{"id":"https://openalex.org/W4320719137","doi":"https://doi.org/10.33483/jfpau.1085253","title":"TAURINE PREVENTS AGAINST 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN-INDUCED OXIDATIVE STRESS IN THE LIVER AND KIDNEY OF RATS","display_name":"TAURINE PREVENTS AGAINST 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN-INDUCED OXIDATIVE STRESS IN THE LIVER AND KIDNEY OF RATS","publication_year":2023,"publication_date":"2023-01-27","ids":{"openalex":"https://openalex.org/W4320719137","doi":"https://doi.org/10.33483/jfpau.1085253"},"language":"en","primary_location":{"id":"doi:10.33483/jfpau.1085253","doi":"https://doi.org/10.33483/jfpau.1085253","is_oa":true,"landing_page_url":"http://dx.doi.org/10.33483/jfpau.1085253","pdf_url":"https://dergipark.org.tr/en/download/article-file/2299744","source":{"id":"https://openalex.org/S4210194989","display_name":"Ankara Universitesi Eczacilik Fakultesi Dergisi","issn_l":"1015-3918","issn":["1015-3918","2564-6524"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4","tr-dizin"],"host_organization":"https://openalex.org/P4310318375","host_organization_name":"Ankara University","host_organization_lineage":["https://openalex.org/P4310318375"],"host_organization_lineage_names":["Ankara University"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ankara Universitesi Eczacilik Fakultesi Dergisi","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://dergipark.org.tr/en/download/article-file/2299744","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102814977","display_name":"Muhammed Fatih Do\u011fan","orcid":"https://orcid.org/0000-0003-4628-2771","observed_orcids":["https://orcid.org/0000-0003-4628-2771"]},"institutions":[{"id":"https://openalex.org/I48843708","display_name":"Pamukkale University","ror":"https://ror.org/01etz1309","country_code":"TR","type":"education","lineage":["https://openalex.org/I48843708"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Muhammed Fatih DO\u011eAN","raw_affiliation_strings":["PAMUKKALE \u00dcN\u0130VERS\u0130TES\u0130, TIP FAK\u00dcLTES\u0130"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PAMUKKALE \u00dcN\u0130VERS\u0130TES\u0130, TIP FAK\u00dcLTES\u0130","institution_ids":["https://openalex.org/I48843708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031429115","display_name":"Oisman \u00c7\u0130FT\u00c7\u0130","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48843708","display_name":"Pamukkale University","ror":"https://ror.org/01etz1309","country_code":"TR","type":"education","lineage":["https://openalex.org/I48843708"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Oisman \u00c7\u0130FT\u00c7\u0130","raw_affiliation_strings":["PAMUKKALE \u00dcN\u0130VERS\u0130TES\u0130, TIP FAK\u00dcLTES\u0130"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PAMUKKALE \u00dcN\u0130VERS\u0130TES\u0130, TIP FAK\u00dcLTES\u0130","institution_ids":["https://openalex.org/I48843708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017434614","display_name":"Ne\u015fe Ba\u015fak T\u00fcrkmen","orcid":"https://orcid.org/0000-0003-3828-0901","observed_orcids":["https://orcid.org/0000-0003-3828-0901"]},"institutions":[{"id":"https://openalex.org/I20126385","display_name":"Inonu University","ror":"https://ror.org/04asck240","country_code":"TR","type":"education","lineage":["https://openalex.org/I20126385"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ne\u015fe BA\u015eAK T\u00dcRKMEN","raw_affiliation_strings":["\u0130N\u00d6N\u00dc \u00dcN\u0130VERS\u0130TES\u0130, ECZACILIK FAK\u00dcLTES\u0130"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u0130N\u00d6N\u00dc \u00dcN\u0130VERS\u0130TES\u0130, ECZACILIK FAK\u00dcLTES\u0130","institution_ids":["https://openalex.org/I20126385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008553151","display_name":"Asl\u0131 \u00c7etin","orcid":"https://orcid.org/0000-0003-3902-3210","observed_orcids":["https://orcid.org/0000-0003-3902-3210"]},"institutions":[{"id":"https://openalex.org/I20126385","display_name":"Inonu University","ror":"https://ror.org/04asck240","country_code":"TR","type":"education","lineage":["https://openalex.org/I20126385"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Asl\u0131 \u00c7ET\u0130N","raw_affiliation_strings":["\u0130N\u00d6N\u00dc \u00dcN\u0130VERS\u0130TES\u0130, TIP FAK\u00dcLTES\u0130"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u0130N\u00d6N\u00dc \u00dcN\u0130VERS\u0130TES\u0130, TIP FAK\u00dcLTES\u0130","institution_ids":["https://openalex.org/I20126385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077463466","display_name":"M\u00fcnevver Nazl\u0131can ZENG\u0130N","orcid":"https://orcid.org/0000-0002-3536-6606","observed_orcids":["https://orcid.org/0000-0002-3536-6606"]},"institutions":[{"id":"https://openalex.org/I48843708","display_name":"Pamukkale University","ror":"https://ror.org/01etz1309","country_code":"TR","type":"education","lineage":["https://openalex.org/I48843708"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"M\u00fcnevver