{"id":"https://openalex.org/W43199141","doi":"https://doi.org/10.4049/jimmunol.182.supp.132.2","title":"Characterization and the Immune Response of a Nanoencapsulated Multivalent Vaccine against Respiratory Syncytial Virus (132.2)","display_name":"Characterization and the Immune Response of a Nanoencapsulated Multivalent Vaccine against Respiratory Syncytial Virus (132.2)","publication_year":2009,"publication_date":"2009-04-01","ids":{"openalex":"https://openalex.org/W43199141","doi":"https://doi.org/10.4049/jimmunol.182.supp.132.2","mag":"43199141"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.182.supp.132.2","doi":"https://doi.org/10.4049/jimmunol.182.supp.132.2","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.182.supp.132.2","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104067147","display_name":"Praseetha Subbarayan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145611464","display_name":"Alabama State University","ror":"https://ror.org/01eedy375","country_code":"US","type":"education","lineage":["https://openalex.org/I145611464"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Praseetha Subbarayan","raw_affiliation_strings":["Center for Nanobiotechnology Research, Alabama State University , Montgomery, Alabama","1Center for Nanobiotechnology Research, Alabama State University, Montgomery, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Nanobiotechnology Research, Alabama State University , Montgomery, Alabama","institution_ids":["https://openalex.org/I145611464"]},{"raw_affiliation_string":"1Center for Nanobiotechnology Research, Alabama State University, Montgomery, Alabama","institution_ids":["https://openalex.org/I145611464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035322699","display_name":"Shreekumar Pillai","orcid":"https://orcid.org/0000-0002-0431-8628","observed_orcids":["https://orcid.org/0000-0002-0431-8628"]},"institutions":[{"id":"https://openalex.org/I145611464","display_name":"Alabama State University","ror":"https://ror.org/01eedy375","country_code":"US","type":"education","lineage":["https://openalex.org/I145611464"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shreekumar Pillai","raw_affiliation_strings":["Center for Nanobiotechnology Research, Alabama State University , Montgomery, Alabama","1Center for Nanobiotechnology Research, Alabama State University, Montgomery, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Nanobiotechnology Research, Alabama State University , Montgomery, Alabama","institution_ids":["https://openalex.org/I145611464"]},{"raw_affiliation_string":"1Center for Nanobiotechnology Research, Alabama State University, Montgomery, Alabama","institution_ids":["https://openalex.org/I145611464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020329611","display_name":"Elijah Nyairo","orcid":"https://orcid.org/0000-0001-9271-9132","observed_orcids":["https://orcid.org/0000-0001-9271-9132"]},"institutions":[{"id":"https://openalex.org/I145611464","display_name":"Alabama State University","ror":"https://ror.org/01eedy375","country_code":"US","type":"education","lineage":["https://openalex.org/I145611464"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elijah Nyairo","raw_affiliation_strings":["Center for Nanobiotechnology Research, Alabama State University , Montgomery, Alabama","1Center for Nanobiotechnology Research, Alabama State University, Montgomery, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Nanobiotechnology Research, Alabama State University , Montgomery, Alabama","institution_ids":["https://openalex.org/I145611464"]},{"raw_affiliation_string":"1Center for Nanobiotechnology Research, Alabama State University, Montgomery, Alabama","institution_ids":["https://openalex.org/I145611464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063851790","display_name":"Vida A. Dennis","orcid":"https://orcid.org/0000-0003-1409-5605","observed_orcids":["https://orcid.org/0000-0003-1409-5605"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vida A Dennis","raw_affiliation_strings":["Tulane National Primate Research Center , Covington, Lousiana","2Tulane National Primate Research Center, Covington, Lousiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tulane National Primate Research Center , Covington, Lousiana","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"2Tulane National Primate Research Center, Covington, Lousiana","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055418907","display_name":"Shree Ram Singh","orcid":"https://orcid.org/0000-0002-3571-2222","observed_orcids":["https://orcid.org/0000-0002-3571-2222"]},"institutions":[{"id":"https://openalex.org/I145611464","display_name":"Alabama State University","ror":"https://ror.org/01eedy375","country_code":"US","type":"education","lineage":["https://openalex.org/I145611464"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shree R Singh","raw_affiliation_strings":["Center for Nanobiotechnology Research, Alabama State University , Montgomery, Alabama","1Center for Nanobiotechnology Research, Alabama State University, Montgomery, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Nanobiotechnology Research, Alabama State University , Montgomery, Alabama","institution_ids":["https://openalex.org/I145611464"]},{"raw_affiliation_string":"1Center for Nanobiotechnology Research, Alabama State