{"id":"https://openalex.org/W4319992832","doi":"https://doi.org/10.14283/jfa.2023.10","title":"Centrally Acting ACE Inhibitor Use and Physical Performance in Older Adults","display_name":"Centrally Acting ACE Inhibitor Use and Physical Performance in Older Adults","publication_year":2023,"publication_date":"2023-01-26","ids":{"openalex":"https://openalex.org/W4319992832","doi":"https://doi.org/10.14283/jfa.2023.10","pmid":"https://pubmed.ncbi.nlm.nih.gov/36946705","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10111793"},"language":"en","primary_location":{"id":"doi:10.14283/jfa.2023.10","doi":"https://doi.org/10.14283/jfa.2023.10","is_oa":true,"landing_page_url":"https://doi.org/10.14283/jfa.2023.10","pdf_url":"https://link.springer.com/content/pdf/10.14283/jfa.2023.10.pdf","source":{"id":"https://openalex.org/S2764945019","display_name":"The Journal of Frailty & Aging","issn_l":"2260-1341","issn":["2260-1341","2273-4309"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Frailty & Aging","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.14283/jfa.2023.10.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010765097","display_name":"Claudene J. George","orcid":"https://orcid.org/0000-0002-0710-027X","observed_orcids":["https://orcid.org/0000-0002-0710-027X"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Claudene J. George","raw_affiliation_strings":["Claudene George MD, MS, RPh, Division of Geriatrics 111 East 210th Street, Bronx, NY 10467, Tel: 718-920-6722, Fax: 718-655-9672, Email: Clgeorge@montefiore.org","Montefiore Medical Center, Division of Geriatrics, Albert Einstein College of Medicine, Bronx, New York, 10467, USA, 111 East 210th Street"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Claudene George MD, MS, RPh, Division of Geriatrics 111 East 210th Street, Bronx, NY 10467, Tel: 718-920-6722, Fax: 718-655-9672, Email: Clgeorge@montefiore.org","institution_ids":[]},{"raw_affiliation_string":"Montefiore Medical Center, Division of Geriatrics, Albert Einstein College of Medicine, Bronx, New York, 10467, USA, 111 East 210th Street","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071209437","display_name":"C.B. Hall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C.B. Hall","raw_affiliation_strings":["Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078622302","display_name":"E.F. Weiss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E.F. Weiss","raw_affiliation_strings":["Department of Neurology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005297461","display_name":"J. Verghese","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Verghese","raw_affiliation_strings":["Division of Cognitive & Motor Aging and Geriatrics, Albert Einstein College of Medicine, Bronx, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cognitive & Motor Aging and Geriatrics, Albert Einstein College of Medicine, Bronx, New York, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043192139","display_name":"Enid Neptune","orcid":"https://orcid.org/0000-0002-9635-1272","observed_orcids":["https://orcid.org/0000-0002-9635-1272"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Neptune","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, John Hopkins University School of Medicine, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, John Hopkins University School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025618178","display_name":"Peter M. Abadir","orcid":"https://orcid.org/0000-0002-8186-0066","observed_orcids":["https://orcid.org/0000-0002-8186-0066"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Abadir","raw_affiliation_strings":["Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5010765097"],"corresponding_institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":0.5518,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.66266755,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"12","issue":"2","first_page":"103","last_page":"108"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.3109999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.3109999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.15039999783039093,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11011","display_name":"Frailty in Older Adults","score":0.0851999968290329,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.9810000061988831},{"id":"https://openalex.org/keywords/physical-performance","display_name":"physical performance","score":0.824999988079071},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.7170000076293945},{"id":"https://openalex.org/keywords/handgrip-strength","display_name":"grip strength","score":0.8510000109672546},{"id":"https://openalex.org/keywords/walking-speed","display_name":"walking speed","score":0.8840000033378601},{"id":"https://openalex.org/keywords/peak-expiratory-flow","display_name":"peak expiratory flow","score":0.9869999885559082},{"id":"https://openalex.org/keywords/lung-function","display_name":"lung function","score":0.9850000143051147},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.7210000157356262},{"id":"https://openalex.org/keywords/antihypertensive-drugs","display_name":"antihypertensive drugs","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9489117860794067},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.42620545625686646},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.39225679636001587},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.33845391869544983},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3282894492149353}],"mesh":[{"descriptor_ui":"D000076604","descriptor_name":"Physical Functional Performance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000806","descriptor_name":"Angiotensin-Converting Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018737","descriptor_name":"Hand Strength","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D053580","descriptor_name":"Muscle