{"id":"https://openalex.org/W4319595286","doi":"https://doi.org/10.1186/s43094-023-00462-8","title":"Targeting efficacy and anticancer activity of polymeric nanoparticles of SN-38 on colon cancer cell lines","display_name":"Targeting efficacy and anticancer activity of polymeric nanoparticles of SN-38 on colon cancer cell lines","publication_year":2023,"publication_date":"2023-02-08","ids":{"openalex":"https://openalex.org/W4319595286","doi":"https://doi.org/10.1186/s43094-023-00462-8"},"language":"en","primary_location":{"id":"doi:10.1186/s43094-023-00462-8","doi":"https://doi.org/10.1186/s43094-023-00462-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s43094-023-00462-8","pdf_url":"https://fjps.springeropen.com/counter/pdf/10.1186/s43094-023-00462-8","source":{"id":"https://openalex.org/S2898388368","display_name":"Future Journal of Pharmaceutical Sciences","issn_l":"2314-7245","issn":["2314-7245","2314-7253"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://fjps.springeropen.com/counter/pdf/10.1186/s43094-023-00462-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001699057","display_name":"Shilpi Prasad","orcid":"https://orcid.org/0000-0002-5983-3950","observed_orcids":["https://orcid.org/0000-0002-5983-3950"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Shilpi Prasad","raw_affiliation_strings":["Department of Pharmaceutics, Siddhi Vinayaka Institute of Technology and Sciences, Mangla, Bilaspur, C.G., 495001, India"],"raw_orcid":"https://orcid.org/0000-0002-5983-3950","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Siddhi Vinayaka Institute of Technology and Sciences, Mangla, Bilaspur, C.G., 495001, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090195799","display_name":"J. S. Dangi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26285277","display_name":"Guru Ghasidas Vishwavidyalaya","ror":"https://ror.org/05bvxq496","country_code":"IN","type":"education","lineage":["https://openalex.org/I26285277"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"J. S. Dangi","raw_affiliation_strings":["Department of Pharmaceutics, S.L.T Institute of Pharmaceutical Sciences, GGV, Bilaspur, C.G., India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, S.L.T Institute of Pharmaceutical Sciences, GGV, Bilaspur, C.G., India","institution_ids":["https://openalex.org/I26285277"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001699057"],"corresponding_institution_ids":[],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":0.401,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.38958519,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"9","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9315999746322632,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9315999746322632,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0414000004529953,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sn-38","display_name":"SN-38","score":0.9940000176429749},{"id":"https://openalex.org/keywords/polymeric-nanoparticles","display_name":"polymeric nanoparticles","score":0.9449999928474426},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.8939999938011169},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.8270000219345093},{"id":"https://openalex.org/keywords/radionuclide-imaging","display_name":"scintigraphy","score":0.7089999914169312},{"id":"https://openalex.org/keywords/organ-distribution","display_name":"organ distribution","score":0.6639999747276306},{"id":"https://openalex.org/keywords/ht-29-cells","display_name":"HT-29 cells","score":0.8939999938011169},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9620000123977661},{"id":"https://openalex.org/keywords/drug-release","display_name":"drug release","score":0.6029999852180481},{"id":"https://openalex.org/keywords/colorectal-cancer-chemotherapy","display_name":"colorectal cancer chemotherapy","score":0.7329999804496765}],"concepts":[{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6041626334190369},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6036580204963684},{"id":"https://openalex.org/C2779902710","wikidata":"https://www.wikidata.org/wiki/Q1130465","display_name":"Scintigraphy","level":2,"score":0.5760699510574341},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4913412630558014},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4829403758049011},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.46585947275161743},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45400476455688477},{"id":"https://openalex.org/C2781074409","wikidata":"https://www.wikidata.org/wiki/Q158716","display_name":"Rectum","level":2,"score":0.4477991461753845},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4403698444366455},{"id":"https://openalex.org/C2778172261","wikidata":"https://www.wikidata.org/wiki/Q3796563","display_name":"Imaging agent","level":3,"score":0.432840496301651},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.42496049404144287},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.42074114084243774},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.418783962726593},{"id":"https://openalex.org/C2776280935","wikidata":"https://www.wikidata.org/wiki/Q11083","display_name":"Large intestine","level":2,"score":0.4110284447669983},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3765649199485779},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36198851466178894},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.29795029759407043},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24264314770698547},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19201737642288208},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17029985785484314},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1186/s43094-023-00462-8","doi":"https://doi.org/10.1186/s43094-023-00462-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s43094-023-00462-8","pdf_url":"https://fjps.springeropen.com/counter/pdf/10.1186/s43094-023-00462-8","source":{"id":"https://openalex.org/S2898388368","display_name":"Future