{"id":"https://openalex.org/W4320076973","doi":"https://doi.org/10.54044/rami.2022.01.04","title":"CLINICAL VALUE OF GALECTIN-3 IN DIFFERENTIATING PAPILLARY THYROID CANCER FROM NODULAR GOITER","display_name":"CLINICAL VALUE OF GALECTIN-3 IN DIFFERENTIATING PAPILLARY THYROID CANCER FROM NODULAR GOITER","publication_year":2022,"publication_date":"2022-03-31","ids":{"openalex":"https://openalex.org/W4320076973","doi":"https://doi.org/10.54044/rami.2022.01.04"},"language":"en","primary_location":{"id":"doi:10.54044/rami.2022.01.04","doi":"https://doi.org/10.54044/rami.2022.01.04","is_oa":true,"landing_page_url":"https://doi.org/10.54044/rami.2022.01.04","pdf_url":"http://dx.doi.org/10.54044/rami.2022.01.04","source":{"id":"https://openalex.org/S2764711809","display_name":"Romanian Archives of Microbiology and Immunology","issn_l":"1222-3891","issn":["1222-3891","2601-9418"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Romanian Archives of Microbiology and Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://dx.doi.org/10.54044/rami.2022.01.04","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"\"","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\"","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032499465","display_name":"C\u01cet\u01celina Poalelungi","orcid":"https://orcid.org/0000-0002-1791-105X","observed_orcids":["https://orcid.org/0000-0002-1791-105X"]},"institutions":[{"id":"https://openalex.org/I141595442","display_name":"University of Bucharest","ror":"https://ror.org/02x2v6p15","country_code":"RO","type":"education","lineage":["https://openalex.org/I141595442"]},{"id":"https://openalex.org/I4210116739","display_name":"Institutul Na\u021bional de Endocrinologie C.I. Parhon","ror":"https://ror.org/02b4rb907","country_code":"RO","type":"facility","lineage":["https://openalex.org/I4210116739"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"C\u0103t\u0103lina Poalelungi","raw_affiliation_strings":["C. I . Parhon National Institute of Endocrinology , Bucharest , Romania","University of Bucharest , Romania"],"raw_orcid":"https://orcid.org/0000-0002-1791-105X","affiliations":[{"raw_affiliation_string":"C. I . Parhon National Institute of Endocrinology , Bucharest , Romania","institution_ids":["https://openalex.org/I4210116739"]},{"raw_affiliation_string":"University of Bucharest , Romania","institution_ids":["https://openalex.org/I141595442"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108830282","display_name":"A Caragheorgheopol","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116739","display_name":"Institutul Na\u021bional de Endocrinologie C.I. Parhon","ror":"https://ror.org/02b4rb907","country_code":"RO","type":"facility","lineage":["https://openalex.org/I4210116739"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Andra-Ileana Caragheorgheopol","raw_affiliation_strings":["C. I . Parhon National Institute of Endocrinology , Bucharest , Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C. I . Parhon National Institute of Endocrinology , Bucharest , Romania","institution_ids":["https://openalex.org/I4210116739"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027225503","display_name":"Sorina Violeta Schipor","orcid":"https://orcid.org/0000-0002-4886-2174","observed_orcids":["https://orcid.org/0000-0002-4886-2174"]},"institutions":[{"id":"https://openalex.org/I4210116739","display_name":"Institutul Na\u021bional de Endocrinologie C.I. Parhon","ror":"https://ror.org/02b4rb907","country_code":"RO","type":"facility","lineage":["https://openalex.org/I4210116739"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Sorina Violeta Schipor","raw_affiliation_strings":["C. I . Parhon National Institute of Endocrinology , Bucharest , Romania"],"raw_orcid":"https://orcid.org/0000-0002-4886-2174","affiliations":[{"raw_affiliation_string":"C. I . Parhon National Institute of Endocrinology , Bucharest , Romania","institution_ids":["https://openalex.org/I4210116739"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"81","issue":"1","first_page":"21","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12387","display_name":"Galectins