{"id":"https://openalex.org/W4319009151","doi":"https://doi.org/10.1161/str.54.suppl_1.tp204","title":"Abstract TP204: Elimination Of Senescent Cells Prevents The Development Of Intracranial Aneurysm Rupture In Mice","display_name":"Abstract TP204: Elimination Of Senescent Cells Prevents The Development Of Intracranial Aneurysm Rupture In Mice","publication_year":2023,"publication_date":"2023-02-01","ids":{"openalex":"https://openalex.org/W4319009151","doi":"https://doi.org/10.1161/str.54.suppl_1.tp204"},"language":"en","primary_location":{"id":"doi:10.1161/str.54.suppl_1.tp204","doi":"https://doi.org/10.1161/str.54.suppl_1.tp204","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/str.54.suppl_1.tp204","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081803004","display_name":"Yushiro Take","orcid":"https://orcid.org/0000-0002-9512-1440","observed_orcids":["https://orcid.org/0000-0002-9512-1440"]},"institutions":[{"id":"https://openalex.org/I1324766304","display_name":"Barrow Neurological Institute","ror":"https://ror.org/01fwrsq33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324766304","https://openalex.org/I1325481341","https://openalex.org/I2802827176"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yushiro Take","raw_affiliation_strings":["barrow neurological institute, Phoenix, AZ","Yushiro Take barrow neurological institute, Phoenix, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"barrow neurological institute, Phoenix, AZ","institution_ids":["https://openalex.org/I1324766304"]},{"raw_affiliation_string":"Yushiro Take barrow neurological institute, Phoenix, AZ","institution_ids":["https://openalex.org/I1324766304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045564352","display_name":"Hiroki Sato","orcid":"https://orcid.org/0000-0002-1838-3797","observed_orcids":["https://orcid.org/0000-0002-1838-3797"]},"institutions":[{"id":"https://openalex.org/I4210132452","display_name":"Saitama International Medical Center","ror":"https://ror.org/03ftky336","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210132452"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroki Sato","raw_affiliation_strings":["Saitama International Med Cntr, Hidaka, Japan","Hiroki Sato Saitama International Med Cntr, Hidaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saitama International Med Cntr, Hidaka, Japan","institution_ids":["https://openalex.org/I4210132452"]},{"raw_affiliation_string":"Hiroki Sato Saitama International Med Cntr, Hidaka, Japan","institution_ids":["https://openalex.org/I4210132452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021649595","display_name":"Jinglu Ai","orcid":"https://orcid.org/0000-0001-7414-0207","observed_orcids":["https://orcid.org/0000-0001-7414-0207"]},"institutions":[{"id":"https://openalex.org/I4210149240","display_name":"Barber-Nichols (United States)","ror":"https://ror.org/03kq1sq34","country_code":"US","type":"company","lineage":["https://openalex.org/I4210149240"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinglu Ai","raw_affiliation_strings":["BNI, Phoenix, AZ","Jinglu Ai BNI, Phoenix, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BNI, Phoenix, AZ","institution_ids":[]},{"raw_affiliation_string":"Jinglu Ai BNI, Phoenix, AZ","institution_ids":["https://openalex.org/I4210149240"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael Lawton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Lawton","raw_affiliation_strings":["Phoenix, AZ","Michael Lawton Phoenix, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Phoenix, AZ","institution_ids":[]},{"raw_affiliation_string":"Michael Lawton Phoenix, AZ","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014880968","display_name":"Tomoki N Hashimoto","orcid":"https://orcid.org/0000-0002-6046-9148","observed_orcids":["https://orcid.org/0000-0002-6046-9148"]},"institutions":[{"id":"https://openalex.org/I1324766304","display_name":"Barrow Neurological Institute","ror":"https://ror.org/01fwrsq33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324766304","https://openalex.org/I1325481341","https://openalex.org/I2802827176"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tomoki N Hashimoto","raw_affiliation_strings":["Barrow Neurological Institute, Phoenix, AZ","Tomoki N Hashimoto Barrow Neurological Institute, Phoenix, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barrow Neurological Institute, Phoenix, AZ","institution_ids":["https://openalex.org/I1324766304"]},{"raw_affiliation_string":"Tomoki N Hashimoto Barrow Neurological Institute, Phoenix, AZ","institution_ids":["https://openalex.org/I1324766304"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"54","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10983","display_name":"Aortic aneurysm repair treatments","score":0.027699999511241913,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9589999914169312},{"id":"https://openalex.org/keywords/intracranial-aneurysm-rupture","display_name":"intracranial aneurysm rupture","score":0.9449999928474426},{"id":"https://openalex.org/keywords/senolytics","display_name":"senolytics","score":0.7490000128746033},{"id":"https://openalex.org/keywords/ganciclovir","display_name":"ganciclovir","score":0.9950000047683716},{"id":"https://openalex.org/keywords/senescence-associated-secretory-phenotype","display_name":"senescence-associated