{"id":"https://openalex.org/W4319600182","doi":"https://doi.org/10.3390/pharmaceutics15020556","title":"Virtual Clinical Trials Guided Design of an Age-Appropriate Formulation and Dosing Strategy of Nifedipine for Paediatric Use","display_name":"Virtual Clinical Trials Guided Design of an Age-Appropriate Formulation and Dosing Strategy of Nifedipine for Paediatric Use","publication_year":2023,"publication_date":"2023-02-07","ids":{"openalex":"https://openalex.org/W4319600182","doi":"https://doi.org/10.3390/pharmaceutics15020556","pmid":"https://pubmed.ncbi.nlm.nih.gov/36839878","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9961156"},"language":"en","primary_location":{"id":"doi:10.3390/pharmaceutics15020556","doi":"https://doi.org/10.3390/pharmaceutics15020556","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics15020556","pdf_url":"https://www.mdpi.com/1999-4923/15/2/556/pdf?version=1675759336","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1999-4923/15/2/556/pdf?version=1675759336","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111110714","display_name":"Dilawar Khan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169199633","display_name":"Aston University","ror":"https://ror.org/05j0ve876","country_code":"GB","type":"education","lineage":["https://openalex.org/I169199633"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Dilawar Khan","raw_affiliation_strings":["Aston Pharmacy School, College of Health and Life Sciences, Aston University, Birmingham B4 7ET, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aston Pharmacy School, College of Health and Life Sciences, Aston University, Birmingham B4 7ET, UK","institution_ids":["https://openalex.org/I169199633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029805964","display_name":"Raj Kumar Singh Badhan","orcid":"https://orcid.org/0000-0002-0904-9324","observed_orcids":["https://orcid.org/0000-0002-0904-9324"]},"institutions":[{"id":"https://openalex.org/I169199633","display_name":"Aston University","ror":"https://ror.org/05j0ve876","country_code":"GB","type":"education","lineage":["https://openalex.org/I169199633"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Raj Badhan","raw_affiliation_strings":["Aston Pharmacy School, College of Health and Life Sciences, Aston University, Birmingham B4 7ET, UK"],"raw_orcid":"https://orcid.org/0000-0002-0904-9324","affiliations":[{"raw_affiliation_string":"Aston Pharmacy School, College of Health and Life Sciences, Aston University, Birmingham B4 7ET, UK","institution_ids":["https://openalex.org/I169199633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049833173","display_name":"Daniel J. Kirby","orcid":"https://orcid.org/0000-0002-0878-2620","observed_orcids":["https://orcid.org/0000-0002-0878-2620"]},"institutions":[{"id":"https://openalex.org/I169199633","display_name":"Aston University","ror":"https://ror.org/05j0ve876","country_code":"GB","type":"education","lineage":["https://openalex.org/I169199633"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Daniel J. Kirby","raw_affiliation_strings":["Aston Pharmacy School, College of Health and Life Sciences, Aston University, Birmingham B4 7ET, UK"],"raw_orcid":"https://orcid.org/0000-0002-0878-2620","affiliations":[{"raw_affiliation_string":"Aston Pharmacy School, College of Health and Life Sciences, Aston University, Birmingham B4 7ET, UK","institution_ids":["https://openalex.org/I169199633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060976871","display_name":"Simon Bryson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089399","display_name":"Proveca (United Kingdom)","ror":"https://ror.org/0090bh305","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210089399"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Simon Bryson","raw_affiliation_strings":["Proveca Ltd., No. 1 Spinningfields, Quay Street, Manchester M3 3JE, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Proveca Ltd., No. 1 Spinningfields, Quay Street, Manchester M3 3JE, UK","institution_ids":["https://openalex.org/I4210089399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113949258","display_name":"Maryam Shah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089399","display_name":"Proveca (United Kingdom)","ror":"https://ror.org/0090bh305","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210089399"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Maryam Shah","raw_affiliation_strings":["Proveca Ltd., No. 1 Spinningfields, Quay Street, Manchester M3 3JE, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Proveca Ltd., No. 1 Spinningfields, Quay Street, Manchester M3 3JE, UK","institution_ids":["https://openalex.org/I4210089399"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022107797","display_name":"Afzal R. Mohammed","orcid":"https://orcid.org/0000-0002-5212-3040","observed_orcids":["https://orcid.org/0000-0002-5212-3040"]},"institutions":[{"id":"https://openalex.org/I169199633","display_name":"Aston University","ror":"https://ror.org/05j0ve876","country_code":"GB","type":"education","lineage":["https://openalex.org/I169199633"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Afzal Rahman Mohammed","raw_affiliation_strings":["Aston Pharmacy School, College