{"id":"https://openalex.org/W4319984580","doi":"https://doi.org/10.3389/fmed.2023.1056506","title":"Persistence of inflammatory and vascular mediators 5 months after hospitalization with COVID-19 infection","display_name":"Persistence of inflammatory and vascular mediators 5 months after hospitalization with COVID-19 infection","publication_year":2023,"publication_date":"2023-02-10","ids":{"openalex":"https://openalex.org/W4319984580","doi":"https://doi.org/10.3389/fmed.2023.1056506","pmid":"https://pubmed.ncbi.nlm.nih.gov/36844209","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9950100"},"language":"en","primary_location":{"id":"doi:10.3389/fmed.2023.1056506","doi":"https://doi.org/10.3389/fmed.2023.1056506","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2023.1056506","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmed.2023.1056506/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fmed.2023.1056506/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"James Melhorn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210088942","display_name":"NIHR Oxford Biomedical Research Centre","ror":"https://ror.org/00aps1a34","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210088942","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James Melhorn","raw_affiliation_strings":["Nuffield Department of Clinical Medicine (NDM), University of Oxford, Oxford, United Kingdom","Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Clinical Medicine (NDM), University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210088942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112866597","display_name":"Asma Alamoudi","orcid":"https://orcid.org/0000-0001-8716-9703","observed_orcids":["https://orcid.org/0000-0001-8716-9703"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Asma Alamoudi","raw_affiliation_strings":["Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042879556","display_name":"Alexander J. Mentzer","orcid":"https://orcid.org/0000-0002-4502-2209","observed_orcids":["https://orcid.org/0000-0002-4502-2209"]},"institutions":[{"id":"https://openalex.org/I1336263701","display_name":"Centre for Human Genetics","ror":"https://ror.org/01rjnta51","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alexander J. Mentzer","raw_affiliation_strings":["Nuffield Department of Clinical Medicine (NDM), University of Oxford, Oxford, United Kingdom","Wellcome Centre for Human Genetics, NDM, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Clinical Medicine (NDM), University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Wellcome Centre for Human Genetics, NDM, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037229827","display_name":"Emily Fraser","orcid":"https://orcid.org/0000-0002-7449-5793","observed_orcids":["https://orcid.org/0000-0002-7449-5793"]},"institutions":[{"id":"https://openalex.org/I4210147381","display_name":"Oxford University Hospitals NHS Trust","ror":"https://ror.org/03h2bh287","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Emily Fraser","raw_affiliation_strings":["Oxford University Hospitals (OUH) NHS Foundation Trust, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oxford University Hospitals (OUH) NHS Foundation Trust, Oxford, United Kingdom","institution_ids":["https://openalex.org/I4210147381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059564614","display_name":"Anastasia Fries","orcid":"https://orcid.org/0000-0003-1609-5991","observed_orcids":["https://orcid.org/0000-0003-1609-5991"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anastasia Fries","raw_affiliation_strings":["Nuffield Department of Clinical Medicine (NDM), University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Clinical Medicine (NDM), University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088212916","display_name":"Mark Philip Cassar","orcid":"https://orcid.org/0000-0001-7192-6917","observed_orcids":["https://orcid.org/0000-0001-7192-6917"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210147381","display_name":"Oxford University Hospitals NHS Trust","ror":"https://ror.org/03h2bh287","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark Philip Cassar","raw_affiliation_strings":["Oxford University Hospitals (OUH) NHS Foundation Trust, Oxford, United Kingdom","Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oxford University Hospitals (OUH) NHS Foundation Trust, Oxford, United Kingdom","institution_ids":["https://openalex.org/I4210147381"]},{"raw_affiliation_string":"Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059190477","display_name":"Andrew John Kwok","orcid":"https://orcid.org/0000-0001-8928-5054","observed_orcids":["https://orcid.org/0000-0001-8928-5054"]},"institutions":[{"id":"https://openalex.org/I1336263701","display_name":"Centre for Human Genetics","ror":"https://ror.org/01rjnta51","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew Kwok","raw_affiliation_strings":["Nuffield Department of Clinical Medicine (NDM), University of Oxford, Oxford, United Kingdom","Wellcome Centre for Human Genetics, NDM, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Clinical Medicine (NDM), University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Wellcome Centre for Human Genetics, NDM, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051498432","display_name":"Julian