{"id":"https://openalex.org/W4321372015","doi":"https://doi.org/10.3390/biomedicines11020612","title":"H2S Prodrug, SG-1002, Protects against Myocardial Oxidative Damage and Hypertrophy In Vitro via Induction of Cystathionine \u03b2-Synthase and Antioxidant Proteins","display_name":"H2S Prodrug, SG-1002, Protects against Myocardial Oxidative Damage and Hypertrophy In Vitro via Induction of Cystathionine \u03b2-Synthase and Antioxidant Proteins","publication_year":2023,"publication_date":"2023-02-18","ids":{"openalex":"https://openalex.org/W4321372015","doi":"https://doi.org/10.3390/biomedicines11020612","pmid":"https://pubmed.ncbi.nlm.nih.gov/36831146","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9953594"},"language":"en","primary_location":{"id":"doi:10.3390/biomedicines11020612","doi":"https://doi.org/10.3390/biomedicines11020612","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines11020612","pdf_url":"https://www.mdpi.com/2227-9059/11/2/612/pdf?version=1676709779","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2227-9059/11/2/612/pdf?version=1676709779","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007198892","display_name":"Rahib K. Islam","orcid":"https://orcid.org/0000-0001-8175-4290","observed_orcids":["https://orcid.org/0000-0001-8175-4290"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rahib Islam","raw_affiliation_strings":["Departments of Pharmacology and Experimental Therapeutics, Genetics, and Physiology, Louisiana State University Health Sciences Center, 1901 Perdido St., New Orleans, LA 70112, USA","Departments of Pharmacology and Experimental Medicine, Genetics, and Physiology, Louisiana State University Health Sciences Center, 1901 Perdido St., New Orleans, LA 70112, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Experimental Therapeutics, Genetics, and Physiology, Louisiana State University Health Sciences Center, 1901 Perdido St., New Orleans, LA 70112, USA","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I75420490"]},{"raw_affiliation_string":"Departments of Pharmacology and Experimental Medicine, Genetics, and Physiology, Louisiana State University Health Sciences Center, 1901 Perdido St., New Orleans, LA 70112, USA","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Erinn Donnelly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erinn Donnelly","raw_affiliation_strings":["Departments of Pharmacology and Experimental Therapeutics, Genetics, and Physiology, Louisiana State University Health Sciences Center, 1901 Perdido St., New Orleans, LA 70112, USA","Departments of Pharmacology and Experimental Medicine, Genetics, and Physiology, Louisiana State University Health Sciences Center, 1901 Perdido St., New Orleans, LA 70112, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Experimental Therapeutics, Genetics, and Physiology, Louisiana State University Health Sciences Center, 1901 Perdido St., New Orleans, LA 70112, USA","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I75420490"]},{"raw_affiliation_string":"Departments of Pharmacology and Experimental Medicine, Genetics, and Physiology, Louisiana State University Health Sciences Center, 1901 Perdido St., New Orleans, LA 70112, USA","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043660253","display_name":"Erminia Donnarumma","orcid":"https://orcid.org/0000-0003-2184-5144","observed_orcids":["https://orcid.org/0000-0003-2184-5144"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]},{"id":"https://openalex.org/I4405277297","display_name":"Biologie cellulaire physiologique et pathologique","ror":"https://ror.org/0267nwx23","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I157536573","https://openalex.org/I4405277297"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Erminia Donnarumma","raw_affiliation_strings":["Mitochondrial Biology Group, Institute Pasteur, CNRS UMR 3691, 75015 Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mitochondrial Biology Group, Institute Pasteur, CNRS UMR 3691, 75015 Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I157536573","https://openalex.org/I4405277297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112379888","display_name":"Fokhrul M. Hossain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fokhrul Hossain","raw_affiliation_strings":["Departments of Pharmacology and Experimental Therapeutics, Genetics, and Physiology, Louisiana State University Health Sciences Center, 1901 Perdido St., New Orleans, LA 70112, USA","Departments of Pharmacology and Experimental Medicine, Genetics, and Physiology, Louisiana State University Health Sciences Center, 1901 Perdido St., New Orleans, LA 70112, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Experimental Therapeutics, Genetics, and Physiology, Louisiana State University Health Sciences Center, 1901 Perdido St., New Orleans, LA 70112, USA","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I75420490"]},{"raw_affiliation_string":"Departments of Pharmacology and Experimental Medicine, Genetics, and Physiology, Louisiana State University Health Sciences Center, 1901 Perdido St., New Orleans, LA 70112, USA","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063293908","display_name":"Jason D. Gardner","orcid":"https://orcid.org/0000-0002-4785-7357","observed_orcids":["https://orcid.org/0000-0002-4785-7357"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Gardner","raw_affiliation_strings":["Departments of Pharmacology and Experimental Therapeutics, Genetics, and Physiology, Louisiana State University Health Sciences Center, 1901 Perdido St., New Orleans, LA 70112, USA","Departments of Pharmacology and Experimental Medicine, Genetics, and Physiology, Louisiana State University Health Sciences Center, 1901 Perdido St., New Orleans, LA 