{"id":"https://openalex.org/W4319081966","doi":"https://doi.org/10.1016/j.jaci.2022.12.758","title":"Subcutaneous immunotherapy with mannan-conjugated birch pollen allergens shows long-term effects already after 2 years of treatment by inducing a significant immune response in birch pollen allergic patients","display_name":"Subcutaneous immunotherapy with mannan-conjugated birch pollen allergens shows long-term effects already after 2 years of treatment by inducing a significant immune response in birch pollen allergic patients","publication_year":2023,"publication_date":"2023-02-01","ids":{"openalex":"https://openalex.org/W4319081966","doi":"https://doi.org/10.1016/j.jaci.2022.12.758"},"language":"en","primary_location":{"id":"doi:10.1016/j.jaci.2022.12.758","doi":"https://doi.org/10.1016/j.jaci.2022.12.758","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1016/j.jaci.2022.12.758","pdf_url":"https://www.jacionline.org/article/S0091-6749(22)02412-5/pdf","source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jacionline.org/article/S0091-6749(22)02412-5/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056856853","display_name":"Esther Raskopf","orcid":"https://orcid.org/0000-0002-6461-8593","observed_orcids":["https://orcid.org/0000-0002-6461-8593"]},"institutions":[{"id":"https://openalex.org/I4210159783","display_name":"Fed\u00ader\u00adal Of\u00adfice of Ad\u00admin\u00adis\u00adtra\u00adtion","ror":"https://ror.org/04n9aye53","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210159783"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Esther Raskopf","raw_affiliation_strings":["ClinComptence Cologne GmbH, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ClinComptence Cologne GmbH, Cologne, Germany","institution_ids":["https://openalex.org/I4210159783"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Laura England","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159783","display_name":"Fed\u00ader\u00adal Of\u00adfice of Ad\u00admin\u00adis\u00adtra\u00adtion","ror":"https://ror.org/04n9aye53","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210159783"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Laura England","raw_affiliation_strings":["ClinComptence Cologne GmbH, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ClinComptence Cologne GmbH, Cologne, Germany","institution_ids":["https://openalex.org/I4210159783"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102726735","display_name":"Hacer Sahin","orcid":"https://orcid.org/0000-0001-5516-2013","observed_orcids":["https://orcid.org/0000-0001-5516-2013"]},"institutions":[{"id":"https://openalex.org/I4210159783","display_name":"Fed\u00ader\u00adal Of\u00adfice of Ad\u00admin\u00adis\u00adtra\u00adtion","ror":"https://ror.org/04n9aye53","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210159783"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hacer Sahin","raw_affiliation_strings":["ClinComptence Cologne GmbH, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ClinComptence Cologne GmbH, Cologne, Germany","institution_ids":["https://openalex.org/I4210159783"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089061305","display_name":"Christoph Zeyen","orcid":"https://orcid.org/0000-0002-3355-8663","observed_orcids":["https://orcid.org/0000-0002-3355-8663"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christoph Zeyen","raw_affiliation_strings":["Medical Faculty, University of Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Faculty, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lea Decker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lea Decker","raw_affiliation_strings":["Medical Faculty, University of Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Faculty, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028336990","display_name":"Friederike H\u00fcffmeier","orcid":"https://orcid.org/0009-0001-4110-0484","observed_orcids":["https://orcid.org/0009-0001-4110-0484"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Friederike H\u00fcffmeier","raw_affiliation_strings":["Medical Faculty, University of Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Faculty, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023726308","display_name":"Elena Xenofontos","orcid":"https://orcid.org/0000-0002-9379-5257","observed_orcids":["https://orcid.org/0000-0002-9379-5257","https://orcid.org/0009-0002-5422-0220"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Elena Xenofontos","raw_affiliation_strings":["Medical Faculty, University of Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Faculty, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007564721","display_name":"Miguel Casanovas","orcid":"https://orcid.org/0000-0003-2330-3963","observed_orcids":["https://orcid.org/0000-0003-2330-3963"]},"institutions":[{"id":"https://openalex.org/I4210105381","display_name":"Inmunotek (Spain)","ror":"https://ror.org/01e2spe61","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210105381"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Miguel Casanovas","raw_affiliation_strings":["Inmunotek S.L., Alcal\u00e1 de Henares, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inmunotek S.L., Alcal\u00e1 de Henares, Madrid, Spain","institution_ids":["https://openalex.org/I4210105381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044711362","display_name":"Jos\u00e9 Luis Subiza","orcid":"https://orcid.org/0000-0002-0134-5321","observed_orcids":["https://orcid.org/0000-0002-0134-5321"]},"institutions":[{"id":"https://openalex.org/I4210105381","display_name":"Inmunotek (Spain)","ror":"https://ror.org/01e2spe61","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210105381"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Subiza","raw_affiliation_strings":["Inmunotek S.L., Alcal\u00e1 de Henares, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inmunotek S.L., Alcal\u00e1 de Henares, Madrid, Spain","institution_ids":["https://openalex.org/I4210105381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022527420","display_name":"Silke Allekotte","orcid":"https://orcid.org/0000-0002-0222-5954","observed_orcids":["https://orcid.org/0000-0002-0222-5954"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Silke Allekotte","raw_affiliation_strings":["ClinCompetence Cologne GmbH, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ClinCompetence Cologne GmbH, Cologne, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108517239","display_name":"Mandy Cuevas","orcid":"https://orcid.org/0009-0007-1117-2210","observed_orcids":["https://orcid.org/0009-0007-1117-2210"]},"institutions":[{"id":"https://openalex.org/I4210162051","display_name":"University Hospital Carl Gustav Carus","ror":"https://ror.org/04za5zm41","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210162051"]},{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mandy Cuevas","raw_affiliation_strings":["University Hospital Carl-Gustav-Carus, Technical University Dresden, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Carl-Gustav-Carus, Technical University Dresden, Dresden, Germany","institution_ids":["https://openalex.org/I4210162051","https://openalex.org/I78650965"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017742394","display_name":"Ralph M\u00f6sges\ufeff","orcid":"https://orcid.org/0000-0002-1928-810X","observed_orcids":["https://orcid.org/0000-0002-1928-810X"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ralph Mosges","raw_affiliation_strings":["ClinCompetence Cologne GmbH, Cologne, Germany; Med. Faculty, University of Cologne, Cologne, Germany","ClinCompetence Cologne GmbH, Cologne, Germany","Med. Faculty, University of Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ClinCompetence Cologne GmbH, Cologne, Germany; Med. Faculty, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"ClinCompetence Cologne GmbH, Cologne, Germany","institution_ids":[]},{"raw_affiliation_string":"Med. Faculty, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4000,"currency":"USD","value_usd":4000},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01303912,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"151","issue":"2","first_page":"AB328","last_page":"AB328"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/subcutaneous-immunotherapy","display_name":"subcutaneous immunotherapy","score":0.8949999809265137},{"id":"https://openalex.org/keywords/birch-pollen-allergy","display_name":"birch pollen allergy","score":0.9070000052452087},{"id":"https://openalex.org/keywords/allergen-immunotherapy","display_name":"allergen immunotherapy","score":0.7799999713897705},{"id":"https://openalex.org/keywords/sige","display_name":"SiGe","score":0.7279999852180481},{"id":"https://openalex.org/keywords/long-term-treatment-outcomes","display_name":"long-term treatment outcomes","score":0.6790000200271606},{"id":"https://openalex.org/keywords/placebo-effect","display_name":"placebo effect","score":0.4490000009536743},{"id":"https://openalex.org/keywords/ige-igg4-ratio","display_name":"IgE/IgG4 ratio","score":0.7400000095367432}],"concepts":[{"id":"https://openalex.org/C2779719659","wikidata":"https://www.wikidata.org/wiki/Q24577942","display_name":"Mannan","level":3,"score":0.7508615255355835},{"id":"https://openalex.org/C2780618852","wikidata":"https://www.wikidata.org/wiki/Q79932","display_name":"Pollen","level":2,"score":0.7091066837310791},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6256645917892456},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5861539244651794},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5129861235618591},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33466482162475586},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32716113328933716},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.24199479818344116},{"id":"https://openalex.org/C100817775","wikidata":"https://www.wikidata.org/wiki/Q134219","display_name":"Polysaccharide","level":2,"score":0.08422383666038513},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.04916393756866455}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jaci.2022.12.758","doi":"https://doi.org/10.1016/j.jaci.2022.12.758","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1016/j.jaci.2022.12.758","pdf_url":"https://www.jacionline.org/article/S0091-6749(22)02412-5/pdf","source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.jaci.2022.12.758","doi":"https://doi.org/10.1016/j.jaci.2022.12.758","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1016/j.jaci.2022.12.758","pdf_url":"https://www.jacionline.org/article/S0091-6749(22)02412-5/pdf","source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.75,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4319081966.pdf","grobid_xml":"https://content.openalex.org/works/W4319081966.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2025726739","https://openalex.org/W2132582661","https://openalex.org/W1760359909","https://openalex.org/W27627444","https://openalex.org/W2004121050","https://openalex.org/W2367739257","https://openalex.org/W2004792658","https://openalex.org/W2042874314","https://openalex.org/W1709657781","https://openalex.org/W2377942199"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}