{"id":"https://openalex.org/W4318924230","doi":"https://doi.org/10.1093/mr/road018","title":"Clinical disease activity is a major determinant of plasma D-dimer elevation in outpatients with rheumatoid arthritis: A hospital-based cross-sectional study","display_name":"Clinical disease activity is a major determinant of plasma D-dimer elevation in outpatients with rheumatoid arthritis: A hospital-based cross-sectional study","publication_year":2023,"publication_date":"2023-02-02","ids":{"openalex":"https://openalex.org/W4318924230","doi":"https://doi.org/10.1093/mr/road018","pmid":"https://pubmed.ncbi.nlm.nih.gov/36726243"},"language":"en","primary_location":{"id":"doi:10.1093/mr/road018","doi":"https://doi.org/10.1093/mr/road018","is_oa":true,"landing_page_url":"https://doi.org/10.1093/mr/road018","pdf_url":"https://academic.oup.com/mr/advance-article-pdf/doi/10.1093/mr/road018/49315010/road018.pdf","source":{"id":"https://openalex.org/S30446230","display_name":"Modern Rheumatology","issn_l":"1439-7595","issn":["1439-7595","1439-7609"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern Rheumatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/mr/advance-article-pdf/doi/10.1093/mr/road018/49315010/road018.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019043029","display_name":"Shunsuke Mori","orcid":"https://orcid.org/0000-0001-7972-4252","observed_orcids":["https://orcid.org/0000-0001-7972-4252","https://orcid.org/0009-0004-7784-1796"]},"institutions":[{"id":"https://openalex.org/I4210137409","display_name":"National Hospital Organization","ror":"https://ror.org/03ntccx93","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210137409"]},{"id":"https://openalex.org/I4210165499","display_name":"Kumamoto Medical Center","ror":"https://ror.org/05sy5w128","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4210165499"]},{"id":"https://openalex.org/I4405254003","display_name":"Kumamoto Saishun Medical Center","ror":"https://ror.org/01a2cdx51","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405254003"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Shunsuke Mori","raw_affiliation_strings":["Department of Rheumatology, Clinical Research Center for Rheumatic Diseases, National Hospital Organization Kumamoto Saishun Medical Center , Kohshi, Kumamoto, Japan"],"raw_orcid":"https://orcid.org/0000-0001-7972-4252","affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Clinical Research Center for Rheumatic Diseases, National Hospital Organization Kumamoto Saishun Medical Center , Kohshi, Kumamoto, Japan","institution_ids":["https://openalex.org/I4210137409","https://openalex.org/I4210165499","https://openalex.org/I4405254003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015115080","display_name":"Hirofumi Soejima","orcid":"https://orcid.org/0000-0002-7520-2008","observed_orcids":["https://orcid.org/0000-0002-7520-2008"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirofumi Soejima","raw_affiliation_strings":["Department of Cardiovascular Medicine, Graduate School of Medical Sciences and Health Care Center, Kumamoto University , Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences and Health Care Center, Kumamoto University , Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002929771","display_name":"Jun Hokamaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137409","display_name":"National Hospital Organization","ror":"https://ror.org/03ntccx93","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210137409"]},{"id":"https://openalex.org/I4210165499","display_name":"Kumamoto Medical Center","ror":"https://ror.org/05sy5w128","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4210165499"]},{"id":"https://openalex.org/I4405254003","display_name":"Kumamoto Saishun Medical Center","ror":"https://ror.org/01a2cdx51","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405254003"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun Hokamaki","raw_affiliation_strings":["Department of Cardiovascular Medicine, National Hospital Organization Kumamoto Saishun Medical Center , Kohshi, Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, National Hospital Organization Kumamoto Saishun Medical Center , Kohshi, Kumamoto, Japan","institution_ids":["https://openalex.org/I4210137409","https://openalex.org/I4210165499","https://openalex.org/I4405254003"]}]},{"author_position":"last","author":{"id":null,"display_name":"Kenichi Tsujita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405285905","display_name":"Center for Metabolic Regulation of Healthy Aging, Kumamoto