{"id":"https://openalex.org/W4322012180","doi":"https://doi.org/10.1016/j.esmoop.2023.100816","title":"36MO Maintenance olaparib plus bevacizumab (bev) in patients (pts) with newly diagnosed advanced ovarian cancer (OC): 5-year (y) progression-free survival (PFS) by molecular subgroup in the PAOLA-1/ENGOT-ov25 trial","display_name":"36MO Maintenance olaparib plus bevacizumab (bev) in patients (pts) with newly diagnosed advanced ovarian cancer (OC): 5-year (y) progression-free survival (PFS) by molecular subgroup in the PAOLA-1/ENGOT-ov25 trial","publication_year":2023,"publication_date":"2023-02-01","ids":{"openalex":"https://openalex.org/W4322012180","doi":"https://doi.org/10.1016/j.esmoop.2023.100816"},"language":"en","primary_location":{"id":"doi:10.1016/j.esmoop.2023.100816","doi":"https://doi.org/10.1016/j.esmoop.2023.100816","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.esmoop.2023.100816","pdf_url":"http://www.esmoopen.com/article/S2059702923000364/pdf","source":{"id":"https://openalex.org/S4210217024","display_name":"ESMO Open","issn_l":"2059-7029","issn":["2059-7029"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ESMO Open","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.esmoopen.com/article/S2059702923000364/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"A.J. Gonzalez Martin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135003","display_name":"Clinica Universidad de Navarra","ror":"https://ror.org/03phm3r45","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135003"]},{"id":"https://openalex.org/I4210154151","display_name":"Spanish Ovarian Cancer Research Group","ror":"https://ror.org/04zw2sa68","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210154151"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"A.J. Gonzalez Martin","raw_affiliation_strings":["1Department of Medical Oncology, Clinica Universidad de Navarra, and GEICO, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Medical Oncology, Clinica Universidad de Navarra, and GEICO, Madrid, Spain","institution_ids":["https://openalex.org/I4210135003","https://openalex.org/I4210154151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062141441","display_name":"Jacques M\u00e9dioni","orcid":"https://orcid.org/0000-0003-1100-5264","observed_orcids":["https://orcid.org/0000-0003-1100-5264"]},"institutions":[{"id":"https://openalex.org/I4210102325","display_name":"H\u00f4pital Europ\u00e9en Georges-Pompidou","ror":"https://ror.org/016vx5156","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102325","https://openalex.org/I4210120235"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J. Medioni","raw_affiliation_strings":["2Service d'Oncologie M\u00e9dicale, H\u00f4pital Europ\u00e9en Georges Pompidou, and GINECO, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Service d'Oncologie M\u00e9dicale, H\u00f4pital Europ\u00e9en Georges Pompidou, and GINECO, Paris, France","institution_ids":["https://openalex.org/I4210102325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081760862","display_name":"P Harter","orcid":"https://orcid.org/0009-0006-1378-1370","observed_orcids":["https://orcid.org/0009-0006-1378-1370"]},"institutions":[{"id":"https://openalex.org/I4210146447","display_name":"Kliniken Essen-Mitte","ror":"https://ror.org/03v958f45","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210146447"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"P. Harter","raw_affiliation_strings":["3Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, and AGO, Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, and AGO, Essen, Germany","institution_ids":["https://openalex.org/I4210146447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038384830","display_name":"Claire Cropet","orcid":"https://orcid.org/0000-0001-9412-5952","observed_orcids":["https://orcid.org/0000-0001-9412-5952"]},"institutions":[{"id":"https://openalex.org/I4210105738","display_name":"Centre L\u00e9on B\u00e9rard","ror":"https://ror.org/01cmnjq37","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210105738"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C. Cropet","raw_affiliation_strings":["4Department of Biostatistics, Centre L\u00e9on B\u00e9rard, and GINECO, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Department of Biostatistics, Centre L\u00e9on B\u00e9rard, and GINECO, Lyon, France","institution_ids":["https://openalex.org/I4210105738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008166009","display_name":"Saverio Cinieri","orcid":"https://orcid.org/0000-0002-5555-0814","observed_orcids":["https://orcid.org/0000-0002-5555-0814"]},"institutions":[{"id":"https://openalex.org/I4210103648","display_name":"Ospedale A. Perrino","ror":"https://ror.org/01ae87070","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210099368","https://openalex.org/I4210103648","https://openalex.org/I4210117053"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S. Cinieri","raw_affiliation_strings":["5UOC