{"id":"https://openalex.org/W4322008191","doi":"https://doi.org/10.1186/s12935-023-02877-y","title":"A novel Menin-MLL1 inhibitor, DS-1594a, prevents the progression of acute leukemia with rearranged MLL1 or mutated NPM1","display_name":"A novel Menin-MLL1 inhibitor, DS-1594a, prevents the progression of acute leukemia with rearranged MLL1 or mutated NPM1","publication_year":2023,"publication_date":"2023-02-25","ids":{"openalex":"https://openalex.org/W4322008191","doi":"https://doi.org/10.1186/s12935-023-02877-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/36841758","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9960487"},"language":"en","primary_location":{"id":"doi:10.1186/s12935-023-02877-y","doi":"https://doi.org/10.1186/s12935-023-02877-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12935-023-02877-y","pdf_url":"https://cancerci.biomedcentral.com/counter/pdf/10.1186/s12935-023-02877-y","source":{"id":"https://openalex.org/S130214813","display_name":"Cancer Cell International","issn_l":"1475-2867","issn":["1475-2867"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Cell International","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://cancerci.biomedcentral.com/counter/pdf/10.1186/s12935-023-02877-y","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112271832","display_name":"Masashi Numata","orcid":"https://orcid.org/0009-0004-6636-6272","observed_orcids":["https://orcid.org/0009-0004-6636-6272"]},"institutions":[{"id":"https://openalex.org/I4210104626","display_name":"Daiichi-Sankyo (Japan)","ror":"https://ror.org/027y26122","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104626"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masashi Numata","raw_affiliation_strings":["Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan","institution_ids":["https://openalex.org/I4210104626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043627463","display_name":"Noriyasu Haginoya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405284387","display_name":"Daiichi Sankyo RD Novare (Japan)","ror":"https://ror.org/03ey07j79","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104626","https://openalex.org/I4405284387"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Noriyasu Haginoya","raw_affiliation_strings":["Daiichi Sankyo RD Novare Co., Ltd, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Daiichi Sankyo RD Novare Co., Ltd, Tokyo, Japan","institution_ids":["https://openalex.org/I4405284387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050724518","display_name":"Machiko Shiroishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104626","display_name":"Daiichi-Sankyo (Japan)","ror":"https://ror.org/027y26122","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104626"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Machiko Shiroishi","raw_affiliation_strings":["Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan","institution_ids":["https://openalex.org/I4210104626"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tsuyoshi Hirata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405284387","display_name":"Daiichi Sankyo RD Novare (Japan)","ror":"https://ror.org/03ey07j79","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104626","https://openalex.org/I4405284387"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsuyoshi Hirata","raw_affiliation_strings":["Daiichi Sankyo RD Novare Co., Ltd, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Daiichi Sankyo RD Novare Co., Ltd, Tokyo, Japan","institution_ids":["https://openalex.org/I4405284387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053082973","display_name":"Aiko Sato\u2010Otsubo","orcid":"https://orcid.org/0000-0002-2528-0702","observed_orcids":["https://orcid.org/0000-0002-2528-0702"]},"institutions":[{"id":"https://openalex.org/I4405286413","display_name":"National Research Institute for Child Health and Development","ror":"https://ror.org/022h8bf50","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210132193","https://openalex.org/I4405286413"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Aiko Sato-Otsubo","raw_affiliation_strings":["Department of Pediatric Hematology and Oncology Research, National Research Institute for Child Health and Development, Tokyo, Japan","Department of Pediatrics, University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Hematology and Oncology Research, National Research Institute for Child Health and Development, Tokyo, Japan","institution_ids":["https://openalex.org/I4405286413"]},{"raw_affiliation_string":"Department of Pediatrics, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101795125","display_name":"Kenji Yoshikawa","orcid":"https://orcid.org/0000-0002-0875-1074","observed_orcids":["https://orcid.org/0000-0002-0875-1074"]},"institutions":[{"id":"https://openalex.org/I4210104626","display_name":"Daiichi-Sankyo (Japan)","ror":"https://ror.org/027y26122","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104626"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Yoshikawa","raw_affiliation_strings":["Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan","institution_ids":["https://openalex.org/I4210104626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110523281","display_name":"Yoshimi Takata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104626","display_name":"Daiichi-Sankyo (Japan)","ror":"https://ror.org/027y26122","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104626"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshimi