{"id":"https://openalex.org/W4318486258","doi":"https://doi.org/10.3390/cancers15030841","title":"Osimertinib Resistance: Molecular Mechanisms and Emerging Treatment Options","display_name":"Osimertinib Resistance: Molecular Mechanisms and Emerging Treatment Options","publication_year":2023,"publication_date":"2023-01-30","ids":{"openalex":"https://openalex.org/W4318486258","doi":"https://doi.org/10.3390/cancers15030841","pmid":"https://pubmed.ncbi.nlm.nih.gov/36765799","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9913144"},"language":"en","primary_location":{"id":"doi:10.3390/cancers15030841","doi":"https://doi.org/10.3390/cancers15030841","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers15030841","pdf_url":"https://www.mdpi.com/2072-6694/15/3/841/pdf?version=1675069322","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6694/15/3/841/pdf?version=1675069322","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025883803","display_name":"Georgia Gomatou","orcid":"https://orcid.org/0000-0002-1031-8261","observed_orcids":["https://orcid.org/0000-0002-1031-8261"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210166756","display_name":"Sotiria General Hospital","ror":"https://ror.org/05gbdc474","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210166756"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Georgia Gomatou","raw_affiliation_strings":["Oncology Unit, Third Department of Medicine, \u201cSotiria\u201d General Hospital for Diseases of the Chest, National and Kapodistrian University of Athens, 11527 Athens, Greece"],"raw_orcid":"https://orcid.org/0000-0002-1031-8261","affiliations":[{"raw_affiliation_string":"Oncology Unit, Third Department of Medicine, \u201cSotiria\u201d General Hospital for Diseases of the Chest, National and Kapodistrian University of Athens, 11527 Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210166756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077025160","display_name":"Nikolaos Konstantinos Syrigos","orcid":"https://orcid.org/0000-0001-8082-594X","observed_orcids":["https://orcid.org/0000-0001-8082-594X"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210166756","display_name":"Sotiria General Hospital","ror":"https://ror.org/05gbdc474","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210166756"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Nikolaos Syrigos","raw_affiliation_strings":["Oncology Unit, Third Department of Medicine, \u201cSotiria\u201d General Hospital for Diseases of the Chest, National and Kapodistrian University of Athens, 11527 Athens, Greece"],"raw_orcid":"https://orcid.org/0000-0001-8082-594X","affiliations":[{"raw_affiliation_string":"Oncology Unit, Third Department of Medicine, \u201cSotiria\u201d General Hospital for Diseases of the Chest, National and Kapodistrian University of Athens, 11527 Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210166756"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054170239","display_name":"Elias Alexandros Kotteas","orcid":"https://orcid.org/0000-0003-2563-0968","observed_orcids":["https://orcid.org/0000-0003-2563-0968"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210166756","display_name":"Sotiria General Hospital","ror":"https://ror.org/05gbdc474","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210166756"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Elias Kotteas","raw_affiliation_strings":["Oncology Unit, Third Department of Medicine, \u201cSotiria\u201d General Hospital for Diseases of the Chest, National and Kapodistrian University of Athens, 11527 Athens, Greece"],"raw_orcid":"https://orcid.org/0000-0003-2563-0968","affiliations":[{"raw_affiliation_string":"Oncology Unit, Third Department of Medicine, \u201cSotiria\u201d General Hospital for Diseases of the Chest, National and Kapodistrian University of Athens, 11527 Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210166756"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5025883803"],"corresponding_institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210166756"],"apc_list":{"value":2600,"currency":"CHF","value_usd":2892},"apc_paid":{"value":2600,"currency":"CHF","value_usd":2892},"fwci":6.5563,"has_fulltext":true,"cited_by_count":145,"citation_normalized_percentile":{"value":0.98686011,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"15","issue":"3","first_page":"841","last_page":"841"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osimertinib","display_name":"osimertinib","score":0.9160000085830688},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.7749999761581421},{"id":"https://openalex.org/keywords/egfr-mutation","display_name":"EGFR mutation","score":0.753000020980835},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9829999804496765},{"id":"https://openalex.org/keywords/egfr-t790m-mutation","display_name":"T790M mutation","score":0.8180000185966492},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.8619999885559082},{"id":"https://openalex.org/keywords/clonal-evolution","display_name":"clonal