{"id":"https://openalex.org/W4319951256","doi":"https://doi.org/10.1038/s41467-023-36450-y","title":"Hedgehog is relayed through dynamic heparan sulfate interactions to shape its gradient","display_name":"Hedgehog is relayed through dynamic heparan sulfate interactions to shape its gradient","publication_year":2023,"publication_date":"2023-02-10","ids":{"openalex":"https://openalex.org/W4319951256","doi":"https://doi.org/10.1038/s41467-023-36450-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/36765094","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9918555"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-023-36450-y","doi":"https://doi.org/10.1038/s41467-023-36450-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-023-36450-y","pdf_url":"https://www.nature.com/articles/s41467-023-36450-y.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-023-36450-y.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074949596","display_name":"Fabian Gude","orcid":"https://orcid.org/0000-0002-0232-8355","observed_orcids":["https://orcid.org/0000-0002-0232-8355"]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Fabian Gude","raw_affiliation_strings":["From the Institute for Physiological Chemistry and Pathobiochemistry, University of M\u00fcnster, 48149, M\u00fcnster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Institute for Physiological Chemistry and Pathobiochemistry, University of M\u00fcnster, 48149, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I22465464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074354823","display_name":"Jurij Froese","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jurij Froese","raw_affiliation_strings":["From the Institute for Physiological Chemistry and Pathobiochemistry, University of M\u00fcnster, 48149, M\u00fcnster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Institute for Physiological Chemistry and Pathobiochemistry, University of M\u00fcnster, 48149, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I22465464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086808669","display_name":"Dominique Manikowski","orcid":"https://orcid.org/0000-0002-1938-3182","observed_orcids":["https://orcid.org/0000-0002-1938-3182"]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dominique Manikowski","raw_affiliation_strings":["From the Institute for Physiological Chemistry and Pathobiochemistry, University of M\u00fcnster, 48149, M\u00fcnster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Institute for Physiological Chemistry and Pathobiochemistry, University of M\u00fcnster, 48149, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I22465464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089601479","display_name":"Daniele Di Iorio","orcid":"https://orcid.org/0000-0002-9672-9773","observed_orcids":["https://orcid.org/0000-0002-9672-9773"]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Daniele Di Iorio","raw_affiliation_strings":["From the Institute for Physiological Chemistry and Pathobiochemistry, University of M\u00fcnster, 48149, M\u00fcnster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Institute for Physiological Chemistry and Pathobiochemistry, University of M\u00fcnster, 48149, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I22465464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077867760","display_name":"Jean\u2010No\u00ebl Grad","orcid":"https://orcid.org/0000-0002-5821-4912","observed_orcids":["https://orcid.org/0000-0002-5821-4912"]},"institutions":[{"id":"https://openalex.org/I100066346","display_name":"University of Stuttgart","ror":"https://ror.org/04vnq7t77","country_code":"DE","type":"education","lineage":["https://openalex.org/I100066346"]},{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jean-No\u00ebl Grad","raw_affiliation_strings":["Institute for Computational Physics, Universit\u00e4t Stuttgart, Allmandring 3, 70569, Stuttgart, Germany","The Institute for Bioinformatics and Computational Biophysics, University of Duisburg-Essen, 45117, Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Computational Physics, Universit\u00e4t Stuttgart, Allmandring 3, 70569, Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346"]},{"raw_affiliation_string":"The Institute for Bioinformatics and Computational Biophysics, University of Duisburg-Essen, 45117, Essen, Germany","institution_ids":["https://openalex.org/I62318514"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064508388","display_name":"Seraphine