org/W1969630931","https://openalex.org/W2165958118","https://openalex.org/W3102321711","https://openalex.org/W1982310992"],"abstract_inverted_index":{"ABSTRACT":[0],"Large":[1,90],"doses":[2,91],"of":[3,35,52,64,92,112,116,198,223,237,304,315],"l-adrenaline":[4],"(A),":[5],"l-noradrenaline":[6],"(NA)":[7],"or":[8,55,86,157,258,280,325],"l-isoprenaline":[9],"(IPNA)":[10],"increased":[11,100],"the":[12,47,75,132,140,151,168,171,177,191,199,208,233,238,265,291,312,319],"blood131I":[13,101],"and":[14,21,39,59,78,95,148,246,297],"plasma":[15],"protein-bound":[16],"131I":[17],"levels":[18,102],"in":[19,22,26,46,103,126,230,311,328],"thyroxine-blocked":[20,104,130],"hypophysectomized":[23],"but":[24,175,214,288],"not":[25,82,166,189],"normal":[27],"mice.":[28,105],"The":[29,160,202],"responses":[30,141,169,210,292],"were":[31],"similar":[32,256,270,278],"to":[33,142,153,170,179,193,196,217,257,279,293],"those":[34],"thyrotrophin,":[36],"5-hydroxytryptamine":[37],"(5-HT)":[38],"dopamine":[40],"(DA).":[41],"It":[42,226],"was":[43,123,155],"concluded":[44],"that,":[45,229],"mouse,":[48],"a":[49,62,114,219,269],"large":[50],"dose":[51],"A,":[53,143],"NA":[54,247],"IPNA,":[56],"like":[57],"5-HT":[58],"DA,":[60,146,242],"induces":[61],"release":[63,115,314],"thyroid":[65,76,117,234,252,316],"hormone,":[66,317],"that":[67,79,254,276,301],"this":[68],"effect":[69,222,271,320],"results":[70],"from":[71],"an":[72,120,302],"action":[73],"within":[74],"gland,":[77],"it":[80],"is":[81,227,321],"caused":[83],"by":[84,251,274],"intra-":[85],"extrathyroidal":[87],"vascular":[88],"changes.":[89],"tryptamine":[93],"(TrA)":[94],"tyramine":[96],"(TyA)":[97],"also":[98,215],"evoked":[99],"Thus":[106],"several":[107],"aromatic":[108,121],"monoamines":[109,240],"seem":[110],"capable":[111],"inducing":[113],"hormone.":[118],"Histamine,":[119],"diamine,":[122],"ineffective":[124],"even":[125,158],"near-lethal":[127],"doses.":[128],"In":[129],"mice":[131],"alpha":[133,203,261,324],"adrenergic":[134,204,262,327],"blocking":[135,162],"drug":[136,163],"phenoxybenzamine":[137],"(PhBA)":[138],"inhibited":[139,176,207],"NA,":[144],"5-HT,":[145,241,295],"TrA":[147],"TyA,":[149,244],"whereas":[150],"response":[152,178,192],"IPNA":[154,194,267],"unaffected":[156],"augmented.":[159],"beta":[161,283,326],"l-propranolol":[164],"did":[165,188,212],"diminish":[167],"first":[172],"six":[173],"amines":[174],"IPNA.":[180,298],"d-Propranolol,":[181],"which":[182],"has":[183,268],"only":[184],"weak":[185],"beta-blocking":[186],"properties,":[187],"affect":[190],"nor":[195],"any":[197],"other":[200],"amines.":[201],"blocker":[205],"phentolamine":[206],"same":[209],"as":[211,323],"PhBA,":[213],"seemed":[216],"have":[218],"slight":[220],"hormone-releasing":[221,235],"its":[224],"own.":[225],"suggested":[228],"conventional":[231],"terms,":[232],"effects":[236],"biogenic":[239],"TrA,":[243],"A":[245,296],"are":[248,255,277],"all":[249],"mediated":[250,273],"receptors":[253,275],"identical":[259,281],"with":[260,282],"receptors,":[263],"while":[264],"non-biogenic":[266],"though":[272],"receptors.":[284],"Theophylline":[285],"pretreatment":[286],"slightly":[287],"significantly":[289],"augmented":[290],"both":[294],"This":[299],"implies":[300],"activation":[303],"thyroidal":[305],"adenyl":[306],"cyclase":[307],"may":[308],"be":[309],"involved":[310],"amine-induced":[313],"whether":[318],"classified":[322],"nature.":[329]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-03-02T00:00:00"}
