{"id":"https://openalex.org/W4319811098","doi":"https://doi.org/10.1002/slct.202204416","title":"Synthesis of Complex Ureas with Brominated Heterocyclic Intermediates","display_name":"Synthesis of Complex Ureas with Brominated Heterocyclic Intermediates","publication_year":2023,"publication_date":"2023-02-01","ids":{"openalex":"https://openalex.org/W4319811098","doi":"https://doi.org/10.1002/slct.202204416"},"language":"en","primary_location":{"id":"doi:10.1002/slct.202204416","doi":"https://doi.org/10.1002/slct.202204416","is_oa":false,"landing_page_url":"https://doi.org/10.1002/slct.202204416","pdf_url":null,"source":{"id":"https://openalex.org/S4210221416","display_name":"ChemistrySelect","issn_l":"2365-6549","issn":["2365-6549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemistrySelect","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082523892","display_name":"Dar\u00edo A. Vargas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I874386039","display_name":"Universidad Nacional de La Plata","ror":"https://ror.org/01tjs6929","country_code":"AR","type":"education","lineage":["https://openalex.org/I874386039"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Dar\u00edo A. Vargas","raw_affiliation_strings":["Centro de Estudio de Compuestos Org\u00e1nicos (CEDECOR) Departamento de Qu\u00edmica Facultad de Ciencias Exactas Universidad Nacional de La Plata (UNLP)  47 y 115 1900 La Plata Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Estudio de Compuestos Org\u00e1nicos (CEDECOR) Departamento de Qu\u00edmica Facultad de Ciencias Exactas Universidad Nacional de La Plata (UNLP)  47 y 115 1900 La Plata Argentina","institution_ids":["https://openalex.org/I874386039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078950977","display_name":"Cintia C. Santiago","orcid":"https://orcid.org/0000-0001-8579-7968","observed_orcids":["https://orcid.org/0000-0001-8579-7968"]},"institutions":[{"id":"https://openalex.org/I874386039","display_name":"Universidad Nacional de La Plata","ror":"https://ror.org/01tjs6929","country_code":"AR","type":"education","lineage":["https://openalex.org/I874386039"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Cintia C. Santiago","raw_affiliation_strings":["Centro de Estudio de Compuestos Org\u00e1nicos (CEDECOR) Departamento de Qu\u00edmica Facultad de Ciencias Exactas Universidad Nacional de La Plata (UNLP)  47 y 115 1900 La Plata Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Estudio de Compuestos Org\u00e1nicos (CEDECOR) Departamento de Qu\u00edmica Facultad de Ciencias Exactas Universidad Nacional de La Plata (UNLP)  47 y 115 1900 La Plata Argentina","institution_ids":["https://openalex.org/I874386039"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062885272","display_name":"Alicia S. C\u00e1nepa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I874386039","display_name":"Universidad Nacional de La Plata","ror":"https://ror.org/01tjs6929","country_code":"AR","type":"education","lineage":["https://openalex.org/I874386039"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"Alicia S. C\u00e1nepa","raw_affiliation_strings":["Centro de Estudio de Compuestos Org\u00e1nicos (CEDECOR) Departamento de Qu\u00edmica Facultad de Ciencias Exactas Universidad Nacional de La Plata (UNLP)  47 y 115 1900 La Plata Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Estudio de Compuestos Org\u00e1nicos (CEDECOR) Departamento de Qu\u00edmica Facultad de Ciencias Exactas Universidad Nacional de La Plata (UNLP)  47 y 115 1900 La Plata Argentina","institution_ids":["https://openalex.org/I874386039"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5062885272"],"corresponding_institution_ids":["https://openalex.org/I874386039"],"apc_list":{"value":3660,"currency":"USD","value_usd":3660},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12973","display_name":"Synthesis of Indole Derivatives","score":0.7616999745368958,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12973","display_name":"Synthesis of Indole Derivatives","score":0.7616999745368958,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13230","display_name":"Synthesis and Reactivity of Heterocycles","score":0.0860000029206276,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12189","display_name":"Sulfur-Based Synthesis Techniques","score":0.01679999940097332,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brominated-heterocycles","display_name":"brominated heterocycles","score":0.7440000176429749},{"id":"https://openalex.org/keywords/n-bromosuccinimide-bromination","display_name":"N-bromosuccinimide bromination","score":0.9160000085830688},{"id":"https://openalex.org/keywords/heterocyclic-intermediates","display_name":"heterocyclic intermediates","score":0.5950000286102295},{"id":"https://openalex.org/keywords/pharmacologically-active-substances","display_name":"pharmacologically active