{"id":"https://openalex.org/W4318220690","doi":"https://doi.org/10.7554/elife.79946","title":"Efficacy and safety of metabolic interventions for the treatment of severe COVID-19: in vitro, observational, and non-randomized open-label interventional study","display_name":"Efficacy and safety of metabolic interventions for the treatment of severe COVID-19: in vitro, observational, and non-randomized open-label interventional study","publication_year":2023,"publication_date":"2023-01-27","ids":{"openalex":"https://openalex.org/W4318220690","doi":"https://doi.org/10.7554/elife.79946","pmid":"https://pubmed.ncbi.nlm.nih.gov/36705566","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9937660"},"language":"en","primary_location":{"id":"doi:10.7554/elife.79946","doi":"https://doi.org/10.7554/elife.79946","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.79946","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.79946","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091599826","display_name":"Avner Ehrlich","orcid":"https://orcid.org/0000-0002-6339-1665","observed_orcids":["https://orcid.org/0000-0002-6339-1665"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Avner Ehrlich","raw_affiliation_strings":["Department of Cell and Developmental Biology, Silberman Institute of Life Sciences","Grass Center for Bioengineering, Benin School of Computer Science and Engineering","Department of Cell and Developmental Biology, Silberman Institute of Life Sciences; Grass Center for Bioengineering, Benin School of Computer Science and Engineering"],"raw_orcid":"https://orcid.org/0000-0002-6339-1665","affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, Silberman Institute of Life Sciences","institution_ids":[]},{"raw_affiliation_string":"Grass Center for Bioengineering, Benin School of Computer Science and Engineering","institution_ids":[]},{"raw_affiliation_string":"Department of Cell and Developmental Biology, Silberman Institute of Life Sciences; Grass Center for Bioengineering, Benin School of Computer Science and Engineering","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047572533","display_name":"Konstantinos Ioannidis","orcid":"https://orcid.org/0000-0002-3998-1171","observed_orcids":["https://orcid.org/0000-0002-3998-1171"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Konstantinos Ioannidis","raw_affiliation_strings":["Department of Cell and Developmental Biology, Silberman Institute of Life Sciences","Grass Center for Bioengineering, Benin School of Computer Science and Engineering","Department of Cell and Developmental Biology, Silberman Institute of Life Sciences; Grass Center for Bioengineering, Benin School of Computer Science and Engineering"],"raw_orcid":"https://orcid.org/0000-0002-3998-1171","affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, Silberman Institute of Life Sciences","institution_ids":[]},{"raw_affiliation_string":"Grass Center for Bioengineering, Benin School of Computer Science and Engineering","institution_ids":[]},{"raw_affiliation_string":"Department of Cell and Developmental Biology, Silberman Institute of Life Sciences; Grass Center for Bioengineering, Benin School of Computer Science and Engineering","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069298628","display_name":"Makram Nasar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802646120","display_name":"Barzilai Medical Center","ror":"https://ror.org/00hmeez77","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2802646120"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Makram Nasar","raw_affiliation_strings":["Division of Infectious Diseases, Barzilai Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Barzilai Medical Center","institution_ids":["https://openalex.org/I2802646120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021389359","display_name":"Ismaeel Abu Alkian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802646120","display_name":"Barzilai Medical Center","ror":"https://ror.org/00hmeez77","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2802646120"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Ismaeel Abu Alkian","raw_affiliation_strings":["Division of Infectious Diseases, Barzilai Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Barzilai Medical Center","institution_ids":["https://openalex.org/I2802646120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057041941","display_name":"Yuval Daskal","orcid":"https://orcid.org/0000-0003-0245-6733","observed_orcids":["https://orcid.org/0000-0003-0245-6733"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuval Daskal","raw_affiliation_strings":["Department of Cell and Developmental Biology, Silberman Institute of Life Sciences","Grass Center for Bioengineering, Benin