{"id":"https://openalex.org/W4319728126","doi":"https://doi.org/10.21203/rs.3.rs-2512875/v1","title":"A Comparison of the Effects of Ticagrelor and Clopidogrel in Patients with Acute ST-Segment Elevation Myocardial Infarction: A systematic review and Meta-analysis","display_name":"A Comparison of the Effects of Ticagrelor and Clopidogrel in Patients with Acute ST-Segment Elevation Myocardial Infarction: A systematic review and Meta-analysis","publication_year":2023,"publication_date":"2023-02-09","ids":{"openalex":"https://openalex.org/W4319728126","doi":"https://doi.org/10.21203/rs.3.rs-2512875/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-2512875/v1","doi":"https://doi.org/10.21203/rs.3.rs-2512875/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-2512875/v1","pdf_url":"https://www.researchsquare.com/article/rs-2512875/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-2512875/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072098897","display_name":"Mehdi Geravandi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]},{"id":"https://openalex.org/I39642139","display_name":"Kermanshah University of Medical Sciences","ror":"https://ror.org/05vspf741","country_code":"IR","type":"education","lineage":["https://openalex.org/I39642139"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mehdi Geravandi","raw_affiliation_strings":["Kermanshah University of Medical Sciences","Kermanshah University of Medical Sciences Mohammad Nourabi Kermanshah University of Medical Sciences","Sepehr Navabifar Kermanshah University of Medical Sciences Sina Dolatshahi Shahid Beheshti University of Medical Sciences","Shiraz University of Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kermanshah University of Medical Sciences","institution_ids":["https://openalex.org/I39642139"]},{"raw_affiliation_string":"Kermanshah University of Medical Sciences Mohammad Nourabi Kermanshah University of Medical Sciences","institution_ids":["https://openalex.org/I39642139"]},{"raw_affiliation_string":"Sepehr Navabifar Kermanshah University of Medical Sciences Sina Dolatshahi Shahid Beheshti University of Medical Sciences","institution_ids":["https://openalex.org/I39642139","https://openalex.org/I58048189"]},{"raw_affiliation_string":"Shiraz University of Medical Sciences","institution_ids":["https://openalex.org/I194604659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008020304","display_name":"Mohammad Nourabi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39642139","display_name":"Kermanshah University of Medical Sciences","ror":"https://ror.org/05vspf741","country_code":"IR","type":"education","lineage":["https://openalex.org/I39642139"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mohammad Nourabi","raw_affiliation_strings":["Kermanshah University of Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kermanshah University of Medical Sciences","institution_ids":["https://openalex.org/I39642139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035639073","display_name":"Sepehr Navabifar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39642139","display_name":"Kermanshah University of Medical Sciences","ror":"https://ror.org/05vspf741","country_code":"IR","type":"education","lineage":["https://openalex.org/I39642139"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Sepehr Navabifar","raw_affiliation_strings":["Kermanshah University of Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kermanshah University of Medical Sciences","institution_ids":["https://openalex.org/I39642139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048784995","display_name":"Sina Dolatshahi","orcid":"https://orcid.org/0000-0002-8810-3666","observed_orcids":["https://orcid.org/0000-0002-8810-3666"]},"institutions":[{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Sina Dolatshahi","raw_affiliation_strings":["Shahid Beheshti University of Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shahid Beheshti University of Medical Sciences","institution_ids":["https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050890431","display_name":"Sara Zand","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]},{"id":"https://openalex.org/I39642139","display_name":"Kermanshah University of Medical Sciences","ror":"https://ror.org/05vspf741","country_code":"IR","type":"education","lineage":["https://openalex.org/I39642139"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]},{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Sara Zand","raw_affiliation_strings":["Tehran University of Medical Sciences","Kermanshah University of Medical Sciences Mohammad Nourabi Kermanshah University of Medical Sciences","Sepehr Navabifar Kermanshah University of Medical Sciences Sina Dolatshahi Shahid Beheshti University of Medical Sciences","Shiraz University of Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tehran University of Medical Sciences","institution_ids":["https://openalex.org/I70640408"]},{"raw_affiliation_string":"Kermanshah