{"id":"https://openalex.org/W4319066483","doi":"https://doi.org/10.1152/ajpregu.00154.2022","title":"Inhibition of IL-6 signaling prevents serum-induced umbilical cord artery dysfunction from patients with severe COVID-19","display_name":"Inhibition of IL-6 signaling prevents serum-induced umbilical cord artery dysfunction from patients with severe COVID-19","publication_year":2023,"publication_date":"2023-02-04","ids":{"openalex":"https://openalex.org/W4319066483","doi":"https://doi.org/10.1152/ajpregu.00154.2022","pmid":"https://pubmed.ncbi.nlm.nih.gov/36737252","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10026982"},"language":"en","primary_location":{"id":"doi:10.1152/ajpregu.00154.2022","doi":"https://doi.org/10.1152/ajpregu.00154.2022","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.00154.2022","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10026982","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086439272","display_name":"Cellyne R de Almeida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090392","display_name":"Universidade Federal de Jata\u00ed","ror":"https://ror.org/00cs91c30","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210090392"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Cellyne R. Almeida","raw_affiliation_strings":["Academic Unit of Health Sciences, Federal University of Jatai, Jatai, Goias, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academic Unit of Health Sciences, Federal University of Jatai, Jatai, Goias, Brazil","institution_ids":["https://openalex.org/I4210090392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077915388","display_name":"J\u00falia F de Lima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090392","display_name":"Universidade Federal de Jata\u00ed","ror":"https://ror.org/00cs91c30","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210090392"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"J\u00falia F. Lima","raw_affiliation_strings":["Academic Unit of Health Sciences, Federal University of Jatai, Jatai, Goias, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academic Unit of Health Sciences, Federal University of Jatai, Jatai, Goias, Brazil","institution_ids":["https://openalex.org/I4210090392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037672980","display_name":"Mirele Resende Machado","orcid":"https://orcid.org/0000-0003-0070-641X","observed_orcids":["https://orcid.org/0000-0003-0070-641X"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Mirele R. Machado","raw_affiliation_strings":["Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034960118","display_name":"Juliano Vilela Alves","orcid":"https://orcid.org/0000-0002-6555-5547","observed_orcids":["https://orcid.org/0000-0002-6555-5547"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Juliano V. Alves","raw_affiliation_strings":["Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-6555-5547","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021085940","display_name":"Ariel E.S. Couto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ariel E.S. Couto","raw_affiliation_strings":["Department of Surgery and Anatomy, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery and Anatomy, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083933320","display_name":"Ligia C.B. Campos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ligia C.B. Campos","raw_affiliation_strings":["Department of Surgery and Anatomy, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery and Anatomy, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008292965","display_name":"Carolina D Avila Mesquita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Carolina D. Avila-Mesquita","raw_affiliation_strings":["Department of Surgery and Anatomy, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery and Anatomy, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076883931","display_name":"Maria Auxiliadora\u2010Martins","orcid":"https://orcid.org/0000-0003-3923-4464","observed_orcids":["https://orcid.org/0000-0003-3923-4464"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria Auxiliadora-Martins","raw_affiliation_strings":["Department of Surgery and Anatomy, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery and Anatomy, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077261111","display_name":"Christiane Becari","orcid":"https://orcid.org/0000-0001-8548-9674","observed_orcids":["https://orcid.org/0000-0001-8548-9674"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Christiane Becari","raw_affiliation_strings":["Department of Surgery and Anatomy, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery and Anatomy, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091102184","display_name":"Paulo Louzada\u2010J\u00fanior","orcid":"https://orcid.org/0000-0003-2585-3870","observed_orcids":["https://orcid.org/0000-0003-2585-3870"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Paulo Louzada-J\u00fanior","raw_affiliation_strings":["Department of Clinical Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081286367","display_name":"Rita C. Tostes","orcid":"https://orcid.org/0000-0002-9446-0707","observed_orcids":["https://orcid.org/0000-0002-9446-0707"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rita C. Tostes","raw_affiliation_strings":["Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-9446-0707","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110702172","display_name":"N\u00fabia Souza Lobato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090392","display_name":"Universidade Federal de