{"id":"https://openalex.org/W4319968051","doi":"https://doi.org/10.1016/j.phrs.2023.106692","title":"Allosteric inhibition of HSP70 in collaboration with STUB1 augments enzalutamide efficacy in antiandrogen resistant prostate tumor and patient-derived models","display_name":"Allosteric inhibition of HSP70 in collaboration with STUB1 augments enzalutamide efficacy in antiandrogen resistant prostate tumor and patient-derived models","publication_year":2023,"publication_date":"2023-02-10","ids":{"openalex":"https://openalex.org/W4319968051","doi":"https://doi.org/10.1016/j.phrs.2023.106692","pmid":"https://pubmed.ncbi.nlm.nih.gov/36773708","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10162009"},"language":"en","primary_location":{"id":"doi:10.1016/j.phrs.2023.106692","doi":"https://doi.org/10.1016/j.phrs.2023.106692","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.phrs.2023.106692","pdf_url":"https://ars.els-cdn.com/content/image/1-s2.0-S1043661823000488-ga1_lrg.jpg","source":{"id":"https://openalex.org/S54485712","display_name":"Pharmacological Research","issn_l":"1043-6618","issn":["1043-6618","1096-1186"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ars.els-cdn.com/content/image/1-s2.0-S1043661823000488-ga1_lrg.jpg","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076559212","display_name":"Pengfei Xu","orcid":"https://orcid.org/0000-0002-9401-9487","observed_orcids":["https://orcid.org/0000-0002-9401-9487"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pengfei Xu","raw_affiliation_strings":["Department of Urologic Surgery, University of California, Davis, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urologic Surgery, University of California, Davis, CA, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086066594","display_name":"Joy C. Yang","orcid":"https://orcid.org/0000-0001-9162-481X","observed_orcids":["https://orcid.org/0000-0001-9162-481X"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joy C. Yang","raw_affiliation_strings":["Department of Urologic Surgery, University of California, Davis, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urologic Surgery, University of California, Davis, CA, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078652096","display_name":"Shu Ning","orcid":"https://orcid.org/0000-0002-6514-0376","observed_orcids":["https://orcid.org/0000-0002-6514-0376"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shu Ning","raw_affiliation_strings":["Department of Urologic Surgery, University of California, Davis, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urologic Surgery, University of California, Davis, CA, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100427385","display_name":"Bo Chen","orcid":"https://orcid.org/0000-0002-9099-6248","observed_orcids":["https://orcid.org/0000-0002-9099-6248","https://orcid.org/0000-0001-8085-197X"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Bo Chen","raw_affiliation_strings":["Department of Urologic Surgery, University of California, Davis, CA, USA; Department of Urology, West China Hospital, Sichuan University, Sichuan, China","Department of Urologic Surgery, University of California, Davis, CA, USA","Department of Urology, West China Hospital, Sichuan University, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urologic Surgery, University of California, Davis, CA, USA; Department of Urology, West China Hospital, Sichuan University, Sichuan, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761","https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Urologic Surgery, University of California, Davis, CA, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Urology, West China Hospital, Sichuan University, Sichuan, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058947634","display_name":"Christopher Nip","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Nip","raw_affiliation_strings":["Department of Urologic Surgery, University of California, Davis, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urologic Surgery, University of California, Davis, CA, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Qiang Wei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiang Wei","raw_affiliation_strings":["Department of Urology, West China Hospital, Sichuan University, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, West China Hospital, Sichuan University, Sichuan, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101910009","display_name":"Liangren Liu","orcid":"https://orcid.org/0000-0001-7597-6241","observed_orcids":["https://orcid.org/0000-0001-7597-6241","https://orcid.org/0000-0002-2946-0663"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liangren Liu","raw_affiliation_strings":["Department of Urology, West China Hospital, Sichuan University, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, West China Hospital, Sichuan