70112, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Experimental Therapeutics, Genetics, and Physiology, Louisiana State University Health Sciences Center, 1901 Perdido St., New Orleans, LA 70112, USA","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I75420490"]},{"raw_affiliation_string":"Departments of Pharmacology and Experimental Medicine, Genetics, and Physiology, Louisiana State University Health Sciences Center, 1901 Perdido St., New Orleans, LA 70112, USA","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102900302","display_name":"Kazi N. Islam","orcid":"https://orcid.org/0000-0001-8348-8934","observed_orcids":["https://orcid.org/0000-0001-8348-8934"]},"institutions":[{"id":"https://openalex.org/I162212782","display_name":"Central State University","ror":"https://ror.org/03xhrps63","country_code":"US","type":"education","lineage":["https://openalex.org/I162212782"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kazi Islam","raw_affiliation_strings":["Agricultural Research Development Program, College of Engineering, Science, Technology and Agriculture, Central State University, 1400 Brush Row Road, Wilberforce, OH 45384, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Agricultural Research Development Program, College of Engineering, Science, Technology and Agriculture, Central State University, 1400 Brush Row Road, Wilberforce, OH 45384, USA","institution_ids":["https://openalex.org/I162212782"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5102900302"],"corresponding_institution_ids":["https://openalex.org/I162212782"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2447},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2447},"fwci":1.4646,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.76343475,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"11","issue":"2","first_page":"612","last_page":"612"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydrogen-sulfide","display_name":"hydrogen sulfide","score":0.8859999775886536},{"id":"https://openalex.org/keywords/cystathionine-beta-synthase","display_name":"cystathionine beta-synthase","score":0.9750000238418579},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.847000002861023},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9089999794960022},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.7409999966621399},{"id":"https://openalex.org/keywords/serum-deprivation","display_name":"serum deprivation","score":0.7300000190734863},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.9539999961853027},{"id":"https://openalex.org/keywords/superoxide-dismutase-1","display_name":"superoxide dismutase 1","score":0.9399999976158142},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":1.0},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.6389999985694885},{"id":"https://openalex.org/keywords/atrial-natriuretic-peptide","display_name":"atrial natriuretic peptide","score":0.9089999794960022},{"id":"https://openalex.org/keywords/galectin-3","display_name":"galectin-3","score":0.8769999742507935},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.8270000219345093},{"id":"https://openalex.org/keywords/antioxidant-proteins","display_name":"antioxidant proteins","score":0.4009999930858612}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7364927530288696},{"id":"https://openalex.org/C16525657","wikidata":"https://www.wikidata.org/wiki/Q5201183","display_name":"Cystathionine beta synthase","level":4,"score":0.5734152793884277},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.524486243724823},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.5188199877738953},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.49455901980400085},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48077768087387085},{"id":"https://openalex.org/C2778069365","wikidata":"https://www.wikidata.org/wiki/Q78185357","display_name":"Atrial natriuretic peptide","level":2,"score":0.4622940719127655},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4438972771167755},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.43183454871177673},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.4191417098045349},{"id":"https://openalex.org/C2775915353","wikidata":"https://www.wikidata.org/wiki/Q1571529","display_name":"Natriuretic peptide","level":3,"score":0.41043663024902344},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.4061287045478821},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.3553435802459717},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33050113916397095},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28092992305755615},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2578813135623932},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.22492992877960205},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/biomedicines11020612","doi":"https://doi.org/10.3390/biomedicines11020612","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines11020612","pdf_url":"https://www.mdpi.com/2227-9059/11/2/612/pdf?version=1676709779","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},{"id":"doi:10.1101/2021.03.28.437435","doi":"https://doi.org/10.1101/2021.03.28.437435","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.03.28.437435","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/03/29/2021.03.28.437435.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:9953594","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9953594","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9953594/pdf/biomedicines-11-00612.