{"id":"https://openalex.org/W4318940698","doi":"https://doi.org/10.1530/endoabs.89.b2","title":"Multiple Layers of Epigenetic Regulation Cooperate to Silence Expression of Somatostatin Receptor Type 2 in Pancreatic Neuroendocrine Tumors","display_name":"Multiple Layers of Epigenetic Regulation Cooperate to Silence Expression of Somatostatin Receptor Type 2 in Pancreatic Neuroendocrine Tumors","publication_year":2023,"publication_date":"2023-02-01","ids":{"openalex":"https://openalex.org/W4318940698","doi":"https://doi.org/10.1530/endoabs.89.b2"},"language":"en","primary_location":{"id":"doi:10.1530/endoabs.89.b2","doi":"https://doi.org/10.1530/endoabs.89.b2","is_oa":false,"landing_page_url":"https://doi.org/10.1530/endoabs.89.b2","pdf_url":null,"source":{"id":"https://openalex.org/S4306509401","display_name":"Endocrine Abstracts","issn_l":"1470-3947","issn":["1470-3947","1479-6848","2046-0368"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Abstracts","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014881195","display_name":"James P. Madigan","orcid":"https://orcid.org/0000-0002-0503-3704","observed_orcids":["https://orcid.org/0000-0002-0503-3704"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James P. Madigan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101737246","display_name":"Rupali Sharma","orcid":"https://orcid.org/0000-0002-0733-1270","observed_orcids":["https://orcid.org/0000-0002-0733-1270"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rupali Sharma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035119201","display_name":"Ethan Mondell","orcid":"https://orcid.org/0000-0002-2534-6206","observed_orcids":["https://orcid.org/0000-0002-2534-6206"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ethan Mondell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5050780818","display_name":"Samira Mercedes Sadowski","orcid":"https://orcid.org/0000-0002-7538-9431","observed_orcids":["https://orcid.org/0000-0002-7538-9431"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samira M. Sadowski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.7993000149726868,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.7993000149726868,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.05920000001788139,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.0215000007301569,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/somatostatin-receptor-2","display_name":"somatostatin receptor 2","score":0.9380000233650208},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.8360000252723694},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.890999972820282},{"id":"https://openalex.org/keywords/pancreatic-neuroendocrine-tumors","display_name":"pancreatic neuroendocrine tumors","score":0.9739999771118164},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.5199999809265137}],"concepts":[{"id":"https://openalex.org/C80115893","wikidata":"https://www.wikidata.org/wiki/Q2067077","display_name":"Somatostatin receptor","level":3,"score":0.7949678897857666},{"id":"https://openalex.org/C2781115785","wikidata":"https://www.wikidata.org/wiki/Q502261","display_name":"Silence","level":2,"score":0.7265976667404175},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6659345626831055},{"id":"https://openalex.org/C2776297358","wikidata":"https://www.wikidata.org/wiki/Q407166","display_name":"Somatostatin","level":2,"score":0.6269767880439758},{"id":"https://openalex.org/C150008808","wikidata":"https://www.wikidata.org/wiki/Q18031731","display_name":"Somatostatin receptor 2","level":4,"score":0.5278249382972717},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49097731709480286},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.48896491527557373},{"id":"https://openalex.org/C2779066768","wikidata":"https://www.wikidata.org/wiki/Q1981276","display_name":"Neuroendocrine tumors","level":2,"score":0.4634988009929657},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4403310716152191},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.43287304043769836},{"id":"https://openalex.org/C64980429","wikidata":"https://www.wikidata.org/wiki/Q18031730","display_name":"Somatostatin receptor 1","level":5,"score":0.4140126705169678},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4076331853866577},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.36338454484939575},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33551478385925293},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2532852292060852},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1443006694316864},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1088402271270752},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08464416861534119},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.06225180625915527},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1530/endoabs.89.b2","doi":"https://doi.org/10.1530/endoabs.89.b2","is_oa":false,"landing_page_url":"https://doi.org/10.1530/endoabs.89.b2","pdf_url":null,"source":{"id":"https://openalex.org/S4306509401","display_name":"Endocrine Abstracts","issn_l":"1470-3947","issn":["1470-3947","1479-6848","2046-0368"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Abstracts","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4414523665","https://openalex.org/W4318942345","https://openalex.org/W2176047322","https://openalex.org/W2400120669","https://openalex.org/W7167366250","https://openalex.org/W2322930168","https://openalex.org/W2093358435","https://openalex.org/W2899696815","https://openalex.org/W4408303179","https://openalex.org/W1446470811"],"abstract_inverted_index":{"Searchable":[0],"abstracts":[1],"of":[2],"presentations":[3],"at":[4],"key":[5],"conferences":[6],"in":[7],"endocrinology":[8],"ISSN":[9,13],"1470-3947":[10],"(print)":[11],"|":[12],"1479-6848":[14],"(online)":[15]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2023-02-03T00:00:00"}