Valeska Wegner","orcid":"https://orcid.org/0000-0002-9072-0858","observed_orcids":["https://orcid.org/0000-0002-9072-0858"]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Seraphine Wegner","raw_affiliation_strings":["From the Institute for Physiological Chemistry and Pathobiochemistry, University of M\u00fcnster, 48149, M\u00fcnster, Germany"],"raw_orcid":"https://orcid.org/0000-0002-9072-0858","affiliations":[{"raw_affiliation_string":"From the Institute for Physiological Chemistry and Pathobiochemistry, University of M\u00fcnster, 48149, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I22465464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074555350","display_name":"Daniel E. Hoffmann","orcid":"https://orcid.org/0000-0003-2973-7869","observed_orcids":["https://orcid.org/0000-0003-2973-7869"]},"institutions":[{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Daniel Hoffmann","raw_affiliation_strings":["The Institute for Bioinformatics and Computational Biophysics, University of Duisburg-Essen, 45117, Essen, Germany"],"raw_orcid":"https://orcid.org/0000-0003-2973-7869","affiliations":[{"raw_affiliation_string":"The Institute for Bioinformatics and Computational Biophysics, University of Duisburg-Essen, 45117, Essen, Germany","institution_ids":["https://openalex.org/I62318514"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Melissa Kennedy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Melissa Kennedy","raw_affiliation_strings":["The Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK","The Bragg Centre for Materials Research, University of Leeds, Leeds, LS2 9JT, UK","The School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK","The School of Physics and Astronomy, Faculty of Engineering and Physical Sciences, University of Leeds, Leeds, LS2 9JT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"The Bragg Centre for Materials Research, University of Leeds, Leeds, LS2 9JT, UK","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"The School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"The School of Physics and Astronomy, Faculty of Engineering and Physical Sciences, University of Leeds, Leeds, LS2 9JT, UK","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046269328","display_name":"Ralf P. Richter","orcid":"https://orcid.org/0000-0003-3071-2837","observed_orcids":["https://orcid.org/0000-0003-3071-2837"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ralf P. Richter","raw_affiliation_strings":["The Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK","The Bragg Centre for Materials Research, University of Leeds, Leeds, LS2 9JT, UK","The School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK","The School of Physics and Astronomy, Faculty of Engineering and Physical Sciences, University of Leeds, Leeds, LS2 9JT, UK"],"raw_orcid":"https://orcid.org/0000-0003-3071-2837","affiliations":[{"raw_affiliation_string":"The Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"The Bragg Centre for Materials Research, University of Leeds, Leeds, LS2 9JT, UK","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"The School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"The School of Physics and Astronomy, Faculty of Engineering and Physical Sciences, University of Leeds, Leeds, LS2 9JT, UK","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008199771","display_name":"Georg Steffes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Georg Steffes","raw_affiliation_strings":["The Institute of Neuro- and Behavioral Biology, University of M\u00fcnster, 48149, M\u00fcnster, Germany. steff_00@uni-muenster.de","The Institute of Neuro- and Behavioral Biology, University of M\u00fcnster, 48149, M\u00fcnster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Neuro- and Behavioral Biology, University of M\u00fcnster, 48149, M\u00fcnster, Germany. steff_00@uni-muenster.de","institution_ids":["https://openalex.org/I22465464"]},{"raw_affiliation_string":"The Institute of Neuro- and Behavioral Biology, University of M\u00fcnster, 48149, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I22465464"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041107408","display_name":"Kay Grobe","orcid":"https://orcid.org/0000-0002-8385-5877","observed_orcids":["https://orcid.org/0000-0002-8385-5877"]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Kay