{"id":"https://openalex.org/W4319984658","doi":"https://doi.org/10.3389/fphys.2023.1144712","title":"Identification of stages of amelogenesis in the continuously growing mandiblular incisor of C57BL/6J male mice throughout life using molar teeth as landmarks","display_name":"Identification of stages of amelogenesis in the continuously growing mandiblular incisor of C57BL/6J male mice throughout life using molar teeth as landmarks","publication_year":2023,"publication_date":"2023-02-10","ids":{"openalex":"https://openalex.org/W4319984658","doi":"https://doi.org/10.3389/fphys.2023.1144712","pmid":"https://pubmed.ncbi.nlm.nih.gov/36846326","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9950101"},"language":"en","primary_location":{"id":"doi:10.3389/fphys.2023.1144712","doi":"https://doi.org/10.3389/fphys.2023.1144712","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2023.1144712","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2023.1144712/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fphys.2023.1144712/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017751673","display_name":"Ai Thu Bui","orcid":"https://orcid.org/0000-0003-2492-4462","observed_orcids":["https://orcid.org/0000-0003-2492-4462"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ai Thu Bui","raw_affiliation_strings":["Center for Craniofacial Regeneration, UPSDM, Pittsburgh, PA, United States","Department of Oral and Craniofacial Sciences, University of Pittsburgh School of Dental Medicine (UPSDM), Pittsburgh, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Craniofacial Regeneration, UPSDM, Pittsburgh, PA, United States","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Oral and Craniofacial Sciences, University of Pittsburgh School of Dental Medicine (UPSDM), Pittsburgh, PA, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103558741","display_name":"Lyudmila Lukashova","orcid":"https://orcid.org/0000-0001-7396-460X","observed_orcids":["https://orcid.org/0000-0001-7396-460X"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lyudmila Lukashova","raw_affiliation_strings":["Center for Craniofacial Regeneration, UPSDM, Pittsburgh, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Craniofacial Regeneration, UPSDM, Pittsburgh, PA, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000918410","display_name":"Kostas Verdelis","orcid":"https://orcid.org/0000-0002-1632-8305","observed_orcids":["https://orcid.org/0000-0002-1632-8305"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kostas Verdelis","raw_affiliation_strings":["Center for Craniofacial Regeneration, UPSDM, Pittsburgh, PA, United States","Department of Endodontics, UPSDM, Pittsburgh, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Craniofacial Regeneration, UPSDM, Pittsburgh, PA, United States","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Endodontics, UPSDM, Pittsburgh, PA, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039185508","display_name":"Brent Vasquez","orcid":"https://orcid.org/0000-0001-5495-9485","observed_orcids":["https://orcid.org/0000-0001-5495-9485"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brent Vasquez","raw_affiliation_strings":["Department of Oral and Craniofacial Sciences, University of Pittsburgh School of Dental Medicine (UPSDM), Pittsburgh, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Craniofacial Sciences, University of Pittsburgh School of Dental Medicine (UPSDM), Pittsburgh, PA, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018521986","display_name":"Lasya Bhogadi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lasya Bhogadi","raw_affiliation_strings":["Department of Oral and Craniofacial Sciences, University of Pittsburgh School of Dental Medicine (UPSDM), Pittsburgh, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Craniofacial Sciences, University of Pittsburgh School of Dental Medicine (UPSDM), Pittsburgh, PA, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072388820","display_name":"Claire M. Gabe","orcid":"https://orcid.org/0000-0002-9427-5130","observed_orcids":["https://orcid.org/0000-0002-9427-5130"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claire M. Gabe","raw_affiliation_strings":["Center for Craniofacial Regeneration, UPSDM, Pittsburgh, PA, United