{"id":"https://openalex.org/W4319984237","doi":"https://doi.org/10.3389/fonc.2023.1070485","title":"GA-OH enhances the cytotoxicity of photon and proton radiation in HPV+ HNSCC cells","display_name":"GA-OH enhances the cytotoxicity of photon and proton radiation in HPV+ HNSCC cells","publication_year":2023,"publication_date":"2023-02-10","ids":{"openalex":"https://openalex.org/W4319984237","doi":"https://doi.org/10.3389/fonc.2023.1070485","pmid":"https://pubmed.ncbi.nlm.nih.gov/36845698","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9950506"},"language":"en","primary_location":{"id":"doi:10.3389/fonc.2023.1070485","doi":"https://doi.org/10.3389/fonc.2023.1070485","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2023.1070485","pdf_url":null,"source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fonc.2023.1070485","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019614723","display_name":"Lennox Chitsike","orcid":"https://orcid.org/0000-0002-2901-353X","observed_orcids":["https://orcid.org/0000-0002-2901-353X"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lennox Chitsike","raw_affiliation_strings":["Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, United States","institution_ids":["https://openalex.org/I26347476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040126130","display_name":"Antonella Bertucci","orcid":"https://orcid.org/0000-0002-9267-1770","observed_orcids":["https://orcid.org/0000-0002-9267-1770"]},"institutions":[{"id":"https://openalex.org/I1293502524","display_name":"Loma Linda University Medical Center","ror":"https://ror.org/03et1qs84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293502524"]},{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antonella Bertucci","raw_affiliation_strings":["Department of Radiation Medicine, Loma Linda University School of Medicine, Loma Linda, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Medicine, Loma Linda University School of Medicine, Loma Linda, CA, United States","institution_ids":["https://openalex.org/I1293502524","https://openalex.org/I26347476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035577185","display_name":"Marcelo E. Vazquez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1293502524","display_name":"Loma Linda University Medical Center","ror":"https://ror.org/03et1qs84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293502524"]},{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcelo Vazquez","raw_affiliation_strings":["Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, United States","Department of Radiation Medicine, Loma Linda University School of Medicine, Loma Linda, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, United States","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"Department of Radiation Medicine, Loma Linda University School of Medicine, Loma Linda, CA, United States","institution_ids":["https://openalex.org/I1293502524","https://openalex.org/I26347476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100650756","display_name":"Steve C. Lee","orcid":"https://orcid.org/0000-0002-4460-4303","observed_orcids":["https://orcid.org/0000-0002-4460-4303"]},"institutions":[{"id":"https://openalex.org/I1293502524","display_name":"Loma Linda University Medical Center","ror":"https://ror.org/03et1qs84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293502524"]},{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steve Lee","raw_affiliation_strings":["Department of Otolaryngology & Head/Neck Surgery, Loma Linda University School of Medicine, Loma Linda, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology & Head/Neck Surgery, Loma Linda University School of Medicine, Loma Linda, CA, United States","institution_ids":["https://openalex.org/I1293502524","https://openalex.org/I26347476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002611376","display_name":"Juli Unternaehrer","orcid":"https://orcid.org/0000-0001-5864-4704","observed_orcids":["https://orcid.org/0000-0001-5864-4704"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juli J. Unternaehrer","raw_affiliation_strings":["Division of Biochemistry, Department of Basic Sciences, Loma Linda University, Loma Linda, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry, Department of Basic Sciences, Loma Linda University, Loma Linda, CA, United States","institution_ids":["https://openalex.org/I26347476"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042664406","display_name":"Penelope J. Duerksen-Hughes","orcid":"https://orcid.org/0000-0002-0998-2157","observed_orcids":["https://orcid.org/0000-0002-0998-2157"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Penelope J. Duerksen-Hughes","raw_affiliation_strings":["Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, United