University of Medical Sciences Mohammad Nourabi Kermanshah University of Medical Sciences","institution_ids":["https://openalex.org/I39642139"]},{"raw_affiliation_string":"Sepehr Navabifar Kermanshah University of Medical Sciences Sina Dolatshahi Shahid Beheshti University of Medical Sciences","institution_ids":["https://openalex.org/I39642139","https://openalex.org/I58048189"]},{"raw_affiliation_string":"Shiraz University of Medical Sciences","institution_ids":["https://openalex.org/I194604659"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080176717","display_name":"Zahra Hooshanginezhad","orcid":"https://orcid.org/0000-0002-8337-9217","observed_orcids":["https://orcid.org/0000-0002-8337-9217"]},"institutions":[{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Zahra Hooshanginezhad","raw_affiliation_strings":["Shiraz University of Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shiraz University of Medical Sciences","institution_ids":["https://openalex.org/I194604659"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ticagrelor","display_name":"ticagrelor","score":1.0},{"id":"https://openalex.org/keywords/clopidogrel","display_name":"clopidogrel","score":1.0},{"id":"https://openalex.org/keywords/st-elevation-myocardial-infarction","display_name":"ST-elevation myocardial infarction","score":0.9700000286102295},{"id":"https://openalex.org/keywords/p2y12-inhibitors","display_name":"P2Y12 inhibitors","score":0.902999997138977},{"id":"https://openalex.org/keywords/dual-antiplatelet-therapy","display_name":"dual antiplatelet therapy","score":0.9660000205039978},{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.718999981880188},{"id":"https://openalex.org/keywords/major-adverse-cardiovascular-events","display_name":"major adverse cardiovascular events","score":0.9359999895095825},{"id":"https://openalex.org/keywords/bleeding-complications","display_name":"bleeding complications","score":0.6759999990463257},{"id":"https://openalex.org/keywords/timi-flow-grade","display_name":"TIMI flow","score":0.7409999966621399},{"id":"https://openalex.org/keywords/reperfusion","display_name":"reperfusion","score":0.718999981880188},{"id":"https://openalex.org/keywords/recurrent-myocardial-infarction","display_name":"reinfarction","score":0.8209999799728394},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C2780890252","wikidata":"https://www.wikidata.org/wiki/Q420542","display_name":"Ticagrelor","level":4,"score":0.9668787717819214},{"id":"https://openalex.org/C2777849778","wikidata":"https://www.wikidata.org/wiki/Q410237","display_name":"Clopidogrel","level":3,"score":0.932559609413147},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.855288565158844},{"id":"https://openalex.org/C2777698277","wikidata":"https://www.wikidata.org/wiki/Q266018","display_name":"Acute coronary syndrome","level":3,"score":0.7159032821655273},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6961219310760498},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.6683758497238159},{"id":"https://openalex.org/C2780739214","wikidata":"https://www.wikidata.org/wiki/Q6723023","display_name":"Mace","level":4,"score":0.6036505103111267},{"id":"https://openalex.org/C2777028646","wikidata":"https://www.wikidata.org/wiki/Q416232","display_name":"Prasugrel","level":4,"score":0.567629337310791},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.5582796931266785},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5548452734947205},{"id":"https://openalex.org/C49059817","wikidata":"https://www.wikidata.org/wiki/Q14916330","display_name":"P2Y12","level":4,"score":0.4962175488471985},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.4686037302017212},{"id":"https://openalex.org/C2780400711","wikidata":"https://www.wikidata.org/wiki/Q2008344","display_name":"Percutaneous coronary intervention","level":3,"score":0.23966622352600098}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-2512875/v1","doi":"https://doi.org/10.21203/rs.3.rs-2512875/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-2512875/v1","pdf_url":"https://www.researchsquare.com/article/rs-2512875/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-2512875/v1","doi":"https://doi.org/10.21203/rs.3.rs-2512875/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-2512875/v1","pdf_url":"https://www.researchsquare.com/article/rs-2512875/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4319728126.pdf","grobid_xml":"https://content.openalex.org/works/W4319728126.