{"id":"https://openalex.org/W4319462010","doi":"https://doi.org/10.1515/hsz-2022-0329","title":"MicroRNA-101-3p inhibits nasopharyngeal carcinoma cell proliferation and cisplatin resistance through ZIC5 down-regulation by targeting SOX2","display_name":"MicroRNA-101-3p inhibits nasopharyngeal carcinoma cell proliferation and cisplatin resistance through ZIC5 down-regulation by targeting SOX2","publication_year":2023,"publication_date":"2023-02-08","ids":{"openalex":"https://openalex.org/W4319462010","doi":"https://doi.org/10.1515/hsz-2022-0329","pmid":"https://pubmed.ncbi.nlm.nih.gov/36752150"},"language":"en","primary_location":{"id":"doi:10.1515/hsz-2022-0329","doi":"https://doi.org/10.1515/hsz-2022-0329","is_oa":false,"landing_page_url":"https://doi.org/10.1515/hsz-2022-0329","pdf_url":null,"source":{"id":"https://openalex.org/S18118477","display_name":"Biological Chemistry","issn_l":"1431-6730","issn":["1431-6730","1437-4315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086283251","display_name":"Tieqi Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210156904","display_name":"Third Xiangya Hospital","ror":"https://ror.org/05akvb491","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156904"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tieqi Li","raw_affiliation_strings":["Department of Otolaryngology Head and Neck Surgery , The Third Xiangya Hospital, Central South University , No. 138 Tongzipo Rd , Changsha 410013 , Hunan , P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology Head and Neck Surgery , The Third Xiangya Hospital, Central South University , No. 138 Tongzipo Rd , Changsha 410013 , Hunan , P. R. China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210156904"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016859809","display_name":"Gehou Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210156904","display_name":"Third Xiangya Hospital","ror":"https://ror.org/05akvb491","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156904"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gehou Zhang","raw_affiliation_strings":["Department of Otolaryngology Head and Neck Surgery , The Third Xiangya Hospital, Central South University , No. 138 Tongzipo Rd , Changsha 410013 , Hunan , P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology Head and Neck Surgery , The Third Xiangya Hospital, Central South University , No. 138 Tongzipo Rd , Changsha 410013 , Hunan , P. R. China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210156904"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100318325","display_name":"W\u011bi Li","orcid":"https://orcid.org/0000-0002-9522-4474","observed_orcids":["https://orcid.org/0000-0002-9522-4474","https://orcid.org/0000-0003-4136-3409","https://orcid.org/0009-0009-9141-6389"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210156904","display_name":"Third Xiangya Hospital","ror":"https://ror.org/05akvb491","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156904"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Li","raw_affiliation_strings":["Department of Otolaryngology Head and Neck Surgery , The Third Xiangya Hospital, Central South University , No. 138 Tongzipo Rd , Changsha 410013 , Hunan , P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology Head and Neck Surgery , The Third Xiangya Hospital, Central South University , No. 138 Tongzipo Rd , Changsha 410013 , Hunan , P. R. China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210156904"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101921641","display_name":"Jian Yun Xiao","orcid":"https://orcid.org/0000-0003-2761-1779","observed_orcids":["https://orcid.org/0000-0003-2761-1779"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210156904","display_name":"Third Xiangya Hospital","ror":"https://ror.org/05akvb491","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156904"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Xiao","raw_affiliation_strings":["Department of Otolaryngology Head and Neck Surgery , The Third Xiangya Hospital, Central South University , No. 138 Tongzipo Rd , Changsha 410013 , Hunan , P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology Head and Neck Surgery , The Third Xiangya Hospital, Central South University , No. 138 Tongzipo Rd , Changsha 410013 , Hunan , P. R. China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210156904"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101987374","display_name":"Zheng Zhou","orcid":"https://orcid.org/0000-0003-1261-5822","observed_orcids":["https://orcid.org/0000-0003-1261-5822"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210156904","display_name":"Third Xiangya Hospital","ror":"https://ror.org/05akvb491","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156904"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zheng Zhou","raw_affiliation_strings":["Department of Otolaryngology Head and Neck Surgery , The Third Xiangya Hospital, Central South University , No. 138 Tongzipo Rd , Changsha 410013 , Hunan , P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology Head and Neck Surgery , The Third Xiangya