States","Department of Oral and Craniofacial Sciences, University of Pittsburgh School of Dental Medicine (UPSDM), Pittsburgh, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Craniofacial Regeneration, UPSDM, Pittsburgh, PA, United States","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Oral and Craniofacial Sciences, University of Pittsburgh School of Dental Medicine (UPSDM), Pittsburgh, PA, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084093578","display_name":"H.C. Margolis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henry C. Margolis","raw_affiliation_strings":["Center for Craniofacial Regeneration, UPSDM, Pittsburgh, PA, United States","Department of Oral and Craniofacial Sciences, University of Pittsburgh School of Dental Medicine (UPSDM), Pittsburgh, PA, United States","Department of Periodontics and Preventive Dentistry, UPSDM, Pittsburgh, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Craniofacial Regeneration, UPSDM, Pittsburgh, PA, United States","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Oral and Craniofacial Sciences, University of Pittsburgh School of Dental Medicine (UPSDM), Pittsburgh, PA, United States","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Periodontics and Preventive Dentistry, UPSDM, Pittsburgh, PA, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082234540","display_name":"Elia Beniash","orcid":"https://orcid.org/0000-0001-9019-5160","observed_orcids":["https://orcid.org/0000-0001-9019-5160"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elia Beniash","raw_affiliation_strings":["Center for Craniofacial Regeneration, UPSDM, Pittsburgh, PA, United States","Department of Oral and Craniofacial Sciences, University of Pittsburgh School of Dental Medicine (UPSDM), Pittsburgh, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Craniofacial Regeneration, UPSDM, Pittsburgh, PA, United States","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Oral and Craniofacial Sciences, University of Pittsburgh School of Dental Medicine (UPSDM), Pittsburgh, PA, United States","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5082234540"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":2.8917,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.89653958,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"14","issue":null,"first_page":"1144712","last_page":"1144712"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11919","display_name":"dental development and anomalies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11919","display_name":"dental development and anomalies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12110","display_name":"Bone and Dental Protein Studies","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amelogenesis","display_name":"amelogenesis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/mandibular-incisors","display_name":"mandibular incisors","score":0.8569999933242798},{"id":"https://openalex.org/keywords/ameloblasts","display_name":"ameloblasts","score":0.7210000157356262},{"id":"https://openalex.org/keywords/enamel-matrix-proteins","display_name":"enamel matrix proteins","score":0.7210000157356262},{"id":"https://openalex.org/keywords/amelx","display_name":"AMELX","score":0.9049999713897705},{"id":"https://openalex.org/keywords/enam","display_name":"e-NAM","score":0.9950000047683716},{"id":"https://openalex.org/keywords/odam","display_name":"ODAM","score":0.9919999837875366},{"id":"https://openalex.org/keywords/enamel-mineralization","display_name":"enamel mineralization","score":0.7620000243186951},{"id":"https://openalex.org/keywords/microdissection","display_name":"microdissection","score":0.5929999947547913},{"id":"https://openalex.org/keywords/c57bl-6j-mice","display_name":"C57BL/6J mice","score":0.8230000138282776},{"id":"https://openalex.org/keywords/skeletal-development","display_name":"skeletal development","score":0.5149999856948853},{"id":"https://openalex.org/keywords/tooth-development","display_name":"tooth