States","institution_ids":["https://openalex.org/I26347476"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5042664406"],"corresponding_institution_ids":["https://openalex.org/I26347476"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":1.3169,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.76673918,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"13","issue":null,"first_page":"1070485","last_page":"1070485"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.053199999034404755,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hpv-positive-oropharyngeal-squamous-cell-carcinoma","display_name":"HPV-positive oropharyngeal squamous cell carcinoma","score":0.8849999904632568},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.9290000200271606},{"id":"https://openalex.org/keywords/proton-radiation","display_name":"proton radiation","score":0.7429999709129333},{"id":"https://openalex.org/keywords/photon-radiation","display_name":"photon radiation","score":0.9649999737739563},{"id":"https://openalex.org/keywords/relative-biological-effectiveness","display_name":"relative biological effectiveness","score":0.8889999985694885},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.8539999723434448},{"id":"https://openalex.org/keywords/radiation-induced-apoptosis","display_name":"radiation-induced apoptosis","score":0.9229999780654907},{"id":"https://openalex.org/keywords/cetuximab","display_name":"cetuximab","score":0.9649999737739563},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9789999723434448}],"concepts":[{"id":"https://openalex.org/C206684579","wikidata":"https://www.wikidata.org/wiki/Q4387689","display_name":"Radiosensitivity","level":3,"score":0.8553293943405151},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6885093450546265},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6372695565223694},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5922417640686035},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5423383116722107},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.4698946475982666},{"id":"https://openalex.org/C19106626","wikidata":"https://www.wikidata.org/wiki/Q230749","display_name":"Bystander effect","level":2,"score":0.4652337431907654},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.45549237728118896},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.41997432708740234},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41851821541786194},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.412864625453949},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40622764825820923},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3973780870437622},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3656938076019287},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31229013204574585},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26665669679641724},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.244430810213089},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.17090895771980286},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.14231473207473755},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09332767128944397},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07102641463279724}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fonc.2023.1070485","doi":"https://doi.org/10.3389/fonc.2023.1070485","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2023.1070485","pdf_url":null,"source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9950506","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9950506","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9950506/pdf/fonc-13-1070485.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Oncol","raw_type":"Text"},{"id":"pmid:36845698","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36845698","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:5134a13a80664b0fb6810bcf1f1d0b6a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5134a13a80664b0fb6810bcf1f1d0b6a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Oncology, Vol 13 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fonc.2023.1070485","doi":"https://doi.org/10.3389/fonc.2023.1070485","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2023.1070485","pdf_url":null,"source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8100000023841858,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6249962013","display_name":"HTS Screening for Inhibitors of HPV 16 E6/Caspase 8 