Grobe","raw_affiliation_strings":["From the Institute for Physiological Chemistry and Pathobiochemistry, University of M\u00fcnster, 48149, M\u00fcnster, Germany. kgrobe@uni-muenster.de","From the Institute for Physiological Chemistry and Pathobiochemistry, University of M\u00fcnster, 48149, M\u00fcnster, Germany"],"raw_orcid":"https://orcid.org/0000-0002-8385-5877","affiliations":[{"raw_affiliation_string":"From the Institute for Physiological Chemistry and Pathobiochemistry, University of M\u00fcnster, 48149, M\u00fcnster, Germany. kgrobe@uni-muenster.de","institution_ids":["https://openalex.org/I22465464"]},{"raw_affiliation_string":"From the Institute for Physiological Chemistry and Pathobiochemistry, University of M\u00fcnster, 48149, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I22465464"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5008199771","https://openalex.org/A5041107408"],"corresponding_institution_ids":["https://openalex.org/I22465464"],"apc_list":{"value":6290,"currency":"USD","value_usd":6290},"apc_paid":{"value":5774,"currency":"EUR","value_usd":6227},"fwci":2.1626,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.89019971,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"14","issue":"1","first_page":"758","last_page":"758"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.9071999788284302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.9071999788284302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.029600000008940697,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.024000000208616257,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heparan-sulfate","display_name":"heparan sulfate","score":0.9110000133514404},{"id":"https://openalex.org/keywords/morphogen-gradient-formation","display_name":"morphogen gradient formation","score":0.9409999847412109},{"id":"https://openalex.org/keywords/drosophila-wing-disc","display_name":"Drosophila wing disc","score":0.777999997138977},{"id":"https://openalex.org/keywords/pattern-formation","display_name":"pattern formation","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C2778041096","wikidata":"https://www.wikidata.org/wiki/Q424668","display_name":"Heparan sulfate","level":3,"score":0.4831523299217224},{"id":"https://openalex.org/C2778539099","wikidata":"https://www.wikidata.org/wiki/Q6120","display_name":"Hedgehog","level":3,"score":0.4677716791629791},{"id":"https://openalex.org/C2777735758","wikidata":"https://www.wikidata.org/wiki/Q817765","display_name":"Path (computing)","level":2,"score":0.44890540838241577},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35775092244148254},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34797149896621704},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33012819290161133},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2923557162284851},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1789848804473877},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.15707233548164368},{"id":"https://openalex.org/C153074725","wikidata":"https://www.wikidata.org/wiki/Q407553","display_name":"Glycosaminoglycan","level":2,"score":0.0940122902393341},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006497","descriptor_name":"Heparan Sulfate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014921","descriptor_name":"Wings, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":10,"locations":[{"id":"doi:10.1038/s41467-023-36450-y","doi":"https://doi.org/10.1038/s41467-023-36450-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-023-36450-y","pdf_url":"https://www.nature.com/articles/s41467-023-36450-y.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9918555","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9918555","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9918555/pdf/41467_2023_Article_36450.