School of Computer Science and Engineering","Department of Cell and Developmental Biology, Silberman Institute of Life Sciences; Grass Center for Bioengineering, Benin School of Computer Science and Engineering"],"raw_orcid":"https://orcid.org/0000-0003-0245-6733","affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, Silberman Institute of Life Sciences","institution_ids":[]},{"raw_affiliation_string":"Grass Center for Bioengineering, Benin School of Computer Science and Engineering","institution_ids":[]},{"raw_affiliation_string":"Department of Cell and Developmental Biology, Silberman Institute of Life Sciences; Grass Center for Bioengineering, Benin School of Computer Science and Engineering","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003002467","display_name":"Nofar Atari","orcid":"https://orcid.org/0000-0002-5819-0033","observed_orcids":["https://orcid.org/0000-0002-5819-0033"]},"institutions":[{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Nofar Atari","raw_affiliation_strings":["Central Virology Laboratory, Public Health Services, Ministry of Health and Sheba Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Virology Laboratory, Public Health Services, Ministry of Health and Sheba Medical Center","institution_ids":["https://openalex.org/I2799810450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021617266","display_name":"Limor Kliker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Limor Kliker","raw_affiliation_strings":["Central Virology Laboratory, Public Health Services, Ministry of Health and Sheba Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Virology Laboratory, Public Health Services, Ministry of Health and Sheba Medical Center","institution_ids":["https://openalex.org/I2799810450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026762642","display_name":"Nir Rainy","orcid":"https://orcid.org/0000-0001-8622-6091","observed_orcids":["https://orcid.org/0000-0001-8622-6091"]},"institutions":[{"id":"https://openalex.org/I4210114157","display_name":"Assaf Harofeh Medical Center","ror":"https://ror.org/02722hp10","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I4210114157"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Nir Rainy","raw_affiliation_strings":["Laboratory Division, Shamir (Assaf Harofeh) Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Division, Shamir (Assaf Harofeh) Medical Center","institution_ids":["https://openalex.org/I4210114157"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045028116","display_name":"Matan Hofree","orcid":"https://orcid.org/0000-0001-8368-0299","observed_orcids":["https://orcid.org/0000-0001-8368-0299"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I4405263553","display_name":"Klarman Cell Observatory","ror":"https://ror.org/02p827605","country_code":"US","type":"facility","lineage":["https://openalex.org/I107606265","https://openalex.org/I4210087191","https://openalex.org/I4405263553"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matan Hofree","raw_affiliation_strings":["Klarman Cell Observatory, The Broad Institute of Harvard and MIT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klarman Cell Observatory, The Broad Institute of Harvard and MIT","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I4405263553","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077031851","display_name":"Sigal Shafran Tikva","orcid":"https://orcid.org/0000-0003-1598-1545","observed_orcids":["https://orcid.org/0000-0003-1598-1545"]},"institutions":[{"id":"https://openalex.org/I192238737","display_name":"Jerusalem College of Technology","ror":"https://ror.org/002kenh51","country_code":"IL","type":"education","lineage":["https://openalex.org/I192238737"]},{"id":"https://openalex.org/I4210114157","display_name":"Assaf Harofeh Medical Center","ror":"https://ror.org/02722hp10","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I4210114157"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Sigal Shafran Tikva","raw_affiliation_strings":["Department of Nursing, Faculty of School of Life and Health Sciences, The Jerusalem College of Technology Lev Academic Center","Hadassah Research and Innovation Center","Laboratory Division, Shamir (Assaf Harofeh) Medical Center","Department of Nursing, Faculty of School of Life and Health Sciences, The Jerusalem College of Technology Lev Academic Center; Hadassah Research and Innovation Center; Laboratory Division, Shamir (Assaf Harofeh) Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nursing, Faculty of School of Life and Health Sciences, The Jerusalem College of Technology Lev Academic Center","institution_ids":["https://openalex.org/I192238737"]},{"raw_affiliation_string":"Hadassah Research and Innovation