and Cancer Biology","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/galectin-3","display_name":"galectin-3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/papillary-thyroid-carcinoma","display_name":"papillary thyroid carcinoma","score":0.9459999799728394},{"id":"https://openalex.org/keywords/nodular-goiter","display_name":"nodular goiter","score":0.996999979019165},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.6679999828338623},{"id":"https://openalex.org/keywords/differential-diagnosis","display_name":"differential diagnosis","score":0.8759999871253967},{"id":"https://openalex.org/keywords/thyroid-nodules","display_name":"thyroid nodules","score":0.9070000052452087},{"id":"https://openalex.org/keywords/preoperative-diagnosis","display_name":"preoperative diagnosis","score":0.9639999866485596},{"id":"https://openalex.org/keywords/thyroidectomy","display_name":"thyroidectomy","score":0.9070000052452087}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7754147052764893},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.6571642160415649},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.649055004119873},{"id":"https://openalex.org/C2781461381","wikidata":"https://www.wikidata.org/wiki/Q2292945","display_name":"Papillary thyroid cancer","level":4,"score":0.6293642520904541},{"id":"https://openalex.org/C2776254400","wikidata":"https://www.wikidata.org/wiki/Q165135","display_name":"Goiter","level":3,"score":0.6045997738838196},{"id":"https://openalex.org/C2776336362","wikidata":"https://www.wikidata.org/wiki/Q18028529","display_name":"Galectin-3","level":2,"score":0.6002597808837891},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5601640939712524},{"id":"https://openalex.org/C2779022025","wikidata":"https://www.wikidata.org/wiki/Q53829","display_name":"Thyroid nodules","level":3,"score":0.5557613372802734},{"id":"https://openalex.org/C2777074255","wikidata":"https://www.wikidata.org/wiki/Q1351681","display_name":"Thyroidectomy","level":3,"score":0.5028009414672852},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4547540247440338},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.442690372467041},{"id":"https://openalex.org/C2776731575","wikidata":"https://www.wikidata.org/wiki/Q2916245","display_name":"Nodule (geology)","level":2,"score":0.420364648103714},{"id":"https://openalex.org/C2780801072","wikidata":"https://www.wikidata.org/wiki/Q837512","display_name":"Differential diagnosis","level":2,"score":0.4163641333580017},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.41103145480155945},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.40434205532073975},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3792784810066223},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.08182939887046814},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06020739674568176},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.54044/rami.2022.01.04","doi":"https://doi.org/10.54044/rami.2022.01.04","is_oa":true,"landing_page_url":"https://doi.org/10.54044/rami.2022.01.04","pdf_url":"http://dx.doi.org/10.54044/rami.2022.01.04","source":{"id":"https://openalex.org/S2764711809","display_name":"Romanian Archives of Microbiology and Immunology","issn_l":"1222-3891","issn":["1222-3891","2601-9418"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Romanian Archives of Microbiology and Immunology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.54044/rami.2022.01.04","doi":"https://doi.org/10.54044/rami.2022.01.04","is_oa":true,"landing_page_url":"https://doi.org/10.54044/rami.2022.01.04","pdf_url":"http://dx.doi.org/10.54044/rami.2022.01.04","source":{"id":"https://openalex.org/S2764711809","display_name":"Romanian Archives of Microbiology and Immunology","issn_l":"1222-3891","issn":["1222-3891","2601-9418"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Romanian Archives of Microbiology and Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.979200005531311}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4320076973.pdf","grobid_xml":"https://content.openalex.org/works/W4320076973.