{"id":"https://openalex.org/W4318933958","doi":"https://doi.org/10.1093/bjs/znac434","title":"Influence of beta-blockers and other non-cancer drugs on outcomes after pancreatic cancer resection","display_name":"Influence of beta-blockers and other non-cancer drugs on outcomes after pancreatic cancer resection","publication_year":2023,"publication_date":"2023-02-02","ids":{"openalex":"https://openalex.org/W4318933958","doi":"https://doi.org/10.1093/bjs/znac434","pmid":"https://pubmed.ncbi.nlm.nih.gov/36726045"},"language":"en","primary_location":{"id":"doi:10.1093/bjs/znac434","doi":"https://doi.org/10.1093/bjs/znac434","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bjs/znac434","pdf_url":"https://academic.oup.com/bjs/article-pdf/110/4/498/49704634/znac434.pdf","source":{"id":"https://openalex.org/S61740008","display_name":"British journal of surgery","issn_l":"0007-1323","issn":["0007-1323","1365-2168"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Surgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bjs/article-pdf/110/4/498/49704634/znac434.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079109239","display_name":"Felix Jakob H\u00fcttner","orcid":"https://orcid.org/0000-0002-2299-964X","observed_orcids":["https://orcid.org/0000-0002-2299-964X"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Felix J H\u00fcttner","raw_affiliation_strings":["Department of General and Visceral Surgery, Ulm University Hospital , Ulm , Germany","Department of General, Visceral and Transplantation Surgery, University of Heidelberg , Heidelberg , Germany"],"raw_orcid":"https://orcid.org/0000-0002-2299-964X","affiliations":[{"raw_affiliation_string":"Department of General and Visceral Surgery, Ulm University Hospital , Ulm , Germany","institution_ids":["https://openalex.org/I4210155144"]},{"raw_affiliation_string":"Department of General, Visceral and Transplantation Surgery, University of Heidelberg , Heidelberg , Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085816944","display_name":"Marius Mauch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marius Mauch","raw_affiliation_strings":["Department of General, Visceral and Transplantation Surgery, University of Heidelberg , Heidelberg , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General, Visceral and Transplantation Surgery, University of Heidelberg , Heidelberg , Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025194090","display_name":"Max Heckler","orcid":"https://orcid.org/0000-0003-3213-5068","observed_orcids":["https://orcid.org/0000-0003-3213-5068"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Max Heckler","raw_affiliation_strings":["Department of General, Visceral and Transplantation Surgery, University of Heidelberg , Heidelberg , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General, Visceral and Transplantation Surgery, University of Heidelberg , Heidelberg , Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000483058","display_name":"Thilo Hackert","orcid":"https://orcid.org/0000-0002-7012-1196","observed_orcids":["https://orcid.org/0000-0002-7012-1196"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thilo Hackert","raw_affiliation_strings":["Department of General, Visceral and Transplantation Surgery, University of Heidelberg , Heidelberg , Germany"],"raw_orcid":"https://orcid.org/0000-0002-7012-1196","affiliations":[{"raw_affiliation_string":"Department of General, Visceral and Transplantation Surgery, University of Heidelberg , Heidelberg , Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036032282","display_name":"Markus Wolfgang B\u00fcchler","orcid":"https://orcid.org/0000-0002-3666-5675","observed_orcids":["https://orcid.org/0000-0002-3666-5675"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Markus W B\u00fcchler","raw_affiliation_strings":["Department of General, Visceral and Transplantation Surgery, University of Heidelberg , Heidelberg , Germany"],"raw_orcid":"https://orcid.org/0000-0002-3666-5675","affiliations":[{"raw_affiliation_string":"Department of General, Visceral and Transplantation Surgery, University of Heidelberg , Heidelberg , Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018838202","display_name":"Pascal Probst","orcid":"https://orcid.org/0000-0002-0895-4015","observed_orcids":["https://orcid.org/0000-0002-0895-4015"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210151503","display_name":"Spital