University, Sichuan, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035082433","display_name":"Oleta T. Johnson","orcid":"https://orcid.org/0000-0001-5170-3003","observed_orcids":["https://orcid.org/0000-0001-5170-3003"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oleta T. Johnson","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048369552","display_name":"Allen C. Gao","orcid":"https://orcid.org/0000-0002-5966-9038","observed_orcids":["https://orcid.org/0000-0002-5966-9038"]},"institutions":[{"id":"https://openalex.org/I4390039352","display_name":"UC Davis Comprehensive Cancer Center","ror":"https://ror.org/02kcc1z29","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160856","https://openalex.org/I4390039352"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allen C. Gao","raw_affiliation_strings":["Department of Urologic Surgery, University of California, Davis, CA, USA; University of California, Davis Comprehensive Cancer Center, CA, USA","Department of Urologic Surgery, University of California, Davis, CA, USA","University of California, Davis Comprehensive Cancer Center, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urologic Surgery, University of California, Davis, CA, USA; University of California, Davis Comprehensive Cancer Center, CA, USA","institution_ids":["https://openalex.org/I4390039352","https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Urologic Surgery, University of California, Davis, CA, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"University of California, Davis Comprehensive Cancer Center, CA, USA","institution_ids":["https://openalex.org/I4390039352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067529915","display_name":"Jason E. Gestwicki","orcid":"https://orcid.org/0000-0002-6125-3154","observed_orcids":["https://orcid.org/0000-0002-6125-3154"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason E. Gestwicki","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088621070","display_name":"Christopher P. Evans","orcid":"https://orcid.org/0000-0001-5626-8901","observed_orcids":["https://orcid.org/0000-0001-5626-8901"]},"institutions":[{"id":"https://openalex.org/I4390039352","display_name":"UC Davis Comprehensive Cancer Center","ror":"https://ror.org/02kcc1z29","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160856","https://openalex.org/I4390039352"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher P. Evans","raw_affiliation_strings":["Department of Urologic Surgery, University of California, Davis, CA, USA; University of California, Davis Comprehensive Cancer Center, CA, USA","Department of Urologic Surgery, University of California, Davis, CA, USA","University of California, Davis Comprehensive Cancer Center, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urologic Surgery, University of California, Davis, CA, USA; University of California, Davis Comprehensive Cancer Center, CA, USA","institution_ids":["https://openalex.org/I4390039352","https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Urologic Surgery, University of California, Davis, CA, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"University of California, Davis Comprehensive Cancer Center, CA, USA","institution_ids":["https://openalex.org/I4390039352"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101592945","display_name":"Chengfei Liu","orcid":"https://orcid.org/0000-0002-2452-8788","observed_orcids":["https://orcid.org/0000-0002-2452-8788"]},"institutions":[{"id":"https://openalex.org/I4390039352","display_name":"UC Davis Comprehensive Cancer Center","ror":"https://ror.org/02kcc1z29","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160856","https://openalex.org/I4390039352"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chengfei Liu","raw_affiliation_strings":["Department of Urologic Surgery, University of California, Davis, CA, USA; University of California, Davis Comprehensive Cancer Center, CA, USA. Electronic address: cffliu@ucdavis.edu","Department of Urologic Surgery, University of California, Davis, CA, USA","University of California, Davis Comprehensive Cancer Center, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urologic Surgery, University of California, Davis, CA, USA; University of California, Davis Comprehensive Cancer Center, CA, USA. Electronic address: cffliu@ucdavis.edu","institution_ids":["https://openalex.org/I4390039352","https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Urologic Surgery, University of California, Davis, CA, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"University of California, Davis Comprehensive Cancer