{"id":"https://openalex.org/W4319787786","doi":"https://doi.org/10.1002/ange.202217047","title":"A Caged In\u2010Source Laser\u2010Cleavable MALDI Matrix with High Vacuum Stability for Extended MALDI\u2010MS Imaging","display_name":"A Caged In\u2010Source Laser\u2010Cleavable MALDI Matrix with High Vacuum Stability for Extended MALDI\u2010MS Imaging","publication_year":2023,"publication_date":"2023-02-09","ids":{"openalex":"https://openalex.org/W4319787786","doi":"https://doi.org/10.1002/ange.202217047"},"language":"en","primary_location":{"id":"doi:10.1002/ange.202217047","doi":"https://doi.org/10.1002/ange.202217047","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ange.202217047","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ange.202217047","source":{"id":"https://openalex.org/S4210200754","display_name":"Angewandte Chemie","issn_l":"0044-8249","issn":["0044-8249","0932-2140","1521-3757"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ange.202217047","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075397743","display_name":"Qiuqin Zhou","orcid":"https://orcid.org/0000-0003-4880-4190","observed_orcids":["https://orcid.org/0000-0003-4880-4190"]},"institutions":[{"id":"https://openalex.org/I112756935","display_name":"Technische Hochschule Mannheim","ror":"https://ror.org/04p61dj41","country_code":"DE","type":"education","lineage":["https://openalex.org/I112756935"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Qiuqin Zhou","raw_affiliation_strings":["Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany"],"raw_orcid":"https://orcid.org/0000-0003-4880-4190","affiliations":[{"raw_affiliation_string":"Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany","institution_ids":["https://openalex.org/I112756935"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077420826","display_name":"Stefano Rizzo","orcid":"https://orcid.org/0000-0003-3346-3389","observed_orcids":["https://orcid.org/0000-0003-3346-3389"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefano Rizzo","raw_affiliation_strings":["Sirius Fine Chemicals SiChem GmbH, Fahrenheitstr. 1, 28359 Bremen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sirius Fine Chemicals SiChem GmbH, Fahrenheitstr. 1, 28359 Bremen, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074094959","display_name":"Janina Oetjen","orcid":"https://orcid.org/0000-0002-4088-5742","observed_orcids":["https://orcid.org/0000-0002-4088-5742"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Janina Oetjen","raw_affiliation_strings":["Bruker Daltonics GmbH & Co. KG Fahrenheitstr. 4 28359 Bremen Germany"],"raw_orcid":"https://orcid.org/0000-0002-4088-5742","affiliations":[{"raw_affiliation_string":"Bruker Daltonics GmbH & Co. KG Fahrenheitstr. 4 28359 Bremen Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006500116","display_name":"Annabelle F\u00fcl\u00f6p","orcid":"https://orcid.org/0000-0003-0938-1092","observed_orcids":["https://orcid.org/0000-0003-0938-1092"]},"institutions":[{"id":"https://openalex.org/I112756935","display_name":"Technische Hochschule Mannheim","ror":"https://ror.org/04p61dj41","country_code":"DE","type":"education","lineage":["https://openalex.org/I112756935"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Annabelle F\u00fcl\u00f6p","raw_affiliation_strings":["Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany"],"raw_orcid":"https://orcid.org/0000-0003-0938-1092","affiliations":[{"raw_affiliation_string":"Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany","institution_ids":["https://openalex.org/I112756935"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053858414","display_name":"Miriam Rittner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miriam Rittner","raw_affiliation_strings":["Sirius Fine Chemicals SiChem GmbH, Fahrenheitstr. 1, 28359 Bremen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sirius Fine Chemicals SiChem GmbH, Fahrenheitstr. 1, 28359 Bremen, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067434551","display_name":"Hartmut Gillandt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hartmut Gillandt","raw_affiliation_strings":["Sirius Fine Chemicals SiChem GmbH, Fahrenheitstr. 1, 28359 Bremen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sirius Fine Chemicals SiChem GmbH, Fahrenheitstr. 