{"id":"https://openalex.org/W4318166199","doi":"https://doi.org/10.1590/0074-02760220072","title":"Coagulopathy and the humoral response against viral proteins in patients at different stages of COVID-19","display_name":"Coagulopathy and the humoral response against viral proteins in patients at different stages of COVID-19","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4318166199","doi":"https://doi.org/10.1590/0074-02760220072","pmid":"https://pubmed.ncbi.nlm.nih.gov/36700578","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9870257"},"language":"en","primary_location":{"id":"doi:10.1590/0074-02760220072","doi":"https://doi.org/10.1590/0074-02760220072","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1590/0074-02760220072","pdf_url":"https://www.scielo.br/j/mioc/a/PqgjsMbfMSJGWHcwTrP9C5c/?lang=en&format=pdf","source":{"id":"https://openalex.org/S165991124","display_name":"Mem\u00f3rias do Instituto Oswaldo Cruz","issn_l":"0074-0276","issn":["0074-0276","1678-8060"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","medline","norway-1","poland-70","russia-white-list-1","scielo"],"host_organization":"https://openalex.org/P4310312016","host_organization_name":"Instituto Oswaldo Cruz, Minist\u00e9rio da Sa\u00fade","host_organization_lineage":["https://openalex.org/P4310312016"],"host_organization_lineage_names":["Instituto Oswaldo Cruz, Minist\u00e9rio da Sa\u00fade"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mem\u00f3rias do Instituto Oswaldo Cruz","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.scielo.br/j/mioc/a/PqgjsMbfMSJGWHcwTrP9C5c/?lang=en&format=pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048181405","display_name":"Fernanda Pereira Monteiro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802951768","display_name":"Universidade Federal do Oeste da Bahia","ror":"https://ror.org/03raeyn57","country_code":"BR","type":"education","lineage":["https://openalex.org/I2802951768"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fernanda Pereira Monteiro","raw_affiliation_strings":["Universidade Federal do Oeste da Bahia,  Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Oeste da Bahia,  Brazil","institution_ids":["https://openalex.org/I2802951768"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102729699","display_name":"Victor de Souza Tavares","orcid":"https://orcid.org/0000-0001-8313-831X","observed_orcids":["https://orcid.org/0000-0001-8313-831X"]},"institutions":[{"id":"https://openalex.org/I2802951768","display_name":"Universidade Federal do Oeste da Bahia","ror":"https://ror.org/03raeyn57","country_code":"BR","type":"education","lineage":["https://openalex.org/I2802951768"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Victor de Souza Tavares","raw_affiliation_strings":["Universidade Federal do Oeste da Bahia,  Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Oeste da Bahia,  Brazil","institution_ids":["https://openalex.org/I2802951768"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030089060","display_name":"Rayane da Silva Oliveira Souza","orcid":"https://orcid.org/0000-0002-6463-5537","observed_orcids":["https://orcid.org/0000-0002-6463-5537"]},"institutions":[{"id":"https://openalex.org/I2802951768","display_name":"Universidade Federal do Oeste da Bahia","ror":"https://ror.org/03raeyn57","country_code":"BR","type":"education","lineage":["https://openalex.org/I2802951768"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rayane da Silva Oliveira Souza","raw_affiliation_strings":["Universidade Federal do Oeste da Bahia,  Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Oeste da Bahia,  Brazil","institution_ids":["https://openalex.org/I2802951768"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019409012","display_name":"Larissa Paola Rodrigues Ven\u00e2ncio","orcid":"https://orcid.org/0000-0003-1814-8954","observed_orcids":["https://orcid.org/0000-0003-1814-8954"]},"institutions":[{"id":"https://openalex.org/I2802951768","display_name":"Universidade Federal do Oeste da Bahia","ror":"https://ror.org/03raeyn57","country_code":"BR","type":"education","lineage":["https://openalex.org/I2802951768"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Larissa Paola Rodrigues Ven\u00e2ncio","raw_affiliation_strings":["Universidade Federal do Oeste da Bahia,  Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Oeste da Bahia,  Brazil","institution_ids":["https://openalex.org/I2802951768"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040650829","display_name":"Mary Hellen Fabres-Klein","orcid":"https://orcid.org/0000-0002-3690-1922","observed_orcids":["https://orcid.org/0000-0002-3690-1922"]},"institutions":[{"id":"https://openalex.org/I2802951768","display_name":"Universidade Federal do Oeste da Bahia","ror":"https://ror.org/03raeyn57","country_code":"BR","type":"education","lineage":["https://openalex.org/I2802951768"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Mary Hellen Fabres-Klein","raw_affiliation_strings":["Universidade Federal do Oeste da Bahia,  Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Oeste da Bahia,  Brazil","institution_ids":["https://openalex.org/I2802951768"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020179339","display_name":"Rodrigo Feliciano do Carmo","orcid":"https://orcid.org/0000-0001-9601-6995","observed_orcids":["https://orcid.org/0000-0001-9601-6995"]},"institutions":[{"id":"https://openalex.org/I59530521","display_name":"Universidade Federal do Vale do S\u00e3o Francisco","ror":"https://ror.org/00devjr72","country_code":"BR","type":"education","lineage":["https://openalex.org/I59530521"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rodrigo Feliciano do Carmo","raw_affiliation_strings":["Universidade Federal do Vale do S\u00e3o Francisco,  Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Vale