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Text"},{"id":"pmid:36831146","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36831146","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d66b691a7aa5492380d2a9ecc542b102","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d66b691a7aa5492380d2a9ecc542b102","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedicines, Vol 11, Iss 2, p 612 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/biomedicines11020612","doi":"https://doi.org/10.3390/biomedicines11020612","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines11020612","pdf_url":"https://www.mdpi.com/2227-9059/11/2/612/pdf?version=1676709779","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4321372015.pdf","grobid_xml":"https://content.openalex.org/works/W4321372015.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W1541015815","https://openalex.org/W1552635840","https://openalex.org/W1576285319","https://openalex.org/W1596237902","https://openalex.org/W1964491974","https://openalex.org/W1974190070","https://openalex.org/W1975746078","https://openalex.org/W1976539175","https://openalex.org/W1979710206","https://openalex.org/W1980654031","https://openalex.org/W1981512919","https://openalex.org/W1985232927","https://openalex.org/W1985846516","https://openalex.org/W1986012170","https://openalex.org/W1994446230","https://openalex.org/W2008697475","https://openalex.org/W2009296914","https://openalex.org/W2020444237","https://openalex.org/W2020990593","https://openalex.org/W2025952153","https://openalex.org/W2033491276","https://openalex.org/W2036934264","https://openalex.org/W2043100807","https://openalex.org/W2054064167","https://openalex.org/W2058242086","https://openalex.org/W2059311343","https://openalex.org/W2064075208","https://openalex.org/W2066963386","https://openalex.org/W2069463594","https://openalex.org/W2073465079","https://openalex.org/W2074730055","https://openalex.org/W2078739145","https://openalex.org/W2079310705","https://openalex.org/W2084982869","https://openalex.org/W2090881549","https://openalex.org/W2091557653","https://openalex.org/W2094705328","https://openalex.org/W2100019254","https://openalex.org/W2107312159","https://openalex.org/W2110899027","https://openalex.org/W2112355340","https://openalex.org/W2112954543","https://openalex.org/W2116488609","https://openalex.org/W2118204731","https://openalex.org/W2120464741","https://openalex.org/W2121003339","https://openalex.org/W2126636055","https://openalex.org/W2133556236","https://openalex.org/W2134850908","https://openalex.org/W2136703555","https://openalex.org/W2144175766","https://openalex.org/W2148637873","https://openalex.org/W2149381773","https://openalex.org/W2156593520","https://openalex.org/W2160081886","https://openalex.org/W2169746496","https://openalex.org/W2171327123","https://openalex.org/W2172763759","https://openalex.org/W2185658412","https://openalex.org/W2197175751","https://openalex.org/W2381837479","https://openalex.org/W2405075560","https://openalex.org/W2492609725","https://openalex.org/W2753995352","https://openalex.org/W2762527413","https://openalex.org/W2792820043","https://openalex.org/W2810055936","https://openalex.org/W2891428585","https://openalex.org/W2912371173","https://openalex.org/W2953555236","https://openalex.org/W2986720590","https://openalex.org/W2988309021","https://openalex.org/W3023609649","https://openalex.org/W3091459717","https://openalex.org/W6710279159"],"related_works":["https://openalex.org/W3149637578","https://openalex.org/W2765408857","https://openalex.org/W2972498242","https://openalex.org/W2354207096","https://openalex.org/W2379955509","https://openalex.org/W3035514363","https://openalex.org/W2982962735","https://openalex.org/W3195830015","https://openalex.org/W198462100","https://openalex.org/W4409146194"],"abstract_inverted_index":{"Endogenously":[0],"produced":[1],"hydrogen":[2],"sulfide":[3],"(H2S)":[4],"is":[5],"critical":[6],"for":[7],"cardiovascular":[8],"homeostasis.":[9],"Therapeutic":[10],"strategies":[11],"aimed":[12],"at":[13],"increasing":[14,176],"H2S":[15,43,75,177,180],"levels":[16,72,178],"have":[17],"proven":[18],"cardioprotective":[19],"in":[20,51,127,148],"models":[21],"of":[22,40,58,73,106,138,145,161],"acute":[23],"myocardial":[24,168],"infarction":[25],"(MI)":[26],"and":[27,78,94,96,125,141,184],"heart":[28],"failure":[29],"(HF).":[30],"The":[31],"present":[32],"study":[33,163],"was":[34],"undertaken":[35],"to":[36],"investigate":[37],"the":[38,71,104],"effects":[39],"a":[41,135,142],"novel":[42],"prodrug,":[44],"SG-1002,":[45],"on":[46],"stress":[47],"induced":[48],"hypertrophic":[49,173],"signaling":[50,174],"murine":[52],"HL-1":[53,59,129,149],"cardiac":[54],"muscle":[55],"cells.":[56,130],"Treatment":[57,131],"cells":[60,150],"with":[61,68,132,157],"SG-1002":[62,101,133,166],"under":[63,151],"serum":[64,152],"starvation":[65,153],"without":[66,155],"or":[67,156,179],"H2O2":[69],"increased":[70],"H2S,":[74],"producing":[76,181],"enzyme,":[77],"cystathionine":[79],"\u03b2-synthase":[80],"(CBS),":[81],"as":[82,84,89,111],"well":[83],"antioxidant":[85,185],"protein":[86,108],"levels,":[87],"such":[88,110],"super":[90],"oxide":[91],"dismutase1":[92],"(SOD1)":[93],"catalase,":[95],"additionally":[97],"decreased":[98,103],"oxidative":[99,170],"stress.":[100],"also":[102],"expression":[105],"hypertrophic/HF":[107],"markers":[109],"atrial":[112],"natriuretic":[113,117],"peptide":[114,118],"(ANP),":[115],"brain":[116],"(BNP),":[119],"galectin-3,":[120],"TIMP1,":[121],"collagen":[122],"type":[123],"III,":[124],"TGF-\u03b21":[126],"stressed":[128],"caused":[134],"significant":[136],"induction":[137],"cell":[139],"viability":[140],"marked":[143],"reduction":[144],"cellular":[146,169],"cytotoxicity":[147],"incubated":[154],"H2O2.":[158],"Experimental":[159],"results":[160],"this":[162],"suggest":[164],"that":[165],"attenuates":[167],"damage":[171],"and/or":[172],"via":[175],"enzymes,":[182],"CBS,":[183],"proteins.":[186]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-02-21T00:00:00"}