{"id":"https://openalex.org/W4319689355","doi":"https://doi.org/10.1097/00003086-198905000-00031","title":"Subcellular Regulation of the Ionized Calcium Pool in Isolated Growth-Plate Chondrocytes","display_name":"Subcellular Regulation of the Ionized Calcium Pool in Isolated Growth-Plate Chondrocytes","publication_year":1989,"publication_date":"1989-05-01","ids":{"openalex":"https://openalex.org/W4319689355","doi":"https://doi.org/10.1097/00003086-198905000-00031","mag":"1964107083","pmid":"https://pubmed.ncbi.nlm.nih.gov/2706859"},"language":"en","primary_location":{"id":"doi:10.1097/00003086-198905000-00031","doi":"https://doi.org/10.1097/00003086-198905000-00031","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00003086-198905000-00031","pdf_url":null,"source":{"id":"https://openalex.org/S191421250","display_name":"Clinical Orthopaedics and Related Research","issn_l":"0009-921X","issn":["0009-921X","1528-1132"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Orthopaedics and Related Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024252310","display_name":"Joseph P. Iannotti","orcid":"https://orcid.org/0000-0001-7806-1872","observed_orcids":["https://orcid.org/0000-0001-7806-1872"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J. P. IANNOTTI","raw_affiliation_strings":["University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043516951","display_name":"Carl T. Brighton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"C. T. BRIGHTON","raw_affiliation_strings":["University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018485924","display_name":"Jeffrey Stambough","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I92156820","display_name":"University of Cincinnati Medical Center","ror":"https://ror.org/02p72h367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I92156820"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J. E. STAMBOUGH","raw_affiliation_strings":["University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania","University of Cincinnati Health Science Center, Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"University of Cincinnati Health Science Center, Cincinnati, Ohio","institution_ids":["https://openalex.org/I63135867","https://openalex.org/I92156820"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5018485924","https://openalex.org/A5024252310","https://openalex.org/A5043516951"],"corresponding_institution_ids":["https://openalex.org/I63135867","https://openalex.org/I79576946","https://openalex.org/I92156820"],"apc_list":null,"apc_paid":null,"fwci":1.3761,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.80944351,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"242","issue":"242","first_page":"285","last_page":"293"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.5746999979019165,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.5746999979019165,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.13950000703334808,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13453","display_name":"Alkaline Phosphatase Research Studies","score":0.06270000338554382,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intracellular-calcium-homeostasis","display_name":"intracellular calcium homeostasis","score":0.8240000009536743},{"id":"https://openalex.org/keywords/growth-plate-chondrocytes","display_name":"growth plate chondrocytes","score":0.9290000200271606},{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"endoplasmic reticulum","score":0.9089999794960022},{"id":"https://openalex.org/keywords/mitochondria","display_name":"mitochondria","score":0.9089999794960022},{"id":"https://openalex.org/keywords/calcium-buffering","display_name":"calcium buffering","score":0.7760000228881836},{"id":"https://openalex.org/keywords/calcium-loading","display_name":"calcium loading","score":0.7390000224113464},{"id":"https://openalex.org/keywords/hypertrophic-chondrocytes","display_name":"hypertrophic chondrocytes","score":0.9240000247955322},{"id":"https://openalex.org/keywords/cartilage-mineralization","display_name":"cartilage calcification","score":0.7170000076293945},{"id":"https://openalex.org/keywords/fracture-healing","display_name":"fracture healing","score":0.8190000057220459},{"id":"https://openalex.org/keywords/skeletal-development","display_name":"skeletal development","score":0.8090000152587891}],"concepts":[{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.873284101486206},{"id":"https://openalex.org/C2781403057","wikidata":"https://www.wikidata.org/wiki/Q775480","display_name":"Chondrocyte","level":3,"score":0.6721188426017761},{"id":"https://openalex.org/C87975464","wikidata":"https://www.wikidata.org/wiki/Q910704","display_name":"Calcium metabolism","level":3,"score":0.6651550531387329},{"id":"https://openalex.org/C181080969","wikidata":"https://www.wikidata.org/wiki/Q60097","display_name":"Calcium