{"id":"https://openalex.org/W4320181702","doi":"https://doi.org/10.1016/j.idcr.2023.e01712","title":"Actinomyces europaeus as an emerging cause of necrotizing fasciitis","display_name":"Actinomyces europaeus as an emerging cause of necrotizing fasciitis","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4320181702","doi":"https://doi.org/10.1016/j.idcr.2023.e01712","pmid":"https://pubmed.ncbi.nlm.nih.gov/36845908","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9945764"},"language":"en","primary_location":{"id":"doi:10.1016/j.idcr.2023.e01712","doi":"https://doi.org/10.1016/j.idcr.2023.e01712","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.idcr.2023.e01712","pdf_url":null,"source":{"id":"https://openalex.org/S2898460781","display_name":"IDCases","issn_l":"2214-2509","issn":["2214-2509"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","ki-jl-1","norway-1","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IDCases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.idcr.2023.e01712","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046122359","display_name":"Nathan Anthony","orcid":"https://orcid.org/0000-0002-5091-1596","observed_orcids":["https://orcid.org/0000-0002-5091-1596"]},"institutions":[{"id":"https://openalex.org/I896114043","display_name":"Edward Via College of Osteopathic Medicine","ror":"https://ror.org/00sda2672","country_code":"US","type":"education","lineage":["https://openalex.org/I896114043"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nathan Anthony","raw_affiliation_strings":["Edward Via College of Osteopathic Medicine-Auburn Campus in Auburn, AL, 910 S Donahue Dr, Auburn, AL 36832, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-5091-1596","affiliations":[{"raw_affiliation_string":"Edward Via College of Osteopathic Medicine-Auburn Campus in Auburn, AL, 910 S Donahue Dr, Auburn, AL 36832, United States of America","institution_ids":["https://openalex.org/I896114043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016839364","display_name":"Nathan T. Douthit","orcid":"https://orcid.org/0000-0002-8314-4207","observed_orcids":["https://orcid.org/0000-0002-8314-4207"]},"institutions":[{"id":"https://openalex.org/I896114043","display_name":"Edward Via College of Osteopathic Medicine","ror":"https://ror.org/00sda2672","country_code":"US","type":"education","lineage":["https://openalex.org/I896114043"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan T. Douthit","raw_affiliation_strings":["East Alabama Medical Center Internal Medicine Residency Core Faculty, 2000 Pepperell Pkwy, Opelika, AL 36801, United States of America","Edward Via College of Osteopathic Medicine-Auburn Campus in Auburn, AL, 910 S Donahue Dr, Auburn, AL 36832, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"East Alabama Medical Center Internal Medicine Residency Core Faculty, 2000 Pepperell Pkwy, Opelika, AL 36801, United States of America","institution_ids":[]},{"raw_affiliation_string":"Edward Via College of Osteopathic Medicine-Auburn Campus in Auburn, AL, 910 S Donahue Dr, Auburn, AL 36832, United States of America","institution_ids":["https://openalex.org/I896114043"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075248766","display_name":"Allen Foster","orcid":"https://orcid.org/0000-0003-2368-4436","observed_orcids":["https://orcid.org/0000-0003-2368-4436"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Allen Foster","raw_affiliation_strings":["East Alabama Medical Center Surgery Department, 2000 Pepperell Pkwy, Opelika, AL 36801, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"East Alabama Medical Center Surgery Department, 2000 Pepperell Pkwy, Opelika, AL 36801, United States of America","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5046122359"],"corresponding_institution_ids":["https://openalex.org/I896114043"],"apc_list":{"value":900,"currency":"USD","value_usd":900},"apc_paid":{"value":900,"currency":"USD","value_usd":900},"fwci":0.9879,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.67275194,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"31","issue":null,"first_page":"e01712","last_page":"e01712"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12317","display_name":"Actinomycetales infections and treatment","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12317","display_name":"Actinomycetales infections and treatment","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11153","display_name":"Streptococcal Infections and Treatments","score":0.02199999988079071,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12297","display_name":"Otolaryngology and Infectious Diseases","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/necrotizing-fasciitis","display_name":"necrotizing fasciitis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/necrotizing-soft-tissue-infection","display_name":"necrotizing soft tissue infection","score":0.9919999837875366},{"id":"https://openalex.org/keywords/coinfection","display_name":"co-infection","score":0.8550000190734863},{"id":"https://openalex.org/keywords/antimicrobial-susceptibility-testing","display_name":"antimicrobial susceptibility testing","score":0.8119999766349792},{"id":"https://openalex.org/keywords/piperacillin-tazobactam","display_name":"piperacillin-tazobactam","score":0.9259999990463257},{"id":"https://openalex.org/keywords/beta-lactamase-resistance","display_name":"beta-lactamase resistance","score":0.9240000247955322},{"id":"https://openalex.org/keywords/emerging-pathogens","display_name":"emerging