Binding","funder_award_id":"R21NS073059","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320310839","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1694492712","https://openalex.org/W1863635992","https://openalex.org/W1927461076","https://openalex.org/W1964184380","https://openalex.org/W1994101733","https://openalex.org/W1998914462","https://openalex.org/W2024592737","https://openalex.org/W2031540685","https://openalex.org/W2059589469","https://openalex.org/W2095983717","https://openalex.org/W2107277218","https://openalex.org/W2114119309","https://openalex.org/W2136877233","https://openalex.org/W2153641948","https://openalex.org/W2171297405","https://openalex.org/W2238041893","https://openalex.org/W2326042739","https://openalex.org/W2328159549","https://openalex.org/W2404488238","https://openalex.org/W2409078986","https://openalex.org/W2557556302","https://openalex.org/W2560996806","https://openalex.org/W2575157150","https://openalex.org/W2756095389","https://openalex.org/W2809159884","https://openalex.org/W2849637512","https://openalex.org/W2889646458","https://openalex.org/W2906249136","https://openalex.org/W2952511708","https://openalex.org/W2957724045","https://openalex.org/W2973957655","https://openalex.org/W2980127597","https://openalex.org/W2981345652","https://openalex.org/W2986574912","https://openalex.org/W2991195404","https://openalex.org/W3000198818","https://openalex.org/W3011345420","https://openalex.org/W3013640632","https://openalex.org/W3018270587","https://openalex.org/W3019603837","https://openalex.org/W3041891326","https://openalex.org/W3047580187","https://openalex.org/W3082602047","https://openalex.org/W3093933677","https://openalex.org/W3137624886","https://openalex.org/W3183583786","https://openalex.org/W3193485212","https://openalex.org/W6674393665","https://openalex.org/W6713191860"],"related_works":["https://openalex.org/W2068106568","https://openalex.org/W3126554249","https://openalex.org/W2114119309","https://openalex.org/W2889972835","https://openalex.org/W2945710829","https://openalex.org/W2040073927","https://openalex.org/W2890459945","https://openalex.org/W2809122032","https://openalex.org/W2404488238","https://openalex.org/W2755417012"],"abstract_inverted_index":{"Introduction:":[0],"Treatment-related":[1],"toxicity":[2],"following":[3],"either":[4,81],"chemo-":[5],"or":[6,83],"radiotherapy":[7],"can":[8],"create":[9],"significant":[10],"clinical":[11],"challenges":[12],"for":[13,41,109,298],"HNSCC":[14,70,144],"cancer":[15],"patients,":[16],"particularly":[17,209],"those":[18],"with":[19,282,300],"HPV-associated":[20],"oropharyngeal":[21,301],"squamous":[22],"cell":[23,71,99,206,212],"carcinoma.":[24],"Identifying":[25],"and":[26,68,75,101,105,112,135,146,278,293],"characterizing":[27],"targeted":[28],"therapy":[29],"agents":[30],"that":[31,46,128,147,170,192,219],"enhance":[32],"the":[33,54,120,152,193,198,215,222,252,273,291],"efficacy":[34],"of":[35,56,151,186,195,225,255,275,295],"radiation":[36,44,129,201,226,235,296],"is":[37,137,268],"a":[38,259],"reasonable":[39],"approach":[40],"developing":[42],"de-escalated":[43],"regimens":[45],"result":[47],"in":[48,139,143,158,183,210,248],"less":[49,178],"radiation-induced":[50],"sequelae.":[51],"We":[52,167],"evaluated":[53],"ability":[55],"our":[57],"recently":[58],"discovered,":[59],"novel":[60],"HPV":[61],"E6":[62,256],"inhibitor":[63],"(GA-OH)":[64],"to":[65,73,80,163,200,261,264,270,289],"radio-sensitize":[66],"HPV+":[67,159,211],"HPV-":[69,165],"lines":[72],"photon":[74,82],"proton":[76,84],"radiation.":[77,265],"Methods:":[78],"Radiosensitivity":[79],"beams":[85],"was":[86,156,172],"assessed":[87],"using":[88],"various":[89],"assays":[90],"such":[91],"as":[92,161,227,258,284,286],"colony":[93,141],"formation":[94,142],"assay,":[95],"DNA":[96],"damage":[97],"markers,":[98,232],"cycle":[100,207],"apoptosis,":[102],"western":[103],"blotting,":[104],"primary":[106],"cells.":[107,153,188],"Calculations":[108],"radiosensitivity":[110,150,185],"indices":[111],"relative":[113],"biological":[114],"effectiveness":[115,294],"(RBE)":[116],"were":[117],"based":[118],"on":[119,197,240],"linear":[121],"quadratic":[122],"model.":[123],"Results:":[124],"Our":[125],"results":[126,216],"showed":[127,218],"derived":[130],"from":[131],"both":[132],"X-ray":[133],"photons":[134],"protons":[136],"effective":[138,174,179],"inhibiting":[140],"cells,":[145],"GA-OH":[148,171,196,220,276],"potentiated":[149],"This":[154],"effect":[155,239],"stronger":[157],"cells":[160,263],"compared":[162],"their":[164],"counterparts.":[166],"also":[168,217],"found":[169,247],"more":[173],"than":[175,180],"cetuximab":[176],"but":[177],"cisplatin":[181],"(CDDP)":[182],"enhancing":[184],"HSNCC":[187],"Further":[189],"tests":[190],"indicated":[191],"effects":[194],"response":[199],"may":[202],"be":[203],"mediated":[204],"through":[205],"arrest,":[208],"lines.":[213],"Importantly,":[214],"increases":[221],"apoptotic":[223,231],"induction":[224],"measured":[228],"by":[229],"several":[230],"even":[233],"though":[234],"alone":[236],"had":[237],"little":[238],"apoptosis.":[241],"Conclusion:":[242],"The":[243],"enhanced":[244],"combinatorial":[245],"cytotoxicity":[246],"this":[249],"study":[250],"indicates":[251],"strong":[253],"potential":[254,288],"inhibition":[257],"strategy":[260],"sensitize":[262],"Future":[266],"research":[267],"warranted":[269],"further":[271],"characterize":[272],"interaction":[274],"derivatives":[277],"other":[279],"E6-specific":[280],"inhibitors":[281],"radiation,":[283],"well":[285],"its":[287],"improve":[290],"safety":[292],"treatment":[297],"patients":[299],"cancer.":[302]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-02-11T00:00:00"}