development","score":0.3370000123977661}],"concepts":[{"id":"https://openalex.org/C199106506","wikidata":"https://www.wikidata.org/wiki/Q2844786","display_name":"Amelogenesis","level":4,"score":0.9430914521217346},{"id":"https://openalex.org/C104392178","wikidata":"https://www.wikidata.org/wiki/Q351499","display_name":"Ameloblast","level":3,"score":0.9271095991134644},{"id":"https://openalex.org/C202271784","wikidata":"https://www.wikidata.org/wiki/Q189218","display_name":"Molar","level":2,"score":0.7901568412780762},{"id":"https://openalex.org/C156887251","wikidata":"https://www.wikidata.org/wiki/Q2386424","display_name":"Enamel paint","level":2,"score":0.7822295427322388},{"id":"https://openalex.org/C2778812414","wikidata":"https://www.wikidata.org/wiki/Q273543","display_name":"Incisor","level":2,"score":0.6975517868995667},{"id":"https://openalex.org/C176860957","wikidata":"https://www.wikidata.org/wiki/Q3355925","display_name":"Enamel organ","level":4,"score":0.5847336649894714},{"id":"https://openalex.org/C2780178515","wikidata":"https://www.wikidata.org/wiki/Q461854","display_name":"Amelogenesis imperfecta","level":3,"score":0.48623839020729065},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4707052409648895},{"id":"https://openalex.org/C29694066","wikidata":"https://www.wikidata.org/wiki/Q118301","display_name":"Orthodontics","level":1,"score":0.40503132343292236},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3877476155757904},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.37056055665016174},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23643586039543152}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fphys.2023.1144712","doi":"https://doi.org/10.3389/fphys.2023.1144712","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2023.1144712","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2023.1144712/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9950101","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9950101","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9950101/pdf/fphys-14-1144712.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Physiol","raw_type":"Text"},{"id":"pmid:36846326","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36846326","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in physiology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d698659e64bc4870bacccc30a6cbf52b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d698659e64bc4870bacccc30a6cbf52b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Physiology, Vol 14 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphys.2023.1144712","doi":"https://doi.org/10.3389/fphys.2023.1144712","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2023.1144712","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2023.1144712/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5892401913","display_name":"Essential role of amelogenin phosphorylation in tooth enamel formation","funder_award_id":"R01DE029211","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G9000863285","display_name":"Pittsburgh Craniofacial Sciences Training Program","funder_award_id":"R90DE032625","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4319984658.pdf","grobid_xml":"https://content.openalex.org/works/W4319984658.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1894737770","https://openalex.org/W1978063268","https://openalex.org/W1979176020","https://openalex.org/W1991942955","https://openalex.org/W1993755430","https://openalex.org/W1995267195","https://openalex.org/W2022682850","https://openalex.org/W2025494232","https://openalex.org/W2039677504","https://openalex.org/W2048906013","https://openalex.org/W2051595112","https://openalex.org/W2052295646","https://openalex.org/W2063734640","https://openalex.org/W2100398384","https://openalex.org/W2104311440","https://openalex.org/W2109207624","https://openalex.org/W2109567227","https://openalex.org/W2121791436","https://openalex.org/W2140915472","https://openalex.org/W2146276608","https://openalex.org/W2151001008","https://openalex.org/W2171334003","https://openalex.org/W2256415255","https://openalex.org/W2593574874","https://openalex.org/W2611809716","https://openalex.org/W2740556022","https://openalex.org/W2752068167","https://openalex.org/W2755675592","https://openalex.org/W2795040309","https://openalex.org/W3000158820","https://openalex.org/W3087790240","https://openalex.org/W4283326259","https://openalex.org/W4298622607"],"related_works":["https://openalex.org/W7170197