Nazl\u0131can ZENG\u0130N","raw_affiliation_strings":["PAMUKKALE \u00dcN\u0130VERS\u0130TES\u0130, TIP FAK\u00dcLTES\u0130"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PAMUKKALE \u00dcN\u0130VERS\u0130TES\u0130, TIP FAK\u00dcLTES\u0130","institution_ids":["https://openalex.org/I48843708"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044492228","display_name":"Bedriye \u00c7\u0130FT\u00c7\u0130","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48843708","display_name":"Pamukkale University","ror":"https://ror.org/01etz1309","country_code":"TR","type":"education","lineage":["https://openalex.org/I48843708"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Bedriye \u00c7\u0130FT\u00c7\u0130","raw_affiliation_strings":["PAMUKKALE \u00dcN\u0130VERS\u0130TES\u0130"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PAMUKKALE \u00dcN\u0130VERS\u0130TES\u0130","institution_ids":["https://openalex.org/I48843708"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0962,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.27446629,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/taurine","display_name":"taurine","score":1.0},{"id":"https://openalex.org/keywords/2-3-7-8-tetrachlorodibenzo-p-dioxin","display_name":"2,3,7,8-tetrachlorodibenzo-p-dioxin","score":0.9879999756813049},{"id":"https://openalex.org/keywords/tcdd","display_name":"TCDD","score":0.7630000114440918},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9649999737739563},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.8090000152587891},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":1.0},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.48500001430511475},{"id":"https://openalex.org/keywords/kidney","display_name":"kidney","score":1.0},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.8600000143051147},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":1.0},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9829999804496765},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C2777352226","wikidata":"https://www.wikidata.org/wiki/Q7669516","display_name":"TBARS","level":4,"score":0.959176778793335},{"id":"https://openalex.org/C2779701627","wikidata":"https://www.wikidata.org/wiki/Q207051","display_name":"Taurine","level":3,"score":0.9556118845939636},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.8182105422019958},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.7766001224517822},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6673949956893921},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6586210131645203},{"id":"https://openalex.org/C2777504301","wikidata":"https://www.wikidata.org/wiki/Q418230","display_name":"Thiobarbituric acid","level":4,"score":0.6584801077842712},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6270996928215027},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.5669122338294983},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5488184690475464},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.5012125968933105},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.49467894434928894},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.47504568099975586},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2765933871269226},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17249831557273865},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14130640029907227},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.12936607003211975},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11159145832061768}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.33483/jfpau.1085253","doi":"https://doi.org/10.33483/jfpau.1085253","is_oa":true,"landing_page_url":"http://dx.doi.org/10.33483/jfpau.1085253","pdf_url":"https://dergipark.org.tr/en/download/article-file/2299744","source":{"id":"https://openalex.org/S4210194989","display_name":"Ankara Universitesi Eczacilik Fakultesi Dergisi","issn_l":"1015-3918","issn":["1015-3918","2564-6524"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4","tr-dizin"],"host_organization":"https://openalex.org/P4310318375","host_organization_name":"Ankara University","host_organization_lineage":["https://openalex.org/P4310318375"],"host_organization_lineage_names":["Ankara University"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ankara Universitesi Eczacilik Fakultesi Dergisi","raw_type":"journal-article"},{"id":"pmh:oai:dergipark.org.tr:article/1085253","doi":null,"is_oa":true,"landing_page_url":"https://dergipark.org.tr/tr/pub/jfpanu/issue/75584/1085253","pdf_url":null,"source":{"id":"https://openalex.org/S4210194989","display_name":"Ankara Universitesi Eczacilik Fakultesi Dergisi","issn_l":"1015-3918","issn":["1015-3918","2564-6524"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4","tr-dizin"],"host_organization":"https://openalex.org/P4310318375","host_organization_name":"Ankara