{"id":"https://openalex.org/W4318955873","doi":"https://doi.org/10.2337/figshare.21892743.v1","title":"Association of Elevated Arterial Stiffness with Cardiac Target Organ Damage and Cardiac Autonomic Neuropathy in Young Adults with Diabetes: The SEARCH for Diabetes in Youth Study","display_name":"Association of Elevated Arterial Stiffness with Cardiac Target Organ Damage and Cardiac Autonomic Neuropathy in Young Adults with Diabetes: The SEARCH for Diabetes in Youth Study","publication_year":2023,"publication_date":"2023-02-02","ids":{"openalex":"https://openalex.org/W4318955873","doi":"https://doi.org/10.2337/figshare.21892743.v1"},"language":"en","primary_location":{"id":"doi:10.2337/figshare.21892743.v1","doi":"https://doi.org/10.2337/figshare.21892743.v1","is_oa":true,"landing_page_url":"https://doi.org/10.2337/figshare.21892743.v1","pdf_url":null,"source":null,"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Diabetes Association","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.2337/figshare.21892743.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049330077","display_name":"Elaine M. Urbina","orcid":"https://orcid.org/0000-0002-5640-6777","observed_orcids":["https://orcid.org/0000-0002-5640-6777"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elaine M. Urbina","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079840473","display_name":"Scott P. Isom","orcid":"https://orcid.org/0000-0002-6658-3865","observed_orcids":["https://orcid.org/0000-0002-6658-3865"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scott Isom","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086940958","display_name":"Dana Dabelea","orcid":"https://orcid.org/0000-0001-9514-8929","observed_orcids":["https://orcid.org/0000-0001-9514-8929"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dana Dabelea","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Ralph D\u2019Agostino, Jr.","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ralph D\u2019Agostino, Jr.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062687198","display_name":"Stephen R. Daniels","orcid":"https://orcid.org/0000-0001-5520-6952","observed_orcids":["https://orcid.org/0000-0001-5520-6952"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen R. Daniels","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052455098","display_name":"Lawrence M. Dolan","orcid":"https://orcid.org/0000-0002-5359-0636","observed_orcids":["https://orcid.org/0000-0002-5359-0636"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lawrence M. Dolan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047563318","display_name":"Giuseppina Imperatore","orcid":"https://orcid.org/0000-0001-7074-8178","observed_orcids":["https://orcid.org/0000-0001-7074-8178"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giuseppina Imperatore","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068686599","display_name":"Eva Lustigova","orcid":"https://orcid.org/0000-0002-6719-6090","observed_orcids":["https://orcid.org/0000-0002-6719-6090"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eva Lustigova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067464347","display_name":"Santica M. Marcovina","orcid":"https://orcid.org/0000-0002-9118-8488","observed_orcids":["https://orcid.org/0000-0002-9118-8488"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Santica Marcovina","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009128263","display_name":"Amy K. Mottl","orcid":"https://orcid.org/0000-0002-4258-1726","observed_orcids":["https://orcid.org/0000-0002-4258-1726"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amy Mottl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037503691","display_name":"Catherine Pihoker","orcid":"https://orcid.org/0000-0001-9074-7770","observed_orcids":["https://orcid.org/0000-0001-9074-7770"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Catherine Pihoker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5047114937","display_name":"AMY SANGHAVI SHAH","orcid":"https://orcid.org/0000-0001-7297-139X","observed_orcids":["https://orcid.org/0000-0001-7297-139X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amy S Shah","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.8744999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.8744999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.12120000272989273,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arterial-stiffness","display_name":"arterial stiffness","score":1.0},{"id":"https://openalex.org/keywords/cardiac-autonomic-neuropathy","display_name":"cardiac autonomic neuropathy","score":0.996999979019165},{"id":"https://openalex.org/keywords/youth-onset-diabetes","display_name":"youth-onset diabetes","score":0.9449999928474426},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.8960000276565552},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":1.0},{"id":"https://openalex.org/keywords/young-adults","display_name":"young