of Health and Life Sciences, Aston University, Birmingham B4 7ET, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aston Pharmacy School, College of Health and Life Sciences, Aston University, Birmingham B4 7ET, UK","institution_ids":["https://openalex.org/I169199633"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5022107797"],"corresponding_institution_ids":["https://openalex.org/I169199633"],"apc_list":{"value":2600,"currency":"CHF","value_usd":2892},"apc_paid":{"value":2600,"currency":"CHF","value_usd":2892},"fwci":0.8352,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.6760761,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"15","issue":"2","first_page":"556","last_page":"556"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nifedipine","display_name":"nifedipine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pediatric-pharmacokinetics","display_name":"pediatric pharmacokinetics","score":0.8709999918937683},{"id":"https://openalex.org/keywords/extended-release-formulation","display_name":"sustained-release formulation","score":0.7049999833106995},{"id":"https://openalex.org/keywords/virtual-clinical-trials","display_name":"virtual clinical trials","score":0.7850000262260437},{"id":"https://openalex.org/keywords/age-appropriate-dosing","display_name":"age-appropriate dosing","score":0.8309999704360962},{"id":"https://openalex.org/keywords/dissolution-profile","display_name":"dissolution profile","score":0.39500001072883606},{"id":"https://openalex.org/keywords/plasma-drug-concentration","display_name":"plasma drug concentration","score":0.4659999907016754},{"id":"https://openalex.org/keywords/patient-adherence","display_name":"patient adherence","score":0.656000018119812},{"id":"https://openalex.org/keywords/antihypertensive-drugs","display_name":"antihypertensive drugs","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.886073648929596},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8183071613311768},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7428436875343323},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5968512892723083},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.554298460483551},{"id":"https://openalex.org/C185867374","wikidata":"https://www.wikidata.org/wiki/Q2562769","display_name":"Physiologically based pharmacokinetic modelling","level":3,"score":0.5131962895393372},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.505608320236206},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4928910732269287},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.490223228931427},{"id":"https://openalex.org/C2779066535","wikidata":"https://www.wikidata.org/wiki/Q39111","display_name":"Nifedipine","level":3,"score":0.48731479048728943},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4186785817146301},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1982528269290924},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/pharmaceutics15020556","doi":"https://doi.org/10.3390/pharmaceutics15020556","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics15020556","pdf_url":"https://www.mdpi.com/1999-4923/15/2/556/pdf?version=1675759336","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9961156","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9961156","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9961156/pdf/pharmaceutics-15-00556.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Text"},{"id":"pmid:36839878","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36839878","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Journal Article"},{"id":"pmh:oai:publications.aston.ac.uk:44782","doi":null,"is_oa":true,"landing_page_url":"https://publications.aston.ac.uk/view/author/869fd81d722941b846d85e904281ace7.html>,","pdf_url":"https://publications.aston.ac.uk/id/eprint/44782/1/Khanetal_2023_VoR.pdf","source":{"id":"https://openalex.org/S4306400483","display_name":"Aston Publications Explorer (Aston University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169199633","host_organization_name":"Aston University","host_organization_lineage":["https://openalex.org/I169199633"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:06ba2c144adc41f5bf7703dd1497da8a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/06ba2c144adc41f5bf7703dd1497da8a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutics, Vol 15, Iss 2, p 556 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/pharmaceutics15020556","doi":"https://doi.org/10.3390/pharmaceutics15020556","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics15020556","pdf_url":"https://www.mdpi.com/1999-4923/15/2/556/pdf?version=1675759336","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323026","display_name":"Aston University","ror":"https://ror.org/05j0ve876"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4319600182.pdf","grobid_xml":"https://content.openalex.org/works/W4319600182.