University, Montgomery, Alabama","institution_ids":["https://openalex.org/I145611464"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"182","issue":"Supplement_1","first_page":"132.2","last_page":"132.2"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.8515999913215637,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.8515999913215637,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.051600001752376556,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.023499999195337296,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/respiratory-syncytial-virus","display_name":"respiratory syncytial virus","score":0.996999979019165},{"id":"https://openalex.org/keywords/multivalent-vaccine","display_name":"multivalent vaccine","score":0.9390000104904175},{"id":"https://openalex.org/keywords/chitosan-nanoparticles","display_name":"chitosan nanoparticles","score":0.8489999771118164},{"id":"https://openalex.org/keywords/nanoencapsulation","display_name":"nanoencapsulation","score":0.75},{"id":"https://openalex.org/keywords/rsv-f-protein","display_name":"RSV F protein","score":0.7599999904632568},{"id":"https://openalex.org/keywords/rsv-g-protein","display_name":"RSV G protein","score":0.9909999966621399},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.34200000762939453},{"id":"https://openalex.org/keywords/ftir-characterization","display_name":"FTIR characterization","score":0.6589999794960022},{"id":"https://openalex.org/keywords/antibody-response","display_name":"antibody response","score":0.8579999804496765},{"id":"https://openalex.org/keywords/balb-c-mice","display_name":"BALB/c mice","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.6645383834838867},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6020931005477905},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5889394283294678},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.5526872873306274},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4968896210193634},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47122442722320557},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.44418686628341675},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4370957314968109},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3945385217666626},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34192362427711487},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3362129330635071},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1852836310863495},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16569367051124573},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.11408734321594238}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.182.supp.132.2","doi":"https://doi.org/10.4049/jimmunol.182.supp.132.2","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.182.supp.132.2","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2033530261","https://openalex.org/W1553478866","https://openalex.org/W2189283703","https://openalex.org/W4392696673","https://openalex.org/W2001197069","https://openalex.org/W122537382","https://openalex.org/W1991970955","https://openalex.org/W6991716945","https://openalex.org/W4313381589","https://openalex.org/W2007023182"],"abstract_inverted_index":{"Abstract":[0],"Development":[1],"of":[2,18,26,30,67,99,122,156,161,208],"a":[3,19,43,64,120],"safe":[4],"and":[5,35,61,102,136,164,176],"effective":[6],"vaccine":[7,21,203],"is":[8],"necessary":[9],"to":[10,79,119,142,146,182],"prevent":[11],"RSV":[12,23,32,188],"infection.":[13],"Our":[14],"project":[15],"involved":[16],"development":[17],"multivalent":[20,73,174],"for":[22,93],"by":[24],"amplification":[25],"the":[27,31,53,85,100,130,137,147,153,157,172,177,183,201,205],"antigenic":[28],"regions":[29],"F,":[33],"G":[34],"M2":[36],"genes":[37],"which":[38,159],"were":[39,91,132,169],"subsequently":[40],"cloned":[41],"into":[42],"bacterial":[44],"vector,":[45],"pET-32.":[46],"The":[47,72,88,113,124,150,191],"recombinant":[48],"clone":[49],"was":[50,75,116,180],"expressed":[51],"from":[52],"transformed":[54],"E.":[55],"coli":[56],"BL21":[57],"(DE3)":[58],"cells":[59],"purified":[60],"analyzed":[62,92],"yielding":[63],"protein":[65,74,81,115,138,175],"band":[66],"38":[68],"kDa":[69],"as":[70,109,111],"predicted.":[71],"encapsulated":[76,82,89,139],"in":[77,96],"chitosan":[78,148],"form":[80],"nanoparticle":[83,140,158],"using":[84,105],"incorporation":[86],"method.":[87],"nanoparticles":[90,131],"temperature":[94,121],"stability,":[95],"vitro":[97],"release":[98],"protein,":[101],"also":[103],"characterized":[104],"cytoviva":[106,125],"bioimaging":[107,126],"system":[108,127],"well":[110],"FTIR.":[112],"nanoencapsulated":[114,173,202],"stable":[117],"up":[118],"1100C.":[123],"revealed":[128,196],"that":[129,197],"irregular":[133],"spherical":[134],"shaped":[135],"appeared":[141],"be":[143],"larger":[144],"compared":[145,181],"alone.":[149],"FTIR":[151],"confirmed":[152],"chemical":[154],"composition":[155],"consisted":[160],"polysaccharide,":[162],"tripolyphosphate":[163],"protein.":[165],"BALB/c":[166],"female":[167],"mice":[168,184,198],"immunized":[170,199],"with":[171,186,200],"antibody":[178,193,209],"response":[179,194],"vaccinated":[185],"live":[187],"or":[189],"PBS":[190],"serum":[192],"data":[195],"had":[204],"highest":[206],"levels":[207],"against":[210],"RSV.":[211],"Keywords:":[212],"RSV,":[213],"Antibody,":[214],"Vaccine,":[215],"Recombinant":[216],"DNA,":[217],"Chitosan":[218],"nanoparticle.":[219],"Sponsors:":[220],"NSF-CREST,":[221],"NIH-MBRS":[222]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}