Jata\u00ed","ror":"https://ror.org/00cs91c30","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210090392"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"N\u00fabia S. Lobato","raw_affiliation_strings":["Academic Unit of Health Sciences, Federal University of Jatai, Jatai, Goias, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academic Unit of Health Sciences, Federal University of Jatai, Jatai, Goias, Brazil","institution_ids":["https://openalex.org/I4210090392"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061773082","display_name":"Rafael Menezes da Costa","orcid":"https://orcid.org/0000-0002-5174-5710","observed_orcids":["https://orcid.org/0000-0002-5174-5710"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4210090392","display_name":"Universidade Federal de Jata\u00ed","ror":"https://ror.org/00cs91c30","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210090392"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Rafael M. Costa","raw_affiliation_strings":["Academic Unit of Health Sciences, Federal University of Jatai, Jatai, Goias, Brazil","Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-5174-5710","affiliations":[{"raw_affiliation_string":"Academic Unit of Health Sciences, Federal University of Jatai, Jatai, Goias, Brazil","institution_ids":["https://openalex.org/I4210090392"]},{"raw_affiliation_string":"Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5061773082"],"corresponding_institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4210090392"],"apc_list":null,"apc_paid":null,"fwci":1.7418,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.83508311,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"324","issue":"4","first_page":"R435","last_page":"R445"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11987","display_name":"COVID-19 Impact on Reproduction","score":0.8999000191688538,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11987","display_name":"COVID-19 Impact on Reproduction","score":0.8999000191688538,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.05299999937415123,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.02319999970495701,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/severe-covid-19","display_name":"severe COVID-19","score":0.8579999804496765},{"id":"https://openalex.org/keywords/il-6-signaling","display_name":"IL-6 signaling","score":0.9100000262260437},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7540000081062317},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8610000014305115},{"id":"https://openalex.org/keywords/nox1","display_name":"NOX1","score":0.7760000228881836},{"id":"https://openalex.org/keywords/rho-kinase","display_name":"Rho kinase","score":0.9819999933242798},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.753000020980835},{"id":"https://openalex.org/keywords/tocilizumab","display_name":"tocilizumab","score":0.8389999866485596},{"id":"https://openalex.org/keywords/vascular-hyperreactivity","display_name":"vascular hyperreactivity","score":0.6510000228881836},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.46399998664855957},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.6607136726379395},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6142295002937317},{"id":"https://openalex.org/C201800478","wikidata":"https://www.wikidata.org/wiki/Q24721770","display_name":"Rho-associated protein kinase","level":3,"score":0.5889165997505188},{"id":"https://openalex.org/C2776955114","wikidata":"https://www.wikidata.org/wiki/Q172563","display_name":"Umbilical cord","level":2,"score":0.5874488353729248},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.5619649887084961},{"id":"https://openalex.org/C2777178219","wikidata":"https://www.wikidata.org/wiki/Q425154","display_name":"Tocilizumab","level":3,"score":0.49091845750808716},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4791921377182007},{"id":"https://openalex.org/C2776061955","wikidata":"https://www.wikidata.org/wiki/Q18038565","display_name":"NOX1","level":4,"score":0.4480569064617157},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.399187296628952},{"id":"https://openalex.org/C2779719074","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NADPH oxidase","level":3,"score":0.38693109154701233},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3677273988723755},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32652682065963745},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.18995288014411926},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.165912926197052},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15626615285873413},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.14493009448051453},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.11653771996498108},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08256730437278748}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000577","descriptor_name":"Amides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010640","descriptor_name":"Phenothiazines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014013","descriptor_name":"1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014470","descriptor_name":"Umbilical Cord","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054460","descriptor_name":"rho-Associated Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1152/ajpregu.00154.2022","doi":"https://doi.org/10.1152/ajpregu.00154.2022","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.00154.2022","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10026982","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10026982","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Regul