evolution","score":0.9200000166893005},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.6660000085830688},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.7580000162124634},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6359999775886536},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C2777626846","wikidata":"https://www.wikidata.org/wiki/Q21506464","display_name":"Osimertinib","level":5,"score":0.9857050180435181},{"id":"https://openalex.org/C2777930144","wikidata":"https://www.wikidata.org/wiki/Q25100112","display_name":"T790M","level":5,"score":0.7613964080810547},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7184348702430725},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6206921339035034},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5442845821380615},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.5369666814804077},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.5195334553718567},{"id":"https://openalex.org/C2778087573","wikidata":"https://www.wikidata.org/wiki/Q418369","display_name":"Erlotinib","level":4,"score":0.4190502464771271},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40058815479278564},{"id":"https://openalex.org/C2780580887","wikidata":"https://www.wikidata.org/wiki/Q417824","display_name":"Gefitinib","level":4,"score":0.38881608843803406},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37468570470809937},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.31926852464675903}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3390/cancers15030841","doi":"https://doi.org/10.3390/cancers15030841","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers15030841","pdf_url":"https://www.mdpi.com/2072-6694/15/3/841/pdf?version=1675069322","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9913144","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9913144","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9913144/pdf/cancers-15-00841.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers (Basel)","raw_type":"Text"},{"id":"pmid:36765799","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36765799","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/cancers15030841","doi":"https://doi.org/10.3390/cancers15030841","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers15030841","pdf_url":"https://www.mdpi.com/2072-6694/15/3/841/pdf?version=1675069322","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4318486258.pdf","grobid_xml":"https://content.openalex.org/works/W4318486258.grobid-xml"},"referenced_works_count":117,"referenced_works":["https://openalex.org/W1546552389","https://openalex.org/W1908940658","https://openalex.org/W1998479997","https://openalex.org/W2003984225","https://openalex.org/W2038670745","https://openalex.org/W2050211354","https://openalex.org/W2059780149","https://openalex.org/W2076178766","https://openalex.org/W2088540000","https://openalex.org/W2159013299","https://openalex.org/W2163351155","https://openalex.org/W2271852462","https://openalex.org/W2416111151","https://openalex.org/W2554688226","https://openalex.org/W2559746652","https://openalex.org/W2560717039","https://openalex.org/W2578673768","https://openalex.org/W2594811626","https://openalex.org/W2605556058","https://openalex.org/W2612786119","https://openalex.org/W2616301769","https://openalex.org/W2729330913","https://openalex.org/W2736887233","https://openalex.org/W2739722804","https://openalex.org/W2748922433","https://openalex.org/W2766316939","https://openalex.org/W2770828094","https://openalex.org/W2772237551","https://openalex.org/W2777461561","https://openalex.org/W2790922923","https://openalex.org/W2792049071","https://openalex.org/W2794676080","https://openalex.org/W2805346544","https://openalex.org/W2806918958","https://openalex.org/W2809120579","https://openalex.org/W2885289995","https://openalex.org/W2887314183","https://openalex.org/W2888262209","https://openalex.org/W2888796573","https://openalex.org/W2889423013","https://openalex.org/W2890599782","https://openalex.org/W2894066036","https://openalex.org/W2896311970","https://openalex.org/W2898171786","https://openalex.org/W2898359687","https://openalex.org/W2898951197","https://openalex.org/W2899325153","https://openalex.org/W2903740294","https://openalex.org/W2905529840","https://openalex.org/W2911891900","https://openalex.org/W2916137642","https://openalex.org/W2924289105","https://openalex.org/W2935797142","https://openalex.org/W2940656811","https://openalex.org/W2944586186","https://openalex.org/W2944732073","https://openalex.org/W2945297162","https://openalex.org/W2946166987","https://openalex.org/W2946721095","https://openalex.org/W2947479209","https://openalex.org/W2952506496","https://openalex.org/W2953576895","https://openalex.org/W2958959836","https://openalex.org/W2964827678","https://openalex.org/W2975117225","https://openalex.org/W2976334328","https://openalex.org/W2976431901","https://openalex.org/W2978342398","https://openalex.org/W2999801017","https://openalex.org/W3001408868","https://openalex.org/W3004