1, 28359 Bremen, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062905648","display_name":"Carsten Hopf","orcid":"https://orcid.org/0000-0003-0802-6451","observed_orcids":["https://orcid.org/0000-0003-0802-6451"]},"institutions":[{"id":"https://openalex.org/I112756935","display_name":"Technische Hochschule Mannheim","ror":"https://ror.org/04p61dj41","country_code":"DE","type":"education","lineage":["https://openalex.org/I112756935"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4387153978","display_name":"Medizinische Fakult\u00e4t Mannheim","ror":"https://ror.org/02m1z0a87","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387153978"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Carsten Hopf","raw_affiliation_strings":["Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany","Mannheim Center for Translational Neuroscience (MCTN) Medical Faculty Mannheim Heidelberg University  Ludolf-Krehl-Stra\u00dfe 13\u201317 68167 Mannheim Germany","Medical Faculty, Heidelberg University, Im Neuenheimer Feld 672, 69120 Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0003-0802-6451","affiliations":[{"raw_affiliation_string":"Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany","institution_ids":["https://openalex.org/I112756935"]},{"raw_affiliation_string":"Mannheim Center for Translational Neuroscience (MCTN) Medical Faculty Mannheim Heidelberg University  Ludolf-Krehl-Stra\u00dfe 13\u201317 68167 Mannheim Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4387153978"]},{"raw_affiliation_string":"Medical Faculty, Heidelberg University, Im Neuenheimer Feld 672, 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5062905648"],"corresponding_institution_ids":["https://openalex.org/I112756935","https://openalex.org/I223822909","https://openalex.org/I4387153978"],"apc_list":{"value":5250,"currency":"USD","value_usd":5250},"apc_paid":{"value":5250,"currency":"USD","value_usd":5250},"fwci":0.1803,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.25546041,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"135","issue":"22","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12166","display_name":"Ion-surface interactions and analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/maldi-matrices","display_name":"MALDI matrix","score":0.8149999976158142},{"id":"https://openalex.org/keywords/vacuum-stability","display_name":"vacuum stability","score":0.9559999704360962},{"id":"https://openalex.org/keywords/maldi-mass-spectrometry-imaging","display_name":"MALDI mass spectrometry imaging","score":0.7419999837875366},{"id":"https://openalex.org/keywords/lipid-imaging","display_name":"lipid imaging","score":0.8080000281333923},{"id":"https://openalex.org/keywords/mouse-brain-tissue","display_name":"mouse brain tissue","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C101092202","wikidata":"https://www.wikidata.org/wiki/Q6714252","display_name":"MALDI imaging","level":5,"score":0.848382830619812},{"id":"https://openalex.org/C75280812","wikidata":"https://www.wikidata.org/wiki/Q190382","display_name":"Matrix-assisted laser desorption/ionization","level":4,"score":0.7194069027900696},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.7079840898513794},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6895543336868286},{"id":"https://openalex.org/C520434653","wikidata":"https://www.wikidata.org/wiki/Q38867","display_name":"Laser","level":2,"score":0.6588445901870728},{"id":"https://openalex.org/C162711632","wikidata":"https://www.wikidata.org/wiki/Q905514","display_name":"Desorption","level":3,"score":0.6152519583702087},{"id":"https://openalex.org/C2779617269","wikidata":"https://www.wikidata.org/wiki/Q18015634","display_name":"DHAP","level":3,"score":0.5574095845222473},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.5547479391098022},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.5232535600662231},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.5171917676925659},{"id":"https://openalex.org/C24066741","wikidata":"https://www.wikidata.org/wiki/Q3796564","display_name":"Mass spectrometry imaging","level":3,"score":0.5090686678886414},{"id":"https://openalex.org/C188224857","wikidata":"https://www.wikidata.org/wiki/Q905291","display_name":"Ion source","level":3,"score":0.4768851101398468},{"id":"https://openalex.org/C198291218","wikidata":"https://www.wikidata.org/wiki/Q190382","display_name":"Ionization","level":3,"score":0.46015670895576477},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.4285832345485687},{"id":"https://openalex.org/C82225425","wikidata":"https://www.wikidata.org/wiki/Q7880334","display_name":"Ultra-high vacuum","level":2,"score":0.4280069172382355},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.319973886013031},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.20929744839668274},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.14734995365142822},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.10688585042953491},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09023353457450867},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0758424699306488},{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/ange.202217047","doi":"https://doi.org/10.1002/ange.202217047","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ange.202217047","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ange.202217047","source":{"id":"https://openalex.org/S4210200754","display_name":"Angewandte