secretory phenotype","score":0.9769999980926514},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8029999732971191},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.7519999742507935},{"id":"https://openalex.org/keywords/elastase-induced-aneurysm","display_name":"elastase-induced aneurysm","score":0.8140000104904175},{"id":"https://openalex.org/keywords/systemic-hypertension","display_name":"systemic hypertension","score":0.7540000081062317},{"id":"https://openalex.org/keywords/aneurysm-prevention","display_name":"aneurysm prevention","score":0.7129999995231628},{"id":"https://openalex.org/keywords/aneurysm-rupture","display_name":"aneurysm rupture","score":0.5139999985694885}],"concepts":[{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.8909804821014404},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7482590675354004},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6385091543197632},{"id":"https://openalex.org/C2776098176","wikidata":"https://www.wikidata.org/wiki/Q189389","display_name":"Aneurysm","level":2,"score":0.6277341842651367},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3658694624900818},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32379382848739624},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30867457389831543},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2050725519657135}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/str.54.suppl_1.tp204","doi":"https://doi.org/10.1161/str.54.suppl_1.tp204","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/str.54.suppl_1.tp204","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4408448128","https://openalex.org/W4319008635","https://openalex.org/W4406992645","https://openalex.org/W3114520834","https://openalex.org/W4319006859","https://openalex.org/W7204557149","https://openalex.org/W3136105103","https://openalex.org/W6910377837","https://openalex.org/W3176360277","https://openalex.org/W7172283460"],"abstract_inverted_index":{"Introduction:":[0],"Aging":[1,12],"is":[2,24,104],"one":[3],"of":[4,29,52,69,80,87,118,126,145,172,229,265,278,290,299,309,312],"the":[5,67,85,91,124,143,154,175,182,204,216,226,232,235,239,247,255,269,282,291,297,306,310],"risk":[6],"factors":[7],"for":[8],"intracranial":[9,155,162],"aneurysm":[10,64,74,92,156,208,266,283,303,322],"rupture.":[11,65,93,304,323],"causes":[13],"various":[14],"changes":[15],"in":[16,109,131,150,178,187,225,246,268,286,321],"cellular":[17,20,31],"homeostasis,":[18],"including":[19],"senescence.":[21],"Cellular":[22],"senescence":[23,53,70,88,111,127,146,248,279,300,313],"defined":[25],"as":[26,215],"a":[27,49,105,169,262,287,317],"state":[28],"irreversible":[30],"growth":[32],"arrest.":[33],"Senescence":[34],"cells":[35,45,71,89,112,128,147,280,301,314],"secrete":[36],"pro-inflammatory":[37,78],"senescence-associated":[38],"secretory":[39],"phenotypes":[40],"(SASPs).":[41],"SASPs":[42],"affect":[43],"surrounding":[44],"and":[46,54,168,234],"contribute":[47],"to":[48,77,184],"vicious":[50],"cycle":[51],"induce":[55,73],"inflammation.":[56],"Recent":[57],"studies":[58],"strongly":[59],"suggest":[60,295],"that":[61,84,296],"inflammation":[62],"promotes":[63],"Therefore,":[66,305],"accumulation":[68,298,311],"may":[72,315],"rupture":[75,157,211,241,267,284],"due":[76],"effects":[79],"SASPs.":[81],"We":[82,160,180,200],"hypothesized":[83],"elimination":[86,125,144,277],"reduces":[90,153],"To":[94],"test":[95],"our":[96],"hypothesis":[97],"we":[98,140],"used":[99,214],"p16-3MR":[100,132,151,188],"mice.":[101,179],"P16-3MR":[102],"mouse":[103,107,288],"transgenic":[106],"model,":[108],"which":[110],"can":[113],"be":[114,316],"eliminated":[115],"by":[116,129,148,164],"treatment":[117,203],"ganciclovir":[119],"(GCV).":[120],"In":[121,137],"previous":[122],"reports,":[123],"GCV":[130,149,185,202,236],"mice":[133,152,191,250],"improved":[134],"senescence-related":[135],"diseases.":[136],"this":[138],"study,":[139],"tested":[141],"whether":[142],"rate.":[158],"Methods:":[159],"induced":[161],"aneurysms":[163,230],"combining":[165],"systemic":[166],"hypertension":[167],"single":[170],"injection":[171],"elastase":[173],"into":[174],"cerebrospinal":[176],"fluid":[177],"compared":[181],"vehicle":[183,194,233],"group":[186,271],"aged":[189],"male":[190],"(10-15":[192],"months,":[193],"vs":[195,198],"GCV:":[196],"9":[197],"6).":[199],"started":[201],"same":[205],"day":[206],"after":[207],"induction.":[209],"Aneurysm":[210],"rate":[212,228,242,285],"was":[213,221,243],"primary":[217],"endpoint.":[218],"Results:":[219],"There":[220],"no":[222],"statistical":[223],"difference":[224],"formation":[227],"between":[231],"group.":[237],"However,":[238],"aneurysmal":[240],"significantly":[244],"lower":[245],"cell-depleted":[249],"(P":[251,272],"<":[252,273],"0.05).":[253,274],"Additionally,":[254],"symptom-free":[256],"curve":[257],"(Kaplan-Meier":[258],"analysis":[259],"curve)":[260],"showed":[261],"significant":[263],"reduction":[264],"GCV-treated":[270],"Conclusions:":[275],"The":[276],"reduced":[281],"model":[289],"aneurysm.":[292],"Our":[293],"results":[294],"induces":[302],"pharmacological":[307],"prevention":[308],"new":[318],"therapeutic":[319],"target":[320]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-02-03T00:00:00"}