905091","https://openalex.org/W3007042140","https://openalex.org/W3008944543","https://openalex.org/W3011732303","https://openalex.org/W3013150216","https://openalex.org/W3020050719","https://openalex.org/W3027340072","https://openalex.org/W3033122334","https://openalex.org/W3033658985","https://openalex.org/W3035099795","https://openalex.org/W3035955877","https://openalex.org/W3043034208","https://openalex.org/W3043371895","https://openalex.org/W3080586916","https://openalex.org/W3087210493","https://openalex.org/W3116532061","https://openalex.org/W3120917995","https://openalex.org/W3133780665","https://openalex.org/W3136317587","https://openalex.org/W3136661591","https://openalex.org/W3137204678","https://openalex.org/W3150192782","https://openalex.org/W3154466284","https://openalex.org/W3157490474","https://openalex.org/W3186228900","https://openalex.org/W3191293440","https://openalex.org/W3191778845","https://openalex.org/W3192167153","https://openalex.org/W3200238080","https://openalex.org/W3201539992","https://openalex.org/W3204380660","https://openalex.org/W3214844045","https://openalex.org/W3216622862","https://openalex.org/W4210992155","https://openalex.org/W4213133535","https://openalex.org/W4221138045","https://openalex.org/W4223899297","https://openalex.org/W4281729249","https://openalex.org/W4283277509","https://openalex.org/W4283310759","https://openalex.org/W4284706731","https://openalex.org/W4284890543","https://openalex.org/W4285590771","https://openalex.org/W4288459215","https://openalex.org/W4297874882","https://openalex.org/W4309368959","https://openalex.org/W4311677159"],"related_works":["https://openalex.org/W4283310759","https://openalex.org/W3205049302","https://openalex.org/W4311677159","https://openalex.org/W4364382189","https://openalex.org/W3132157244","https://openalex.org/W4407240505","https://openalex.org/W2976334328","https://openalex.org/W4366822282","https://openalex.org/W4292575500","https://openalex.org/W4392613553"],"abstract_inverted_index":{"The":[0],"development":[1],"of":[2,20,97,137,143,204,220,229],"tyrosine":[3],"kinase":[4],"inhibitors":[5],"(TKIs)":[6],"targeting":[7],"the":[8,17,53,95,135,175,218,227],"mutant":[9],"epidermal":[10],"growth":[11],"factor":[12],"receptor":[13],"(EGFR)":[14],"protein":[15],"initiated":[16],"success":[18],"story":[19],"targeted":[21,90,155],"therapies":[22],"in":[23,38,49,79,116,128,183,190,223],"non-small-cell":[24],"lung":[25,192],"cancer":[26,193],"(NSCLC).":[27],"Osimertinib,":[28],"a":[29,129,158,187],"third-generation":[30],"EGFR-TKI,":[31],"is":[32,126,162,186],"currently":[33],"indicated":[34],"as":[35,46,63,106,108],"first-line":[36,130],"therapy":[37,48,65],"patients":[39,50,67,80],"with":[40,42,59,68,81,167],"NSCLC":[41,185],"sensitizing":[43],"EGFR":[44,74],"mutations,":[45],"second-line":[47,132],"who":[51],"present":[52],"resistance-associated":[54],"mutation":[55],"T790M":[56],"after":[57,149,198,232],"treatment":[58,196],"previous":[60],"EGFR-TKIs,":[61],"and":[62,102,140,164,171,177,208],"adjuvant":[64],"for":[66],"early":[69],"stage":[70],"resected":[71],"NSCLC,":[72,83],"harboring":[73],"mutations.":[75],"Despite":[76],"durable":[77],"responses":[78],"advanced":[82],"resistance":[84,121],"to":[85,88,151,179,200,225,234],"osimertinib,":[86],"similar":[87],"other":[89,154],"therapies,":[91,156],"inevitably":[92],"develops.":[93],"Understanding":[94],"mechanisms":[96,122],"resistance,":[98],"including":[99],"both":[100],"EGFR-dependent":[101],"-independent":[103],"molecular":[104,230],"pathways,":[105],"well":[107],"their":[109],"therapeutic":[110,147,206],"potential,":[111],"represents":[112],"an":[113],"unmet":[114],"need":[115],"thoracic":[117],"oncology.":[118],"Interestingly,":[119],"differential":[120],"develop":[123],"when":[124,157,176],"osimertinib":[125,152,201],"administered":[127],"versus":[131],"setting,":[133],"indicating":[134],"importance":[136],"selection":[138],"pressure":[139],"clonal":[141],"evolution":[142],"tumor":[144],"cells.":[145],"Standard":[146],"approaches":[148,207],"progression":[150,199,233],"include":[153],"targetable":[159],"genetic":[160],"alteration":[161],"detected,":[163],"cytotoxic":[165],"chemotherapy":[166],"or":[168],"without":[169],"antiangiogenic":[170],"immunotherapeutic":[172,181],"agents.":[173],"Deciphering":[174],"how":[178],"use":[180],"agents":[182],"EGFR-positive":[184],"current":[188],"challenge":[189],"clinical":[191],"research.":[194],"Emerging":[195],"options":[197],"involve":[202],"combinations":[203],"different":[205],"novel":[209],"EGFR-TKI":[210],"inhibitors.":[211],"Research":[212],"should":[213],"also":[214],"be":[215],"focused":[216],"on":[217],"standardization":[219],"liquid":[221],"biopsies":[222],"order":[224],"facilitate":[226],"monitoring":[228],"alterations":[231],"osimertinib.":[235]},"counts_by_year":[{"year":2026,"cited_by_count":39},{"year":2025,"cited_by_count":52},{"year":2024,"cited_by_count":45},{"year":2023,"cited_by_count":9}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2023-01-30T00:00:00"}