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1653920301","https://openalex.org/W2022381318","https://openalex.org/W2037709494","https://openalex.org/W2040234951","https://openalex.org/W2057506947","https://openalex.org/W2061069818","https://openalex.org/W2071543617","https://openalex.org/W2122779695","https://openalex.org/W2150740314","https://openalex.org/W2156098321","https://openalex.org/W2157004057","https://openalex.org/W2182393455","https://openalex.org/W2263900768","https://openalex.org/W2278268741","https://openalex.org/W2289820321","https://openalex.org/W2295175909","https://openalex.org/W2325733448","https://openalex.org/W2597299390","https://openalex.org/W2605335011","https://openalex.org/W2737845351","https://openalex.org/W2748721858","https://openalex.org/W2748953078","https://openalex.org/W2766200864","https://openalex.org/W2770523298","https://openalex.org/W2793325200","https://openalex.org/W2793455050","https://openalex.org/W2802491260","https://openalex.org/W2809434376","https://openalex.org/W2883526230","https://openalex.org/W2898357052","https://openalex.org/W2916389078","https://openalex.org/W2951387500","https://openalex.org/W3019423044","https://openalex.org/W3046911977","https://openalex.org/W3189376968","https://openalex.org/W3193365717","https://openalex.org/W4200347960","https://openalex.org/W4210619255","https://openalex.org/W4213285159","https://openalex.org/W4283759114","https://openalex.org/W4283772046","https://openalex.org/W4287010319","https://openalex.org/W4308792281"],"related_works":["https://openalex.org/W2056724561","https://openalex.org/W1686411234","https://openalex.org/W2522148824","https://openalex.org/W2127586058","https://openalex.org/W2565381353","https://openalex.org/W2809232109","https://openalex.org/W2979889017","https://openalex.org/W2042883253","https://openalex.org/W2185577209","https://openalex.org/W3109162736"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Rupture":[2],"of":[3,22,37,56,69,77,83,95,144,186,210,224,285],"unstable":[4],"coronary":[5,24],"atherosclerotic":[6],"plaque":[7],"leads":[8],"to":[9,73,125,136,214,238,276,288,293,306],"acute":[10,23],"ST":[11],"segment":[12],"elevation":[13],"myocardial":[14,226,252],"infarction":[15,235,253],"which":[16,60],"is":[17,29,41,52,61,72],"the":[18,31,35,44,75,112,116,138,169,176,187,198,202,208,211,222,266,277,283,289],"most":[19,49],"critical":[20],"type":[21],"syndrome.":[25],"Dual":[26],"anti-platelet":[27],"therapy":[28],"one":[30],"main":[32],"treatments":[33],"and":[34,39,79,98,115,131,172,193,201,246,265,302,310],"combination":[36],"Aspirin":[38],"Clopidogrel":[40,80,177,203],"recognized":[42],"as":[43],"standard":[45],"oral":[46],"regimen":[47],"in":[48,81,159,168,175,197,251,299,312],"cases.":[50],"Ticagrelor":[51,78,170,199,216,281],"a":[53,62,151,218],"new":[54],"generation":[55],"P2Y12":[57,64],"receptor":[58,65],"inhibitors,":[59],"direct":[63],"antagonist.":[66],"The":[67,119,128,181],"goal":[68],"this":[70,87,160,259],"study":[71],"compare":[74],"effect":[76,220,260],"treatment":[82],"STEMI.":[84],"Methods":[85],"In":[86],"study,":[88,279],"Pub":[89],"Med,":[90],"Scopus,":[91],"Google":[92],"Scholar":[93],"Web":[94],"Science,":[96],"Embase":[97],"Cochrane":[99],"library":[100],"clinical":[101],"trials.gov":[102],"databases":[103],"were":[104,134,157,179],"investigated.":[105],"Inhomogeneity":[106],"between":[107],"studies":[108,156],"was":[109,123,149,189,261,269,296],"assessed":[110],"using":[111],"I2":[113],"index":[114],"Q":[117],"statistic.":[118],"random":[120],"effects":[121],"model":[122],"used":[124,135],"combine":[126],"studies.":[127],"Funnel":[129],"plot":[130],"Egger's":[132],"test":[133],"assess":[137],"publication":[139,267],"bias.":[140],"A":[141],"probability":[142],"value":[143],"less":[145],"than":[146],"5":[147],"percent":[148],"considered":[150],"significant":[152,272],"level.":[153],"Results":[154],"Eleven":[155],"included":[158],"meta-analysis.":[161],"Five":[162],"thousand":[163],"two":[164],"hundred":[165],"seventy-four":[166],"patients":[167,174,188,313],"group":[171,178,200],"5,295":[173],"examined.":[180],"mean":[182],"(standard":[183],"deviation)":[184],"age":[185],"58.84":[190],"years":[191,195],"(2.70)":[192],"59.92":[194],"(3.19)":[196],"group,":[204],"respectively.":[205],"Based":[206],"on":[207,221],"results":[209],"meta-analysis,":[212],"compared":[213,292],"Clopidogrel,":[215,294],"had":[217],"protective":[219],"outcomes":[223],"recurrent":[225],"infarction,":[227],"stroke,":[228,307],"Major":[229],"Adverse":[230],"Cardiovascular":[231],"Events":[232],"(MACE),":[233],"post-myocardial":[234],"bleeding":[236,286],"according":[237,287],"Bleeding":[239],"Academic":[240],"Research":[241],"Consortium":[242],"(BARC)":[243],"criteria,":[244],"mortality,":[245,308],"reperfusion":[247],"state":[248],"regarding":[249],"thrombolysis":[250],"(TIMI)":[254],"Flow":[255],"Grading":[256],"system.":[257],"However,":[258],"not":[262,270],"statistically":[263,271],"significant,":[264],"bias":[268],"either.":[273],"Conclusions":[274],"According":[275],"present":[278],"although":[280],"increased":[282],"chance":[284],"BARC":[290],"score,":[291],"there":[295],"more":[297],"improvement":[298],"TIMI":[300],"score":[301],"fewer":[303],"problems":[304],"related":[305],"MI,":[309],"MACE":[311],"who":[314],"took":[315],"Ticagrelor.":[316]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-10-10T00:00:00"}