Takata","raw_affiliation_strings":["Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan","institution_ids":["https://openalex.org/I4210104626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041201931","display_name":"Reina Nagase","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104626","display_name":"Daiichi-Sankyo (Japan)","ror":"https://ror.org/027y26122","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104626"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Reina Nagase","raw_affiliation_strings":["Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan","institution_ids":["https://openalex.org/I4210104626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014243329","display_name":"Yoshinori Kashimoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405284387","display_name":"Daiichi Sankyo RD Novare (Japan)","ror":"https://ror.org/03ey07j79","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104626","https://openalex.org/I4405284387"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshinori Kashimoto","raw_affiliation_strings":["Daiichi Sankyo RD Novare Co., Ltd, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Daiichi Sankyo RD Novare Co., Ltd, Tokyo, Japan","institution_ids":["https://openalex.org/I4405284387"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Makoto Suzuki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405284387","display_name":"Daiichi Sankyo RD Novare (Japan)","ror":"https://ror.org/03ey07j79","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104626","https://openalex.org/I4405284387"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Suzuki","raw_affiliation_strings":["Daiichi Sankyo RD Novare Co., Ltd, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Daiichi Sankyo RD Novare Co., Ltd, Tokyo, Japan","institution_ids":["https://openalex.org/I4405284387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003298241","display_name":"Nina Schulte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I179904914","display_name":"Daiichi Sankyo (Germany)","ror":"https://ror.org/01qhj1g70","country_code":"DE","type":"company","lineage":["https://openalex.org/I179904914","https://openalex.org/I4210104626"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nina Schulte","raw_affiliation_strings":["Daiichi Sankyo Europe GmbH, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Daiichi Sankyo Europe GmbH, Munich, Germany","institution_ids":["https://openalex.org/I179904914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040299208","display_name":"Gernot Polier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I179904914","display_name":"Daiichi Sankyo (Germany)","ror":"https://ror.org/01qhj1g70","country_code":"DE","type":"company","lineage":["https://openalex.org/I179904914","https://openalex.org/I4210104626"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gernot Polier","raw_affiliation_strings":["Daiichi Sankyo Europe GmbH, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Daiichi Sankyo Europe GmbH, Munich, Germany","institution_ids":["https://openalex.org/I179904914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034598788","display_name":"Akiko Kurimoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104626","display_name":"Daiichi-Sankyo (Japan)","ror":"https://ror.org/027y26122","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104626"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akiko Kurimoto","raw_affiliation_strings":["Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan","institution_ids":["https://openalex.org/I4210104626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039068309","display_name":"Yumiko Tomoe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104626","display_name":"Daiichi-Sankyo (Japan)","ror":"https://ror.org/027y26122","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104626"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yumiko Tomoe","raw_affiliation_strings":["Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan","institution_ids":["https://openalex.org/I4210104626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024496543","display_name":"Akiko Toyota","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104626","display_name":"Daiichi-Sankyo (Japan)","ror":"https://ror.org/027y26122","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104626"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akiko Toyota","raw_affiliation_strings":["Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan","institution_ids":["https://openalex.org/I4210104626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106266664","display_name":"Tomoko Yoneyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405284387","display_name":"Daiichi Sankyo RD Novare (Japan)","ror":"https://ror.org/03ey07j79","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104626","https://openalex.org/I4405284387"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoko Yoneyama","raw_affiliation_strings":["Daiichi Sankyo RD Novare Co., Ltd, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Daiichi Sankyo RD Novare Co., Ltd, Tokyo, Japan","institution_ids":["https://openalex.org/I4405284387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049905118","display_name":"Emi Imai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405284387","display_name":"Daiichi Sankyo RD Novare (Japan)","ror":"https://ror.org/03ey07j79","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104626","https://openalex.org/I4405284387"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Emi Imai","raw_affiliation_strings":["Daiichi Sankyo RD Novare Co., Ltd, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Daiichi Sankyo RD Novare Co., Ltd, Tokyo, Japan","institution_ids":["https://openalex.org/I4405284387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101983872","display_name":"Kenji Watanabe","orcid":"https://orcid.org/0000-0002-0301-8906","observed_orcids":["https://orcid.org/0000-0002-0301-8906"]},"institutions":[{"id":"https://openalex.org/I4210104626","display_name":"Daiichi-Sankyo (Japan)","ror":"https://ror.org/027y26122","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104626"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Watanabe","raw_affiliation_strings":["Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan","institution_ids":["https://openalex.org/I4210104626"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tomoaki Hamada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104626","display_name":"Daiichi-Sankyo (Japan)","ror":"https://ror.org/027y26122","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104626"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoaki Hamada","raw_affiliation_strings":["Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan","institution_ids":["https://openalex.org/I4210104626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031691811","display_name":"Ryutaro Kanada","orcid":"https://orcid.org/0000-0002-3915-6948","observed_orcids":["https://orcid.org/0000-0002-3915-6948"]},"institutions":[{"id":"https://openalex.org/I4210104626","display_name":"Daiichi-Sankyo (Japan)","ror":"https://ror.org/027y26122","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104626"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryutaro Kanada","raw_affiliation_strings":["Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan","institution_ids":["https://openalex.org/I4210104626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060021930","display_name":"Jun Watanabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104626","display_name":"Daiichi-Sankyo (Japan)","ror":"https://ror.org/027y26122","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104626"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun Watanabe","raw_affiliation_strings":["Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan","institution_ids":["https://openalex.org/I4210104626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012250548","display_name":"Yoshiko Kagoshima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104626","display_name":"Daiichi-Sankyo (Japan)","ror":"https://ror.org/027y26122","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104626"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiko Kagoshima","raw_affiliation_strings":["Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan","institution_ids":["https://openalex.org/I4210104626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078795360","display_name":"Eri Tokumaru","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104626","display_name":"Daiichi-Sankyo (Japan)","ror":"https://ror.org/027y26122","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104626"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eri Tokumaru","raw_affiliation_strings":["Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan","institution_ids":["https://openalex.org/I4210104626"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kenji Murata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104626","display_name":"Daiichi-Sankyo (Japan)","ror":"https://ror.org/027y26122","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104626"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Murata","raw_affiliation_strings":["Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan","institution_ids":["https://openalex.org/I4210104626"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Takayuki Baba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104626","display_name":"Daiichi-Sankyo (Japan)","ror":"https://ror.org/027y26122","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104626"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayuki Baba","raw_affiliation_strings":["Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan","institution_ids":["https://openalex.org/I4210104626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016231221","display_name":"Taeko Shinozaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104626","display_name":"Daiichi-Sankyo (Japan)","ror":"https://ror.org/027y26122","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104626"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taeko Shinozaki","raw_affiliation_strings":["Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan","institution_ids":["https://openalex.org/I4210104626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103405902","display_name":"Masami Ohtsuka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104626","display_name":"Daiichi-Sankyo (Japan)","ror":"https://ror.org/027y26122","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104626"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masami Ohtsuka","raw_affiliation_strings":["Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan","institution_ids":["https://openalex.org/I4210104626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037461196","display_name":"K\u014dichi