University","host_organization_lineage":["https://openalex.org/P4310318375"],"host_organization_lineage_names":["Ankara University"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal de la Facult\u00e9 de Pharmacie de l'Universit\u00e9 d'Ankara","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.33483/jfpau.1085253","doi":"https://doi.org/10.33483/jfpau.1085253","is_oa":true,"landing_page_url":"http://dx.doi.org/10.33483/jfpau.1085253","pdf_url":"https://dergipark.org.tr/en/download/article-file/2299744","source":{"id":"https://openalex.org/S4210194989","display_name":"Ankara Universitesi Eczacilik Fakultesi Dergisi","issn_l":"1015-3918","issn":["1015-3918","2564-6524"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4","tr-dizin"],"host_organization":"https://openalex.org/P4310318375","host_organization_name":"Ankara University","host_organization_lineage":["https://openalex.org/P4310318375"],"host_organization_lineage_names":["Ankara University"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ankara Universitesi Eczacilik Fakultesi Dergisi","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4320719137.pdf","grobid_xml":"https://content.openalex.org/works/W4320719137.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W171326655","https://openalex.org/W301449119","https://openalex.org/W345073802","https://openalex.org/W1497538265","https://openalex.org/W1525128476","https://openalex.org/W1831384234","https://openalex.org/W1932417464","https://openalex.org/W2013716486","https://openalex.org/W2021316804","https://openalex.org/W2039785894","https://openalex.org/W2040325751","https://openalex.org/W2052262833","https://openalex.org/W2056543199","https://openalex.org/W2062318487","https://openalex.org/W2080625189","https://openalex.org/W2086881941","https://openalex.org/W2110401457","https://openalex.org/W2116165084","https://openalex.org/W2117672859","https://openalex.org/W2118894711","https://openalex.org/W2138011143","https://openalex.org/W2142195363","https://openalex.org/W2147172423","https://openalex.org/W2159305277","https://openalex.org/W2165627850","https://openalex.org/W2167110681","https://openalex.org/W2284854014","https://openalex.org/W2315810631","https://openalex.org/W2730817564","https://openalex.org/W2768017369","https://openalex.org/W2797440643","https://openalex.org/W2897629888","https://openalex.org/W2905132607","https://openalex.org/W2936367977","https://openalex.org/W2970648456","https://openalex.org/W3012836258","https://openalex.org/W3175798988","https://openalex.org/W3183594513","https://openalex.org/W4206946799"],"related_works":["https://openalex.org/W2372085817","https://openalex.org/W3129768374","https://openalex.org/W2800402246","https://openalex.org/W1993517410","https://openalex.org/W3012836258","https://openalex.org/W1987844765","https://openalex.org/W2372153590","https://openalex.org/W3042418232","https://openalex.org/W2188774248","https://openalex.org/W3183594513"],"abstract_inverted_index":{"Objective:":[0],"The":[1,21,138],"aim":[2],"of":[3,12,57,128,152,158,167],"the":[4,9,53,147,156,165],"study":[5],"was":[6,68],"to":[7],"investigate":[8],"preventive":[10,55],"effects":[11],"Taurine":[13,34,169],"against":[14],"2,3,7,8-tetracholorodibenzo-p-dioxin":[15],"(TCDD)-induced":[16],"organ":[17,41,63],"damage":[18,64],"in":[19,29,40,70,126,146],"rats.":[20],"environmental":[22],"toxin":[23],"TCDD":[24,67,119,142],"has":[25,44],"a":[26,51],"high":[27],"toxicity":[28],"animal":[30],"and":[31,45,48,62,73,84,92,117,131,136,149,160,163],"human":[32],"tissues.":[33],"is":[35],"an":[36],"amino":[37],"acid":[38,86],"found":[39],"cells":[42],"that":[43,141],"antioxidant":[46],"properties":[47],"anti-inflammatory.":[49],"As":[50],"result,":[52],"potential":[54],"effect":[56],"taurine":[58,121],"on":[59],"oxidative":[60,144],"stress":[61,145],"caused":[65,143],"by":[66,76,154],"investigated":[69],"rat":[71],"liver":[72,148],"kidney":[74,150],"tissues":[75,151],"measuring":[77],"glutathione":[78],"(GSH),":[79],"superoxide":[80],"dismutase":[81],"(SOD)":[82],"activity,":[83],"thiobarbituric":[85],"reactive":[87],"substances":[88],"(TBARS)":[89],"levels.":[90],"Material":[91],"Method:":[93],"Adult":[94],"male":[95],"Wistar":[96],"rats":[97,153],"(250-300":[98],"g,":[99],"12-13":[100],"weeks,":[101],"n":[102],"=":[103,112],"32)":[104],"were":[105,122],"randomly":[106],"allocted":[107],"into":[108],"four":[109],"groups":[110],"(n":[111],"8/group):":[113],"Control,":[114],"TCDD,":[115],"TAU,":[116],"TCDD+TAU.":[118],"and/or":[120],"administered":[123],"via":[124],"gavage":[125],"doses":[127],"2":[129],"\u03bcg/kg/week":[130],"200":[132],"mg/kg/day,":[133],"respectively.":[134],"Result":[135],"Discussion:":[137],"results":[139],"showed":[140],"decreasing":[155],"levels":[157,166,174],"GSH":[159],"SOD":[161],"activity":[162],"increasing":[164],"TBARS.":[168],"treatment":[170],"significantly":[171],"reduced":[172],"TBARS":[173],"(p":[175]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2023-02-15T00:00:00"}