Oncologia Medica, Ospedale Senatore Antonio Perrino, and MITO, Brindisi, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5UOC Oncologia Medica, Ospedale Senatore Antonio Perrino, and MITO, Brindisi, Italy","institution_ids":["https://openalex.org/I4210103648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007504348","display_name":"Ursula Denison","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089076","display_name":"Klinik Hietzing","ror":"https://ror.org/00621wh10","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210089076","https://openalex.org/I4210117134"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"U. Denison","raw_affiliation_strings":["6Department of Gynecology and Obstetrics, Institute for Gynaecological Oncology und Senology - Karl Landsteiner, Klinik Hietzing, and AGO AU, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Department of Gynecology and Obstetrics, Institute for Gynaecological Oncology und Senology - Karl Landsteiner, Klinik Hietzing, and AGO AU, Vienna, Austria","institution_ids":["https://openalex.org/I4210089076"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046361460","display_name":"H. Fujiwara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H. Fujiwara","raw_affiliation_strings":["7Department of Obstetrics and Gynecology, Jichi Medical University, and GOTIC, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Department of Obstetrics and Gynecology, Jichi Medical University, and GOTIC, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058535647","display_name":"Ignace B. Vergote","orcid":"https://orcid.org/0000-0002-7589-8981","observed_orcids":["https://orcid.org/0000-0002-7589-8981"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"I.B. Vergote","raw_affiliation_strings":["8Department of Obstetrics and Gynaecology, University Hospital Leuven, Leuven Cancer Institute, and BGOG, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8Department of Obstetrics and Gynaecology, University Hospital Leuven, Leuven Cancer Institute, and BGOG, Leuven, Belgium","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001356724","display_name":"Alessandra Bologna","orcid":"https://orcid.org/0000-0001-7901-5499","observed_orcids":["https://orcid.org/0000-0001-7901-5499"]},"institutions":[{"id":"https://openalex.org/I4210090508","display_name":"Azienda Sanitaria Unit\u00e0 Locale di Reggio Emilia","ror":"https://ror.org/001bbwj30","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210090508"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Bologna","raw_affiliation_strings":["9Azienda USL, IRCCS di Reggio Emilia, and MANGO, Reggio Emilia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"9Azienda USL, IRCCS di Reggio Emilia, and MANGO, Reggio Emilia, Italy","institution_ids":["https://openalex.org/I4210090508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081022486","display_name":"Sakari Hietanen","orcid":"https://orcid.org/0000-0003-4734-4743","observed_orcids":["https://orcid.org/0000-0003-4734-4743"]},"institutions":[{"id":"https://openalex.org/I2801970007","display_name":"Turku University Hospital","ror":"https://ror.org/05dbzj528","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2801970007","https://openalex.org/I4210127022"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"S. Hietanen","raw_affiliation_strings":["10Department of Obstetrics and Gynecology, Turku University Hospital, and NSGO, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"10Department of Obstetrics and Gynecology, Turku University Hospital, and NSGO, Turku, Finland","institution_ids":["https://openalex.org/I2801970007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049445132","display_name":"Manuel Jorge Rodrigues","orcid":"https://orcid.org/0000-0002-5443-0802","observed_orcids":["https://orcid.org/0000-0002-5443-0802"]},"institutions":[{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M.J. Rodrigues","raw_affiliation_strings":["11D\u00e9partement d'Oncologie Medical, Institut Curie - Hopital Claudius R\u00e9gaud, and GINECO, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"11D\u00e9partement d'Oncologie Medical, Institut Curie - Hopital Claudius R\u00e9gaud, and GINECO, Paris, France","institution_ids":["https://openalex.org/I80043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019934933","display_name":"LC Hanker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"L.C. Hanker","raw_affiliation_strings":["12Department of Gynecology and Obstetrics, Universit\u00e4tsklinikum Schleswig-Holstein, Universit\u00e4tfrauenklinik, Campus L\u00fcbeck, and AGO, L\u00fcbeck, Schleswig-Holstein, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"12Department of Gynecology and Obstetrics, Universit\u00e4tsklinikum Schleswig-Holstein, Universit\u00e4tfrauenklinik, Campus L\u00fcbeck, and