Center","institution_ids":[]},{"raw_affiliation_string":"Laboratory Division, Shamir (Assaf Harofeh) Medical Center","institution_ids":["https://openalex.org/I4210114157"]},{"raw_affiliation_string":"Department of Nursing, Faculty of School of Life and Health Sciences, The Jerusalem College of Technology Lev Academic Center; Hadassah Research and Innovation Center; Laboratory Division, Shamir (Assaf Harofeh) Medical Center","institution_ids":["https://openalex.org/I192238737","https://openalex.org/I4210114157"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067258615","display_name":"Inbal Houri","orcid":"https://orcid.org/0000-0002-6397-6604","observed_orcids":["https://orcid.org/0000-0002-6397-6604"]},"institutions":[{"id":"https://openalex.org/I2799807261","display_name":"Tel Aviv Sourasky Medical Center","ror":"https://ror.org/04nd58p63","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799807261"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Inbal Houri","raw_affiliation_strings":["Department of Gastroenterology, Sourasky Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Sourasky Medical Center","institution_ids":["https://openalex.org/I2799807261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068440626","display_name":"Arrigo F.G. Cicero","orcid":"https://orcid.org/0000-0002-4367-3884","observed_orcids":["https://orcid.org/0000-0002-4367-3884"]},"institutions":[{"id":"https://openalex.org/I4210097083","display_name":"IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola","ror":"https://ror.org/00t4vnv68","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210097083"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Arrigo Cicero","raw_affiliation_strings":["IRCSS S.Orsola-Malpighi University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCSS S.Orsola-Malpighi University Hospital","institution_ids":["https://openalex.org/I4210097083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033496320","display_name":"Chiara Pavanello","orcid":"https://orcid.org/0000-0001-5892-9857","observed_orcids":["https://orcid.org/0000-0001-5892-9857"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210094195","display_name":"Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda","ror":"https://ror.org/00htrxv69","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210094195"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Pavanello","raw_affiliation_strings":["Centro Dislipidemie, Niguarda Hospital","Centro Grossi Paoletti, Dipartimento di Scienze Farmacologiche e Biomolecolari, Universit\u00e0 degli Studi di Milano"],"raw_orcid":"https://orcid.org/0000-0001-5892-9857","affiliations":[{"raw_affiliation_string":"Centro Dislipidemie, Niguarda Hospital","institution_ids":["https://openalex.org/I4210094195"]},{"raw_affiliation_string":"Centro Grossi Paoletti, Dipartimento di Scienze Farmacologiche e Biomolecolari, Universit\u00e0 degli Studi di Milano","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012961676","display_name":"Cesare Riccardo Sirtori","orcid":"https://orcid.org/0000-0001-6224-5538","observed_orcids":["https://orcid.org/0000-0001-6224-5538"]},"institutions":[{"id":"https://openalex.org/I4210094195","display_name":"Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda","ror":"https://ror.org/00htrxv69","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210094195"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cesare R Sirtori","raw_affiliation_strings":["Centro Dislipidemie, Niguarda Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Dislipidemie, Niguarda Hospital","institution_ids":["https://openalex.org/I4210094195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090367811","display_name":"Jordana B. Cohen","orcid":"https://orcid.org/0000-0003-4649-079X","observed_orcids":["https://orcid.org/0000-0003-4649-079X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jordana B Cohen","raw_affiliation_strings":["Perelman School of Medicine, University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Perelman School of Medicine, University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004778903","display_name":"Julio A. Chirinos","orcid":"https://orcid.org/0000-0001-9035-5670","observed_orcids":["https://orcid.org/0000-0001-9035-5670"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julio A Chirinos","raw_affiliation_strings":["Perelman School of Medicine, University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Perelman School of Medicine, University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055594254","display_name":"Lisa Deutsch","orcid":"https://orcid.org/0000-0002-2445-7561","observed_orcids":["https://orcid.org/0000-0002-2445-7561"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lisa Deutsch","raw_affiliation_strings":["BioStats