compounds","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C65973085","wikidata":"https://www.wikidata.org/wiki/Q888529","display_name":"Halogenation","level":2,"score":0.8981408476829529},{"id":"https://openalex.org/C118792377","wikidata":"https://www.wikidata.org/wiki/Q108584245","display_name":"Selectivity","level":3,"score":0.7898092865943909},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7225430607795715},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5241920351982117},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.5224725008010864},{"id":"https://openalex.org/C203036418","wikidata":"https://www.wikidata.org/wiki/Q284256","display_name":"Crystallization","level":2,"score":0.49238455295562744},{"id":"https://openalex.org/C51724486","wikidata":"https://www.wikidata.org/wiki/Q908955","display_name":"Column chromatography","level":2,"score":0.48878976702690125},{"id":"https://openalex.org/C42058472","wikidata":"https://www.wikidata.org/wiki/Q810214","display_name":"Base (topology)","level":2,"score":0.45165738463401794},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.4415940046310425},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.04583096504211426},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/slct.202204416","doi":"https://doi.org/10.1002/slct.202204416","is_oa":false,"landing_page_url":"https://doi.org/10.1002/slct.202204416","pdf_url":null,"source":{"id":"https://openalex.org/S4210221416","display_name":"ChemistrySelect","issn_l":"2365-6549","issn":["2365-6549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemistrySelect","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2723984215","display_name":null,"funder_award_id":"11X/863","funder_id":"https://openalex.org/F4320322227","funder_display_name":"Universidad Nacional de La Plata"}],"funders":[{"id":"https://openalex.org/F4320322227","display_name":"Universidad Nacional de La Plata","ror":"https://ror.org/01tjs6929"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1966497477","https://openalex.org/W1973759397","https://openalex.org/W1977098959","https://openalex.org/W1989661885","https://openalex.org/W1991923613","https://openalex.org/W1992057182","https://openalex.org/W1992286972","https://openalex.org/W1994410565","https://openalex.org/W1995728387","https://openalex.org/W2004152798","https://openalex.org/W2012668920","https://openalex.org/W2026493896","https://openalex.org/W2027068424","https://openalex.org/W2029498552","https://openalex.org/W2033458490","https://openalex.org/W2035340588","https://openalex.org/W2036936860","https://openalex.org/W2047019726","https://openalex.org/W2048277731","https://openalex.org/W2050026187","https://openalex.org/W2060438885","https://openalex.org/W2065893558","https://openalex.org/W2068383036","https://openalex.org/W2072677818","https://openalex.org/W2074885970","https://openalex.org/W2080447602","https://openalex.org/W2087580985","https://openalex.org/W2088251339","https://openalex.org/W2089436593","https://openalex.org/W2090667103","https://openalex.org/W2090957144","https://openalex.org/W2135133228","https://openalex.org/W2155004885","https://openalex.org/W2155305202","https://openalex.org/W2256859012","https://openalex.org/W2261062967","https://openalex.org/W2312224342","https://openalex.org/W2518347874","https://openalex.org/W2609680876","https://openalex.org/W2761679026","https://openalex.org/W2952496396","https://openalex.org/W2952675054","https://openalex.org/W2953021780","https://openalex.org/W2994791399","https://openalex.org/W3005357226","https://openalex.org/W3026396376","https://openalex.org/W3087206871","https://openalex.org/W4296456028","https://openalex.org/W4386677372"],"related_works":["https://openalex.org/W2973942257","https://openalex.org/W4241469139","https://openalex.org/W7120343053","https://openalex.org/W1979126792","https://openalex.org/W2951938260","https://openalex.org/W3216377132","https://openalex.org/W2799621968","https://openalex.org/W4213367461","https://openalex.org/W1986970494","https://openalex.org/W2346737479"],"abstract_inverted_index":{"Abstract":[0],"Herein":[1],"we":[2],"present":[3],"an":[4,40],"efficient":[5],"method":[6],"to":[7],"synthesize":[8],"novel":[9,59],"complex":[10,58],"ureas":[11,62],"from":[12],"simple":[13,75],"ureas,":[14],"with":[15,50,74],"potential":[16],"pharmacological":[17],"activity.":[18],"First,":[19],"3\u2010methylindole":[20],"ketones":[21],"are":[22,63],"protected":[23],"via":[24],"a":[25],"two\u2010phase":[26],"N":[27],"\u2010tosylation":[28],"reaction":[29],"catalyzed":[30],"by":[31],"NBu":[32],"4":[33,35],"HSO":[34],"as":[36],"the":[37,44],"PTC.":[38],"Second,":[39],"NBS":[41],"bromination":[42],"of":[43],"terminal":[45],"methyl":[46],"group":[47],"is":[48],"performed":[49],"high":[51,95],"selectivity":[52,98],"and":[53,60,77,97],"very":[54,94],"good":[55],"yields.":[56],"Finally,":[57],"promising":[61],"synthesized":[64],"in":[65],"46":[66],"%\u201392":[67],"%":[68],"yields":[69,96],"using":[70],"non\u2010base\u2010catalyzed":[71],"substitution":[72],"reactions":[73],"monosubstituted":[76],"disubstituted":[78],"ureas.":[79],"All":[80],"products":[81],"were":[82],"easily":[83],"purified":[84],"through":[85],"column":[86],"chromatography":[87],"and/or":[88],"crystallization.":[89],"The":[90],"overall":[91],"procedure":[92],"produces":[93],"for":[99],"bromination.":[100]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-02-11T00:00:00"}