Goto","orcid":"https://orcid.org/0000-0002-3023-2510","observed_orcids":["https://orcid.org/0000-0002-3023-2510"]},"institutions":[{"id":"https://openalex.org/I4210104626","display_name":"Daiichi-Sankyo (Japan)","ror":"https://ror.org/027y26122","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104626"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koichi Goto","raw_affiliation_strings":["Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan","institution_ids":["https://openalex.org/I4210104626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008663113","display_name":"Tsuyoshi Karibe","orcid":"https://orcid.org/0009-0005-7205-4889","observed_orcids":["https://orcid.org/0009-0005-7205-4889"]},"institutions":[{"id":"https://openalex.org/I4210104626","display_name":"Daiichi-Sankyo (Japan)","ror":"https://ror.org/027y26122","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104626"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsuyoshi Karibe","raw_affiliation_strings":["Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan","institution_ids":["https://openalex.org/I4210104626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035340824","display_name":"Takao Deguchi","orcid":"https://orcid.org/0000-0001-9932-4299","observed_orcids":["https://orcid.org/0000-0001-9932-4299"]},"institutions":[{"id":"https://openalex.org/I4210132193","display_name":"National Center For Child Health and Development","ror":"https://ror.org/03fvwxc59","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210132193"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takao Deguchi","raw_affiliation_strings":["Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan","institution_ids":["https://openalex.org/I4210132193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027737589","display_name":"Yoshihiro Gocho","orcid":"https://orcid.org/0000-0001-8136-0187","observed_orcids":["https://orcid.org/0000-0001-8136-0187"]},"institutions":[{"id":"https://openalex.org/I4210132193","display_name":"National Center For Child Health and Development","ror":"https://ror.org/03fvwxc59","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210132193"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiro Gocho","raw_affiliation_strings":["Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan","institution_ids":["https://openalex.org/I4210132193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018787868","display_name":"Masanori Yoshida","orcid":"https://orcid.org/0000-0002-9171-7335","observed_orcids":["https://orcid.org/0000-0002-9171-7335","https://orcid.org/0000-0002-1032-1014"]},"institutions":[{"id":"https://openalex.org/I4405286413","display_name":"National Research Institute for Child Health and Development","ror":"https://ror.org/022h8bf50","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210132193","https://openalex.org/I4405286413"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masanori Yoshida","raw_affiliation_strings":["Department of Pediatric Hematology and Oncology Research, National Research Institute for Child Health and Development, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Hematology and Oncology Research, National Research Institute for Child Health and Development, Tokyo, Japan","institution_ids":["https://openalex.org/I4405286413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029932023","display_name":"Daisuke Tomizawa","orcid":"https://orcid.org/0000-0003-1520-7007","observed_orcids":["https://orcid.org/0000-0003-1520-7007"]},"institutions":[{"id":"https://openalex.org/I4210132193","display_name":"National Center For Child Health and Development","ror":"https://ror.org/03fvwxc59","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210132193"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Daisuke Tomizawa","raw_affiliation_strings":["Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan","institution_ids":["https://openalex.org/I4210132193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078387402","display_name":"Motohiro Kato","orcid":"https://orcid.org/0000-0001-5145-1774","observed_orcids":["https://orcid.org/0000-0001-5145-1774"]},"institutions":[{"id":"https://openalex.org/I4210132193","display_name":"National Center For Child Health and Development","ror":"https://ror.org/03fvwxc59","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210132193"]},{"id":"https://openalex.org/I4405286413","display_name":"National Research Institute for Child Health and Development","ror":"https://ror.org/022h8bf50","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210132193","https://openalex.org/I4405286413"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Motohiro Kato","raw_affiliation_strings":["Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan","Department of Pediatric Hematology and Oncology Research, National Research Institute for Child Health and Development, Tokyo, Japan","Department of Pediatrics, University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan","institution_ids":["https://openalex.org/I4210132193"]},{"raw_affiliation_string":"Department of Pediatric Hematology and Oncology Research, National Research Institute for Child Health and Development, Tokyo, Japan","institution_ids":["https://openalex.org/I4405286413"]},{"raw_affiliation_string":"Department of Pediatrics, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005574192","display_name":"Shinji Tsutsumi","orcid":"https://orcid.org/0000-0003-4790-0041","observed_orcids":["https://orcid.org/0000-0003-4790-0041"]},"institutions":[{"id":"https://openalex.org/I4210104626","display_name":"Daiichi-Sankyo (Japan)","ror":"https://ror.org/027y26122","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104626"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinji Tsutsumi","raw_affiliation_strings":["Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan","institution_ids":["https://openalex.org/I4210104626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109970721","display_name":"Mayumi Kitagawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104626","display_name":"Daiichi-Sankyo (Japan)","ror":"https://ror.org/027y26122","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104626"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Mayumi Kitagawa","raw_affiliation_strings":["Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan. kitagawa.mayumi.zr@daiichisankyo.co.jp","Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan. kitagawa.mayumi.zr@daiichisankyo.co.jp","institution_ids":["https://openalex.org/I4210104626"]},{"raw_affiliation_string":"Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan","institution_ids":["https://openalex.org/I4210104626"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035406837","display_name":"Yuki Abe","orcid":"https://orcid.org/0000-0002-5352-724X","observed_orcids":["https://orcid.org/0000-0002-5352-724X"]},"institutions":[{"id":"https://openalex.org/I4210104626","display_name":"Daiichi-Sankyo (Japan)","ror":"https://ror.org/027y26122","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104626"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuki Abe","raw_affiliation_strings":["Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shinagawa R&D Center, Daiichi Sankyo Co., Ltd, 1-2-5 Hiromachi, Shinagawa-Ku, Tokyo, 140-0005, Japan","institution_ids":["https://openalex.org/I4210104626"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5109970721"],"corresponding_institution_ids":["https://openalex.org/I4210104626"],"apc_list":{"value":2890,"currency":"USD","value_usd":2890},"apc_paid":{"value":2890,"currency":"USD","value_usd":2890},"fwci":6.9078,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.97763381,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"23","issue":"1","first_page":"36","last_page":"36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/npm1-mutation","display_name":"NPM1 mutation","score":0.875},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9390000104904175},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/leukemia-initiating-cells","display_name":"leukemia-initiating cells","score":0.7639999985694885},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.7960000038146973},{"id":"https://openalex.org/keywords/oral-anticancer-drugs","display_name":"oral anticancer drugs","score":0.7670000195503235},{"id":"https://openalex.org/keywords/molm-13-cells","display_name":"MOLM-13 cells","score":0.7820000052452087}],"concepts":[{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.6371569037437439},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.5969992876052856},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5896009802818298},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5698392987251282},{"id":"https://openalex.org/C2483381","wikidata":"https://www.wikidata.org/wiki/Q18030194","display_name":"NPM1","level":5,"score":0.47841793298721313},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4107828140258789},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36652618646621704},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21249186992645264},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10639217495918274},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10317027568817139},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07247352600097656},{"id":"https://openalex.org/C53226629","wikidata":"https://www.wikidata.org/wiki/Q189967","display_name":"Karyotype","level":4,"score":0.0},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s12935-023-02877-y","doi":"https://doi.org/10.1186/s12935-023-02877-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12935-023-02877-y","pdf_url":"https://cancerci.biomedcentral.com/counter/pdf/10.1186/s12935-023-02877-y","source":{"id":"https://openalex.org/S130214813","display_name":"Cancer Cell International","issn_l":"1475-2867","issn":["1475-2867"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Cell International","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9960487","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9960487","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9960487/pdf/12935_2023_Article_2877.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Cell Int","raw_type":"Text"},{"id":"pmid:36841758","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36841758","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer cell international","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f86d0f97c6f6435c8a15c5b3055bcdf2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f86d0f97c6f6435c8a15c5b3055bcdf2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Cell International, Vol 23, Iss 1, Pp 1-16 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12935-023-02877-y","doi":"https://doi.org/10.1186/s12935-023-02877-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12935-023-02877-y","pdf_url":"https://cancerci.biomedcentral.com/counter/pdf/10.1186/s12935-023-02877-y","source":{"id":"https://openalex.org/S130214813","display_name":"Cancer Cell International","issn_l":"1475-2867","issn":["1475-2867"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Cell International","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321625","display_name":"Daiichi-Sankyo","ror":"https://ror.org/027y26122"},{"id":"https://openalex.org/F4320323878","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60"},{"id":"https://openalex.org/F4320338262","display_name":"Daiichi Sankyo Europe","ror":"https://ror.org/01qhj1g70"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4322008191.pdf","grobid_xml":"https://content.openalex.org/works/W4322008191.