032","https://openalex.org/W2121791436","https://openalex.org/W2901700735","https://openalex.org/W2118260963","https://openalex.org/W2156370937","https://openalex.org/W2077529784","https://openalex.org/W3083925587","https://openalex.org/W2152187980","https://openalex.org/W3118976836","https://openalex.org/W2221200121"],"abstract_inverted_index":{"Continuously":[0],"growing":[1],"mouse":[2,71,350],"incisors":[3,92,181,216],"are":[4,21,315],"widely":[5],"used":[6],"to":[7,43,105,143,150,161,191,249],"study":[8,33],"amelogenesis,":[9],"since":[10],"all":[11],"stages":[12,58,84],"of":[13,59,76,85,90,163,180,185,196,207,217,252,321,333,341,347],"this":[14],"process":[15],"(i.e.,":[16],"secretory,":[17,225],"transition":[18,198,230,283,308],"and":[19,93,115,128,130,137,141,149,182,239,247,262,267,286,293,304,309,337],"maturation)":[20],"present":[22],"in":[23,116,154,288,349],"a":[24],"spatially":[25],"determined":[26],"sequence":[27],"at":[28],"any":[29],"given":[30],"time.":[31],"To":[32,203],"biological":[34],"changes":[35,153],"associated":[36],"with":[37,97,100,107,159,317],"enamel":[38,54,146,186,212,256,322],"formation,":[39,55],"it":[40],"is":[41],"important":[42],"develop":[44],"reliable":[45],"methods":[46],"for":[47,65,81,345],"collecting":[48,66],"ameloblasts,":[49],"the":[50,62,88,178,183,197,205,208,273,318,330,339],"cells":[51],"that":[52,171],"regulate":[53],"from":[56,70,122,214],"different":[57],"amelogenesis.":[60,86],"Micro-dissection,":[61],"key":[63,255],"method":[64,336],"distinct":[67],"ameloblast":[68,155],"populations":[69],"incisors,":[72],"relies":[73],"on":[74],"positions":[75,89,162],"molar":[77,192],"teeth":[78],"as":[79],"landmarks":[80,344],"identifying":[82],"critical":[83],"However,":[87],"mandibular":[91,215],"their":[94,279],"spatial":[95],"relationships":[96,111],"molars":[98],"change":[99],"age.":[101],"Our":[102],"goal":[103],"was":[104,299],"identify":[106,151],"high":[108,331],"precision":[109],"these":[110],"throughout":[112,172,307],"skeletal":[113,174],"growth":[114,175],"older,":[117],"skeletally":[118],"mature":[119],"animals.":[120],"Mandibles":[121],"2,":[123],"4,":[124,292],"8,":[125],"12,":[126],"16,":[127],"24-week-old,":[129],"18-month-old":[131],"C57BL/6J":[132],"male":[133],"mice,":[134],"were":[135,245,269],"collected":[136],"studied":[138],"using":[139,264],"micro-CT":[140],"histology":[142],"obtain":[144],"incisal":[145],"mineralization":[147,187],"profiles":[148,314],"corresponding":[152],"morphology":[156],"during":[157,272,282,302],"amelogenesis":[158,348],"respect":[160],"molars.":[164],"As":[165],"reported":[166],"here,":[167],"we":[168,210],"have":[169],"found":[170],"active":[173],"(weeks":[176],"2\u201316)":[177],"apices":[179],"onset":[184],"move":[188],"distally":[189],"relative":[190],"teeth.":[193],"The":[194],"position":[195],"stage":[199,275],"also":[200],"moves":[201],"distally.":[202],"test":[204],"accuracy":[206,332],"landmarks,":[209],"micro-dissected":[211],"epithelium":[213],"12-week-old":[218],"animals":[219],"into":[220],"five":[221],"segments,":[222],"including":[223],"1)":[224],"2)":[226,285],"late":[227,241],"secretory":[228,274],"-":[229,231],"early":[232,235],"maturation,":[233,236],"3)":[234],"4)":[237],"mid-maturation":[238],"5)":[240],"maturation.":[242],"Isolated":[243],"segments":[244],"pooled":[246],"subjected":[248],"expression":[250,280,298,313],"analyses":[251],"genes":[253],"encoding":[254],"matrix":[257,323],"proteins":[258,324],"(EMPs),":[259],"Amelx,":[260],"Enam,":[261],"Odam,":[263],"RT-qPCR.":[265],"Amelx":[266],"Enam":[268],"strongly":[270],"expressed":[271],"(segment":[276,284],"1),":[277],"while":[278],"diminished":[281],"ceased":[287],"maturation":[289,310],"(segments":[290],"3,":[291],"5).":[294],"In":[295],"contrast,":[296],"Odam\u2019s":[297],"very":[300],"low":[301],"secretion":[303],"increased":[305],"dramatically":[306],"stages.":[311],"These":[312],"consistent":[316],"consensus":[319],"understanding":[320],"expression.":[325],"Overall,":[326],"our":[327,334],"results":[328],"demonstrate":[329],"landmarking":[335],"emphasize":[338],"importance":[340],"selecting":[342],"age-appropriate":[343],"studies":[346],"incisors.":[351]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-02-11T00:00:00"}