adults","score":0.8859999775886536},{"id":"https://openalex.org/keywords/left-ventricular-mass","display_name":"left ventricular mass","score":0.9200000166893005},{"id":"https://openalex.org/keywords/diastolic-function","display_name":"diastolic function","score":0.8090000152587891},{"id":"https://openalex.org/keywords/systolic-function","display_name":"systolic function","score":0.9300000071525574},{"id":"https://openalex.org/keywords/search-for-diabetes-in-youth-study","display_name":"SEARCH for Diabetes in Youth","score":0.8600000143051147}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8401895761489868},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7787927389144897},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.7737849354743958},{"id":"https://openalex.org/C2775850156","wikidata":"https://www.wikidata.org/wiki/Q4797538","display_name":"Arterial stiffness","level":3,"score":0.6443524956703186},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.6115206480026245},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.6037070751190186},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5765440464019775},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.4973130524158478},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.48995843529701233},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.47418293356895447},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.4732416570186615},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.44915997982025146},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.41860640048980713},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.3325563073158264},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.24433273077011108}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2337/figshare.21892743.v1","doi":"https://doi.org/10.2337/figshare.21892743.v1","is_oa":true,"landing_page_url":"https://doi.org/10.2337/figshare.21892743.v1","pdf_url":null,"source":null,"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Diabetes Association","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.2337/figshare.21892743.v1","doi":"https://doi.org/10.2337/figshare.21892743.v1","is_oa":true,"landing_page_url":"https://doi.org/10.2337/figshare.21892743.v1","pdf_url":null,"source":null,"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Diabetes Association","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4281662707","https://openalex.org/W1630172557","https://openalex.org/W2808896335","https://openalex.org/W2916199430","https://openalex.org/W2948756954","https://openalex.org/W2153455246","https://openalex.org/W2070684671","https://openalex.org/W7100089996","https://openalex.org/W1632888466","https://openalex.org/W4282942533"],"abstract_inverted_index":{"Background:":[0],"Adults":[1],"with":[2,32,40,48,114,131,187,193],"diabetes":[3,82,89,124],"are":[4],"at":[5],"risk":[6,156],"of":[7,68],"cardiovascular":[8],"(CV)":[9],"events,":[10],"possibly":[11],"due":[12],"to":[13,25,108,200],"increased":[14,55],"arterial":[15],"stiffness":[16],"(AS)":[17],"and":[18,60,101,117,119,144,162,181],"cardiac":[19,33,115,132,188,205],"autonomic":[20],"neuropathy":[21],"(CAN).":[22],"We":[23],"sought":[24],"determine":[26,109],"if":[27,110,120],"1)":[28],"AS":[29,56,100,111,127,161,184,196],"is":[30,46,185],"associated":[31,47,113,130,186],"target":[34],"organ":[35],"damage":[36],"in":[37,57,77,178,190,207],"young":[38,191],"adults":[39,192],"youth-onset":[41],"diabetes,":[42],"2)":[43],"whether":[44,62],"CAN":[45,102,118,163],"AS,":[49],"as":[50],"one":[51],"possible":[52],"etiology":[53,203],"for":[54,75,154,204],"this":[58,208],"cohort,":[59],"3)":[61],"these":[63],"relationships":[64,121,174],"differed":[65,122],"by":[66,123],"type":[67,87],"diabetes.":[69,194],"Methods:":[70],"Participants":[71],"from":[72],"the":[73],"SEARCH":[74],"Diabetes":[76],"Youth":[78],"Study":[79],"(type":[80],"1":[81],"mellitus,":[83,90],"T1D":[84,180],"=":[85,92],"222,":[86],"2":[88],"T2D":[91],"177,":[93],"mean":[94],"23":[95],"years)":[96],"had":[97],"clinical,":[98],"echocardiographic,":[99],"assessed.":[103],"Linear":[104],"regression":[105],"was":[106,112,128,164],"performed":[107],"changes":[116,189],"type.":[125],"Results:":[126],"significantly":[129],"structure":[133],"(left":[134],"ventricular":[135],"mass":[136],"index,":[137],"p<0.0001),":[138],"systolic":[139],"function":[140,146],"(ejection":[141],"fraction,":[142],"p=0.03)":[143],"diastolic":[145],"(E/A":[147],"ratio,":[148],"p=0.008;":[149],"e\u2019/a\u2019,":[150],"p=0.02)":[151],"after":[152],"adjustments":[153],"CV":[155],"factors.":[157],"The":[158],"association":[159],"between":[160],"not":[165,198],"significant":[166],"when":[167],"other":[168],"important":[169],"covariates":[170],"were":[171,175],"added.":[172],"These":[173],"mostly":[176],"similar":[177],"both":[179],"T2D.":[182],"Conclusions:":[183],"CAN-induced":[195],"does":[197],"appear":[199],"be":[201],"an":[202],"abnormalities":[206],"cohort.":[209]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2023-02-03T00:00:00"}