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1968812902","https://openalex.org/W1989713769","https://openalex.org/W2117817789","https://openalex.org/W2119494676","https://openalex.org/W2312637315","https://openalex.org/W2642438413","https://openalex.org/W2742787964","https://openalex.org/W2747297301","https://openalex.org/W2760481066","https://openalex.org/W2775139356","https://openalex.org/W2781977477","https://openalex.org/W2789752648","https://openalex.org/W2955944631","https://openalex.org/W3006542607","https://openalex.org/W3048133072","https://openalex.org/W3136454867","https://openalex.org/W3167406212","https://openalex.org/W3195592136"],"related_works":["https://openalex.org/W1989713769","https://openalex.org/W2136039329","https://openalex.org/W4417275013","https://openalex.org/W2353337370","https://openalex.org/W2374384444","https://openalex.org/W2380520147","https://openalex.org/W2428004565","https://openalex.org/W1977598600","https://openalex.org/W2298959109","https://openalex.org/W2363869081"],"abstract_inverted_index":{"\"Introduction:":[0],"Thyroid":[1],"cancer":[2,30,39,65],"in":[3,26,36,42,60,181,232,243],"one":[4],"of":[5,29,55,71,160,166,248],"the":[6,16,52,106,147,152,157,161],"most":[7],"common":[8],"cancers":[9],"worldwide,":[10],"with":[11,76,185,236],"an":[12],"increasing":[13],"incidence":[14],"over":[15],"last":[17],"decades.":[18],"Serum":[19,98],"Galectin-3":[20,58,130],"(Gal-3)":[21],"is":[22],"used":[23],"as":[24],"biomarker":[25,176,227],"different":[27],"types":[28],"(gastric,":[31],"hepatic),":[32],"but":[33,239],"its":[34,240],"utility":[35],"papillary":[37,63,91,257],"thyroid":[38,64,77,92,249,255,258],"differential":[40],"diagnostic":[41,53],"still":[43],"inconclusive.":[44],"Objectives:":[45],"The":[46],"present":[47],"study":[48,153],"aims":[49],"to":[50],"evaluate":[51],"value":[54,180,231,242],"preoperative":[56,244],"serum":[57,72,206],"levels":[59,100],"differentiating":[61],"between":[62,205],"and":[66,90,109,136,151,209,246],"nodular":[67,84],"goiter.":[68],"Methods:":[69],"277":[70],"samples":[73],"from":[74],"patients":[75,112,183,187,234],"lesions":[78],"were":[79,101,139,199],"divided":[80],"into":[81],"two":[82],"subgroups:":[83],"goiter":[85],"(NG;":[86],"n":[87,95],"=":[88,96,194],"121)":[89],"carcinoma":[93],"(PTC;":[94],"136).":[97],"Gal-3":[99,123,171,207,222],"measured":[102,119,125],"before":[103,196],"surgery":[104],"for":[105,110],"entire":[107],"group,":[108],"62":[111],"(33":[113],"NG,":[114],"29":[115],"PTC)":[116],"it":[117],"was":[118,124,154],"a":[120,178,229],"month":[121],"post-surgery.":[122],"by":[126,156],"ELISA,":[127],"using":[128,141],"Human":[129],"Quantikinine":[131],"ELISA":[132],"kit":[133],"(R&D":[134],"Systems)":[135],"statistical":[137,203],"analysis":[138],"performed":[140],"MedCalc":[142],"Software.":[143],"All":[144],"paticipants":[145],"signed":[146],"written":[148],"informed":[149],"consent":[150],"approved":[155],"Ethics":[158],"Commitee":[159],"C.I.":[162],"Parhon":[163],"National":[164],"Institute":[165],"Endocrinology,":[167],"Bucharest.":[168],"Results:":[169],"Circulating":[170],"values":[172,208,223],"show":[173,224],"that":[174,225],"this":[175,226],"has":[177,228],"higher":[179,230],"PTC":[182,233],"compared":[184,235],"NG":[186,237],"(7.17":[188],"ng/ml":[189],"vs.":[190],"8.285":[191],"ng/ml,":[192],"p":[193],"0.0038),":[195],"thyroidectomy.":[197],"There":[198],"not":[200],"observed":[201],"significant":[202],"correlations":[204],"histological":[210],"subtype,":[211],"focality,":[212],"invasivity":[213],"or":[214],"dominant":[215],"nodule":[216],"dimension.":[217],"Conclusion:":[218],"Our":[219],"results":[220],"regarding":[221],"patients,":[238],"clinical":[241],"diagnosis":[245],"evaluation":[247],"nodules":[250],"needs":[251],"further":[252],"investigations.":[253],"Keywords:":[254],"cancer,":[256],"carcinoma,":[259],"galectin-3\"":[260]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2023-02-12T00:00:00"}