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:36765094","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36765094","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.whiterose.ac.uk:196345","doi":null,"is_oa":true,"landing_page_url":"https://eprints.whiterose.ac.uk/196345/6/s41467-023-36450-y.pdf","pdf_url":"https://eprints.whiterose.ac.uk/196345/6/s41467-023-36450-y.pdf","source":{"id":"https://openalex.org/S4306400854","display_name":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:wwu.de:bb9f50fc-e6b4-4704-b5df-53a99b2480d2","doi":null,"is_oa":true,"landing_page_url":"https://nbn-resolving.org/urn:nbn:de:hbz:6-24908451691","pdf_url":"https://repositorium.uni-muenster.de/transfer/miami/bb9f50fc-e6b4-4704-b5df-53a99b2480d2","source":{"id":"https://openalex.org/S4306402051","display_name":"URN:NBN Resolver for Germany & Switzerland (German National Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802635041","host_organization_name":"Technische Informationsbibliothek (TIB)","host_organization_lineage":["https://openalex.org/I2802635041"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36450-y","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-023-36450-y","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:716e902b0b7e4784b0dc71931f62a5e0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/716e902b0b7e4784b0dc71931f62a5e0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)","raw_type":"article"},{"id":"pmh:oai:elib.uni-stuttgart.de:11682/16169","doi":null,"is_oa":true,"landing_page_url":"https://elib.uni-stuttgart.de/handle/11682/16169","pdf_url":null,"source":{"id":"https://openalex.org/S4306401556","display_name":"OPUS Publication Server of the University of Stuttgart (University of Stuttgart)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I100066346","host_organization_name":"University of Stuttgart","host_organization_lineage":["https://openalex.org/I100066346"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"doi:10.17879/44908630267","doi":"https://doi.org/10.17879/44908630267","is_oa":true,"landing_page_url":"https://doi.org/10.17879/44908630267","pdf_url":null,"source":{"id":"https://openalex.org/S7407053005","display_name":"Universit\u00e4ts- und Landesbibliothek M\u00fcnster","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.18419/opus-16150","doi":"https://doi.org/10.18419/opus-16150","is_oa":true,"landing_page_url":"https://doi.org/10.18419/opus-16150","pdf_url":null,"source":{"id":"https://openalex.org/S7407052998","display_name":"Universit\u00e4tsbibliothek Stuttgart","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Other"}],"best_oa_location":{"id":"doi:10.1038/s41467-023-36450-y","doi":"https://doi.org/10.1038/s41467-023-36450-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-023-36450-y","pdf_url":"https://www.nature.com/articles/s41467-023-36450-y.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1743551051","display_name":null,"funder_award_id":"CiM FF-2015-02","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G19393846","display_name":null,"funder_award_id":"GRK 1549","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G2040026598","display_name":null,"funder_award_id":"120010","funder_id":"https://openalex.org/F4320311371","funder_display_name":"Mizutani Foundation for Glycoscience"},{"id":"https://openalex.org/G2104066719","display_name":null,"funder_award_id":"MA8629/1\u20103","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G233773735","display_name":null,"funder_award_id":"GR1748/8-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G3806373540","display_name":null,"funder_award_id":"GRK1549/1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G663650614","display_name":null,"funder_award_id":"GR1748/7-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G7920248328","display_name":null,"funder_award_id":"GR1748/9-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320311371","display_name":"Mizutani Foundation for Glycoscience","ror":"https://ror.org/052ywng59"},{"id":"https://openalex.org/F4320313937","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4319951256.pdf","grobid_xml":"https://content.openalex.org/works/W4319951256.grobid-xml"},"referenced_works_count":85,"referenced_works":["https://openalex.org/W1566448969","https://openalex.org/W1965550615","https://openalex.org/W1965881121","https://openalex.org/W1967086605","https://openalex.org/W1967801153","https://openalex.org/W1968717680","https://openalex.org/W1970160633","https://openalex.org/W1977027703","https://openalex.org/W1977909615","https://openalex.org/W1985648712","https://openalex.org/W1993612557","https://openalex.org/W1994844861","https://openalex.org/W2005434843","https://openalex.org/W2009331672","https://openalex.org/W2009370805","https://openalex.org/W2015722572","https://openalex.org/W2029582401","https://openalex.org/W2030239760","https://openalex.org/W2030590304","https://openalex.org/W2031380343","https://openalex.org/W2033543895","https://openalex.org/W2035997436