Statistical Consulting Ltd"],"raw_orcid":"https://orcid.org/0000-0002-2445-7561","affiliations":[{"raw_affiliation_string":"BioStats Statistical Consulting Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022384420","display_name":"Merav Cohen","orcid":"https://orcid.org/0000-0001-7802-0499","observed_orcids":["https://orcid.org/0000-0001-7802-0499"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Merav Cohen","raw_affiliation_strings":["Department of Cell and Developmental Biology, Silberman Institute of Life Sciences","Grass Center for Bioengineering, Benin School of Computer Science and Engineering","Department of Cell and Developmental Biology, Silberman Institute of Life Sciences; Grass Center for Bioengineering, Benin School of Computer Science and Engineering"],"raw_orcid":"https://orcid.org/0000-0001-7802-0499","affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, Silberman Institute of Life Sciences","institution_ids":[]},{"raw_affiliation_string":"Grass Center for Bioengineering, Benin School of Computer Science and Engineering","institution_ids":[]},{"raw_affiliation_string":"Department of Cell and Developmental Biology, Silberman Institute of Life Sciences; Grass Center for Bioengineering, Benin School of Computer Science and Engineering","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085238102","display_name":"Amichai Gottlieb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802646120","display_name":"Barzilai Medical Center","ror":"https://ror.org/00hmeez77","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2802646120"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Amichai Gottlieb","raw_affiliation_strings":["Division of Infectious Diseases, Barzilai Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Barzilai Medical Center","institution_ids":["https://openalex.org/I2802646120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060332717","display_name":"Adina Bar\u2010Chaim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114157","display_name":"Assaf Harofeh Medical Center","ror":"https://ror.org/02722hp10","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I4210114157"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Adina Bar-Chaim","raw_affiliation_strings":["Laboratory Division, Shamir (Assaf Harofeh) Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Division, Shamir (Assaf Harofeh) Medical Center","institution_ids":["https://openalex.org/I4210114157"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042378104","display_name":"Oren Shibolet","orcid":"https://orcid.org/0000-0003-0081-3872","observed_orcids":["https://orcid.org/0000-0003-0081-3872"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Oren Shibolet","raw_affiliation_strings":["Sackler Faculty of Medicine, Tel Aviv University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sackler Faculty of Medicine, Tel Aviv University","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090111671","display_name":"Michal Mandelboim","orcid":"https://orcid.org/0000-0002-5997-7241","observed_orcids":["https://orcid.org/0000-0002-5997-7241"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Michal Mandelboim","raw_affiliation_strings":["Sackler Faculty of Medicine, Tel Aviv University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sackler Faculty of Medicine, Tel Aviv University","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107841940","display_name":"Shlomo L Maayan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802646120","display_name":"Barzilai Medical Center","ror":"https://ror.org/00hmeez77","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2802646120"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Shlomo L Maayan","raw_affiliation_strings":["Division of Infectious Diseases, Barzilai Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Barzilai Medical Center","institution_ids":["https://openalex.org/I2802646120"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013918067","display_name":"Yaakov Nahmias","orcid":"https://orcid.org/0000-0002-6051-616X","observed_orcids":["https://orcid.org/0000-0002-6051-616X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yaakov Nahmias","raw_affiliation_strings":["Department of Cell and Developmental Biology, Silberman Institute of Life Sciences","Grass Center for Bioengineering, Benin School of Computer Science and Engineering","Department of Cell and Developmental Biology, Silberman Institute of Life Sciences; Grass Center for Bioengineering, Benin School of Computer Science and Engineering"],"raw_orcid":"https://orcid.org/0000-0002-6051-616X","affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, Silberman Institute of Life Sciences","institution_ids":[]},{"raw_affiliation_string":"Grass