Charles Knight","orcid":"https://orcid.org/0000-0002-0377-5536","observed_orcids":["https://orcid.org/0000-0002-0377-5536"]},"institutions":[{"id":"https://openalex.org/I1336263701","display_name":"Centre for Human Genetics","ror":"https://ror.org/01rjnta51","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210088942","display_name":"NIHR Oxford Biomedical Research Centre","ror":"https://ror.org/00aps1a34","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210088942","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Julian Charles Knight","raw_affiliation_strings":["Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, United Kingdom","Nuffield Department of Clinical Medicine (NDM), University of Oxford, Oxford, United Kingdom","Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom","Wellcome Centre for Human Genetics, NDM, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Nuffield Department of Clinical Medicine (NDM), University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210088942"]},{"raw_affiliation_string":"Wellcome Centre for Human Genetics, NDM, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030207119","display_name":"Betty Raman","orcid":"https://orcid.org/0000-0002-1239-9608","observed_orcids":["https://orcid.org/0000-0002-1239-9608"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210147381","display_name":"Oxford University Hospitals NHS Trust","ror":"https://ror.org/03h2bh287","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Betty Raman","raw_affiliation_strings":["Oxford University Hospitals (OUH) NHS Foundation Trust, Oxford, United Kingdom","Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oxford University Hospitals (OUH) NHS Foundation Trust, Oxford, United Kingdom","institution_ids":["https://openalex.org/I4210147381"]},{"raw_affiliation_string":"Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047349436","display_name":"Nick P. Talbot","orcid":"https://orcid.org/0000-0002-9186-8950","observed_orcids":["https://orcid.org/0000-0002-9186-8950"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210088942","display_name":"NIHR Oxford Biomedical Research Centre","ror":"https://ror.org/00aps1a34","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210088942","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I4210147381","display_name":"Oxford University Hospitals NHS Trust","ror":"https://ror.org/03h2bh287","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nick P Talbot","raw_affiliation_strings":["Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom","Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom","Oxford University Hospitals (OUH) NHS Foundation Trust, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210088942"]},{"raw_affiliation_string":"Oxford University Hospitals (OUH) NHS Foundation Trust, Oxford, United Kingdom","institution_ids":["https://openalex.org/I4210147381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087311719","display_name":"Nayia Petousi","orcid":"https://orcid.org/0000-0002-5524-020X","observed_orcids":["https://orcid.org/0000-0002-5524-020X"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210088942","display_name":"NIHR Oxford Biomedical Research Centre","ror":"https://ror.org/00aps1a34","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210088942","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I4210147381","display_name":"Oxford University Hospitals NHS Trust","ror":"https://ror.org/03h2bh287","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Nayia Petousi","raw_affiliation_strings":["Nuffield Department of Clinical Medicine (NDM), University of Oxford, Oxford, United Kingdom","Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom","Oxford University Hospitals (OUH) NHS Foundation Trust, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Clinical Medicine (NDM), University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210088942"]},{"raw_affiliation_string":"Oxford University Hospitals (OUH) NHS Foundation Trust, Oxford, United Kingdom","institution_ids":["https://openalex.org/I4210147381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5087311719"],"corresponding_institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210088942","https://openalex.org/I4210147381"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":2.329,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.87573956,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":null,"first_page":"1056506","last_page":"1056506"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.8690999746322632,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.8690999746322632,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11368","display_name":"Long-Term Effects of COVID-19","score":0.12290000170469284,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.8640000224113464},{"id":"https://openalex.org/keywords/long-covid","display_name":"long COVID","score":0.7329999804496765},{"id":"https://openalex.org/keywords/covid-19-pneumonia","display_name":"COVID-19 pneumonia","score":0.7440000176429749},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.7250000238418579},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.7549999952316284},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.9190000295639038},{"id":"https://openalex.org/keywords/endothelial-injury","display_name":"endothelial