Strength","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.14283/jfa.2023.10","doi":"https://doi.org/10.14283/jfa.2023.10","is_oa":true,"landing_page_url":"https://doi.org/10.14283/jfa.2023.10","pdf_url":"https://link.springer.com/content/pdf/10.14283/jfa.2023.10.pdf","source":{"id":"https://openalex.org/S2764945019","display_name":"The Journal of Frailty & Aging","issn_l":"2260-1341","issn":["2260-1341","2273-4309"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Frailty & Aging","raw_type":"journal-article"},{"id":"pmid:36946705","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36946705","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of frailty & aging","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10111793","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10111793","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10111793/pdf/nihms-1888227.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Frailty Aging","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.14283/jfa.2023.10","doi":"https://doi.org/10.14283/jfa.2023.10","is_oa":true,"landing_page_url":"https://doi.org/10.14283/jfa.2023.10","pdf_url":"https://link.springer.com/content/pdf/10.14283/jfa.2023.10.pdf","source":{"id":"https://openalex.org/S2764945019","display_name":"The Journal of Frailty & Aging","issn_l":"2260-1341","issn":["2260-1341","2273-4309"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Frailty & Aging","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3162516022","display_name":"Utility of Centrally Acting Angiotensin Converting Enzyme Inhibitors to slow the progression of Dementia","funder_award_id":"K23AG062807","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4319992832.pdf","grobid_xml":"https://content.openalex.org/works/W4319992832.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W140747653","https://openalex.org/W1529163119","https://openalex.org/W1974370899","https://openalex.org/W2004774226","https://openalex.org/W2055427232","https://openalex.org/W2065413005","https://openalex.org/W2067782125","https://openalex.org/W2071986322","https://openalex.org/W2077477091","https://openalex.org/W2117980765","https://openalex.org/W2146131666","https://openalex.org/W2150042773","https://openalex.org/W2153835671","https://openalex.org/W2160272053","https://openalex.org/W2163863130","https://openalex.org/W2268277946","https://openalex.org/W2322366453","https://openalex.org/W2406650010","https://openalex.org/W2558125867","https://openalex.org/W2617171469","https://openalex.org/W2735296126","https://openalex.org/W2778600864","https://openalex.org/W2969871466","https://openalex.org/W3020455905","https://openalex.org/W3091639901","https://openalex.org/W6767480143"],"related_works":["https://openalex.org/W2112055579","https://openalex.org/W2033089503","https://openalex.org/W3040737837","https://openalex.org/W1152948630","https://openalex.org/W4391452610","https://openalex.org/W2268811322","https://openalex.org/W2071986322","https://openalex.org/W2150042773","https://openalex.org/W2331111053","https://openalex.org/W4244641196"],"abstract_inverted_index":{"BACKGROUND:":[0],"There":[1],"is":[2,70],"conflicting":[3],"evidence":[4],"regarding":[5],"the":[6,61,93,168,192],"role":[7],"of":[8,42,67,194],"angiotensin-converting":[9,43,77,131,196,204],"enzyme":[10,44,78,132,197,205],"inhibitors":[11,198,206],"and":[12,23,95,119,151],"physical":[13,24,73],"function.":[14],"While":[15],"some":[16],"studies":[17],"show":[18,27],"improvements":[19],"in":[20,89,92,113,162,170,189,213],"muscle":[21],"strength":[22,145],"function,":[25],"others":[26],"no":[28],"significant":[29,174],"difference":[30,112,169],"or":[31,53],"decreased":[32],"performance.":[33],"This":[34],"ambiguity":[35],"could":[36],"be":[37,49],"due":[38],"to":[39,59,71,126,200],"differential":[40],"effects":[41],"inhibitor":[45,79,133],"subtypes":[46],"which":[47],"can":[48],"categorized":[50],"as":[51],"centrally":[52],"peripherally-acting":[54,130],"based":[55],"upon":[56],"their":[57],"ability":[58],"cross":[60],"blood-brain":[62],"barrier.":[63],"OBJECTIVE:":[64],"The":[65],"objective":[66],"this":[68],"study":[69],"compare":[72],"performance":[74],"measures":[75],"among":[76],"subtype":[80],"users.":[81],"METHODS:":[82],"Design:":[83],"Cross-sectional":[84],"Setting:":[85],"Ambulatory":[86],"Participants:":[87],"Performed":[88],"364":[90],"participants":[91,127],"Health":[94],"Retirement":[96],"Study":[97],"cohort":[98],"who":[99],"were":[100],"\u2265":[101],"65":[102],"years":[103],"(median":[104],"age":[105],"(IQR)":[106],"74.00":[107],"(69-80)":[108],"years.":[109],"MEASUREMENTS:":[110],"Average":[111],"hand":[114],"grip":[115,144],"(kg),":[116],"gait":[117],"speed(m/s)":[118],"peak":[120,153],"expiratory":[121,154],"flow":[122,155],"(L/min).":[123],"RESULTS:":[124],"Compared":[125],"on":[128,137],"a":[129,138,201],"(113":[134],"(31%)),":[135],"those":[136],"centrally-acting":[139,195],"agent":[140],"(251(69%))":[141],"had":[142],"stronger":[143],"28.9":[146],"\u00b11.0":[147],"vs":[148],"26.3\u00b11.0,":[149],"p=.011":[150],"higher":[152],"rates":[156],"316.8\u00b1130.4":[157],"vs.":[158],"280.0\u00b1118.5,":[159],"p=":[160],".011":[161],"unadjusted":[163],"analysis.":[164],"After":[165],"multiple":[166],"adjustments":[167],"PEF":[171],"remained":[172],"statistically":[173],"(Estimate(CI)":[175],"26.5,":[176],"95%":[177],"CI":[178],"2.24,":[179],"50.5,":[180],"p":[181],"=":[182],"0.032).":[183],"CONCLUSION:":[184],"Our":[185],"results":[186],"suggest":[187],"that":[188],"older":[190,214],"adults":[191],"use":[193],"compared":[199],"peripherally":[202],"acting":[203],"was":[207],"associated":[208],"with":[209],"better":[210],"lung":[211],"function":[212],"individuals.":[215]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2023-02-11T00:00:00"}