Thurgau (Switzerland)","ror":"https://ror.org/04qnzk495","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210151503"]},{"id":"https://openalex.org/I4210167399","display_name":"Kantonsspital Frauenfeld","ror":"https://ror.org/05yabwx33","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210151503","https://openalex.org/I4210167399"]}],"countries":["CH","DE"],"is_corresponding":false,"raw_author_name":"Pascal Probst","raw_affiliation_strings":["Department of General, Visceral and Transplantation Surgery, University of Heidelberg , Heidelberg , Germany","Department of Surgery, Cantonal Hospital Thurgau , Frauenfeld , Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-0895-4015","affiliations":[{"raw_affiliation_string":"Department of General, Visceral and Transplantation Surgery, University of Heidelberg , Heidelberg , Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"Department of Surgery, Cantonal Hospital Thurgau , Frauenfeld , Switzerland","institution_ids":["https://openalex.org/I4210151503","https://openalex.org/I4210167399"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029412852","display_name":"Markus K. Diener","orcid":"https://orcid.org/0000-0003-0319-3090","observed_orcids":["https://orcid.org/0000-0003-0319-3090"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus K Diener","raw_affiliation_strings":["Department of General and Visceral Surgery, University Medical Centre Freiburg , Freiburg , Germany","Department of General, Visceral and Transplantation Surgery, University of Heidelberg , Heidelberg , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General and Visceral Surgery, University Medical Centre Freiburg , Freiburg , Germany","institution_ids":["https://openalex.org/I2801240073"]},{"raw_affiliation_string":"Department of General, Visceral and Transplantation Surgery, University of Heidelberg , Heidelberg , Germany","institution_ids":["https://openalex.org/I223822909"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5036032282"],"corresponding_institution_ids":["https://openalex.org/I223822909"],"apc_list":{"value":3039,"currency":"GBP","value_usd":3780},"apc_paid":null,"fwci":0.8669,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.71398489,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"110","issue":"4","first_page":"498","last_page":"499"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12020","display_name":"Enhanced Recovery After Surgery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.8330000042915344},{"id":"https://openalex.org/keywords/pancreatic-cancer-surgery","display_name":"pancreatic cancer surgery","score":0.7979999780654907},{"id":"https://openalex.org/keywords/perioperative-medication","display_name":"perioperative drug therapy","score":0.6570000052452087},{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.9459999799728394},{"id":"https://openalex.org/keywords/cyclooxygenase-inhibitors","display_name":"cyclooxygenase inhibitors","score":0.8510000109672546},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.8379999995231628},{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.871999979019165},{"id":"https://openalex.org/keywords/angiotensin-receptor-blockers","display_name":"angiotensin receptor blockers","score":0.890999972820282},{"id":"https://openalex.org/keywords/calcium-channel-blockers","display_name":"calcium channel blockers","score":0.9950000047683716},{"id":"https://openalex.org/keywords/postoperative-morbidity","display_name":"postoperative morbidity","score":0.8330000042915344},{"id":"https://openalex.org/keywords/postoperative-mortality","display_name":"postoperative mortality","score":0.9670000076293945},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.968999981880188},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.8080000281333923},{"id":"https://openalex.org/keywords/perioperative-stress-response","display_name":"perioperative stress response","score":0.6010000109672546},{"id":"https://openalex.org/keywords/pancreatic-fistula","display_name":"pancreatic fistula","score":0.6880000233650208}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9797286987304688},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.7430416345596313},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5808324813842773},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.5661288499832153},{"id":"https://openalex.org/C159110652","wikidata":"https://www.wikidata.org/wiki/Q17078201","display_name":"Resection","level":2,"score":0.503361165523529},{"id":"https://openalex.org/C3020340455","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Cancer