Center for Bioengineering, Benin School of Computer Science and Engineering","institution_ids":[]},{"raw_affiliation_string":"Department of Cell and Developmental Biology, Silberman Institute of Life Sciences; Grass Center for Bioengineering, Benin School of Computer Science and Engineering","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5013918067"],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":2.5037,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.88629957,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"12","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/severe-covid-19","display_name":"severe COVID-19","score":0.9629999995231628},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9679999947547913},{"id":"https://openalex.org/keywords/fenofibrate","display_name":"fenofibrate","score":0.847000002861023},{"id":"https://openalex.org/keywords/pparalpha","display_name":"PPAR\u03b1","score":0.8029999732971191},{"id":"https://openalex.org/keywords/metabolic-intervention","display_name":"metabolic intervention","score":0.5070000290870667},{"id":"https://openalex.org/keywords/lung-epithelial-cells","display_name":"lung epithelial cells","score":0.9190000295639038},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.7490000128746033},{"id":"https://openalex.org/keywords/lipid-accumulation","display_name":"lipid accumulation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/sars-cov-2-replication","display_name":"SARS-CoV-2 replication","score":0.8539999723434448},{"id":"https://openalex.org/keywords/immune-inflammation","display_name":"immune inflammation","score":0.875},{"id":"https://openalex.org/keywords/pparalpha-agonists","display_name":"PPAR\u03b1 agonist","score":0.6629999876022339},{"id":"https://openalex.org/keywords/covid-19-treatment","display_name":"COVID-19 treatment","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C2778110834","wikidata":"https://www.wikidata.org/wiki/Q419724","display_name":"Fenofibrate","level":2,"score":0.800050675868988},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6854991316795349},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5776628851890564},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.5712549090385437},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49103713035583496},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.4751738905906677},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.440494179725647},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3554617464542389},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011345","descriptor_name":"Fenofibrate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047493","descriptor_name":"PPAR alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.7554/elife.79946","doi":"https://doi.org/10.7554/elife.79946","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.79946","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-770724/v1","doi":"https://doi.org/10.21203/rs.3.rs-770724/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-770724/v1","pdf_url":"https://www.researchsquare.com/article/rs-770724/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:9937660","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9937660","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Text"},{"id":"pmid:36705566","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36705566","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Clinical Trial"},{"id":"pmh:oai:cris.unibo.it:11585/938054","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36705566/","pdf_url":"https://cris.unibo.it/bitstream/11585/938054/1/Ehrlich%20A_Efficacy%20and%20safety%20of%20metabolic%20intervention_eLife%202023_compressed.pdf","source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:air.unimi.it:2434/952616","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2434/952616","pdf_url":null,"source":{"id":"https://openalex.org/S4306400516","display_name":"Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I189158943","host_organization_name":"University of Milan","host_organization_lineage":["https://openalex.org/I189158943"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:e2c42bb8edf74ef282600cb66a73a2be","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e2c42bb8edf74ef282600cb66a73a2be","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife, Vol 12 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.7554/elife.79946","doi":"https://doi.org/10.7554/elife.79946","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.79946","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G4648527325","display_name":null,"funder_award_id":"681870","funder_id":"https://openalex.org/F4320334678","funder_display_name":"European Research