{"id":"https://openalex.org/W4318754167","doi":"https://doi.org/10.1002/cbdv.202200847","title":"Novel VEGFR\u20102 Kinase Inhibitors as Anticancer Agents: A Review Focusing on SAR and Molecular Docking Studies (2016\u20132021)","display_name":"Novel VEGFR\u20102 Kinase Inhibitors as Anticancer Agents: A Review Focusing on SAR and Molecular Docking Studies (2016\u20132021)","publication_year":2023,"publication_date":"2023-01-31","ids":{"openalex":"https://openalex.org/W4318754167","doi":"https://doi.org/10.1002/cbdv.202200847","pmid":"https://pubmed.ncbi.nlm.nih.gov/36721068"},"language":"en","primary_location":{"id":"doi:10.1002/cbdv.202200847","doi":"https://doi.org/10.1002/cbdv.202200847","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cbdv.202200847","pdf_url":null,"source":{"id":"https://openalex.org/S206700086","display_name":"Chemistry & Biodiversity","issn_l":"1612-1872","issn":["1612-1872","1612-1880"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & Biodiversity","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013565723","display_name":"S. Vishakha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092982","display_name":"Indo Soviet Friendship College of Pharmacy","ror":"https://ror.org/00fd30e02","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210092982"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vishakha S.","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Moga, 142001 Punjab, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Moga, 142001 Punjab, India","institution_ids":["https://openalex.org/I4210092982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026802871","display_name":"Kumari Kajal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092982","display_name":"Indo Soviet Friendship College of Pharmacy","ror":"https://ror.org/00fd30e02","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210092982"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kumari Kajal","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Moga, 142001 Punjab, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Moga, 142001 Punjab, India","institution_ids":["https://openalex.org/I4210092982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064971346","display_name":"Sitanshu Mondal","orcid":"https://orcid.org/0000-0002-8412-6676","observed_orcids":["https://orcid.org/0000-0002-8412-6676"]},"institutions":[{"id":"https://openalex.org/I4210092982","display_name":"Indo Soviet Friendship College of Pharmacy","ror":"https://ror.org/00fd30e02","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210092982"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sitanshu Mondal","raw_affiliation_strings":["Department of Pharmaceutical Analysis, ISF College of Pharmacy, Moga, 142001 Punjab, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Analysis, ISF College of Pharmacy, Moga, 142001 Punjab, India","institution_ids":["https://openalex.org/I4210092982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003375358","display_name":"Simranpreet K. Wahan","orcid":"https://orcid.org/0000-0003-0923-6821","observed_orcids":["https://orcid.org/0000-0003-0923-6821"]},"institutions":[{"id":"https://openalex.org/I4210092982","display_name":"Indo Soviet Friendship College of Pharmacy","ror":"https://ror.org/00fd30e02","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210092982"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Simranpreet K. Wahan","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Moga, 142001 Punjab, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Moga, 142001 Punjab, India","institution_ids":["https://openalex.org/I4210092982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078798407","display_name":"Balak Das Kurmi","orcid":"https://orcid.org/0000-0001-8470-6622","observed_orcids":["https://orcid.org/0000-0001-8470-6622"]},"institutions":[{"id":"https://openalex.org/I4210092982","display_name":"Indo Soviet Friendship College of Pharmacy","ror":"https://ror.org/00fd30e02","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210092982"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Balak Das Kurmi","raw_affiliation_strings":["Department of Pharmaceutics, ISF College of Pharmacy, Moga, 142001 Punjab, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, ISF College of Pharmacy, Moga, 142001 Punjab, India","institution_ids":["https://openalex.org/I4210092982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063780561","display_name":"Ghanshyam Das Gupta","orcid":"https://orcid.org/0000-0002-5377-1082","observed_orcids":["https://orcid.org/0000-0002-5377-1082"]},"institutions":[{"id":"https://openalex.org/I4210092982","display_name":"Indo Soviet Friendship College of