Center, CA, USA","institution_ids":["https://openalex.org/I4390039352"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5101592945"],"corresponding_institution_ids":["https://openalex.org/I4390039352","https://openalex.org/I84218800"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":3.8614,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.94694095,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"189","issue":null,"first_page":"106692","last_page":"106692"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.030799999833106995,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hsp70","display_name":"HSP70","score":0.8690000176429749},{"id":"https://openalex.org/keywords/stub1","display_name":"STUB1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/enzalutamide-resistance","display_name":"enzalutamide resistance","score":0.8500000238418579},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.8510000109672546},{"id":"https://openalex.org/keywords/ar-v7","display_name":"AR-V7","score":0.824999988079071},{"id":"https://openalex.org/keywords/ubiquitin-proteasome-system","display_name":"ubiquitin-proteasome system","score":0.7990000247955322},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.8349999785423279},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8489999771118164},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.5260000228881836},{"id":"https://openalex.org/keywords/patient-derived-organoids","display_name":"patient-derived organoids","score":0.7129999995231628},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7440000176429749}],"concepts":[{"id":"https://openalex.org/C2776551883","wikidata":"https://www.wikidata.org/wiki/Q1996756","display_name":"Enzalutamide","level":5,"score":0.8336145877838135},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.7190951108932495},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6503727436065674},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6030929684638977},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.48888248205184937},{"id":"https://openalex.org/C68991219","wikidata":"https://www.wikidata.org/wiki/Q419102","display_name":"Hsp70","level":4,"score":0.4508506953716278},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43161740899086},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.420853853225708},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35702332854270935},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34140920639038086},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.28949877619743347},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22941634058952332},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20229694247245789},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1853117048740387},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.16894397139549255},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11678251624107361},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000726","descriptor_name":"Androgen Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000726","descriptor_name":"Androgen Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000726","descriptor_name":"Androgen Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000726","descriptor_name":"Androgen Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000726","descriptor_name":"Androgen Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000728","descriptor_name":"Androgens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000728","descriptor_name":"Androgens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000728","descriptor_name":"Androgens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000728","descriptor_name":"Androgens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000728","descriptor_name":"Androgens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010669","descriptor_name":"Phenylthiohydantoin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010669","descriptor_name":"Phenylthiohydantoin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018840","descriptor_name":"HSP70 Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018840","descriptor_name":"HSP70 Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018840","descriptor_name":"HSP70 Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018840","descriptor_name":"HSP70 Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018840","descriptor_name":"HSP70 Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018840","descriptor_name":"HSP70 Heat-Shock Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018840","descriptor_name":"HSP70 Heat-Shock Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018840","descriptor_name":"HSP70 Heat-Shock Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018840","descriptor_name":"HSP70 Heat-Shock Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018840","descriptor_name":"HSP70 Heat-Shock Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059002","descriptor_name":"Androgen Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059002","descriptor_name":"Androgen Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059002","descriptor_name":"Androgen Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059002","descriptor_name":"Androgen Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059002","descriptor_name":"Androgen Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064129","descriptor_name":"Prostatic