Council"},{"id":"https://openalex.org/G678829150","display_name":"Tracking the Dynamics of Human Metabolism using Spectroscopy-Integrated Liver-on-Chip Microdevices","funder_award_id":"681870","funder_id":"https://openalex.org/F4320338335","funder_display_name":"H2020 European Research Council"},{"id":"https://openalex.org/G9000864550","display_name":"Informing optimal first-line antihypertensive therapy: A rigorous comparative effectiveness analysis of ARBs vs. ACEIs on long-term risk of dementia, cancer, heart disease, and quality of life","funder_award_id":"R01AG074989","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000879377","display_name":"Cardiovascular Risk, Vascular and Kidney Damage in COVID-19 Survivors","funder_award_id":"R01HL157108","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320334678","display_name":"European Research Council","ror":"https://ror.org/0472cxd90"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320338335","display_name":"H2020 European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4318220690.pdf","grobid_xml":"https://content.openalex.org/works/W4318220690.grobid-xml"},"referenced_works_count":122,"referenced_works":["https://openalex.org/W121241693","https://openalex.org/W1566831845","https://openalex.org/W1591032344","https://openalex.org/W1603103547","https://openalex.org/W1875842236","https://openalex.org/W1902027874","https://openalex.org/W1967067985","https://openalex.org/W1969697094","https://openalex.org/W1971450364","https://openalex.org/W1971894038","https://openalex.org/W1974212760","https://openalex.org/W1991854939","https://openalex.org/W1996968822","https://openalex.org/W2001584091","https://openalex.org/W2007387279","https://openalex.org/W2007582789","https://openalex.org/W2012034410","https://openalex.org/W2014556626","https://openalex.org/W2015366764","https://openalex.org/W2024081693","https://openalex.org/W2033123069","https://openalex.org/W2044988896","https://openalex.org/W2051583212","https://openalex.org/W2057072852","https://openalex.org/W2057098927","https://openalex.org/W2073578030","https://openalex.org/W2074888484","https://openalex.org/W2078853769","https://openalex.org/W2087874254","https://openalex.org/W2095968062","https://openalex.org/W2102707478","https://openalex.org/W2112600232","https://openalex.org/W2114104545","https://openalex.org/W2118531942","https://openalex.org/W2127690615","https://openalex.org/W2129617524","https://openalex.org/W2143681046","https://openalex.org/W2148014629","https://openalex.org/W2152403935","https://openalex.org/W2155820299","https://openalex.org/W2156201868","https://openalex.org/W2158217645","https://openalex.org/W2214074259","https://openalex.org/W2257921033","https://openalex.org/W2262022772","https://openalex.org/W2323326409","https://openalex.org/W2345368448","https://openalex.org/W2531604762","https://openalex.org/W2592588133","https://openalex.org/W2620359328","https://openalex.org/W2742048789","https://openalex.org/W2746482698","https://openalex.org/W2769288280","https://openalex.org/W2788749894","https://openalex.org/W2810065091","https://openalex.org/W2874045491","https://openalex.org/W2885499809","https://openalex.org/W2900044275","https://openalex.org/W2908901070","https://openalex.org/W2910499089","https://openalex.org/W2910632137","https://openalex.org/W2919134736","https://openalex.org/W2951912016","https://openalex.org/W2954760406","https://openalex.org/W2965008065","https://openalex.org/W2974984390","https://openalex.org/W2996045117","https://openalex.org/W3001195213","https://openalex.org/W3003637715","https://openalex.org/W3007940623","https://openalex.org/W3014194455","https://openalex.org/W3015280639","https://openalex.org/W3019187481","https://openalex.org/W3019210634","https://openalex.org/W3021684016","https://openalex.org/W3022285953","https://openalex.org/W3024193040","https://openalex.org/W3024643080","https://openalex.org/W3026002191","https://openalex.org/W3030748957","https://openalex.org/W3030834164","https://openalex.org/W3033126715","https://openalex.org/W3034448873","https://openalex.org/W3034988278","https://openalex.org/W3036255694","https://openalex.org/W3036683212","https://openalex.org/W3043335823","https://openalex.org/W3044711307","https://openalex.org/W3044799813","https://openalex.org/W3044927477","https://openalex.org/W3047144258","https://openalex.org/W3047208380","https://openalex.org/W3048310131","https://openalex.org/W3073804858","https://openalex.org/W3080517202","https://openalex.org/W3087151262","https://openalex.org/W3091664484","https://openalex.org/W3093885234","https://openalex.org/W3095699680","https://openalex.org/W3097267546","https://openalex.org/W3098810014","https://openalex.org/W3100375649","https://openalex.