{"id":"https://openalex.org/W4319081840","doi":"https://doi.org/10.3390/ijms24032998","title":"Salivary Polyamines Help Detect High-Risk Patients with Pancreatic Cancer: A Prospective Validation Study","display_name":"Salivary Polyamines Help Detect High-Risk Patients with Pancreatic Cancer: A Prospective Validation Study","publication_year":2023,"publication_date":"2023-02-03","ids":{"openalex":"https://openalex.org/W4319081840","doi":"https://doi.org/10.3390/ijms24032998","pmid":"https://pubmed.ncbi.nlm.nih.gov/36769322"},"language":"en","primary_location":{"id":"doi:10.3390/ijms24032998","doi":"https://doi.org/10.3390/ijms24032998","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms24032998","pdf_url":"https://www.mdpi.com/1422-0067/24/3/2998/pdf?version=1675854039","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/24/3/2998/pdf?version=1675854039","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042879777","display_name":"Daisuke Nose","orcid":"https://orcid.org/0000-0003-1760-2991","observed_orcids":["https://orcid.org/0000-0003-1760-2991"]},"institutions":[{"id":"https://openalex.org/I31784960","display_name":"Fukuoka University","ror":"https://ror.org/04nt8b154","country_code":"JP","type":"education","lineage":["https://openalex.org/I31784960"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Daisuke Nose","raw_affiliation_strings":["Department of Cardiology, Fukuoka Heartnet Hospital, Fukuoka 819-0002, Japan","Department of Cardiology, Fukuoka University Faculty of Medicine, Fukuoka 814-0180, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Fukuoka Heartnet Hospital, Fukuoka 819-0002, Japan","institution_ids":[]},{"raw_affiliation_string":"Department of Cardiology, Fukuoka University Faculty of Medicine, Fukuoka 814-0180, Japan","institution_ids":["https://openalex.org/I31784960"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071767668","display_name":"Masahiro Sugimoto","orcid":"https://orcid.org/0000-0003-3316-2543","observed_orcids":["https://orcid.org/0000-0003-3316-2543"]},"institutions":[{"id":"https://openalex.org/I158929114","display_name":"Tokyo Medical University","ror":"https://ror.org/00k5j5c86","country_code":"JP","type":"education","lineage":["https://openalex.org/I158929114"]},{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Sugimoto","raw_affiliation_strings":["Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata 997-0052, Japan","Institute of Medical Science, Tokyo Medical University, Shinjuku, Tokyo 160-8402, Japan"],"raw_orcid":"https://orcid.org/0000-0003-3316-2543","affiliations":[{"raw_affiliation_string":"Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata 997-0052, Japan","institution_ids":["https://openalex.org/I203951103"]},{"raw_affiliation_string":"Institute of Medical Science, Tokyo Medical University, Shinjuku, Tokyo 160-8402, Japan","institution_ids":["https://openalex.org/I158929114"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027362018","display_name":"Tsuneo Muta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125681","display_name":"Imamura Hospital","ror":"https://ror.org/02xt2gf57","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210125681"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsuneo Muta","raw_affiliation_strings":["Department of Health Care Center, Imamura Hospital, Saga 841-0061, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Care Center, Imamura Hospital, Saga 841-0061, Japan","institution_ids":["https://openalex.org/I4210125681"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105938100","display_name":"Shin-ichiro Miura","orcid":"https://orcid.org/0000-0003-4904-0217","observed_orcids":["https://orcid.org/0000-0003-4904-0217"]},"institutions":[{"id":"https://openalex.org/I31784960","display_name":"Fukuoka University","ror":"https://ror.org/04nt8b154","country_code":"JP","type":"education","lineage":["https://openalex.org/I31784960"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shin-Ichiro Miura","raw_affiliation_strings":["Department of Cardiology, Fukuoka University Faculty of Medicine, Fukuoka 814-0180, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Fukuoka University Faculty of Medicine, Fukuoka 814-0180, Japan","institution_ids":["https://openalex.org/I31784960"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5042879777"],"corresponding_institution_ids":["https://openalex.org/I31784960"],"apc_list":{"value":2500,"currency":"CHF","value_usd":2780},"apc_paid":{"value":2500,"currency":"CHF","value_usd":2780},"fwci":0.968,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.7120662,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"24","issue":"3","first_page":"2998","last_page":"2998"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.9150000214576721,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.9150000214576721,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.06210000067949295,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9399999976158142},{"id":"https://openalex.org/keywords/early-detection","display_name":"early