injury","score":0.8109999895095825},{"id":"https://openalex.org/keywords/angiogenic-mediators","display_name":"angiogenic mediators","score":0.9570000171661377},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9049999713897705},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8880000114440918},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.8899999856948853},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.6610000133514404},{"id":"https://openalex.org/keywords/tie2","display_name":"Tie2","score":0.5789999961853027},{"id":"https://openalex.org/keywords/flt-1","display_name":"Flt-1","score":0.7269999980926514},{"id":"https://openalex.org/keywords/plasma-biomarkers","display_name":"plasma biomarkers","score":0.6349999904632568},{"id":"https://openalex.org/keywords/pulmonary-inflammation","display_name":"lung inflammation","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C2781009140","wikidata":"https://www.wikidata.org/wiki/Q7170389","display_name":"Persistence (discontinuity)","level":2,"score":0.9153132438659668},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.7625100612640381},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.528287947177887},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.5003571510314941},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4868242144584656},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.46997231245040894},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.34816449880599976},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3246796131134033},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.31568264961242676},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2500521242618561},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.10486242175102234},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.09470918774604797},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.059583455324172974},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C187320778","wikidata":"https://www.wikidata.org/wiki/Q1349130","display_name":"Geotechnical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fmed.2023.1056506","doi":"https://doi.org/10.3389/fmed.2023.1056506","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2023.1056506","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmed.2023.1056506/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9950100","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9950100","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9950100/pdf/fmed-10-1056506.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Med (Lausanne)","raw_type":"Text"},{"id":"pmid:36844209","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36844209","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in medicine","raw_type":"Journal Article"},{"id":"pmh:oai:ora.ox.ac.uk:uuid:125cc34d-2efc-4637-ae52-f3ed662221ca","doi":null,"is_oa":true,"landing_page_url":"https://ora.ox.ac.uk/objects/uuid:125cc34d-2efc-4637-ae52-f3ed662221ca","pdf_url":"https://ora.ox.ac.uk/objects/uuid:125cc34d-2efc-4637-ae52-f3ed662221ca/files/smw22v710g","source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Symplectic Elements","raw_type":"Journal article"},{"id":"pmh:oai:doaj.org/article:e6f7c94444bd4c858af9ae900fda82b7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e6f7c94444bd4c858af9ae900fda82b7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Medicine, Vol 10 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fmed.2023.1056506","doi":"https://doi.org/10.3389/fmed.2023.1056506","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2023.1056506","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmed.2023.1056506/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3276968844","display_name":null,"funder_award_id":"CL-2018-13-007","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G3295457392","display_name":"Research Excellence (round 3)","funder_award_id":"RE/18/3/34214","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G3595237711","display_name":null,"funder_award_id":"NIHR-INF-1867","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G489130273","display_name":null,"funder_award_id":"COVID RESPONSE FUND (BRD00230)","funder_id":"https://openalex.org/F4320320290","funder_display_name":"University of Oxford"},{"id":"https://openalex.org/G520856161","display_name":null,"funder_award_id":"2018\u2010I2M\u20102\u2010002","funder_id":"https://openalex.org/F4320323137","funder_display_name":"Chinese Academy of Medical Sciences"},{"id":"https://openalex.org/G5720903014","display_name":"Characterising extreme innate immune response phenotypes informative for disease using a functional genomics approach","funder_award_id":"204969/Z/16/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G5918494183","display_name":null,"funder_award_id":"COVID-19","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G6657896816","display_name":"MICA: Interrogating the functional impact of novel asthma genetic variants using genomics and inducible pluripotent stem cell-derived epithelial cells","funder_award_id":"MR/X000974/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G7091706460","display_name":null,"funder_award_id":"BRC pump-priming