Journal of Pharmaceutical Sciences","issn_l":"2314-7245","issn":["2314-7245","2314-7253"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Journal of Pharmaceutical Sciences","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:7d9989185c4f4a49bd6f7641c8b5972c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7d9989185c4f4a49bd6f7641c8b5972c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Future Journal of Pharmaceutical Sciences, Vol 9, Iss 1, Pp 1-9 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s43094-023-00462-8","doi":"https://doi.org/10.1186/s43094-023-00462-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s43094-023-00462-8","pdf_url":"https://fjps.springeropen.com/counter/pdf/10.1186/s43094-023-00462-8","source":{"id":"https://openalex.org/S2898388368","display_name":"Future Journal of Pharmaceutical Sciences","issn_l":"2314-7245","issn":["2314-7245","2314-7253"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"},{"id":"https://openalex.org/F4320324337","display_name":"All-India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71"},{"id":"https://openalex.org/F4320324473","display_name":"Indian Institute of Technology Delhi","ror":"https://ror.org/049tgcd06"},{"id":"https://openalex.org/F4320329650","display_name":"Evonik Industries","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4319595286.pdf","grobid_xml":"https://content.openalex.org/works/W4319595286.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1500849292","https://openalex.org/W1865319416","https://openalex.org/W1881526180","https://openalex.org/W1967110146","https://openalex.org/W1982468047","https://openalex.org/W1996998905","https://openalex.org/W2000941201","https://openalex.org/W2002698112","https://openalex.org/W2012520028","https://openalex.org/W2013600522","https://openalex.org/W2018988859","https://openalex.org/W2019867999","https://openalex.org/W2026270259","https://openalex.org/W2027542963","https://openalex.org/W2031676888","https://openalex.org/W2039883923","https://openalex.org/W2045026063","https://openalex.org/W2047432753","https://openalex.org/W2064788032","https://openalex.org/W2086052902","https://openalex.org/W2093918270","https://openalex.org/W2098685157","https://openalex.org/W2109689528","https://openalex.org/W2111630287","https://openalex.org/W2117655985","https://openalex.org/W2118822263","https://openalex.org/W2131063689","https://openalex.org/W2147286931","https://openalex.org/W2152050601","https://openalex.org/W2318821477","https://openalex.org/W2345478270","https://openalex.org/W2492194066","https://openalex.org/W3087639804","https://openalex.org/W3108407054","https://openalex.org/W4282829258"],"related_works":["https://openalex.org/W2098685157","https://openalex.org/W6902020864","https://openalex.org/W1797555978","https://openalex.org/W1991130662","https://openalex.org/W7042538746","https://openalex.org/W2004432296","https://openalex.org/W2953171848","https://openalex.org/W2216435986","https://openalex.org/W7155884879","https://openalex.org/W1941592426"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Colorectal":[2],"cancer":[3,9,90,241],"is":[4,178,230],"the":[5,11,34,145,191],"third":[6],"most":[7],"prevailing":[8],"in":[10,62,84,142,148,168,180,192],"whole":[12],"world.":[13],"Chemotherapeutic":[14],"agents":[15],"which":[16,129],"are":[17],"used":[18],"for":[19,57,71],"treatment":[20],"have":[21,27,207],"severe":[22],"side":[23],"effects":[24],"and":[25,45,55,61,83,116,126,152,174,182,220,233],"also":[26],"unwanted":[28],"exposure":[29],"to":[30,236],"healthy":[31],"cells.":[32],"In":[33,134,161],"present":[35],"study,":[36],"polymeric":[37],"nanoparticles":[38],"of":[39,98,104,163,196,214,223],"SN-38":[40],"were":[41,49],"prepared":[42],"(using":[43],"cationic":[44],"anionic":[46],"polymers).":[47],"They":[48],"optimized":[50],"by":[51,75],"Box":[52],"Behnken":[53],"design":[54],"characterized":[56],"its":[58,72],"physicochemical":[59],"properties":[60],"vitro":[63,85,193],"drug":[64,128],"release.":[65],"Optimized":[66],"formulation":[67],"(CsENP)":[68],"was":[69,140,156,166,234],"evaluated":[70],"targeting":[73,232],"efficacy":[74],"Gamma":[76],"Scintigraphy":[77],"studies":[78],"on":[79],"Swiss":[80,105,224],"Albino":[81,106,225],"mice":[82,107,226],"Cytotoxic":[86],"assay":[87],"against":[88,239],"colon":[89,181,240],"cell":[91,194,242],"line,":[92],"viz.":[93],"HT-29.":[94],"Results":[95],"The":[96,211],"images":[97],"Whole":[99,215],"body":[100,216],"gamma":[101,217],"scintigraphy":[102,218],"imaging":[103,122,219],"show":[108,227],"that":[109,118,205,228],"CsENP":[110,164,206,229],"remained":[111],"intact":[112],"till":[113,131],"2":[114,172],"h":[115,121,173,201],"after":[117,158,171,185,199],"at":[119],"4":[120,186],"it":[123],"started":[124],"dispersing":[125],"releasing":[127],"continued":[130],"20":[132],"h.":[133,160,187],"Organ":[135],"distribution":[136,222],"studies,":[137],"no":[138],"radioactivity":[139,155,165],"traced":[141],"heart":[143],"from":[144],"formulation.":[146],"Even":[147],"liver,":[149],"spleen,":[150],"kidney":[151],"lung":[153],"trace":[154],"seen":[157,167,179],"6":[159],"case":[162],"small":[169],"intestine":[170],"maximum":[175],"(87.8%":[176],"radioactivity)":[177],"rectum":[183],"area":[184],"At":[188],"equivalent":[189],"concentrations,":[190],"viability":[195],"HT-29":[197],"cells":[198],"72":[200],"incubation":[202],"time":[203],"showed":[204],"enhanced":[208],"cytotoxicity.":[209],"Conclusions":[210],"results":[212],"obtained":[213],"organ":[221],"Colon":[231],"found":[235],"be":[237],"effective":[238],"lines.":[243]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2023-02-09T00:00:00"}