drugs","level":3,"score":0.4677116274833679},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4349023401737213},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4255684018135071},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2930254340171814},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bjs/znac434","doi":"https://doi.org/10.1093/bjs/znac434","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bjs/znac434","pdf_url":"https://academic.oup.com/bjs/article-pdf/110/4/498/49704634/znac434.pdf","source":{"id":"https://openalex.org/S61740008","display_name":"British journal of surgery","issn_l":"0007-1323","issn":["0007-1323","1365-2168"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Surgery","raw_type":"journal-article"},{"id":"pmid:36726045","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36726045","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of surgery","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/bjs/znac434","doi":"https://doi.org/10.1093/bjs/znac434","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bjs/znac434","pdf_url":"https://academic.oup.com/bjs/article-pdf/110/4/498/49704634/znac434.pdf","source":{"id":"https://openalex.org/S61740008","display_name":"British journal of surgery","issn_l":"0007-1323","issn":["0007-1323","1365-2168"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Surgery","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4318933958.pdf","grobid_xml":"https://content.openalex.org/works/W4318933958.grobid-xml"},"referenced_works_count":5,"referenced_works":["https://openalex.org/W2883488884","https://openalex.org/W2892830226","https://openalex.org/W2894574865","https://openalex.org/W3089876597","https://openalex.org/W3192882316"],"related_works":["https://openalex.org/W4388570687","https://openalex.org/W7131416623","https://openalex.org/W2997226056","https://openalex.org/W2610295697","https://openalex.org/W7118165899","https://openalex.org/W3044579423","https://openalex.org/W3089876597","https://openalex.org/W3119816362","https://openalex.org/W6921118562","https://openalex.org/W2576741810"],"abstract_inverted_index":{"The":[0,13,211,257,389,417,466,504,591,598],"mainstay":[1],"of":[2,30,54,65,78,87,114,131,152,190,200,214,222,245,409,414,443,570,603],"therapy":[3,233,445],"for":[4,62,118,185,195,290,355,486,548],"pancreatic":[5,82,119,196,276,588],"cancer":[6,197,454,589],"with":[7,425,446,507,521],"curative":[8],"intent":[9],"remains":[10],"surgical":[11],"resection.":[12],"perioperative":[14,73,110,546],"phase":[15,547],"is":[16,59,518,554,565],"characterized":[17],"by":[18,26,45,162,490],"physiological":[19],"and":[20,32,48,67,105,112,138,141,177,220,236,249,253,265,283,303,346,360,384,450,480,500,575],"psychological":[21],"stress":[22],"reactions":[23],"mediated":[24],"mainly":[25],"an":[27,241],"excess":[28],"release":[29],"catecholamines":[31],"prostaglandins,":[33],"which":[34,473,517,564],"may":[35,579],"have":[36,240,438,580,593],"protumorigenic":[37],"effects1.":[38],"These":[39,456],"effects":[40,457],"could":[41,458],"potentially":[42,509],"be":[43,460,484,533],"inhibited":[44],"usual":[46],"beta-blockers":[47,66,288],"cyclo-oxygenase":[49],"(COX)":[50],"inhibitors":[51],"in":[52,71,267,320,342,348,358,462,469,477,494,496,519,536,558,584],"terms":[53],"drug":[55],"repurposing,":[56],"but":[57],"there":[58],"conflicting":[60],"evidence":[61],"the":[63,72,79,85,129,132,150,163,167,215,223,321,336,343,349,463,470,478,487,491,497,545,559,568],"influence":[64,86,130,151,261],"other":[68,178,254,327,540],"non-cancer":[69],"drugs":[70],"setting.":[74],"This":[75],"retrospective":[76],"analysis":[77,413,418],"institution\u2019s":[80],"prospective":[81],"database":[83],"assessed":[84],"beta-blockers,":[88],"acetylsalicylic":[89,306],"acid":[90,307],"as":[91,93,275],"well":[92],"their":[94,501],"combined":[95],"use,":[96,516],"angiotensin-converting":[97,430],"inhibitors/angiotensin":[98],"II":[99],"receptor":[100,434],"type":[101],"1":[102,158,160],"antagonists,":[103],"statins,":[104],"calcium":[106],"channel":[107],"blockers":[108],"on":[109,135,155,262,271,333,339,512],"outcome":[111],"survival":[113,319,323,340,416,467