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1963931468","https://openalex.org/W1968101595","https://openalex.org/W1970536865","https://openalex.org/W1981389330","https://openalex.org/W1982231896","https://openalex.org/W1983300151","https://openalex.org/W1984452104","https://openalex.org/W2001465846","https://openalex.org/W2002203912","https://openalex.org/W2006974408","https://openalex.org/W2007156835","https://openalex.org/W2030529857","https://openalex.org/W2032269212","https://openalex.org/W2052264803","https://openalex.org/W2057174170","https://openalex.org/W2060320802","https://openalex.org/W2060536249","https://openalex.org/W2074152762","https://openalex.org/W2079663656","https://openalex.org/W2080049876","https://openalex.org/W2082224281","https://openalex.org/W2092805838","https://openalex.org/W2095347586","https://openalex.org/W2105817834","https://openalex.org/W2106073810","https://openalex.org/W2115439624","https://openalex.org/W2121254971","https://openalex.org/W2144968903","https://openalex.org/W2155414682","https://openalex.org/W2169426321","https://openalex.org/W2342033936","https://openalex.org/W2507987915","https://openalex.org/W2511976576","https://openalex.org/W2727420541","https://openalex.org/W2783271827","https://openalex.org/W2796350663","https://openalex.org/W2898866644","https://openalex.org/W2899444542","https://openalex.org/W2936487549","https://openalex.org/W2972717137","https://openalex.org/W2973146481","https://openalex.org/W3014529563","https://openalex.org/W3020736546","https://openalex.org/W3044975603","https://openalex.org/W3098681737","https://openalex.org/W3112099781","https://openalex.org/W3131758556","https://openalex.org/W3153190431","https://openalex.org/W3162929978","https://openalex.org/W3168852393","https://openalex.org/W3172653130","https://openalex.org/W3186330753","https://openalex.org/W3200763211","https://openalex.org/W4210348184","https://openalex.org/W4300717255","https://openalex.org/W4308932449","https://openalex.org/W6749596037","https://openalex.org/W7071343043"],"related_works":["https://openalex.org/W2034598985","https://openalex.org/W2002203912","https://openalex.org/W1506789998","https://openalex.org/W7049239874","https://openalex.org/W2266272160","https://openalex.org/W4405171609","https://openalex.org/W2933374048","https://openalex.org/W7100841425","https://openalex.org/W1481215652","https://openalex.org/W3080983898"],"abstract_inverted_index":{"The":[0,218],"rapid":[1],"onset":[2],"of":[3,5,52,62,94,100,105,127,145,162,167,173,201,213,242,251],"action":[4],"nifedipine":[6,39,53],"causes":[7],"a":[8,35,60,248],"precipitous":[9],"reduction":[10],"in":[11,68,87,97],"blood":[12],"pressure":[13],"leading":[14],"to":[15,80,116,131,140,149],"adverse":[16],"effects":[17],"associated":[18],"with":[19,198],"reflex":[20],"sympathetic":[21],"nervous":[22],"system":[23],"(SNS)":[24],"activation,":[25],"including":[26],"tachycardia":[27],"and":[28,31,58,77,82,135,207,233],"worsening":[29],"myocardial":[30],"cerebrovascular":[32],"ischemia.":[33],"As":[34],"result,":[36],"short":[37],"acting":[38],"preparations":[40,51],"are":[41,47],"not":[42],"recommended.":[43],"However,":[44,96],"importantly,":[45],"there":[46],"no":[48],"modified":[49],"release":[50,193,202],"authorised":[54],"for":[55,124],"paediatric":[56,101,128,151],"use,":[57],"hence":[59],"paucity":[61],"clinical":[63,136,154],"studies":[64],"reporting":[65],"pharmacokinetics":[66,110,119],"data":[67],"paediatrics.":[69],"Pharmacokinetic":[70],"parameters":[71],"may":[72],"differ":[73],"significantly":[74],"between":[75],"children":[76],"adults":[78],"due":[79],"anatomical":[81],"physiological":[83],"differences,":[84],"often":[85],"resulting":[86,219],"sub":[88],"therapeutic":[89,183],"and/or":[90],"toxic":[91],"plasma":[92,129,178,245],"concentrations":[93,130,179],"medication.":[95],"the":[98,103,114,143,150,160,165,171,181,186,199],"field":[99],"pharmacokinetics,":[102],"use":[104,166],"pharmacokinetic":[106],"modelling,":[107],"particularly":[108],"physiological-based":[109],"(PBPK),":[111],"has":[112],"revolutionised":[113],"ability":[115],"extrapolate":[117],"drug":[118,133,244],"across":[120],"age":[121],"groups,":[122],"allowing":[123],"pragmatic":[125],"determination":[126,172],"support":[132],"licensing":[134],"dosing.":[137],"In":[138,159],"order":[139],"pragmatically":[141],"assess":[142],"translation":[144],"resultant":[146],"dissolution":[147],"profiles":[148,237],"populations,":[152],"virtual":[153],"trials":[155],"simulations":[156],"were":[157],"conducted.":[158],"context":[161],"formulation":[163,220],"development,":[164],"PBPK":[168],"modelling":[169],"allowed":[170],"optimised":[174,210],"formulations":[175],"that":[176],"achieved":[177],"within":[180],"target":[182],"window":[184],"throughout":[185],"dosing":[187,211,223],"strategy.":[188],"A":[189],"5":[190],"mg":[191],"sustained":[192,249],"mini-tablet":[194],"was":[195],"successfully":[196],"developed":[197],"duration":[200],"extending":[203],"over":[204,247],"24":[205],"h":[206],"an":[208],"informed":[209],"strategy":[212],"450":[214],"\u00b5g/kg":[215],"twice":[216],"daily.":[217],"provides":[221],"flexible":[222],"opportunities,":[224],"improves":[225],"patient":[226,235],"adherence":[227],"by":[228,238],"reducing":[229],"frequent":[230],"administration":[231],"burden":[232],"enhances":[234],"safety":[236],"maintaining":[239],"efficacious":[240],"levels":[241,246],"consistent":[243],"period":[250],"time.":[252]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-02-09T00:00:00"}