","https://openalex.org/W2039806395","https://openalex.org/W2042335929","https://openalex.org/W2045500010","https://openalex.org/W2047399603","https://openalex.org/W2049435858","https://openalex.org/W2051836149","https://openalex.org/W2053698830","https://openalex.org/W2055419484","https://openalex.org/W2060809301","https://openalex.org/W2061814831","https://openalex.org/W2063254082","https://openalex.org/W2063266633","https://openalex.org/W2065283382","https://openalex.org/W2066715151","https://openalex.org/W2072190752","https://openalex.org/W2072757906","https://openalex.org/W2078519210","https://openalex.org/W2082372465","https://openalex.org/W2085116878","https://openalex.org/W2092751827","https://openalex.org/W2101032230","https://openalex.org/W2102386127","https://openalex.org/W2102993309","https://openalex.org/W2108707301","https://openalex.org/W2110823478","https://openalex.org/W2115330624","https://openalex.org/W2120023703","https://openalex.org/W2120391968","https://openalex.org/W2120525124","https://openalex.org/W2128584428","https://openalex.org/W2137756512","https://openalex.org/W2140163994","https://openalex.org/W2142112187","https://openalex.org/W2146150648","https://openalex.org/W2146712325","https://openalex.org/W2147791888","https://openalex.org/W2150561062","https://openalex.org/W2150681944","https://openalex.org/W2157227019","https://openalex.org/W2164677099","https://openalex.org/W2169542532","https://openalex.org/W2171706407","https://openalex.org/W2182759383","https://openalex.org/W2279626446","https://openalex.org/W2284894778","https://openalex.org/W2467422224","https://openalex.org/W2735810574","https://openalex.org/W2782853396","https://openalex.org/W2792277372","https://openalex.org/W2796439542","https://openalex.org/W2811347531","https://openalex.org/W2890577735","https://openalex.org/W2898060952","https://openalex.org/W2940607611","https://openalex.org/W2963261492","https://openalex.org/W2976291415","https://openalex.org/W3009747298","https://openalex.org/W3048331025","https://openalex.org/W3137099086","https://openalex.org/W3148619234","https://openalex.org/W4210308632","https://openalex.org/W4211057669","https://openalex.org/W4283760563"],"related_works":["https://openalex.org/W4321497378","https://openalex.org/W4377940695","https://openalex.org/W2127720765","https://openalex.org/W2145644314","https://openalex.org/W7009267321","https://openalex.org/W2037079073","https://openalex.org/W2140261464","https://openalex.org/W2855239543","https://openalex.org/W2051399767","https://openalex.org/W2037703253"],"abstract_inverted_index":{"Cellular":[0],"differentiation":[1],"is":[2,40,43,48],"directly":[3,75],"determined":[4],"by":[5],"concentration":[6],"gradients":[7],"of":[8,69,131],"morphogens.":[9],"As":[10],"a":[11,143],"central":[12],"model":[13],"for":[14],"gradient":[15,123],"formation":[16,32],"during":[17],"development,":[18],"Hedgehog":[19],"(Hh)":[20],"morphogens":[21],"spread":[22,47],"away":[23],"from":[24],"their":[25],"source":[26],"to":[27,84,111],"direct":[28,132],"growth":[29],"and":[30,36,50,76,118,129],"pattern":[31],"in":[33,106,116,120,125,147],"Drosophila":[34],"wing":[35],"eye":[37],"discs.":[38],"What":[39],"not":[41],"known":[42],"how":[44,51],"extracellular":[45],"Hh":[46,71,90,122,133,140],"achieved":[49],"it":[52],"translates":[53],"into":[54],"precise":[55],"gradients.":[56],"Here":[57],"we":[58],"show":[59],"that":[60],"two":[61,79],"separate":[62],"binding":[63,95],"areas":[64],"located":[65],"on":[66],"opposite":[67],"sides":[68],"the":[70,87,139],"molecule":[72],"can":[73],"interact":[74],"simultaneously":[77],"with":[78],"heparan":[80],"sulfate":[81],"(HS)":[82],"chains":[83,115],"temporarily":[85],"cross-link":[86],"chains.":[88],"Mutated":[89],"lacking":[91],"one":[92],"fully":[93],"functional":[94],"site":[96],"still":[97],"binds":[98],"HS":[99,103,136],"but":[100],"shows":[101],"reduced":[102],"cross-linking.":[104],"This,":[105],"turn,":[107],"impairs":[108],"Hhs":[109],"ability":[110],"switch":[112],"between":[113,135],"both":[114],"vitro":[117],"results":[119],"striking":[121],"hypomorphs":[124],"vivo.":[126],"The":[127],"speed":[128],"propensity":[130],"switching":[134],"therefore":[137],"shapes":[138],"gradient,":[141],"revealing":[142],"scalable":[144],"design":[145],"principle":[146],"morphogen-patterned":[148],"tissues.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-02-11T00:00:00"}