AGO, L\u00fcbeck, Schleswig-Holstein, Germany","institution_ids":["https://openalex.org/I4210112713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018118709","display_name":"Claudio Zamagni","orcid":"https://orcid.org/0000-0003-0052-2581","observed_orcids":["https://orcid.org/0000-0003-0052-2581"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C. Zamagni","raw_affiliation_strings":["13Addarii Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, and MITO, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"13Addarii Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, and MITO, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005787629","display_name":"S. Hernando Polo","orcid":"https://orcid.org/0000-0002-6991-8376","observed_orcids":["https://orcid.org/0000-0002-6991-8376"]},"institutions":[{"id":"https://openalex.org/I4210101151","display_name":"Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n","ror":"https://ror.org/01435q086","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210101151","https://openalex.org/I4210139293"]},{"id":"https://openalex.org/I4210154151","display_name":"Spanish Ovarian Cancer Research Group","ror":"https://ror.org/04zw2sa68","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210154151"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"S. Hernando Polo","raw_affiliation_strings":["14Medical Oncology Department, Fundaci\u00f3n Hospital de Alcorc\u00f3n, and GEICO, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"14Medical Oncology Department, Fundaci\u00f3n Hospital de Alcorc\u00f3n, and GEICO, Madrid, Spain","institution_ids":["https://openalex.org/I4210101151","https://openalex.org/I4210154151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079081967","display_name":"Diana Bello Roufai","orcid":"https://orcid.org/0000-0002-2817-7866","observed_orcids":["https://orcid.org/0000-0002-2817-7866"]},"institutions":[{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"D. Bello Roufai","raw_affiliation_strings":["15Medical Oncology Department, Institut Curie - Saint-Cloud, and GINECO, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"15Medical Oncology Department, Institut Curie - Saint-Cloud, and GINECO, Paris, France","institution_ids":["https://openalex.org/I80043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080994672","display_name":"Dirk Bauerschlag","orcid":"https://orcid.org/0000-0001-8157-6121","observed_orcids":["https://orcid.org/0000-0001-8157-6121"]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"D. Bauerschlag","raw_affiliation_strings":["16Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, UKSH, and AGO, Campus Kiel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"16Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, UKSH, and AGO, Campus Kiel, Germany","institution_ids":["https://openalex.org/I4210112713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073787373","display_name":"Beno\u00eet You","orcid":"https://orcid.org/0000-0002-3177-8857","observed_orcids":["https://orcid.org/0000-0002-3177-8857"]},"institutions":[{"id":"https://openalex.org/I4210100596","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596"]},{"id":"https://openalex.org/I4210113288","display_name":"H\u00f4pital Lyon Sud","ror":"https://ror.org/023xgd207","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210113288"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"B. You","raw_affiliation_strings":["17Medical Oncology Department, HCL \u2013 Centre Hospitalier Lyon Sud, and GINECO, Pierre-B\u00e9nite, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"17Medical Oncology Department, HCL \u2013 Centre Hospitalier Lyon Sud, and GINECO, Pierre-B\u00e9nite, France","institution_ids":["https://openalex.org/I4210100596","https://openalex.org/I4210113288"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001140861","display_name":"Peter Hillemanns","orcid":"https://orcid.org/0000-0001-9829-3531","observed_orcids":["https://orcid.org/0000-0001-9829-3531"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Hillemanns","raw_affiliation_strings":["18Department of Obstetrics and Gynecology, Dedizinische Hochschule Hannover, and AGO, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"18Department of Obstetrics and Gynecology, Dedizinische Hochschule Hannover, and AGO, Hannover, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073063132","display_name":"\u00c9ric Pujade-Lauraine","orcid":"https://orcid.org/0000-0002-0759-7263","observed_orcids":["https://orcid.org/0000-0002-0759-7263"]},"institutions":[{"id":"https://openalex.org/I4210134629","display_name":"Arcagy Gineco","ror":"https://ror.org/03mzxvt76","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210134629"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"E. Pujade-Lauraine","raw_affiliation_strings":["19Medical Oncology Department, ARCAGY Research, and GINECO, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"19Medical Oncology Department, ARCAGY Research, and