award (BRC4PP-02)","funder_id":"https://openalex.org/F4320336045","funder_display_name":"NIHR Oxford Biomedical Research Centre"},{"id":"https://openalex.org/G8520093626","display_name":null,"funder_award_id":"CL-2013-13-003","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320319992","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04"},{"id":"https://openalex.org/F4320320290","display_name":"University of Oxford","ror":"https://ror.org/052gg0110"},{"id":"https://openalex.org/F4320323137","display_name":"Chinese Academy of Medical Sciences","ror":"https://ror.org/03cve4549"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320336045","display_name":"NIHR Oxford Biomedical Research Centre","ror":"https://ror.org/00aps1a34"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4319984580.pdf","grobid_xml":"https://content.openalex.org/works/W4319984580.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1994844769","https://openalex.org/W2099543104","https://openalex.org/W2106530602","https://openalex.org/W2156182815","https://openalex.org/W3001118548","https://openalex.org/W3009859788","https://openalex.org/W3009885589","https://openalex.org/W3014003872","https://openalex.org/W3018517500","https://openalex.org/W3018529391","https://openalex.org/W3027918021","https://openalex.org/W3036563213","https://openalex.org/W3042270788","https://openalex.org/W3042781587","https://openalex.org/W3045085017","https://openalex.org/W3089043805","https://openalex.org/W3118061239","https://openalex.org/W3130206057","https://openalex.org/W3135942249","https://openalex.org/W3143401256","https://openalex.org/W3147374446","https://openalex.org/W3175672910","https://openalex.org/W3200535744","https://openalex.org/W3201253246","https://openalex.org/W4206396480","https://openalex.org/W4211096971","https://openalex.org/W4220737225","https://openalex.org/W4220939068","https://openalex.org/W4224316910","https://openalex.org/W4283270353","https://openalex.org/W6839316923"],"related_works":["https://openalex.org/W4312653137","https://openalex.org/W3147374446","https://openalex.org/W4387059104","https://openalex.org/W4318193131","https://openalex.org/W7143537715","https://openalex.org/W3144796705","https://openalex.org/W3158696895","https://openalex.org/W4416529779","https://openalex.org/W4287377797","https://openalex.org/W4399655635"],"abstract_inverted_index":{"Background":[0],"and":[1,12,31,48,59,74,111,126,135,137,145,165,196,212,220,234,246,269],"aim":[2,25],"In":[3,21],"acute":[4,108,181,258],"severe":[5,57,109],"COVID-19,":[6],"patients":[7,36,54,84,100,153],"present":[8],"with":[9,41,51,96,107,117,177,203,223],"lung":[10],"inflammation":[11],"vascular":[13,32,71,247],"injury,":[14],"accompanied":[15],"by":[16],"an":[17],"exaggerated":[18],"cytokine":[19],"response.":[20],"this":[22],"study,":[23],"our":[24],"was":[26],"to":[27,155,169,265],"describe":[28],"the":[29,80,132,157,170,178],"inflammatory":[30,245],"mediator":[33,250],"profiles":[34],"in":[35,53,60,79,131,151,160,192,254],"who":[37],"were":[38,77,94,128,139,147,167,198],"previously":[39],"hospitalized":[40,95],"COVID-19":[42,97,182,259],"pneumonitis,":[43],"months":[44,91,104,256],"after":[45,92,105],"their":[46],"recovery,":[47],"compare":[49],"them":[50],"those":[52],"recovering":[55],"from":[56],"sepsis":[58],"healthy":[61,113,118],"controls.":[62,114],"Methods":[63],"A":[64,243],"total":[65],"of":[66,82,180],"27":[67],"different":[68],"cytokine,":[69],"chemokine,":[70],"endothelial":[72,248],"injury":[73],"angiogenic":[75],"mediators":[76],"measured":[78],"plasma":[81,255],"forty-nine":[83],"5.0":[85],"\u00b1":[86,89,102],"1.9":[87],"(mean":[88],"SD)":[90],"they":[93],"pneumonia,":[98],"eleven":[99],"5.4":[101],"2.9":[103],"hospitalization":[106],"sepsis,":[110],"18":[112],"Results":[115],"Compared":[116],"controls,":[119,156],"IL-6,":[120,143],"TNF\u03b1,":[121,161],"SAA,":[122],"CRP,":[123],"Tie-2,":[124,162],"Flt1,":[125],"PIGF":[127],"significantly":[129,140,149,175],"increased":[130],"post-COVID":[133,171,193],"group,":[134],"IL-7":[136,164],"bFGF":[138,166],"reduced.":[141],"While":[142],"PIGF,":[144],"CRP":[146,197],"also":[148],"elevated":[150],"post-Sepsis":[152],"compared":[154],"observed":[158],"differences":[159],"Flt-1,":[163],"unique":[168,244],"group.":[172],"TNF\u03b1":[173],"levels":[174],"correlated":[176,202,222],"severity":[179],"illness":[183],"(spearman\u2019s":[184,208],"r":[185,209,213,235],"=":[186,210,214,232,236],"0.30,":[187],"p":[188,217,238],"<":[189,218,239],"0.05).":[190],"Furthermore,":[191],"patients,":[194],"IL-6":[195],"each":[199],"strongly":[200],"negatively":[201],"gas":[204],"transfer":[205],"factor":[206],"%predicted":[207],"\u20130.51":[211],"\u20130.57,":[215],"respectively,":[216],"0.002)":[219],"positively":[221],"computed":[224],"tomography":[225],"(CT)":[226],"abnormality":[227],"scores":[228],"at":[229],"recovery":[230],"(r":[231],"0.28":[233],"0.46,":[237],"0.05,":[240],"respectively).":[241],"Conclusion":[242],"damage":[249],"signature":[251],"is":[252,263],"found":[253],"following":[257],"infection.":[260],"Further":[261],"research":[262],"required":[264],"determine":[266],"its":[267],"pathophysiological":[268],"clinical":[270],"significance.":[271]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2023-02-11T00:00:00"}
