{"id":"https://openalex.org/W4319082962","doi":"https://doi.org/10.1016/j.jaci.2022.12.223","title":"ADX-629, A Reactive Aldehyde Species (RASP) Inhibitor, Reduced Eosinophilia In Asthmatic Subjects After Bronchial Allergen Challenge (BAC)","display_name":"ADX-629, A Reactive Aldehyde Species (RASP) Inhibitor, Reduced Eosinophilia In Asthmatic Subjects After Bronchial Allergen Challenge (BAC)","publication_year":2023,"publication_date":"2023-02-01","ids":{"openalex":"https://openalex.org/W4319082962","doi":"https://doi.org/10.1016/j.jaci.2022.12.223"},"language":"en","primary_location":{"id":"doi:10.1016/j.jaci.2022.12.223","doi":"https://doi.org/10.1016/j.jaci.2022.12.223","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jaci.2022.12.223","pdf_url":null,"source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015229094","display_name":"Patricia Couroux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123727","display_name":"Cliantha (India)","ror":"https://ror.org/02rmzps48","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210123727"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Patricia Couroux","raw_affiliation_strings":["Cliantha Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cliantha Research","institution_ids":["https://openalex.org/I4210123727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010058102","display_name":"Anne Marie Salapatek","orcid":"https://orcid.org/0000-0002-3224-5673","observed_orcids":["https://orcid.org/0000-0002-3224-5673"]},"institutions":[{"id":"https://openalex.org/I4210123727","display_name":"Cliantha (India)","ror":"https://ror.org/02rmzps48","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210123727"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Anne Marie Salapatek","raw_affiliation_strings":["Cliantha Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cliantha Research","institution_ids":["https://openalex.org/I4210123727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014609415","display_name":"Petrus Stols","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123727","display_name":"Cliantha (India)","ror":"https://ror.org/02rmzps48","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210123727"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Petrus Stols","raw_affiliation_strings":["Cliantha Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cliantha Research","institution_ids":["https://openalex.org/I4210123727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076048323","display_name":"Yasmeen Goyal","orcid":"https://orcid.org/0000-0001-7433-1441","observed_orcids":["https://orcid.org/0000-0001-7433-1441"]},"institutions":[{"id":"https://openalex.org/I4210123727","display_name":"Cliantha (India)","ror":"https://ror.org/02rmzps48","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210123727"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Yasmeen Goyal","raw_affiliation_strings":["Cliantha Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cliantha Research","institution_ids":["https://openalex.org/I4210123727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042554314","display_name":"Ewan Desilva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123727","display_name":"Cliantha (India)","ror":"https://ror.org/02rmzps48","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210123727"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ewan Desilva","raw_affiliation_strings":["Cliantha Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cliantha Research","institution_ids":["https://openalex.org/I4210123727"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079979065","display_name":"Todd C. Brady","orcid":"https://orcid.org/0000-0003-3399-4673","observed_orcids":["https://orcid.org/0000-0003-3399-4673"]},"institutions":[{"id":"https://openalex.org/I4405267294","display_name":"Aldeyra Therapeutics, Inc. (United States)","ror":"https://ror.org/0227gj303","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267294"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd Brady","raw_affiliation_strings":["Aldeyra Therapeutics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aldeyra Therapeutics","institution_ids":["https://openalex.org/I4405267294"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4000,"currency":"USD","value_usd":4000},"apc_paid":null,"fwci":0.1636,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.43005493,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"151","issue":"2","first_page":"AB70","last_page":"AB70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12208","display_name":"Occupational exposure and asthma","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allergic-asthma","display_name":"allergic asthma","score":0.828000009059906},{"id":"https://openalex.org/keywords/eosinophilia","display_name":"eosinophilia","score":0.953000009059906},{"id":"https://openalex.org/keywords/bronchial-allergen-challenge","display_name":"bronchial allergen challenge","score":0.9319999814033508},{"id":"https://openalex.org/keywords/house-dust-mites","display_name":"house dust mites","score":0.8820000290870667},{"id":"https://openalex.org/keywords/pet-dander","display_name":"pet dander","score":0.7950000166893005},{"id":"https://openalex.org/keywords/airway-hypersensitivity","display_name":"airway hypersensitivity","score":0.8190000057220459},{"id":"https://openalex.org/keywords/methacholine-challenge","display_name":"methacholine challenge","score":0.9819999933242798},{"id":"https://openalex.org/keywords/exhaled-nitric-oxide","display_name":"exhaled nitric oxide","score":0.9359999895095825},{"id":"https://openalex.org/keywords/sputum-eosinophils","display_name":"sputum eosinophils","score":0.9210000038146973},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C2777129736","wikidata":"https://www.wikidata.org/wiki/Q505142","display_name":"Eosinophilia","level":2,"score":0.7359779477119446},{"id":"https://openalex.org/C2780510475","wikidata":"https://www.wikidata.org/wiki/Q186752","display_name":"Allergen","level":3,"score":0.6986138224601746},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5414746403694153},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34057748317718506},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.19656038284301758}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jaci.2022.12.223","doi":"https://doi.org/10.1016/j.jaci.2022.12.223","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jaci.2022.12.223","pdf_url":null,"source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W831743371","https://openalex.org/W1999715467","https://openalex.org/W2112594957","https://openalex.org/W3194019377","https://openalex.org/W2170073337","https://openalex.org/W137035631","https://openalex.org/W2138048992","https://openalex.org/W2791179498","https://openalex.org/W7145749004","https://openalex.org/W2389790076"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-02-04T00:00:00"}