GINECO, Paris, France","institution_ids":["https://openalex.org/I4210134629"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038283066","display_name":"I. Ray-Coquard","orcid":"https://orcid.org/0000-0003-2472-8306","observed_orcids":["https://orcid.org/0000-0003-2472-8306"]},"institutions":[{"id":"https://openalex.org/I4210105738","display_name":"Centre L\u00e9on B\u00e9rard","ror":"https://ror.org/01cmnjq37","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210105738"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"I.L. Ray-Coquard","raw_affiliation_strings":["20Department of Medical Oncology, Centre L\u00e9on B\u00e9rard, and GINECO, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"20Department of Medical Oncology, Centre L\u00e9on B\u00e9rard, and GINECO, Lyon, France","institution_ids":["https://openalex.org/I4210105738"]}]}],"institutions":[],"countries_distinct_count":8,"institutions_distinct_count":19,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3290,"currency":"USD","value_usd":3290},"apc_paid":{"value":3290,"currency":"USD","value_usd":3290},"fwci":0.4813,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.59079451,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"8","issue":"1","first_page":"100816","last_page":"100816"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/advanced-ovarian-cancer","display_name":"advanced ovarian cancer","score":0.8299999833106995},{"id":"https://openalex.org/keywords/olaparib","display_name":"olaparib","score":0.9449999928474426},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.9990000128746033},{"id":"https://openalex.org/keywords/maintenance-therapy","display_name":"maintenance therapy","score":0.8989999890327454},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8450000286102295},{"id":"https://openalex.org/keywords/homologous-recombination-deficiency","display_name":"homologous recombination deficiency","score":0.968999981880188},{"id":"https://openalex.org/keywords/brca-mutations","display_name":"BRCA mutations","score":0.9259999990463257},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.7680000066757202},{"id":"https://openalex.org/keywords/paola-1-trial","display_name":"PAOLA-1 trial","score":0.75},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.5929999947547913},{"id":"https://openalex.org/keywords/platinum-based-chemotherapy","display_name":"platinum-based chemotherapy","score":0.7940000295639038},{"id":"https://openalex.org/keywords/molecular-subtypes","display_name":"molecular subtypes","score":0.5429999828338623},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.5690000057220459},{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.5199999809265137}],"concepts":[{"id":"https://openalex.org/C2779962180","wikidata":"https://www.wikidata.org/wiki/Q7083106","display_name":"Olaparib","level":5,"score":0.9361584186553955},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7962014675140381},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6835267543792725},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6234865784645081},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.6221688389778137},{"id":"https://openalex.org/C2780739268","wikidata":"https://www.wikidata.org/wiki/Q2112244","display_name":"Progression-free survival","level":3,"score":0.47295519709587097},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.4653545022010803},{"id":"https://openalex.org/C187960798","wikidata":"https://www.wikidata.org/wiki/Q7631152","display_name":"Subgroup analysis","level":3,"score":0.45862454175949097},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.4297086298465729},{"id":"https://openalex.org/C2780194787","wikidata":"https://www.wikidata.org/wiki/Q4836333","display_name":"BRCA mutation","level":4,"score":0.42871519923210144},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3628649115562439},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2994474172592163},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.1288672387599945},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07774579524993896},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.0},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.esmoop.2023.100816","doi":"https://doi.org/10.1016/j.esmoop.2023.100816","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.esmoop.2023.100816","pdf_url":"http://www.esmoopen.com/article/S2059702923000364/pdf","source":{"id":"https://openalex.org/S4210217024","display_name":"ESMO Open","issn_l":"2059-7029","issn":["2059-7029"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ESMO Open","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.esmoop.2023.100816","doi":"https://doi.org/10.1016/j.esmoop.2023.100816","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.esmoop.2023.100816","pdf_url":"http://www.esmoopen.com/article/S2059702923000364/pdf","source":{"id":"https://openalex.org/S4210217024","display_name":"ESMO Open","issn_l":"2059-7029","issn":["2059-7029"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ESMO Open","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4322012180.pdf","grobid_xml":"https://content.openalex.org/works/W4322012180.