detection","score":0.6990000009536743},{"id":"https://openalex.org/keywords/tumor-screening","display_name":"cancer screening","score":0.9279999732971191},{"id":"https://openalex.org/keywords/high-risk-patients","display_name":"high-risk patients","score":0.6899999976158142},{"id":"https://openalex.org/keywords/noninvasive-biomarkers","display_name":"non-invasive biomarkers","score":0.9309999942779541},{"id":"https://openalex.org/keywords/chronic-pancreatitis","display_name":"chronic pancreatitis","score":0.9100000262260437},{"id":"https://openalex.org/keywords/pancreatic-cysts","display_name":"pancreatic cysts","score":0.9950000047683716},{"id":"https://openalex.org/keywords/gallbladder-cancer","display_name":"gallbladder cancer","score":0.7670000195503235},{"id":"https://openalex.org/keywords/salivary-biomarkers","display_name":"salivary biomarkers","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.8895815014839172},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.754738450050354},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6224203109741211},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.6178873777389526},{"id":"https://openalex.org/C2775967933","wikidata":"https://www.wikidata.org/wiki/Q1527888","display_name":"Pancreatitis","level":2,"score":0.5971567034721375},{"id":"https://openalex.org/C2776737053","wikidata":"https://www.wikidata.org/wiki/Q7130407","display_name":"Pancreatic disease","level":3,"score":0.518851637840271},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5170593857765198},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.49849629402160645},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4405204951763153},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.41943663358688354},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.4114255905151367},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.4054751992225647},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3601696491241455},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10668468475341797},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010182","descriptor_name":"Pancreatic Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010182","descriptor_name":"Pancreatic Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010182","descriptor_name":"Pancreatic Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010182","descriptor_name":"Pancreatic Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D011073","descriptor_name":"Polyamines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011073","descriptor_name":"Polyamines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011073","descriptor_name":"Polyamines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011073","descriptor_name":"Polyamines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms24032998","doi":"https://doi.org/10.3390/ijms24032998","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms24032998","pdf_url":"https://www.mdpi.com/1422-0067/24/3/2998/pdf?version=1675854039","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmid:36769322","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36769322","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9918012","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9918012","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9918012/pdf/ijms-24-02998.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Int J Mol Sci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/ijms24032998","doi":"https://doi.org/10.3390/ijms24032998","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms24032998","pdf_url":"https://www.mdpi.com/1422-0067/24/3/2998/pdf?version=1675854039","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7900000214576721}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1264649403","display_name":null,"funder_award_id":"16-GL00-20200327-003378","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G290034153","display_name":null,"funder_award_id":"20H05743","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G522151759","display_name":null,"funder_award_id":"003444","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6402237806","display_name":"\u96c6\u56e3\u5065\u8a3a\u306b\u304a\u3051\u308b\u553e\u6db2\u304c\u3093\u691c\u67fb\u306b\u307f\u3089\u308c\u308b\u65b0\u898f\u8ffd\u52a0\u691c\u8a3a\u9805\u76ee\u306e\u6709\u7528\u6027","funder_award_id":"21K17238","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7681069553","display_name":null,"funder_award_id":"003059","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4319081840.pdf","grobid_xml":"https://content.openalex.org/works/W4319081840.