Chemie","issn_l":"0044-8249","issn":["0044-8249","0932-2140","1521-3757"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1002/ange.202217047","doi":"https://doi.org/10.1002/ange.202217047","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ange.202217047","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ange.202217047","source":{"id":"https://openalex.org/S4210200754","display_name":"Angewandte Chemie","issn_l":"0044-8249","issn":["0044-8249","0932-2140","1521-3757"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1484300134","display_name":null,"funder_award_id":"ZF4560208SB8","funder_id":"https://openalex.org/F4320321469","funder_display_name":"Bundesministerium f\u00fcr Wirtschaft und Technologie"},{"id":"https://openalex.org/G3404685753","display_name":null,"funder_award_id":"ZF4020704SB8","funder_id":"https://openalex.org/F4320321469","funder_display_name":"Bundesministerium f\u00fcr Wirtschaft und Technologie"},{"id":"https://openalex.org/G3582244340","display_name":"MALDITOF/TOFMassenspektrometer mit Matrixsprayer","funder_award_id":"262133997","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G3864531759","display_name":null,"funder_award_id":"161L0212F","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G580505566","display_name":"FH-Impuls 2016: ADCtox-3D - Digitale Technologien zur Bewertung der Nierentoxizit\u00e4t von Antik\u00f6rper-Wirkstoff-Konjugaten in humanen Organoiden","funder_award_id":"13FH8E01IA","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320321469","display_name":"Bundesministerium f\u00fcr Wirtschaft und Technologie","ror":"https://ror.org/02vgg2808"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4319787786.pdf"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1454386623","https://openalex.org/W1921773582","https://openalex.org/W1972486575","https://openalex.org/W2010601897","https://openalex.org/W2022381933","https://openalex.org/W2024868969","https://openalex.org/W2034516685","https://openalex.org/W2036847748","https://openalex.org/W2084236003","https://openalex.org/W2125160663","https://openalex.org/W2136698583","https://openalex.org/W2163196658","https://openalex.org/W2327396795","https://openalex.org/W2444320521","https://openalex.org/W2521123562","https://openalex.org/W2553485752","https://openalex.org/W2597429704","https://openalex.org/W2802254037","https://openalex.org/W2887446181","https://openalex.org/W3028365683","https://openalex.org/W3089472526","https://openalex.org/W3104920271","https://openalex.org/W3119456587","https://openalex.org/W4206324811","https://openalex.org/W4212911524","https://openalex.org/W4250676149","https://openalex.org/W4294710511"],"related_works":["https://openalex.org/W4366251433","https://openalex.org/W4366251353","https://openalex.org/W4376643521","https://openalex.org/W4400731219","https://openalex.org/W3215147606","https://openalex.org/W2887446181","https://openalex.org/W1921773582","https://openalex.org/W2943315626","https://openalex.org/W2159814657","https://openalex.org/W2976311665"],"abstract_inverted_index":{"Abstract":[0],"Insufficient":[1],"vacuum":[2,53],"stability":[3],"of":[4,20,42,63,84],"matrix":[5,99],"chemicals":[6],"is":[7,48,89,101],"a":[8,51,97],"major":[9],"limitation":[10],"in":[11,50,74,81,95],"matrix\u2010assisted":[12],"laser":[13,71,105],"desorption/ionization":[14],"(MALDI)":[15],"mass":[16],"spectrometry":[17],"imaging":[18],"(MSI)":[19],"large":[21],"tissue":[22,45],"sample":[23],"cohorts.":[24],"Here,":[25],"we":[26],"designed":[27],"and":[28,36,111],"synthesized":[29],"the":[30,64,69,75,80,92,108],"photo\u2010cleavable":[31],"caged":[32],"molecule":[33],"4,5\u2010dimethoxy\u20102\u2010nitrobenzyl\u20102,5\u2010dihydroxyacetophenone":[34],"(DMNB\u20102,5\u2010DHAP)":[35],"employed":[37],"it":[38],"for":[39,57,91],"lipid":[40,114],"MALDI\u2010MSI":[41],"mouse":[43],"brain":[44],"sections.":[46],"DMNB\u20102,5\u2010DHAP":[47],"vacuum\u2010stable":[49],"high":[52],"MALDI":[54,76,98],"ion":[55,77,115],"source":[56,78],"at":[58],"least":[59],"72":[60],"h.":[61],"Investigation":[62],"uncaging":[65],"process":[66],"suggested":[67],"that":[68,100,112],"built\u2010in":[70],"(355":[72],"nm)":[73],"promoted":[79],"situ":[82],"generation":[83],"2,5\u2010DHAP.":[85],"A":[86],"caging":[87],"group":[88],"used":[90],"first":[93],"time":[94],"designing":[96],"vacuum\u2010stable,":[102],"uncaged":[103],"upon":[104],"irradiation":[106],"during":[107],"measurement":[109],"process,":[110],"boosts":[113],"intensity":[116],"with":[117],"MALDI\u20102":[118],"laser\u2010induced":[119],"postionization.":[120]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-02-11T00:00:00"}