Neoplasms, Castration-Resistant","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064129","descriptor_name":"Prostatic Neoplasms, Castration-Resistant","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064129","descriptor_name":"Prostatic Neoplasms, Castration-Resistant","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064129","descriptor_name":"Prostatic Neoplasms, Castration-Resistant","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064129","descriptor_name":"Prostatic Neoplasms, Castration-Resistant","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.phrs.2023.106692","doi":"https://doi.org/10.1016/j.phrs.2023.106692","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.phrs.2023.106692","pdf_url":"https://ars.els-cdn.com/content/image/1-s2.0-S1043661823000488-ga1_lrg.jpg","source":{"id":"https://openalex.org/S54485712","display_name":"Pharmacological Research","issn_l":"1043-6618","issn":["1043-6618","1096-1186"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research","raw_type":"journal-article"},{"id":"pmid:36773708","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36773708","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10162009","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10162009","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10162009/pdf/nihms-1892140.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Pharmacol Res","raw_type":"Text"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt1md57000","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/1md57000","pdf_url":"https://escholarship.org/content/qt1md57000/qt1md57000.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmacological Research, vol 189","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:0aa5beefd47948149ef46484906a60a3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0aa5beefd47948149ef46484906a60a3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmacological Research, Vol 189, Iss , Pp 106692- (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.phrs.2023.106692","doi":"https://doi.org/10.1016/j.phrs.2023.106692","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.phrs.2023.106692","pdf_url":"https://ars.els-cdn.com/content/image/1-s2.0-S1043661823000488-ga1_lrg.jpg","source":{"id":"https://openalex.org/S54485712","display_name":"Pharmacological Research","issn_l":"1043-6618","issn":["1043-6618","1096-1186"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.75,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1585092768","display_name":null,"funder_award_id":"NCI P30CA093373","funder_id":"https://openalex.org/F4320337900","funder_display_name":"Comprehensive Cancer Center, University of California, Davis"},{"id":"https://openalex.org/G2075359013","display_name":null,"funder_award_id":"P30CA093373","funder_id":"https://openalex.org/F4320332564","funder_display_name":"University of California, Davis"},{"id":"https://openalex.org/G3035950223","display_name":null,"funder_award_id":"NCI P30 CA093373","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3086813145","display_name":null,"funder_award_id":"T32 GM145304","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3955564880","display_name":null,"funder_award_id":"R37CA249108","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G414851490","display_name":null,"funder_award_id":"DoD PC180716","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G510075810","display_name":null,"funder_award_id":"K12GM081266","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5231708371","display_name":null,"funder_award_id":"DoD PC180716","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G5705938078","display_name":null,"funder_award_id":"NCI P30CA093373","funder_id":"https://openalex.org/F4320332564","funder_display_name":"University of California, Davis"},{"id":"https://openalex.org/G7938659809","display_name":null,"funder_award_id":"P30CA093373","funder_id":"https://openalex.org/F4320337900","funder_display_name":"Comprehensive Cancer Center, University of California, Davis"},{"id":"https://openalex.org/G9000215573","display_name":"Modulating HSP70/STUB1 machinery in therapy-resistant prostate cancer","funder_award_id":"R01CA251253","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000268188","display_name":null,"funder_award_id":"R37CA249108","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000885888","display_name":"Cancer Center Support Grant P30","funder_award_id":"P30CA093373","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000892101","display_name":"Molecular Chaperones and Small Molecules","funder_award_id":"R01NS059690","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332564","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337900","display_name":"Comprehensive Cancer Center, University of California, Davis","ror":"https://ror.org/02kcc1z29"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4319968051.pdf","grobid_xml":"https://content.openalex.org/works/W4319968051.