{"id":"https://openalex.org/W4319008679","doi":"https://doi.org/10.1161/str.54.suppl_1.tmp116","title":"Abstract TMP116: A Novel Microfluidic Model Of Ischemic Stroke Recapitulating Arterial Occlusion And Prolonged Retraction","display_name":"Abstract TMP116: A Novel Microfluidic Model Of Ischemic Stroke Recapitulating Arterial Occlusion And Prolonged Retraction","publication_year":2023,"publication_date":"2023-02-01","ids":{"openalex":"https://openalex.org/W4319008679","doi":"https://doi.org/10.1161/str.54.suppl_1.tmp116"},"language":"en","primary_location":{"id":"doi:10.1161/str.54.suppl_1.tmp116","doi":"https://doi.org/10.1161/str.54.suppl_1.tmp116","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/str.54.suppl_1.tmp116","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077556700","display_name":"Rassam M. G. Rassam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rassam Rassam","raw_affiliation_strings":["Univ of Pittsburgh, Pittsburgh, PA","Rassam Rassam Univ of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Rassam Rassam Univ of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022703051","display_name":"Emily P. Mihalko","orcid":"https://orcid.org/0000-0001-9580-1078","observed_orcids":["https://orcid.org/0000-0001-9580-1078"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Mihalko","raw_affiliation_strings":["Univ of Pittsburgh, Pittsburgh, PA","Emily Mihalko Univ of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Emily Mihalko Univ of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016424099","display_name":"Shahid Mehdi Nimjee","orcid":"https://orcid.org/0000-0002-0317-8731","observed_orcids":["https://orcid.org/0000-0002-0317-8731"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shahid M Nimjee","raw_affiliation_strings":["THE OHIO STATE UNIVERSITY MED CENTE, Columbus, OH","Shahid M Nimjee THE OHIO STATE UNIVERSITY MED CENTE, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"THE OHIO STATE UNIVERSITY MED CENTE, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Shahid M Nimjee THE OHIO STATE UNIVERSITY MED CENTE, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012799801","display_name":"Susan M. Shea","orcid":"https://orcid.org/0000-0003-3756-2747","observed_orcids":["https://orcid.org/0000-0003-3756-2747"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan M Shea","raw_affiliation_strings":["Dept of Surgery, Univ of Pittsburgh, Pittsburgh, PA","Susan M Shea Dept of Surgery, Univ of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Surgery, Univ of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Susan M Shea Dept of Surgery, Univ of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"54","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.4408999979496002,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.4408999979496002,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.3571999967098236,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.08630000054836273,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.9729999899864197},{"id":"https://openalex.org/keywords/thrombotic-occlusion","display_name":"thrombotic occlusion","score":0.8009999990463257},{"id":"https://openalex.org/keywords/thrombolysis","display_name":"thrombolysis","score":0.7680000066757202},{"id":"https://openalex.org/keywords/alteplase","display_name":"alteplase","score":0.9929999709129333},{"id":"https://openalex.org/keywords/microfluidic-model","display_name":"microfluidic model","score":0.8550000190734863},{"id":"https://openalex.org/keywords/ex-vivo-model","display_name":"ex vivo model","score":0.7789999842643738},{"id":"https://openalex.org/keywords/arterial-stenosis","display_name":"arterial stenosis","score":0.9449999928474426},{"id":"https://openalex.org/keywords/reperfusion","display_name":"reperfusion","score":0.8199999928474426},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.4300000071525574},{"id":"https://openalex.org/keywords/middle-cerebral-artery","display_name":"middle cerebral artery","score":0.6060000061988831},{"id":"https://openalex.org/keywords/platelet-imaging","display_name":"platelet