Integr Comp Physiol","raw_type":"Text"},{"id":"pmid:36737252","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36737252","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Regulatory, integrative and comparative physiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10026982","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10026982","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Regul Integr Comp Physiol","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3874708113","display_name":null,"funder_award_id":"2013/08216- 2","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G7481940774","display_name":null,"funder_award_id":"433898/2018-06","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"}],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1501928163","https://openalex.org/W2007439546","https://openalex.org/W2023762001","https://openalex.org/W2054435322","https://openalex.org/W2110481067","https://openalex.org/W2110953677","https://openalex.org/W2115582439","https://openalex.org/W2128635872","https://openalex.org/W2155504581","https://openalex.org/W2560643765","https://openalex.org/W2810051724","https://openalex.org/W3006783394","https://openalex.org/W3008827533","https://openalex.org/W3011127849","https://openalex.org/W3012813435","https://openalex.org/W3015578679","https://openalex.org/W3017101807","https://openalex.org/W3022407124","https://openalex.org/W3024439234","https://openalex.org/W3025830962","https://openalex.org/W3034858522","https://openalex.org/W3037168483","https://openalex.org/W3037676127","https://openalex.org/W3038641822","https://openalex.org/W3041831245","https://openalex.org/W3041950427","https://openalex.org/W3043979081","https://openalex.org/W3044614759","https://openalex.org/W3046256437","https://openalex.org/W3048606103","https://openalex.org/W3049564595","https://openalex.org/W3102159737","https://openalex.org/W3115700180","https://openalex.org/W3118350455","https://openalex.org/W3120144664","https://openalex.org/W3120305145","https://openalex.org/W3132154886","https://openalex.org/W3145440008","https://openalex.org/W3146392721","https://openalex.org/W3173560675","https://openalex.org/W3192973313","https://openalex.org/W3206155087","https://openalex.org/W3212252498","https://openalex.org/W3215834080","https://openalex.org/W4205458601","https://openalex.org/W4206735146","https://openalex.org/W4292454240"],"related_works":["https://openalex.org/W3125334936","https://openalex.org/W4205198921","https://openalex.org/W4291221315","https://openalex.org/W4380869705","https://openalex.org/W3211109431","https://openalex.org/W3187352952","https://openalex.org/W3080714364","https://openalex.org/W7140325953","https://openalex.org/W3111832460","https://openalex.org/W7118895686"],"abstract_inverted_index":{"Coronavirus":[0],"disease":[1],"2019":[2],"(COVID-19)":[3],"infection":[4],"has":[5],"a":[6],"negative":[7],"impact":[8],"on":[9],"the":[10,26,29,43,58,77,83,128,140,159,189,245],"cytokine":[11],"profile":[12],"of":[13,18,28,45,60,85,132,191,244],"pregnant":[14],"women.":[15],"Increased":[16,213],"levels":[17],"proinflammatory":[19],"cytokines":[20,41,224],"seem":[21],"to":[22,33,35,125,173,182,237],"be":[23],"correlated":[24],"with":[25,62,87,108,115,177,202,227],"severity":[27],"disease,":[30],"in":[31,57,82,127,188,225],"addition":[32],"predisposing":[34],"miscarriage":[36],"or":[37,130],"premature":[38],"birth.":[39],"Proinflammatory":[40],"increase":[42],"generation":[44,98,155,208],"reactive":[46],"oxygen":[47],"species":[48],"(ROS).":[49],"It":[50],"is":[51,235],"unclear":[52],"how":[53],"interleukin-6":[54],"(IL-6)":[55],"found":[56],"circulation":[59,84],"patients":[61],"severe":[63,88,116,178,203,228],"COVID-19":[64,89,179,204,229],"might":[65],"affect":[66],"gestational":[67],"health,":[68],"particularly":[69],"concerning":[70],"umbilical":[71,91,231],"cord":[72,92,104],"function.":[73],"This":[74,184],"study":[75],"tested":[76],"hypothesis":[78],"that":[79],"IL-6":[80,141,234],"present":[81],"women":[86,112,114,176,201,226],"causes":[90],"artery":[93,232],"dysfunction":[94],"by":[95,158,166,219],"increasing":[96],"ROS":[97,154,207],"and":[99,113,149,162,195,209,221,242],"activating":[100],"redox-sensitive":[101],"proteins.":[102],"Umbilical":[103,170],"arteries":[105,171],"were":[106,180],"incubated":[107],"serum":[109,174,199],"from":[110,175,200],"healthy":[111],"COVID-19.":[117],"Vascular":[118],"function":[119],"was":[120,156,186,217],"assessed":[121,157],"using":[122],"concentration-effect":[123],"curves":[124],"serotonin":[126],"presence":[129,190],"absence":[131],"pharmacological":[133],"agents,":[134],"such":[135],"as":[136],"tocilizumab":[137,220],"(antibody":[138],"against":[139],"receptor),":[142],"tiron":[143],"(ROS":[144],"scavenger),":[145],"ML171":[146],"(Nox1":[147],"inhibitor),":[148],"Y27632":[150],"(Rho":[151],"kinase":[152,164,211,215,247],"inhibitor).":[153],"dihydroethidine":[160],"probe":[161],"Rho":[163,210,214,246],"activity":[165,216],"an":[167],"enzymatic":[168],"assay.":[169],"exposed":[172],"hyperreactive":[181],"serotonin.":[183],"effect":[185],"abolished":[187,218],"tocilizumab,":[192],"tiron,":[193],"ML171,":[194],"Y27632.":[196],"In":[197],"addition,":[198],"increased":[205],"Nox1-dependent":[206],"activity.":[212],"tiron.":[222],"Serum":[223],"promote":[230],"dysfunction.":[233],"key":[236],"Nox-linked":[238],"vascular":[239],"oxidative":[240],"stress":[241],"activation":[243],"pathway.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2023-02-04T00:00:00"}