org/W3104457129","https://openalex.org/W3112500788","https://openalex.org/W3134414787","https://openalex.org/W3136829303","https://openalex.org/W3137149656","https://openalex.org/W3137702166","https://openalex.org/W3143169770","https://openalex.org/W3151960558","https://openalex.org/W3152358810","https://openalex.org/W3153493739","https://openalex.org/W3157263169","https://openalex.org/W3158998799","https://openalex.org/W3159762970","https://openalex.org/W3165248908","https://openalex.org/W3184615400","https://openalex.org/W3184729641","https://openalex.org/W3190996386","https://openalex.org/W3202872287","https://openalex.org/W3211342055","https://openalex.org/W6785541549"],"related_works":["https://openalex.org/W6958176491","https://openalex.org/W4308437194","https://openalex.org/W4285076420","https://openalex.org/W4401389190","https://openalex.org/W3043335823","https://openalex.org/W3120452895","https://openalex.org/W4379768951","https://openalex.org/W4290721163","https://openalex.org/W3193861399","https://openalex.org/W3095699680"],"abstract_inverted_index":{"Background:":[0],"Viral":[1],"infection":[2,32,120,270],"is":[3],"associated":[4,124],"with":[5,53,102,125,209,216],"a":[6,91,145,230,236,264],"significant":[7],"rewire":[8],"of":[9,26,56,63,109,116,155,174,219,257,279],"the":[10,23,57,79,84,114,192,245,273,277,305,309],"host":[11],"metabolic":[12,16,24],"pathways,":[13],"presenting":[14],"attractive":[15],"targets":[17],"for":[18,268],"intervention.":[19],"Methods:":[20],"We":[21,59],"chart":[22],"response":[25],"lung":[27,49],"epithelial":[28,50],"cells":[29,51],"to":[30,68,113,161,224,241,275],"SARS-CoV-2":[31,119,142,269],"in":[33,42,76,83,97,148,164,189,222,233,281],"primary":[34,48],"cultures":[35],"and":[36,40,70,78,128,140,151,176,191,235,271,301,308,311],"COVID-19":[37,69,104,162],"patient":[38],"samples":[39],"perform":[41,60,90],"vitro":[43,165],"metabolism-focused":[44],"drug":[45,132],"screen":[46,133],"on":[47,205],"infected":[52],"different":[54],"strains":[55],"virus.":[58],"observational":[61],"analysis":[62,73,186],"Israeli":[64,157],"patients":[65,100,158,207,213,242],"hospitalized":[66,101,159,208],"due":[67,160],"comparative":[71,184],"epidemiological":[72,185],"from":[74,187,304],"cohorts":[75,188],"Italy":[77],"Veteran's":[80],"Health":[81],"Administration":[82],"United":[85,193],"States.":[86,194],"In":[87],"addition,":[88],"we":[89],"prospective":[92,197],"non-randomized":[93,198],"interventional":[94,199,317],"open-label":[95,200],"study":[96,201,278,318],"which":[98],"15":[99,206],"severe":[103,210],"were":[105,214],"given":[106],"145":[107,217],"mg/day":[108,218],"nanocrystallized":[110,220],"fenofibrate":[111,136,221,228,280],"added":[112],"standard":[115],"care.":[117],"Results:":[118],"produced":[121],"transcriptional":[122],"changes":[123],"increased":[126],"glycolysis":[127],"lipid":[129,138],"accumulation.":[130],"Metabolism-focused":[131],"showed":[134,170],"that":[135,254],"reversed":[137],"accumulation":[139],"blocked":[141],"replication":[143],"through":[144],"PPAR\u03b1-dependent":[146],"mechanism":[147],"both":[149],"alpha":[150],"delta":[152],"variants.":[153],"Analysis":[154],"3233":[156],"supported":[163,320],"findings.":[166],"Patients":[167,226],"taking":[168],"fibrates":[169],"significantly":[171,237],"lower":[172],"markers":[173],"immunoinflammation":[175],"faster":[177,238],"recovery.":[178],"Additional":[179],"corroboration":[180],"was":[181,202,289,319],"received":[182],"by":[183,291,321],"Europe":[190],"A":[195],"subsequent":[196],"carried":[203],"out":[204],"COVID-19.":[211],"The":[212,316],"treated":[215],"addition":[223],"standard-of-care.":[225],"receiving":[227],"demonstrated":[229],"rapid":[231],"reduction":[232],"inflammation":[234],"recovery":[239],"compared":[240],"admitted":[243],"during":[244],"same":[246],"period.":[247],"Conclusions:":[248],"Taken":[249],"together,":[250],"our":[251],"data":[252],"suggest":[253],"pharmacological":[255],"modulation":[256],"PPAR\u03b1":[258],"should":[259],"be":[260],"strongly":[261],"considered":[262],"as":[263],"potential":[265],"therapeutic":[266],"approach":[267],"emphasizes":[272],"need":[274],"complete":[276],"large":[282],"randomized":[283],"controlled":[284],"clinical":[285],"trials.":[286],"Funding:":[287],"Funding":[288],"provided":[290],"European":[292],"Research":[293],"Council":[294],"Consolidator":[295],"Grants":[296],"OCLD":[297],"(project":[298,323],"no.":[299],"681870)":[300],"generous":[302],"gifts":[303],"Nikoh":[306],"Foundation":[307,314],"Sam":[310],"Rina":[312],"Frankel":[313],"(YN).":[315],"Abbott":[322],"FENOC0003).":[324],"Clinical":[325],"trial":[326],"number:":[327],"NCT04661930.":[328]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-01-27T00:00:00"}