Pharmacy","ror":"https://ror.org/00fd30e02","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210092982"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ghanshyam Das Gupta","raw_affiliation_strings":["Department of Pharmaceutics, ISF College of Pharmacy, Moga, 142001 Punjab, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, ISF College of Pharmacy, Moga, 142001 Punjab, India","institution_ids":["https://openalex.org/I4210092982"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054433339","display_name":"Preeti Patel","orcid":"https://orcid.org/0000-0003-1606-2241","observed_orcids":["https://orcid.org/0000-0003-1606-2241"]},"institutions":[{"id":"https://openalex.org/I4210092982","display_name":"Indo Soviet Friendship College of Pharmacy","ror":"https://ror.org/00fd30e02","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210092982"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Preeti Patel","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Moga, 142001 Punjab, India"],"raw_orcid":"https://orcid.org/0000-0003-1606-2241","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Moga, 142001 Punjab, India","institution_ids":["https://openalex.org/I4210092982"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5054433339","https://openalex.org/A5078798407"],"corresponding_institution_ids":["https://openalex.org/I4210092982"],"apc_list":{"value":3660,"currency":"USD","value_usd":3660},"apc_paid":null,"fwci":0.624,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.55140392,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"20","issue":"2","first_page":"e202200847","last_page":"e202200847"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.014000000432133675,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-vegf-therapy","display_name":"anti-VEGF therapy","score":0.7360000014305115},{"id":"https://openalex.org/keywords/angiogenesis-inhibitors","display_name":"angiogenesis inhibitors","score":0.7760000228881836},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.9430000185966492},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8100000023841858},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.9829999804496765},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinases","display_name":"receptor tyrosine kinase","score":0.7680000066757202},{"id":"https://openalex.org/keywords/anticancer-drug-design","display_name":"anticancer drug design","score":0.6399999856948853},{"id":"https://openalex.org/keywords/vegf-signaling-pathway","display_name":"VEGF pathway","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.8131494522094727},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5867406725883484},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.5528042316436768},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.541296124458313},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.519425630569458},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5169574618339539},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.47189268469810486},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45381563901901245},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3535193204879761},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2861345708370209},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.25006893277168274},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22767135500907898},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12049439549446106},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D040301","descriptor_name":"Vascular Endothelial Growth Factor Receptor-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/cbdv.202200847","doi":"https://doi.org/10.1002/cbdv.202200847","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cbdv.202200847","pdf_url":null,"source":{"id":"https://openalex.org/S206700086","display_name":"Chemistry & Biodiversity","issn_l":"1612-1872","issn":["1612-1872","1612-1880"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & Biodiversity","raw_type":"journal-article"},{"id":"pmid:36721068","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36721068","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & biodiversity","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":92,"referenced_works":["https://openalex.org/W109492528","https://openalex.org/W1969001441","https://openalex.org/W2011887296","https://openalex.org/W2051546786","https://openalex.org/W2064360454","https://openalex.org/W2067851515","https://openalex.org/W2086189298","https://openalex.org/W2140859187","https://openalex.org/W2141046053","https://openalex.org/W2141167667","https://openalex.org/W2177929699","https://openalex.org/W2198846735","https://openalex.org/W2212092506","https://openalex.org/W2259096617","https://openalex.org/W2340808473","https://openalex.org/W2506684899","https://openalex.org/W2530719862","https://openalex.org/W2549976854","https://openalex.org/W2609237181","https://openalex.org/W2626381435","https://openalex.org/W2769328077","https://openalex.org/W2784280942","https://openalex.org/W2786582663","https://openalex.org/W2796761370","https://openalex.org/W2800401523","https://openalex.org/W2888829038","https://openalex.org/W2889749701","https://openalex.org/W2896595935","https://openalex.org/W2896980868","https://openalex.org/W2907064064","https://openalex.org/W2916750536","https://openalex.org/W2950970941","https://openalex.org/W2963182710","https://openalex.org/W2967351647","https://openalex.org/W2968668987","https://openalex.org/W2973180485","https://openalex.org/W2988361120","https://openalex.org/W2996198546","https://openalex.org/W3002443851","https://openalex.org/W3003025448","https://openalex.org/W3024712524","https://openalex.org/W3033659767","https://openalex.org/W3041829346","https://openalex.org/W3080745443","https://openalex.org/W3082029771","https://openalex.org/W3082446551","https://openalex.org/W3084545457","https://openalex.org/W3092270666","https://openalex.org/W3096002562","https://openalex.org/W3103854394","https://openalex.org/W3104755560","https://openalex.org/W3108504839","https://openalex.org/W3111795998","https://openalex.org/W3112436986","https://openalex.org/W3114846931","https://openalex.org/W3120990062","https://openalex.org/W3122976576","https://openalex.org/W3124339721","https://openalex.org/W3125102830","https://openalex.org/W3125341679","https://openalex.org/W3126929933","https://openalex.org/W3127764969","https://openalex.org/W3128226085","https://openalex.org/W3128272978","https://openalex.org/W3128520342","https://openalex.org/W3133533360","https://openalex.org/W3153206655","https://openalex.org/W3156930071","https://openalex.org/W3157992644","https://openalex.org/W3159182064","https://openalex.org/W3161418045","https://openalex.org/W3166539551","https://openalex.org/W3168645700","https://openalex.org/W3173245900","https://openalex.org/W3174095671","https://openalex.org/W3175857254","https://openalex.org/W3179357658","https://openalex.org/W3187698246","https://openalex.org/W3192223626","https://openalex.org/W3193513064","https://openalex.org/W3194462699","https://openalex.org/W3196385819","https://openalex.org/W3201424131","https://openalex.org/W3201492729","https://openalex.org/W3211097250","https://openalex.org/W3214388858","https://openalex.org/W4200475025","https://openalex.org/W4205183812","https://openalex.org/W4205710779","https://openalex.org/W4206254303","https://openalex.org/W4206327847","https://openalex.org/W4206680950"],"related_works":["https://openalex.org/W152699184","https://openalex.org/W2284829122","https://openalex.org/W1985666931","https://openalex.org/W2147426661","https://openalex.org/W4410497706","https://openalex.org/W2125561465","https://openalex.org/W2981810096","https://openalex.org/W4411894206","https://openalex.org/W2015985366","https://openalex.org/W2322614519"],"abstract_inverted_index":{"Cancer":[0],"growth,":[1,71],"annexation,":[2],"and":[3,33,45,72,78,117],"metastatic":[4],"spread":[5,46],"are":[6],"all":[7],"aided":[8],"by":[9],"the":[10,20,102],"formation":[11],"of":[12,19,40,93,104,120],"new":[13],"blood":[14,56],"vessels":[15],"(angiogenesis).":[16],"The":[17,38],"commencement":[18],"VEGF":[21],"pathway":[22],"leads":[23],"to":[24,43,52,85],"signal":[25],"transduction":[26],"that":[27,67],"enhances":[28],"endothelial":[29],"cell":[30,70],"survival,":[31],"relocation,":[32],"divergence":[34],"from":[35],"pre-existing":[36],"vasculature.":[37],"ability":[39,51],"solid":[41],"malignancies":[42],"bloom":[44],"depends":[47],"critically":[48],"on":[49,115],"their":[50,54],"establish":[53],"independent":[55],"circulation":[57],"(tumor":[58],"angiogenesis).":[59],"VEGFR":[60,82],"is":[61],"a":[62,87,91],"major":[63],"receptor":[64],"tyrosine":[65],"kinase":[66],"regulates":[68],"angiogenesis,":[69],"metastasis,":[73],"diminishing":[74],"apoptosis,":[75],"cytoskeletal":[76],"function,":[77],"other":[79],"biological":[80],"processes":[81],"has":[83],"proven":[84],"be":[86],"remarkable":[88],"focus":[89],"for":[90],"variety":[92],"anticancer":[94],"medicines":[95],"in":[96],"clinical":[97],"studies.":[98],"This":[99,111],"Review":[100],"explores":[101],"development":[103],"anti-VEGF-based":[105],"antiangiogenic":[106],"therapies":[107],"having":[108],"different":[109],"scaffolds.":[110],"review":[112],"had":[113],"focused":[114],"SAR":[116],"docking":[118],"studies":[119],"previously":[121],"reported":[122],"molecules.":[123]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-02-02T00:00:00"}