imaging","score":0.44699999690055847}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8652102947235107},{"id":"https://openalex.org/C2781362458","wikidata":"https://www.wikidata.org/wiki/Q1588755","display_name":"Thrombus","level":2,"score":0.8415025472640991},{"id":"https://openalex.org/C2776268601","wikidata":"https://www.wikidata.org/wiki/Q968808","display_name":"Occlusion","level":2,"score":0.6864504814147949},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.5849138498306274},{"id":"https://openalex.org/C2779581417","wikidata":"https://www.wikidata.org/wiki/Q1931577","display_name":"Thrombolysis","level":3,"score":0.581634521484375},{"id":"https://openalex.org/C2780007028","wikidata":"https://www.wikidata.org/wiki/Q2343082","display_name":"Stenosis","level":2,"score":0.5094712376594543},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.47331273555755615},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.45859259366989136},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.45240527391433716},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.39601343870162964},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3411877751350403},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.31379711627960205},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2849353551864624},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.07415521144866943},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/str.54.suppl_1.tmp116","doi":"https://doi.org/10.1161/str.54.suppl_1.tmp116","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/str.54.suppl_1.tmp116","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W848775253","https://openalex.org/W4319015576","https://openalex.org/W6967238742","https://openalex.org/W4403847912","https://openalex.org/W1509236765","https://openalex.org/W6944278917","https://openalex.org/W2068892221","https://openalex.org/W4391448425","https://openalex.org/W2507824981","https://openalex.org/W6925065070"],"abstract_inverted_index":{"To":[0],"our":[1],"knowledge,":[2],"an":[3,68,290],"ex":[4,58,291],"vivo":[5,59,292],"model":[6],"of":[7,41,74,195,209,233,248,273,297],"thrombotic":[8],"occlusion":[9],"that":[10,51,212],"(1)":[11],"mimics":[12],"arterial":[13,299],"setting,":[14],"(2)":[15],"allows":[16],"true":[17],"occlusion,":[18,300],"and":[19,43,71,78,101,113,126,144,150,260,282,308,318],"(3)":[20],"drug":[21,306,319],"delivery":[22],"without":[23,236],"disturbing":[24],"the":[25,90,151,163,176,224,234],"thrombus":[26,235,245,301],"does":[27],"not":[28],"exist.":[29],"A":[30,65],"platform":[31,60],"with":[32,67,87,105,167,253,258,263,276,280,285],"these":[33,53],"capabilities":[34],"would":[35],"allow":[36],"for":[37,134,189,315],"high-throughput":[38],"mechanistic":[39,316],"study":[40,62],"thrombosis":[42],"thrombolysis.":[44,309],"Here":[45],"we":[46],"present":[47],"a":[48,56,72,118,180,215,242,271],"microfluidic":[49,82],"system":[50,295,311],"achieves":[52],"goals,":[54],"providing":[55],"biofidelic":[57],"to":[61,80,130,146,214,229],"ischemic":[63],"stroke.":[64],"mold":[66],"upstream":[69,232],"Y":[70,177],"region":[73],"stenosis":[75],"was":[76,94,121,173,227],"fabricated":[77],"used":[79,145,314],"manufacture":[81],"chambers.":[83],"Channels":[84],"were":[85,103,109,128,142],"coated":[86],"collagen":[88],"at":[89,111],"stenosis.":[91],"Heparinized":[92],"blood":[93],"collected":[95,116],"from":[96,162,223],"healthy":[97],"human":[98],"donors":[99],"(N=3)":[100],"platelets":[102],"labelled":[104],"fluorescent":[106],"anti-CD41.":[107],"Samples":[108],"perfused":[110,174],"10000/s":[112],"outflow":[114],"mass":[115,124],"on":[117],"scale.":[119],"Occlusion":[120],"indicated":[122],"by":[123,154],"plateau,":[125],"thrombi":[127,198],"left":[129],"retract":[131],"in":[132,157,241,244,270,303],"situ":[133,304],"0":[135],"or":[136,169],"6":[137,193,219,267],"hrs.":[138],"Kinetic":[139],"immunofluorescent":[140],"images":[141],"captured":[143],"derive":[147],"surface":[148,246],"area":[149,247],"image":[152],"profile":[153],"averaging":[155],"MFI":[156,202,210],"each":[158],"pixel":[159],"column.":[160],"Sample":[161],"same":[164,225],"donor":[165,226],"dosed":[166],"0.7":[168],"7nM":[170],"alteplase":[171],"(ALT)":[172],"using":[175,179],"inlet":[178],"constant":[181],"pressure":[182],"head":[183],"(1000/s;":[184],"mimicking":[185],"middle":[186],"cerebral":[187],"artery)":[188],"120":[190],"min.":[191],"After":[192],"hours":[194],"post-occlusion":[196,211],"retraction,":[197],"substantially":[199],"remodeled.":[200],"The":[201],"curves":[203],"(Fig":[204],"1)":[205],"demonstrate":[206],"even":[207],"distribution":[208],"shifts":[213],"central":[216],"peak":[217],"after":[218,266],"hr.":[220],"Dosed":[221],"sample":[222],"able":[228],"be":[230,313],"delivered":[231],"disruption.":[237],"Immediate":[238],"reperfusion":[239],"resulted":[240,269],"reduction":[243,272],"(mean":[249],"(SD))":[250],"2%":[251],"(10%)":[252],"0.7nM":[254],"ALT,":[255],"23%":[256],"(7%)":[257],"7nM,":[259,281],"15%":[261],"(1%)":[262],"vehicle.":[264,286],"Reperfusion":[265],"hrs":[268],"14%":[274],"(14%)":[275],"0.7nM,":[277],"45%":[278],"(12%)":[279],"17%":[283],"(8%)":[284],"We":[287],"have":[288],"established":[289],"high":[293],"throughput":[294],"capable":[296],"recapitulating":[298],"retraction":[302],",":[305],"delivery,":[307],"This":[310],"can":[312],"inquiry":[317],"discovery.":[320]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2023-02-03T00:00:00"}