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2977575205","https://openalex.org/W4377115689","https://openalex.org/W4322012149","https://openalex.org/W4310754056","https://openalex.org/W4297821473","https://openalex.org/W3087864157","https://openalex.org/W4390078374","https://openalex.org/W3029090848","https://openalex.org/W3089235797","https://openalex.org/W3169132548"],"abstract_inverted_index":{"The":[0,348],"first-line":[1],"setting":[2],"represents":[3],"the":[4,30,37,100,152,189,206,214,222,232,241,355,371],"only":[5],"opportunity":[6],"for":[7,68,102,120,130,246],"cure":[8,17,374],"in":[9,58,105,175,205,213,221,231,240,317,375,393],"advanced":[10,63,379],"OC.":[11],"5-y":[12,92,190,349],"PFS":[13,93,144,173,191,268,352],"rates":[14,353],"may":[15,369],"predict":[16],"as":[18,388],"most":[19],"pts":[20,59,159,177,394],"not":[21],"relapsing":[22],"at":[23,151],"5":[24],"years":[25],"are":[26],"potentially":[27],"cured.":[28],"In":[29],"final":[31,153],"overall":[32],"survival":[33],"(OS)":[34],"analysis":[35,145],"of":[36,81,260,262,357,366,373,383,391,399],"Phase":[38],"III":[39],"PAOLA-1/ENGOT-ov25":[40],"trial":[41],"(NCT02477644),":[42],"maintenance":[43,384],"olaparib":[44,116,163,196,359,385],"+":[45,56,110,125,137,164,170,197,203,271,273,275,277,279,281,386],"bev":[46,57,111,126,165,171,198,204,361,387],"provided":[47],"a":[48,318,389],"clinically":[49],"meaningful":[50],"OS":[51,154],"benefit":[52,356],"vs":[53,199,210,218,228,237],"placebo":[54],"(pbo)":[55],"with":[60,195,201,395],"newly":[61,377],"diagnosed":[62,378],"OC":[64],"who":[65],"tested":[66],"positive":[67],"homologous":[69],"recombination":[70],"deficiency":[71],"(HRD+;":[72],"tumour":[73],"BRCA1/2":[74],"mutation":[75],"[tBRCAm]":[76],"and/or":[77],"genomic":[78],"instability)":[79],"regardless":[80,398],"tBRCAm":[82,215,225,294,325,400],"status":[83,295,301,326,332],"(Ray-Coquard":[84],"et":[85],"al.":[86],"Ann":[87],"Oncol":[88],"2022:LBA29).":[89],"We":[90],"evaluated":[91],"by":[94,146,296,302,327,333],"molecular":[95,147],"subgroup":[96,148],"to":[97,115,122,132,162,168,248,360],"help":[98],"inform":[99],"potential":[101,372],"cure.":[103],"Pts":[104],"response":[106],"after":[107],"platinum-based":[108],"chemotherapy":[109],"were":[112,160],"randomized":[113,161],"2:1":[114],"(300":[117],"mg":[118],"bid":[119],"up":[121,131],"24":[123],"months)":[124,134],"(15":[127],"mg/kg":[128],"q3w":[129],"15":[133],"or":[135,250,254],"pbo":[136,169,202],"bev.":[138],"A":[139],"post":[140],"hoc,":[141],"updated":[142,350],"descriptive":[143,351],"was":[149,178,193],"conducted":[150],"data":[155,245],"cutoff":[156],"(DCO).":[157],"537":[158],"and":[166,180,235,299,330,368],"269":[167],"(median":[172],"follow-up":[174],"censored":[176],"56.7":[179],"57.8":[181],"months,":[182],"respectively).":[183],"At":[184],"DCO":[185],"(22":[186],"March":[187],"2022),":[188],"rate":[192],"46%":[194],"19%":[200],"HRD+":[207,223,376,396],"group,":[208,216,226,234],"50%":[209],"25%,":[211],"respectively,":[212,220,230,239],"41%":[217],"15%,":[219],"excluding":[224,286],"13%":[227],"13%,":[229],"HRD\u2212/unknown":[233],"8%":[236],"12%,":[238],"HRD\u2212":[242],"group.":[243],"Updated":[244],"time":[247],"first":[249],"second":[251],"subsequent":[252],"therapy":[253],"death":[255],"will":[256],"be":[257],"presented.Table:":[258],"36MONo.":[259],"events/no.":[261],"pts5-y":[263],"Median":[264],"PFSHR":[265],"(95%":[266],"CI)5-y":[267],"rate,*":[269],"(%)Olaparib":[270],"bevPbo":[272,276,280],"bevOlaparib":[274,278],"bevITT366/537222/26922.916.60.63":[282],"(0.53\u20130.74)2916HRD+136/255104/13246.817.60.41":[283],"(0.32\u20130.54)4619tBRCAm78/15758/8060.721.70.45":[284],"(0.32\u20130.64)5025HRD+":[285],"tBRCAm58/9746/5530.016.60.47":[287],"(0.32\u20130.70)4115HRD\u2212/unknown230/282118/13717.316.00.90":[288],"(0.72\u20131.13)1313HRD\u2212167/19274/8516.616.21.01":[289],"(0.77\u20131.33)812Investigator":[290],"assessed":[291,322],"(RECIST":[292,323],"1.1).":[293,324],"central":[297,328],"labs":[298,329],"HRD":[300,305,331,336],"Myriad":[303,334],"MyChoice":[304,335],"Plus.*Kaplan\u2013Meier":[306],"estimates.CI,":[307],"confidence":[308,341],"interval;":[309,342],"HR,":[310,343],"hazard":[311,344],"ratio;":[312,345],"ITT,":[313,346],"intent-to-treat.":[314,347],"Open":[315],"table":[316],"new":[319],"tab":[320],"Investigator":[321],"Plus.":[337],"*Kaplan\u2013Meier":[338],"estimates.":[339],"CI,":[340],"suggest":[354],"adding":[358],"is":[362],"sustained":[363],"beyond":[364],"end":[365],"treatment":[367],"indicate":[370],"OC,":[380],"supporting":[381],"use":[382],"standard":[390],"care":[392],"tumours,":[397],"status.":[401]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-02-26T00:00:00"}