University","ror":"https://ror.org/00mwqfc25","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405285905","https://openalex.org/I96036126"]},{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenichi Tsujita","raw_affiliation_strings":["Department of Cardiovascular Medicine, Graduate School of Medical Sciences and Center of Metabolic Regulation of Healthy Aging, Kumamoto University , Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences and Center of Metabolic Regulation of Healthy Aging, Kumamoto University , Kumamoto, Japan","institution_ids":["https://openalex.org/I4405285905","https://openalex.org/I96036126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5019043029"],"corresponding_institution_ids":["https://openalex.org/I4210137409","https://openalex.org/I4210165499","https://openalex.org/I4405254003"],"apc_list":{"value":2995,"currency":"USD","value_usd":2995},"apc_paid":{"value":2995,"currency":"USD","value_usd":2995},"fwci":1.8794,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.84850282,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"34","issue":"2","first_page":"313","last_page":"321"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.5473999977111816,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.5473999977111816,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.4106000065803528,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/d-dimer","display_name":"D-dimer","score":0.9359999895095825},{"id":"https://openalex.org/keywords/clinical-disease-activity","display_name":"clinical disease activity","score":0.9279999732971191},{"id":"https://openalex.org/keywords/deep-vein-thrombosis","display_name":"deep vein thrombosis","score":0.9860000014305115},{"id":"https://openalex.org/keywords/venous-thromboembolism","display_name":"venous thromboembolism","score":0.9589999914169312},{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.8999999761581421},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.9819999933242798},{"id":"https://openalex.org/keywords/outpatients","display_name":"outpatients","score":0.6259999871253967},{"id":"https://openalex.org/keywords/age","display_name":"age","score":0.31299999356269836},{"id":"https://openalex.org/keywords/venous-ultrasound","display_name":"venous ultrasound","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9558484554290771},{"id":"https://openalex.org/C2779519742","wikidata":"https://www.wikidata.org/wiki/Q198526","display_name":"D-dimer","level":2,"score":0.8800007104873657},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.720801591873169},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.7098640203475952},{"id":"https://openalex.org/C2780011451","wikidata":"https://www.wikidata.org/wiki/Q2751330","display_name":"Venous thrombosis","level":3,"score":0.520553708076477},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5155172348022461},{"id":"https://openalex.org/C2778959117","wikidata":"https://www.wikidata.org/wiki/Q430892","display_name":"Deep vein","level":3,"score":0.5070352554321289},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.5069072842597961},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.46421316266059875}],"mesh":[{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005338","descriptor_name":"Fibrin Fibrinogen Degradation Products","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010045","descriptor_name":"Outpatients","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020246","descriptor_name":"Venous Thrombosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D020246","descriptor_name":"Venous Thrombosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D054556","descriptor_name":"Venous Thromboembolism","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D054556","descriptor_name":"Venous Thromboembolism","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/mr/road018","doi":"https://doi.org/10.1093/mr/road018","is_oa":true,"landing_page_url":"https://doi.org/10.1093/mr/road018","pdf_url":"https://academic.oup.com/mr/advance-article-pdf/doi/10.1093/mr/road018/49315010/road018.pdf","source":{"id":"https://openalex.org/S30446230","display_name":"Modern Rheumatology","issn_l":"1439-7595","issn":["1439-7595","1439-7609"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern Rheumatology","raw_type":"journal-article"},{"id":"pmid:36726243","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36726243","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern rheumatology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/mr/road018","doi":"https://doi.org/10.1093/mr/road018","is_oa":true,"landing_page_url":"https://doi.org/10.1093/mr/road018","pdf_url":"https://academic.oup.com/mr/advance-article-pdf/doi/10.1093/mr/road018/49315010/road018.pdf","source":{"id":"https://openalex.org/S30446230","display_name":"Modern Rheumatology","issn_l":"1439-7595","issn":["1439-7595","1439-7609"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern Rheumatology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4318924230.pdf","grobid_xml":"https://content.openalex.org/works/W4318924230.