,513],"patients":[115,224,495,586],"undergoing":[116,193,587],"resection":[117,194,386],"cancer.":[120],"A":[121,188],"logistic":[122],"regression":[123,144,412],"model":[124],"was":[125,181,217,394,474,514],"used":[126],"to":[127,148,183,239,298,311,405,448,532,543,596],"assess":[128],"different":[133],"medications":[134,258,328],"postoperative":[136,263],"morbidity":[137,264],"mortality.":[139],"Univariable":[140],"multivariable":[142,344,363],"Cox":[143],"models":[145],"were":[146,198,206,228,234,368],"computed":[147],"evaluate":[149],"individual":[153],"variables":[154,168],"survival.":[156,334],"Furthermore,":[157],":":[159],"matching":[161],"nearest-neighbour":[164],"method,":[165],"considering":[166],"age,":[169],"sex,":[170],"AJCC":[171,381],"stage,":[172],"ASA":[173,242,376],"grade,":[174],"arterial":[175],"hypertension,":[176],"cardiovascular":[179,255],"co-morbidities,":[180,250],"performed":[182],"adjust":[184],"baseline":[186,356],"imbalances.":[187],"total":[189],"914":[191,420],"adults":[192],"analysed,":[199],"whom":[201],"263":[202],"(28.8":[203],"per":[204,226,294,401],"cent)":[205,227],"receiving":[207],"concurrent":[208,395],"beta-blocker":[209,232,444,498],"therapy.":[210,550],"mean(s.d.)":[212],"age":[213,359,369],"cohort":[216,352],"65.6(10.3)":[218],"years":[219],"422":[221],"(46.2":[225],"women.":[229],"Patients":[230,286],"under":[231],"older,":[235],"more":[237],"likely":[238],"fitness":[243],"grade":[244,377],"III":[246,378],"or":[247,379],"higher":[248],"especially":[251],"hypertension":[252],"co-morbidities.":[256,361],"had":[259,330],"no":[260,269,331,594,601],"mortality,":[266],"particular":[268],"effect":[270,442,511,583],"pancreas-specific":[272],"complications":[273],"such":[274,552],"fistula,":[277],"postpancreatectomy":[278],"haemorrhage,":[279],"delayed":[280],"gastric":[281],"emptying,":[282],"intra-abdominal":[284],"abscess.":[285],"using":[287],"(HR":[289,308,398],"death":[291],"1.19,":[292],"95":[293,400],"cent":[295,402],"c.i.":[296,403],"1.00":[297],"1.41;":[299],"P":[300,313],"=":[301,314],"0.047)":[302],"those":[304],"taking":[305],"1.24,":[309],"1.01":[310],"1.54;":[312],"0.044)":[315],"showed":[316],"impaired":[317],"overall":[318,415],"unadjusted":[322,471],"analyses,":[324,472,482],"whereas":[325],"all":[326],"investigated":[329,557],"impact":[332,338],"However,":[335],"negative":[337,365],"diminished":[341],"analysis,":[345,364],"also":[347],"propensity":[350],"score-matched":[351],"after":[353,453],"adjusting":[354],"imbalances":[357],"In":[362],"prognostic":[366,392],"factors":[367],"at":[370],"least":[371],"67":[372],"years,":[373],"neoadjuvant":[374],"therapy,":[375],"higher,":[380],"stage":[382],"III,":[383],"R1":[385],"(Fig.":[387],"1).":[388],"only":[390,505],"positive":[391,441,510,582],"factor":[393],"statin":[396,515],"use":[397],"0.76,":[399],"0.58":[404],"0.99).":[406],"Forest":[407],"plot":[408],"multivariate":[410],"cox":[411],"included":[419],"patients.":[421],"HRs":[422],"are":[423],"shown":[424],"95%":[426],"confidence":[427],"intervals.":[428],"ACE,":[429],"enzyme;":[431],"ARB,":[432],"angiotensin":[433],"blocker.":[435],"Several":[436],"studies":[437,538],"reported":[439],"a":[440,508,522,572,577,581],"regard":[447],"short-term2":[449],"long-term3":[451],"outcomes":[452],"surgery.":[455],"not":[459,475],"reproduced":[461],"present":[464,476],"study.":[465],"difference":[468],"adjusted":[479],"matched":[481],"can":[483],"explained":[485],"main":[488],"part":[489],"greater":[492],"co-morbidity":[493],"group":[499],"older":[502],"age.":[503],"medication":[506],"line":[520],"recent":[523],"population-based":[524],"study":[525],"from":[526],"Norway4.":[527],"Nevertheless,":[528],"this":[529],"finding":[530],"needs":[531],"further":[534],"explored":[535],"future":[537],"alongside":[539],"innovative":[541],"approaches":[542],"harnessing":[544],"cancer-directed":[549],"One":[551],"approach":[553],"currently":[555],"being":[556],"randomized":[560],"controlled":[561],"PROSPER":[562],"trial,":[563],"assessing":[566],"whether":[567],"combination":[569],"propranolol,":[571],"non-selective":[573],"beta-blocker,":[574],"etodolac,":[576],"COX-2-inhibitor,":[578],"beta-blocker-naive":[585],"surgery5.":[590],"authors":[592,599],"funding":[595],"declare.":[597],"declare":[600],"conflict":[602],"interest.":[604]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-02-03T00:00:00"}