Hospital, Central South University , No. 138 Tongzipo Rd , Changsha 410013 , Hunan , P. R. China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210156904"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101863623","display_name":"Guolin Tan","orcid":"https://orcid.org/0000-0003-0714-4827","observed_orcids":["https://orcid.org/0000-0003-0714-4827","https://orcid.org/0000-0003-1295-7953"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210156904","display_name":"Third Xiangya Hospital","ror":"https://ror.org/05akvb491","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156904"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guolin Tan","raw_affiliation_strings":["Department of Otolaryngology Head and Neck Surgery , The Third Xiangya Hospital, Central South University , No. 138 Tongzipo Rd , Changsha 410013 , Hunan , P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology Head and Neck Surgery , The Third Xiangya Hospital, Central South University , No. 138 Tongzipo Rd , Changsha 410013 , Hunan , P. R. China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210156904"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078781086","display_name":"Jingang Ai","orcid":"https://orcid.org/0000-0002-8571-8884","observed_orcids":["https://orcid.org/0000-0002-8571-8884"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210156904","display_name":"Third Xiangya Hospital","ror":"https://ror.org/05akvb491","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156904"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jingang Ai","raw_affiliation_strings":["Department of Otolaryngology Head and Neck Surgery , The Third Xiangya Hospital, Central South University , No. 138 Tongzipo Rd , Changsha 410013 , Hunan , P. R. China"],"raw_orcid":"https://orcid.org/0000-0002-8571-8884","affiliations":[{"raw_affiliation_string":"Department of Otolaryngology Head and Neck Surgery , The Third Xiangya Hospital, Central South University , No. 138 Tongzipo Rd , Changsha 410013 , Hunan , P. R. China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210156904"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5078781086"],"corresponding_institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210156904"],"apc_list":{"value":2000,"currency":"EUR","value_usd":2163},"apc_paid":null,"fwci":0.4933,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.53569757,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"404","issue":"10","first_page":"961","last_page":"975"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nasopharyngeal-carcinoma","display_name":"nasopharyngeal carcinoma","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cisplatin-resistance","display_name":"cisplatin resistance","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sox2","display_name":"SOX2","score":0.9710000157356262},{"id":"https://openalex.org/keywords/zic5","display_name":"ZIC5","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6330000162124634},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9769999980926514},{"id":"https://openalex.org/keywords/tumor-cell-migration","display_name":"tumor cell migration","score":0.6200000047683716},{"id":"https://openalex.org/keywords/xenograft-tumor-growth","display_name":"xenograft tumor growth","score":0.699999988079071},{"id":"https://openalex.org/keywords/microrna-target-regulation","display_name":"microRNA target regulation","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.9307388067245483},{"id":"https://openalex.org/C2778997737","wikidata":"https://www.wikidata.org/wiki/Q1693598","display_name":"Nasopharyngeal carcinoma","level":3,"score":0.7419267892837524},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.7376537919044495},{"id":"https://openalex.org/C2777933648","wikidata":"https://www.wikidata.org/wiki/Q21114866","display_name":"SOX2","level":4,"score":0.6605408787727356},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6359173655509949},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6309319138526917},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5304098725318909},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5253288745880127},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5043262243270874},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4625491499900818},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4233975112438202},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.41125795245170593},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.407324880361557},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3028624653816223},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19032150506973267},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.13190314173698425},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12698665261268616},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10019376873970032},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0876496434211731},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0660400390625},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0441204309463501},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077274","descriptor_name":"Nasopharyngeal Carcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000077274","descriptor_name":"Nasopharyngeal Carcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009303","descriptor_name":"Nasopharyngeal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009303","descriptor_name":"Nasopharyngeal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009303","descriptor_name":"Nasopharyngeal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055748","descriptor_name":"SOXB1 Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055748","descriptor_name":"SOXB1 Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1515/hsz-2022-0329","doi":"https://doi.org/10.1515/hsz-2022-0329","is_oa":false,"landing_page_url":"https://doi.org/10.1515/hsz-2022-0329","pdf_url":null,"source":{"id":"https://openalex.org/S18118477","display_name":"Biological Chemistry","issn_l":"1431-6730","issn":["1431-6730","1437-4315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:36752150","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36752150","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1621089256","display_name":null,"funder_award_id":"2021JJ40913","funder_id":"https://openalex.org/F4320322843","funder_display_name":"Natural Science Foundation of\u00a0Hunan Province"},{"id":"https://openalex.org/G2994381268","display_name":null,"funder_award_id":"81902785","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322843","display_name":"Natural Science Foundation of\u00a0Hunan Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W2067693899","https://openalex.org/W2103373618","https://openalex.org/W2108792373","https://openalex.org/W2521933796","https://openalex.org/W2525203343","https://openalex.org/W2574610998","https://openalex.org/W2586556497","https://openalex.org/W2737530694","https://openalex.org/W2760859192","https://openalex.org/W2795286314","https://openalex.org/W2801430015","https://openalex.org/W2886112385","https://openalex.org/W2887190758","https://openalex.org/W2888342869","https://openalex.org/W2964767539","https://openalex.org/W2971198922","https://openalex.org/W2990380946","https://openalex.org/W3004108255","https://openalex.org/W3015759765","https://openalex.org/W3025146412","https://openalex.org/W3041377023","https://openalex.org/W3048955281","https://openalex.org/W3119806908","https://openalex.org/W3122016759","https://openalex.org/W3181823941","https://openalex.org/W3208413231","https://openalex.org/W3216305620"],"related_works":["https://openalex.org/W2100087085","https://openalex.org/W4214752193","https://openalex.org/W4416795959","https://openalex.org/W3037538369","https://openalex.org/W2601709601","https://openalex.org/W4312095360","https://openalex.org/W2529260763","https://openalex.org/W3024064793","https://openalex.org/W3197674997","https://openalex.org/W4394748312"],"abstract_inverted_index":{"This":[0],"study":[1],"aims":[2],"to":[3,102],"explore":[4],"the":[5,13,192],"mechanism":[6],"of":[7,15,18,86,106,112,115,172],"microRNA":[8],"(miR)-101-3p-mediated":[9],"SOX2/ZIC5":[10],"axis":[11,194],"in":[12,32,119,125,163,180,197,204],"progression":[14],"cisplatin":[16,70,135,150,178,202],"resistance":[17,151,179,203],"nasopharyngeal":[19],"carcinoma":[20],"(NPC).":[21],"ZIC5":[22,57,79,116,124,188],"expression":[23,58],"was":[24,59,88,117,161,185,195],"analyzed":[25],"with":[26,43,90,98],"a":[27,139],"bioinformatics":[28],"database":[29],"and":[30,39,56,63,78,100,109,133,144,149,152,167,177,201],"detected":[31],"NPC":[33,87,121,126,165],"cell":[34,129,154],"lines.":[35],"Cisplatin-resistant":[36],"cells":[37,92,127,166],"(HNE-1/DDP":[38],"C666-1/DDP)":[40],"were":[41,67,80],"transfected":[42,94,97],"sh-ZIC5,":[44],"sh-SOX2,":[45],"sh-SOX2":[46],"+":[47,52],"pcDNA3.1-ZIC5,":[48],"or":[49,95],"miR-101-3p":[50,107,160,173],"Agomir":[51,108],"pcDNA3.1-SOX2.":[53],"MiR-101-3p,":[54],"SOX2,":[55,77],"assessed":[60],"after":[61,69],"transfection,":[62],"cancer":[64,198],"associated":[65,199],"phenotypes":[66,200],"evaluated":[68],"treatment.":[71],"The":[72],"potential":[73],"relationships":[74],"among":[75],"miR-101-3p,":[76],"analyzed.":[81],"A":[82],"xenograft":[83,181],"mouse":[84,182],"model":[85],"established":[89],"HNE-1":[91],"stably":[93],"not":[96],"oe-ZIC5":[99],"subjected":[101],"tail":[103],"vein":[104],"injection":[105,111],"intraperitoneal":[110],"cisplatin.":[113],"Overexpression":[114,171],"found":[118],"cisplatin-resistant":[120,164],"cells.":[122],"Downregulating":[123],"decreased":[128,162],"viability,":[130],"promoted":[131,146],"apoptosis,":[132],"reduced":[134],"resistance.":[136],"SOX2":[137,145],"had":[138],"binding":[140],"site":[141],"on":[142],"ZIC5,":[143],"proliferation,":[147],"migration,":[148],"inhibited":[153,174],"apoptosis":[155],"by":[156,187],"up-regulating":[157],"ZIC5.":[158],"Mechanistically,":[159],"negatively":[168],"targeted":[169],"SOX2.":[170],"tumor":[175],"growth":[176],"model,":[183],"which":[184],"reversed":[186],"overexpression.":[189],"In":[190],"conclusion,":[191],"miR-101-3p/SOX2/ZIC5":[193],"implicated":[196],"NPC.":[205]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-02-09T00:00:00"}