in biology","level":3,"score":0.6333301067352295},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.582470178604126},{"id":"https://openalex.org/C101571972","wikidata":"https://www.wikidata.org/wiki/Q3396061","display_name":"Calcium ATPase","level":4,"score":0.5559843182563782},{"id":"https://openalex.org/C935647","wikidata":"https://www.wikidata.org/wiki/Q17113155","display_name":"Calcium pump","level":4,"score":0.5249084234237671},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5242229700088501},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.44907480478286743},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4294130206108093},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32981613278388977},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3035241365432739},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2629976272583008},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25779592990875244},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25545719265937805},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.05275169014930725},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006132","descriptor_name":"Growth Plate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006132","descriptor_name":"Growth Plate","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050723","descriptor_name":"Fractures, Bone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/00003086-198905000-00031","doi":"https://doi.org/10.1097/00003086-198905000-00031","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00003086-198905000-00031","pdf_url":null,"source":{"id":"https://openalex.org/S191421250","display_name":"Clinical Orthopaedics and Related Research","issn_l":"0009-921X","issn":["0009-921X","1528-1132"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Orthopaedics and Related Research","raw_type":"journal-article"},{"id":"pmid:2706859","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2706859","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical orthopaedics and related research","raw_type":"Journal Article"},{"id":"mag:1964107083","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2706859","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2031339910","https://openalex.org/W4299521139","https://openalex.org/W2413582681","https://openalex.org/W2419238617","https://openalex.org/W2072318013","https://openalex.org/W4396557950","https://openalex.org/W1981966393","https://openalex.org/W2030727016","https://openalex.org/W4391763608","https://openalex.org/W4249275581"],"abstract_inverted_index":{"At":[0],"a":[1,22,74,141,162,193,210],"low":[2,23,142],"total":[3],"endogenous":[4],"calcium":[5,19,45,51,71,95,98,121,138,149,159,169,202,205,223,228],"content,":[6],"as":[7,60,108,192],"in":[8,39,61,90,104,124,155,177,186,196,212,225,232],"the":[9,40,43,62,66,92,105,109,112,125,128,131,136,156,178,182,189,197,219,233],"reserve":[10],"and":[11,28,80,161,185,204,239],"proliferative":[12],"zone":[13,64],"chondrocyte,":[14,65],"cells":[15,67],"buffer":[16,68,135],"their":[17,69],"ionized":[18,44,70,94,137,158],"pool":[20,46,72,96,139],"at":[21,73,140],"steady":[24,76,143],"state":[25,77],"between":[26,78],"150":[27],"300":[29],"nM.":[30,82],"The":[31,83],"endoplasmic":[32,132],"reticulum":[33,133],"appears":[34],"to":[35,55,86,134,208],"be":[36,87],"primarily":[37,88],"effective":[38,89],"regulation":[41],"of":[42,53,119,127,130,148,167,181,199,217,227,236],"under":[47],"these":[48,146],"conditions.":[49],"With":[50],"loading":[52],"20":[54],"30":[56],"nmol":[57],"Ca+2/mg":[58],"protein,":[59],"hypertrophic":[63],"higher":[75],"600":[79],"700":[81],"mitochondria":[84],"appear":[85,207],"buffering":[91,166],"cytosolic":[93],"after":[97],"loading.":[99],"These":[100],"data":[101],"suggest":[102],"that":[103,122],"growth":[106,183],"plate":[107,184],"chondrocyte":[110,220],"approaches":[111],"mineralization":[113],"front,":[114],"there":[115,151],"is":[116,152,230],"an":[117,153],"accumulation":[118,203,229],"intracellular":[120,157,222],"results":[123],"saturation":[126],"capacity":[129],"state.":[144],"Under":[145],"conditions":[147],"loading,":[150],"increase":[154],"concentration":[160],"shift":[163],"toward":[164],"mitochondrial":[165],"this":[168],"pool.":[170],"This":[171],"study":[172],"has":[173],"clinical":[174],"relevance":[175],"because":[176],"cartilaginous":[179],"tissues":[180],"fracture":[187,240],"callus,":[188],"matrix":[190,213],"mineralizes":[191],"prerequisite":[194],"step":[195],"formation":[198],"bone.":[200],"Intracellular":[201],"release":[206],"play":[209],"role":[211],"mineralization.":[214],"An":[215],"understanding":[216,235],"how":[218],"regulates":[221],"homeostasis":[224],"states":[226],"important":[231],"overall":[234],"bone":[237],"development":[238],"healing.":[241]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-02-10T00:00:00"}