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1527861124","https://openalex.org/W1968048144","https://openalex.org/W1982261265","https://openalex.org/W2018786081","https://openalex.org/W2025570007","https://openalex.org/W2049346761","https://openalex.org/W2061881437","https://openalex.org/W2069591815","https://openalex.org/W2069918359","https://openalex.org/W2082592723","https://openalex.org/W2087214029","https://openalex.org/W2109336877","https://openalex.org/W2110726136","https://openalex.org/W2123719503","https://openalex.org/W2151718828","https://openalex.org/W2154218976","https://openalex.org/W2170515966","https://openalex.org/W2362534374","https://openalex.org/W2587240909","https://openalex.org/W2602681209","https://openalex.org/W2735774793","https://openalex.org/W2804175528","https://openalex.org/W2916162780","https://openalex.org/W2981210082","https://openalex.org/W2982435333","https://openalex.org/W2993435749","https://openalex.org/W3004043543","https://openalex.org/W3011384934","https://openalex.org/W3017051127","https://openalex.org/W3127239358","https://openalex.org/W3159397045","https://openalex.org/W3167620265","https://openalex.org/W3175888527","https://openalex.org/W3211091265","https://openalex.org/W3213199459","https://openalex.org/W4241093998","https://openalex.org/W4242135586"],"related_works":["https://openalex.org/W3180944734","https://openalex.org/W4310108962","https://openalex.org/W6902201208","https://openalex.org/W4282938078","https://openalex.org/W4242135586","https://openalex.org/W3212772886","https://openalex.org/W4402988620","https://openalex.org/W4393085664","https://openalex.org/W4409645183","https://openalex.org/W4415952006"],"abstract_inverted_index":{"BACKGROUND:":[0],"Mixed":[1],"lineage":[2],"leukemia":[3,7,104,107,209],"1-rearranged":[4],"(MLL1-r)":[5],"acute":[6,55,102,208],"patients":[8,48],"respond":[9],"poorly":[10],"to":[11,20,127,247],"currently":[12],"available":[13,220],"treatments":[14],"and":[15,38,67,87,98,124,149,161,182,188,194,200,241,253],"there":[16],"is":[17,42],"a":[18,43,216,249],"need":[19],"develop":[21],"more":[22],"effective":[23],"therapies":[24],"directly":[25],"disrupting":[26],"the":[27,33,63,73,140,152,224,245],"Menin\u2012MLL1":[28],"complex.":[29],"Small-molecule-mediated":[30],"inhibition":[31,132],"of":[32,76,85,93,154,204,223,239],"protein\u2012protein":[34],"interaction":[35],"between":[36],"Menin":[37],"MLL1":[39],"fusion":[40],"proteins":[41],"potential":[44,155,165,246],"therapeutic":[45],"strategy":[46],"for":[47,258],"with":[49,129,138],"MLL1-r":[50,115,167,205],"or":[51,116,206],"mutated-nucleophosmin":[52],"1":[53],"(NPM1c)":[54],"leukemia.":[56],"In":[57],"this":[58],"study,":[59],"we":[60],"preclinically":[61],"evaluated":[62,72],"new":[64,250],"compound":[65],"DS-1594a":[66,77,232,243],"its":[68],"salts.":[69],"METHODS:":[70],"We":[71,213],"preclinical":[74],"efficacy":[75,193],"as":[78,80,144],"well":[79],"DS-1594a\u00b7HCl":[81,148,187],"(the":[82,89],"HCl":[83],"salt":[84,92],"DS-1594a)":[86],"DS-1594a\u00b7succinate":[88,150,189],"succinic":[90],"acid":[91],"DS-1594a,":[94],"DS-1594b)":[95],"in":[96,99,166,170,197,210],"vitro":[97],"vivo":[100],"using":[101],"myeloid":[103],"(AML)/acute":[105],"lymphoblastic":[106],"(ALL)":[108],"models.":[109],"RESULTS:":[110],"Our":[111,228],"results":[112,173,229],"showed":[113],"that":[114,231,242],"NPM1c":[117,207],"human":[118],"leukemic":[119],"cell":[120,199],"lines":[121],"were":[122,174],"selectively":[123],"highly":[125],"sensitive":[126],"DS-1594a\u00b7HCl,":[128],"50%":[130],"growth":[131],"values":[133],"<":[134],"30":[135],"nM.":[136],"Compared":[137],"cytrabine,":[139],"standard":[141],"chemotherapy":[142],"drug":[143],"AML":[145,168],"therapy,":[146],"both":[147],"mediated":[151],"eradication":[153],"leukemia-initiating":[156],"cells":[157,169],"by":[158,176],"enhancing":[159],"differentiation":[160],"reducing":[162],"serial":[163],"colony-forming":[164],"vitro.":[171],"The":[172],"confirmed":[175],"flow":[177],"cytometry,":[178],"RNA":[179],"sequencing,":[180],"RT\u2012qPCR":[181],"chromatin":[183],"immunoprecipitation":[184],"sequencing":[185],"analyses.":[186],"exhibited":[190],"significant":[191],"antitumor":[192],"survival":[195],"benefit":[196],"MOLM-13":[198],"patient-derived":[201],"xenograft":[202],"models":[203],"vivo.":[211],"CONCLUSION:":[212],"have":[214],"generated":[215],"novel,":[217],"potent,":[218],"orally":[219],"small-molecule":[221],"inhibitor":[222],"Menin-MLL1":[225],"interaction,":[226],"DS-1594a.":[227],"suggest":[230],"has":[233,244],"medicinal":[234],"properties":[235],"distinct":[236],"from":[237],"those":[238],"cytarabine":[240],"be":[248],"anticancer":[251],"therapy":[252],"support":[254],"oral":[255],"dosing":[256],"regimen":[257],"clinical":[259],"studies":[260],"(NCT04752163).":[261]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-02-26T00:00:00"}