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W135423147","https://openalex.org/W1588830049","https://openalex.org/W1919512980","https://openalex.org/W2007334137","https://openalex.org/W2012067226","https://openalex.org/W2017919614","https://openalex.org/W2035730185","https://openalex.org/W2051025382","https://openalex.org/W2056911532","https://openalex.org/W2082581177","https://openalex.org/W2083926838","https://openalex.org/W2085834972","https://openalex.org/W2103545212","https://openalex.org/W2122796143","https://openalex.org/W2123566216","https://openalex.org/W2128715380","https://openalex.org/W2148172443","https://openalex.org/W2156923287","https://openalex.org/W2162066969","https://openalex.org/W2170985807","https://openalex.org/W2176548633","https://openalex.org/W2181283187","https://openalex.org/W2255555283","https://openalex.org/W2278392405","https://openalex.org/W2343736576","https://openalex.org/W2471912558","https://openalex.org/W2581675136","https://openalex.org/W2598884790","https://openalex.org/W2612804612","https://openalex.org/W2657656066","https://openalex.org/W2748316362","https://openalex.org/W2803583781","https://openalex.org/W2810892605","https://openalex.org/W2896349409","https://openalex.org/W2898747775","https://openalex.org/W2921497169","https://openalex.org/W2945508549","https://openalex.org/W2966912474","https://openalex.org/W2967202514","https://openalex.org/W3015250703","https://openalex.org/W3027418027","https://openalex.org/W3128646645","https://openalex.org/W3208040040","https://openalex.org/W4206379853","https://openalex.org/W4210655694","https://openalex.org/W4229451510","https://openalex.org/W4285098634","https://openalex.org/W4289521547","https://openalex.org/W4297236487","https://openalex.org/W4303621916","https://openalex.org/W4303700150","https://openalex.org/W6635200130","https://openalex.org/W6685175151"],"related_works":["https://openalex.org/W4360747755","https://openalex.org/W3022181927","https://openalex.org/W2898747775","https://openalex.org/W4251464454","https://openalex.org/W2941815861","https://openalex.org/W2896349409","https://openalex.org/W2921728092","https://openalex.org/W4362596438","https://openalex.org/W3083939957","https://openalex.org/W2133173963"],"abstract_inverted_index":{"Ubiquitin":[0],"proteasome":[1],"activity":[2],"is":[3],"suppressed":[4,66,80,142,166],"in":[5,26,51,83,103],"enzalutamide":[6,76,160],"resistant":[7,104],"prostate":[8,53,94,148],"cancer":[9,95,149],"cells,":[10,150],"and":[11,18,30,70,74,89,106,125,152,159,165,186],"the":[12,116,122,143,146,155],"heat":[13],"shock":[14],"protein":[15,20,33,184],"70/STIP1":[16],"homology":[17],"U-box-containing":[19],"1":[21],"(HSP70/STUB1)":[22],"machinery":[23],"are":[24],"involved":[25],"androgen":[27,46],"receptor":[28,47],"(AR)":[29],"AR":[31],"variant":[32],"stabilization.":[34],"Targeting":[35],"HSP70":[36,61,173],"could":[37],"be":[38],"a":[39,59,134],"viable":[40],"strategy":[41],"to":[42,45,111,181],"overcome":[43],"resistance":[44],"signaling":[48],"inhibitor":[49],"(ARSI)":[50],"advanced":[52,93],"cancer.":[54],"Here,":[55],"we":[56],"showed":[57],"that":[58],"novel":[60,175],"allosteric":[62],"inhibitor,":[63],"JG98,":[64,140],"significantly":[65,120],"drug-resistant":[67,147],"C4-2B":[68],"MDVR":[69],"CWR22Rv1":[71,167],"cell":[72,81,86],"growth,":[73],"enhanced":[75],"treatment.":[77],"JG98":[78,99],"also":[79],"growth":[82,144],"conditional":[84],"reprogramed":[85],"cultures":[87],"(CRCs)":[88],"organoids":[90],"derived":[91],"from":[92,139],"patient":[96],"samples.":[97],"Mechanistically,":[98],"degraded":[100],"AR/AR-V7":[101,163,183],"expression":[102,164],"cells":[105],"promoted":[107],"STUB1":[108,119,180],"nuclear":[109],"translocation":[110],"bind":[112],"AR-V7.":[113],"Knockdown":[114],"of":[115,131,145,157,172],"E3":[117],"ligase":[118],"diminished":[121],"anticancer":[123],"effects":[124,130],"partially":[126],"restored":[127],"AR-V7":[128],"inhibitory":[129],"JG98.":[132],"JG231,":[133],"more":[135],"potent":[136],"analog":[137],"developed":[138],"effectively":[141],"CRCs,":[151],"organoids.":[153],"Notably,":[154],"combination":[156],"JG231":[158],"synergistically":[161],"inhibited":[162],"xenograft":[168],"tumor":[169],"growth.":[170],"Inhibition":[171],"using":[174],"small-molecule":[176],"inhibitors":[177],"coordinates":[178],"with":[179],"regulate":[182],"stabilization":[185],"ARSI":[187],"resistance.":[188]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":8}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-02-11T00:00:00"}