pathogens","score":0.5360000133514404},{"id":"https://openalex.org/keywords/actinomycosis","display_name":"actinomycosis","score":0.8180000185966492}],"concepts":[{"id":"https://openalex.org/C2777217379","wikidata":"https://www.wikidata.org/wiki/Q1870975","display_name":"Fasciitis","level":2,"score":0.9130481481552124},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7031662464141846},{"id":"https://openalex.org/C2780940764","wikidata":"https://www.wikidata.org/wiki/Q312213","display_name":"Actinomyces","level":3,"score":0.674228310585022},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6209506988525391},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.485638290643692},{"id":"https://openalex.org/C2778193466","wikidata":"https://www.wikidata.org/wiki/Q423787","display_name":"Piperacillin","level":4,"score":0.46587511897087097},{"id":"https://openalex.org/C2992397963","wikidata":"https://www.wikidata.org/wiki/Q189790","display_name":"Anaerobic bacteria","level":3,"score":0.4513470530509949},{"id":"https://openalex.org/C2778266534","wikidata":"https://www.wikidata.org/wiki/Q423376","display_name":"Tazobactam","level":5,"score":0.41682425141334534},{"id":"https://openalex.org/C2780960513","wikidata":"https://www.wikidata.org/wiki/Q2720082","display_name":"Fusobacterium","level":4,"score":0.4102741777896881},{"id":"https://openalex.org/C2778168646","wikidata":"https://www.wikidata.org/wiki/Q133186","display_name":"Bacteroides","level":3,"score":0.4042194187641144},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2273280918598175},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.15398958325386047},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.14544609189033508},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.11348044872283936},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.0},{"id":"https://openalex.org/C2779631663","wikidata":"https://www.wikidata.org/wiki/Q425152","display_name":"Imipenem","level":4,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.idcr.2023.e01712","doi":"https://doi.org/10.1016/j.idcr.2023.e01712","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.idcr.2023.e01712","pdf_url":null,"source":{"id":"https://openalex.org/S2898460781","display_name":"IDCases","issn_l":"2214-2509","issn":["2214-2509"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","ki-jl-1","norway-1","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IDCases","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9945764","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9945764","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9945764/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IDCases","raw_type":"Text"},{"id":"pmid:36845908","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36845908","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IDCases","raw_type":"Case Reports"},{"id":"pmh:oai:doaj.org/article:c56efae96a05439381f5ac3666f9e488","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c56efae96a05439381f5ac3666f9e488","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IDCases, Vol 31, Iss , Pp e01712- (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.idcr.2023.e01712","doi":"https://doi.org/10.1016/j.idcr.2023.e01712","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.idcr.2023.e01712","pdf_url":null,"source":{"id":"https://openalex.org/S2898460781","display_name":"IDCases","issn_l":"2214-2509","issn":["2214-2509"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","ki-jl-1","norway-1","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IDCases","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320319805","display_name":"Edward Via College of Osteopathic Medicine","ror":"https://ror.org/00sda2672"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4320181702.pdf","grobid_xml":"https://content.openalex.org/works/W4320181702.grobid-xml"},"referenced_works_count":8,"referenced_works":["https://openalex.org/W1995306183","https://openalex.org/W2028490361","https://openalex.org/W2053058114","https://openalex.org/W2114910756","https://openalex.org/W2190055894","https://openalex.org/W2981236274","https://openalex.org/W3187487291","https://openalex.org/W7075700270"],"related_works":["https://openalex.org/W7128293646","https://openalex.org/W4312747700","https://openalex.org/W4200561675","https://openalex.org/W4412649388","https://openalex.org/W2981236274","https://openalex.org/W4407268339","https://openalex.org/W2126383520","https://openalex.org/W18201995","https://openalex.org/W7101013812","https://openalex.org/W2572399546"],"abstract_inverted_index":{"Necrotizing":[0],"fasciitis":[1,35],"is":[2,44,94],"a":[3,45],"type":[4],"of":[5,24,65,85,123,126,133],"necrotizing":[6,34,138],"soft":[7],"tissue":[8],"infection":[9],"(NSTI)":[10],"that":[11,50,105],"can":[12],"be":[13,100],"polymicrobial":[14,97],"or":[15,27],"monomicrobial":[16],"in":[17,55,68],"origin.":[18],"Polymicrobial":[19],"infections":[20],"typically":[21],"involve":[22],"anaerobes":[23],"the":[25,66,69,120,131],"Clostridium":[26],"Bacteroides":[28],"family.":[29],"This":[30],"case":[31],"report":[32,58],"highlights":[33],"caused":[36],"by":[37],"an":[38],"unusual":[39],"culprit,":[40],"Actinomyces":[41],"europaeus,":[42],"which":[43],"gram-positive":[46],"anaerobic":[47],"filamentous":[48],"bacillus":[49],"has":[51],"only":[52],"been":[53],"documented":[54],"one":[56],"prior":[57],"to":[59,74,99,136],"cause":[60,137],"NSTI.":[61],"Currently,":[62],"about":[63],"half":[64],"hospitals":[67,86],"United":[70],"States":[71],"are":[72,106],"equipped":[73],"perform":[75],"antibiotic":[76],"susceptibility":[77],"testing":[78],"for":[79,96],"anaerobes,":[80,112],"but":[81],"less":[82],"than":[83],"one-quarter":[84],"actually":[87],"utilize":[88],"these":[89],"tests":[90],"routinely.":[91],"Thus,":[92],"it":[93],"common":[95],"actinomycoses":[98],"blindly":[101],"treated":[102],"with":[103,115],"antibiotics":[104],"beta-lactamase":[107],"resistant":[108],"and":[109],"active":[110],"against":[111],"such":[113],"as":[114,128,130],"piperacillin-tazobactam.":[116],"Here":[117],"we":[118],"examine":[119],"potential":[121],"impact":[122],"this":[124],"lack":[125],"testing,":[127],"well":[129],"evolution":[132],"A.":[134],"europaeus":[135],"fasciitis.":[139]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-02-13T00:00:00"}