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W132722136","https://openalex.org/W1586128162","https://openalex.org/W1597337165","https://openalex.org/W1970822699","https://openalex.org/W2003972816","https://openalex.org/W2013710547","https://openalex.org/W2015114982","https://openalex.org/W2027891192","https://openalex.org/W2048849187","https://openalex.org/W2084672356","https://openalex.org/W2121960517","https://openalex.org/W2124329650","https://openalex.org/W2126525702","https://openalex.org/W2128952811","https://openalex.org/W2140707981","https://openalex.org/W2152348310","https://openalex.org/W2157340889","https://openalex.org/W2167728254","https://openalex.org/W2294236942","https://openalex.org/W2336061167","https://openalex.org/W2344977044","https://openalex.org/W2413466481","https://openalex.org/W2487378561","https://openalex.org/W2557620153","https://openalex.org/W2623617647","https://openalex.org/W2800080432","https://openalex.org/W2971121646","https://openalex.org/W2974844397","https://openalex.org/W3005497321","https://openalex.org/W3090209681","https://openalex.org/W3092440431","https://openalex.org/W3164140140","https://openalex.org/W3176953668","https://openalex.org/W3199205944","https://openalex.org/W3216388706","https://openalex.org/W4211111012","https://openalex.org/W4226061113","https://openalex.org/W4284965512","https://openalex.org/W4285388679","https://openalex.org/W4295030595","https://openalex.org/W6839186184"],"related_works":["https://openalex.org/W4413841045","https://openalex.org/W2381289384","https://openalex.org/W2371085445","https://openalex.org/W3164140140","https://openalex.org/W2392463967","https://openalex.org/W4312065881","https://openalex.org/W4295030595","https://openalex.org/W7213766990","https://openalex.org/W7217554305","https://openalex.org/W4226061113"],"abstract_inverted_index":{"OBJECTIVES:":[0],"To":[1],"identify":[2],"factors":[3,46,133,143],"associated":[4,145],"with":[5,11,52,146,152,173,176],"plasma":[6,81,197],"D-dimer":[7,54,82,90,148,153,166,198],"levels":[8,55,91,154,167],"in":[9,161,171,200],"outpatients":[10],"rheumatoid":[12],"arthritis":[13],"(RA).":[14],"METHODS:":[15],"We":[16],"consecutively":[17],"recruited":[18],"460":[19],"RA":[20,201],"patients":[21,151,172],"who":[22],"visited":[23],"our":[24],"hospital":[25],"for":[26,80],"routine":[27],"follow-ups":[28],"between":[29],"June":[30],"and":[31,39,41,85,114,125,165],"October":[32],"2021.":[33],"Plasma":[34],"D-dimer,":[35],"RA-related":[36],"characteristics,":[37],"comorbidities,":[38],"cardiovascular":[40],"venous":[42,58],"thromboembolism":[43],"(VTE)":[44],"risk":[45,132],"were":[47,78,139,168],"examined":[48],"at":[49],"enrolment.":[50],"Patients":[51],"elevated":[53],"underwent":[56],"whole-leg":[57],"ultrasonography":[59],"to":[60,196],"diagnose":[61],"deep":[62],"vein":[63],"thrombosis":[64],"(DVT).":[65],"RESULTS:":[66],"Participants":[67],"had":[68,88,159],"no":[69],"DVT":[70,160,174],"signs":[71],"or":[72,130],"symptoms.":[73],"Among":[74,150],"them,":[75],"252":[76],"(54.8%)":[77],"positive":[79],"(\u22650.5":[83],"\u03bcg/ml)":[84],"40":[86],"(8.7%)":[87],"high":[89,113,147],"(\u22653":[92],"\u03bcg/ml).":[93],"The":[94],"mean":[95],"was":[96],"1.07":[97],"\u03bcg/ml.":[98],"After":[99],"adjustments,":[100],"age":[101],"[odds":[102],"ratio":[103],"(OR)":[104],"1.88":[105],"per":[106],"additional":[107],"10":[108,157],"years,":[109],"P":[110,122,136,185],"=":[111,137],".003],":[112],"moderate":[115],"clinical":[116],"disease":[117,190],"activity":[118,191],"index":[119],"(OR":[120,134],"8.79,":[121],"<":[123,186],".001),":[124],"the":[126,142],"presence":[127],"of":[128],"comorbidities":[129],"cardiovascular/VTE":[131],"2.94,":[135],".017)":[138],"identified":[140],"as":[141],"independently":[144],"levels.":[149],"\u22653":[155],"\u03bcg/ml,":[156,184],"(25%)":[158],"their":[162],"lower":[163],"limbs,":[164],"significantly":[169],"higher":[170],"compared":[175],"those":[177],"without":[178],"it":[179],"(mean":[180],"6.0":[181],"vs.":[182],"4.1":[183],".001).":[187],"CONCLUSIONS:":[188],"Clinical":[189],"is":[192],"a":[193],"major":[194],"contributor":[195],"elevation":[199],"outpatients.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-02-03T00:00:00"}