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W1516666861","https://openalex.org/W1608611847","https://openalex.org/W1912827889","https://openalex.org/W1981257861","https://openalex.org/W2019696954","https://openalex.org/W2025102445","https://openalex.org/W2027929052","https://openalex.org/W2028953339","https://openalex.org/W2031385223","https://openalex.org/W2059221926","https://openalex.org/W2066809635","https://openalex.org/W2070327750","https://openalex.org/W2073328988","https://openalex.org/W2081963274","https://openalex.org/W2102208341","https://openalex.org/W2108354906","https://openalex.org/W2125884347","https://openalex.org/W2127496116","https://openalex.org/W2142594944","https://openalex.org/W2147460661","https://openalex.org/W2158604971","https://openalex.org/W2172697812","https://openalex.org/W2318156113","https://openalex.org/W2476068333","https://openalex.org/W2551390059","https://openalex.org/W2574399626","https://openalex.org/W2575543752","https://openalex.org/W2598027675","https://openalex.org/W2749296525","https://openalex.org/W2749891932","https://openalex.org/W2770203743","https://openalex.org/W2782990469","https://openalex.org/W2784734859","https://openalex.org/W2789300829","https://openalex.org/W2803439891","https://openalex.org/W2803465100","https://openalex.org/W2886984850","https://openalex.org/W2898368508","https://openalex.org/W2899696276","https://openalex.org/W2901421803","https://openalex.org/W2906807473","https://openalex.org/W2957986133","https://openalex.org/W2989137505","https://openalex.org/W2995132756","https://openalex.org/W3001603296","https://openalex.org/W3011169222","https://openalex.org/W3096862189","https://openalex.org/W3120208712","https://openalex.org/W3128346754","https://openalex.org/W3195869131","https://openalex.org/W4205148275","https://openalex.org/W4206841660","https://openalex.org/W4210960412","https://openalex.org/W4211046208","https://openalex.org/W4211233079","https://openalex.org/W4220855315","https://openalex.org/W4233651632","https://openalex.org/W4283591775","https://openalex.org/W4286264999","https://openalex.org/W4313453490","https://openalex.org/W6681952737"],"related_works":["https://openalex.org/W3145873378","https://openalex.org/W2552414513","https://openalex.org/W2025542867","https://openalex.org/W96241287","https://openalex.org/W78957798","https://openalex.org/W2405244484","https://openalex.org/W2413957002","https://openalex.org/W2105518228","https://openalex.org/W2409651645","https://openalex.org/W2031725843"],"abstract_inverted_index":{"Pancreatic":[0],"cancer":[1,8,45,99],"is":[2,16,32,50,148],"one":[3],"of":[4,24,27,43,59,87],"the":[5,25,40,85,116,144],"most":[6],"malignant":[7],"types":[9],"and":[10,94,132,135],"has":[11],"a":[12,36,51,57,149],"poor":[13],"prognosis.":[14],"It":[15],"often":[17],"diagnosed":[18],"at":[19],"an":[20],"advanced":[21],"stage":[22],"because":[23],"absence":[26],"typical":[28],"symptoms.":[29],"Therefore,":[30],"it":[31],"necessary":[33],"to":[34,83],"establish":[35],"screening":[37,91,154],"method":[38],"for":[39,90,112],"early":[41],"detection":[42],"pancreatic":[44,92,98,105,126,133,152],"in":[46,56],"high-risk":[47],"individuals.":[48],"This":[49],"prospective":[52],"validation":[53],"study":[54],"conducted":[55],"cohort":[58],"1033":[60],"Japanese":[61],"individuals":[62,118],"(male,":[63],"n":[64,74],"=":[65,68,75,78],"467,":[66],"age":[67,77],"63.3":[69],"\u00b1":[70,80],"11.5":[71],"years;":[72],"female,":[73],"566,":[76],"64.2":[79],"10.6":[81],"years)":[82],"evaluate":[84],"use":[86],"salivary":[88,121,145],"polyamines":[89],"diseases":[93,106],"cancers.":[95],"Patients":[96],"with":[97,119],"were":[100,107],"not":[101],"included;":[102],"however,":[103],"other":[104],"treated":[108],"as":[109,129],"positive":[110],"cases":[111],"accuracy":[113],"verification.":[114],"Of":[115],"135":[117],"elevated":[120],"polyamine":[122,146],"markers,":[123],"66":[124],"had":[125,137],"diseases,":[127],"such":[128],"chronic":[130],"pancreatitis":[131],"cysts,":[134],"1":[136],"gallbladder":[138],"cancer.":[139],"These":[140],"results":[141],"suggest":[142],"that":[143],"panel":[147],"useful":[150],"noninvasive":[151],"disease":[153],"tool.":[155]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}