{"id":"https://openalex.org/W4319082201","doi":"https://doi.org/10.1016/j.jaci.2022.12.634","title":"MRGPRX2 Antagonist EP262 Potently Inhibits Agonist-Induced Mast Cell Degranulation In Vitro and In Vivo","display_name":"MRGPRX2 Antagonist EP262 Potently Inhibits Agonist-Induced Mast Cell Degranulation In Vitro and In Vivo","publication_year":2023,"publication_date":"2023-02-01","ids":{"openalex":"https://openalex.org/W4319082201","doi":"https://doi.org/10.1016/j.jaci.2022.12.634"},"language":"en","primary_location":{"id":"doi:10.1016/j.jaci.2022.12.634","doi":"https://doi.org/10.1016/j.jaci.2022.12.634","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jaci.2022.12.634","pdf_url":null,"source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018746393","display_name":"Joshua Wollam","orcid":"https://orcid.org/0009-0003-7444-5109","observed_orcids":["https://orcid.org/0009-0003-7444-5109","https://orcid.org/0000-0001-7225-1990"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joshua Wollam","raw_affiliation_strings":["Escient Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Escient Pharmaceuticals","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108648430","display_name":"Michelle Solomon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michelle Solomon","raw_affiliation_strings":["Escient Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Escient Pharmaceuticals","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052916432","display_name":"Christiane Villescaz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christiane Villescaz","raw_affiliation_strings":["Escient Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Escient Pharmaceuticals","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082610274","display_name":"Marion C. Lanier","orcid":"https://orcid.org/0000-0001-5167-7263","observed_orcids":["https://orcid.org/0000-0001-5167-7263"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marion Lanier","raw_affiliation_strings":["Escient Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Escient Pharmaceuticals","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jennifer Brooks","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer Brooks","raw_affiliation_strings":["Escient Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Escient Pharmaceuticals","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100682978","display_name":"Andrew H. Kim","orcid":"https://orcid.org/0000-0002-0044-0212","observed_orcids":["https://orcid.org/0000-0002-0044-0212"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew Kim","raw_affiliation_strings":["Escient Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Escient Pharmaceuticals","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Samantha Anderson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samantha Anderson","raw_affiliation_strings":["Escient Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Escient Pharmaceuticals","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015959942","display_name":"David E. Freeman","orcid":"https://orcid.org/0000-0002-7777-7569","observed_orcids":["https://orcid.org/0000-0002-7777-7569"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Freeman","raw_affiliation_strings":["Escient Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Escient Pharmaceuticals","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Alexis Vasquez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexis Vasquez","raw_affiliation_strings":["Escient Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Escient Pharmaceuticals","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014531646","display_name":"Corinne Pisacane","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Corinne Pisacane","raw_affiliation_strings":["Escient Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Escient Pharmaceuticals","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000773853","display_name":"Brittney Charlot","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brittney Charlot","raw_affiliation_strings":["Escient Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Escient Pharmaceuticals","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088203987","display_name":"Alan Vest","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alan Vest","raw_affiliation_strings":["Escient Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Escient Pharmaceuticals","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053455244","display_name":"Jim Napora","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jim Napora","raw_affiliation_strings":["Escient Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Escient Pharmaceuticals","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065823956","display_name":"Christine Cavarlez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christine Cavarlez","raw_affiliation_strings":["Escient Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Escient Pharmaceuticals","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069182697","display_name":"Lisa K. Dvorak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lisa Dvorak","raw_affiliation_strings":["Escient Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Escient Pharmaceuticals","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074543291","display_name":"Brandon R. Selfridge","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brandon Selfridge","raw_affiliation_strings":["Escient Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Escient Pharmaceuticals","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034904172","display_name":"Liming Huang","orcid":"https://orcid.org/0000-0001-9422-0853","observed_orcids":["https://orcid.org/0000-0001-9422-0853"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liming Huang","raw_affiliation_strings":["Escient Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Escient Pharmaceuticals","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018162720","display_name":"Marcos Sainz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marcos Sainz","raw_affiliation_strings":["Escient Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Escient Pharmaceuticals","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039461290","display_name":"Andres J. Nevarez","orcid":"https://orcid.org/0000-0002-8337-6454","observed_orcids":["https://orcid.org/0000-0002-8337-6454"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andres Nevarez","raw_affiliation_strings":["Escient Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Escient Pharmaceuticals","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081864161","display_name":"Harry Dedman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Harry Dedman","raw_affiliation_strings":["Escient Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Escient Pharmaceuticals","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113650310","display_name":"Gregg A. Timony","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gregg Timony","raw_affiliation_strings":["Escient Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Escient Pharmaceuticals","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027690239","display_name":"Esther Martinborough","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Esther Martinborough","raw_affiliation_strings":["Escient Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Escient Pharmaceuticals","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087576440","display_name":"Veena Viswanath","orcid":"https://orcid.org/0000-0001-8078-5589","observed_orcids":["https://orcid.org/0000-0001-8078-5589"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Veena Viswanath","raw_affiliation_strings":["Escient Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Escient Pharmaceuticals","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110621017","display_name":"Marcus F. Boehm","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marcus Boehm","raw_affiliation_strings":["Escient Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Escient Pharmaceuticals","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4000,"currency":"USD","value_usd":4000},"apc_paid":null,"fwci":0.6582,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.61183763,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"151","issue":"2","first_page":"AB203","last_page":"AB203"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mrgprx2","display_name":"MRGPRX2","score":0.996999979019165},{"id":"https://openalex.org/keywords/mast-cell-degranulation","display_name":"mast cell degranulation","score":0.8679999709129333},{"id":"https://openalex.org/keywords/small-molecule-antagonists","display_name":"small molecule antagonists","score":0.7210000157356262},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.7120000123977661},{"id":"https://openalex.org/keywords/neuropeptides","display_name":"neuropeptides","score":0.9350000023841858},{"id":"https://openalex.org/keywords/inflammatory-diseases","display_name":"inflammatory diseases","score":0.37299999594688416}],"concepts":[{"id":"https://openalex.org/C49802076","wikidata":"https://www.wikidata.org/wiki/Q5251810","display_name":"Degranulation","level":3,"score":0.8403768539428711},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7423073053359985},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.7030395865440369},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.665812611579895},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6304696202278137},{"id":"https://openalex.org/C2779726688","wikidata":"https://www.wikidata.org/wiki/Q191989","display_name":"Mast cell","level":2,"score":0.5914750695228577},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5031160712242126},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4874001145362854},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33809036016464233},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3257714509963989},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20665675401687622},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.12687420845031738},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08213889598846436},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jaci.2022.12.634","doi":"https://doi.org/10.1016/j.jaci.2022.12.634","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jaci.2022.12.634","pdf_url":null,"source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4391534927","https://openalex.org/W4400370518","https://openalex.org/W4302283182","https://openalex.org/W2576245251","https://openalex.org/W4388415574","https://openalex.org/W3208759157","https://openalex.org/W7171564639","https://openalex.org/W2956919789","https://openalex.org/W4416446331","https://openalex.org/W3028854187"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2023-02-04T00:00:00"}