do S\u00e3o Francisco,  Brazil","institution_ids":["https://openalex.org/I59530521"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046905038","display_name":"Raphael Contelli Klein","orcid":"https://orcid.org/0000-0003-2945-7103","observed_orcids":["https://orcid.org/0000-0003-2945-7103"]},"institutions":[{"id":"https://openalex.org/I2802951768","display_name":"Universidade Federal do Oeste da Bahia","ror":"https://ror.org/03raeyn57","country_code":"BR","type":"education","lineage":["https://openalex.org/I2802951768"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Raphael Contelli Klein","raw_affiliation_strings":["Universidade Federal do Oeste da Bahia,  Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Oeste da Bahia,  Brazil","institution_ids":["https://openalex.org/I2802951768"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063659896","display_name":"Jonilson Berlink Lima","orcid":"https://orcid.org/0000-0002-1403-4768","observed_orcids":["https://orcid.org/0000-0002-1403-4768"]},"institutions":[{"id":"https://openalex.org/I2802951768","display_name":"Universidade Federal do Oeste da Bahia","ror":"https://ror.org/03raeyn57","country_code":"BR","type":"education","lineage":["https://openalex.org/I2802951768"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jonilson Berlink Lima","raw_affiliation_strings":["Universidade Federal do Oeste da Bahia,  Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Oeste da Bahia,  Brazil","institution_ids":["https://openalex.org/I2802951768"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020659658","display_name":"Th\u00e9o Ara\u00fajo-Santos","orcid":"https://orcid.org/0000-0001-9861-6660","observed_orcids":["https://orcid.org/0000-0001-9861-6660"]},"institutions":[{"id":"https://openalex.org/I2802951768","display_name":"Universidade Federal do Oeste da Bahia","ror":"https://ror.org/03raeyn57","country_code":"BR","type":"education","lineage":["https://openalex.org/I2802951768"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Th\u00e9o Ara\u00fajo-Santos","raw_affiliation_strings":["Universidade Federal do Oeste da Bahia,  Brazil"],"raw_orcid":"https://orcid.org/0000-0001-9861-6660","affiliations":[{"raw_affiliation_string":"Universidade Federal do Oeste da Bahia,  Brazil","institution_ids":["https://openalex.org/I2802951768"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5020659658"],"corresponding_institution_ids":["https://openalex.org/I2802951768"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"117","issue":null,"first_page":"e220072","last_page":"e220072"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9106000065803528,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9106000065803528,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.08500000089406967,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11368","display_name":"Long-Term Effects of COVID-19","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9980000257492065},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9900000095367432},{"id":"https://openalex.org/keywords/coagulopathy","display_name":"coagulopathy","score":0.9800000190734863},{"id":"https://openalex.org/keywords/d-dimer","display_name":"D-dimer","score":0.9919999837875366},{"id":"https://openalex.org/keywords/humoral-immune-response","display_name":"humoral immune response","score":0.9700000286102295},{"id":"https://openalex.org/keywords/igg","display_name":"IgG","score":0.7670000195503235},{"id":"https://openalex.org/keywords/nucleocapsid-protein","display_name":"nucleocapsid protein","score":0.8209999799728394},{"id":"https://openalex.org/keywords/spike-receptor-binding-domain","display_name":"spike protein receptor-binding domain","score":0.8679999709129333},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.9860000014305115},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C2779936836","wikidata":"https://www.wikidata.org/wiki/Q890200","display_name":"Coagulopathy","level":2,"score":0.7202960252761841},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.694259762763977},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6199014782905579},{"id":"https://openalex.org/C2779519742","wikidata":"https://www.wikidata.org/wiki/Q198526","display_name":"D-dimer","level":2,"score":0.5944539904594421},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.563774585723877},{"id":"https://openalex.org/C60325843","wikidata":"https://www.wikidata.org/wiki/Q419245","display_name":"Nucleoprotein","level":3,"score":0.5053887367248535},{"id":"https://openalex.org/C2777648638","wikidata":"https://www.wikidata.org/wiki/Q57751738","display_name":"Coronavirus","level":5,"score":0.5008902549743652},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.47086966037750244},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.4443740248680115},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.41970160603523254},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.4151734411716461},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3912823796272278},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.30423927307128906},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27521592378616333},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.14208939671516418}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001778","descriptor_name":"Blood Coagulation Disorders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005338","descriptor_name":"Fibrin Fibrinogen Degradation Products","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056724","descriptor_name":"Immunity, Humoral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1590/0074-02760220072","doi":"https://doi.org/10.1590/0074-02760220072","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1590/0074-02760220072","pdf_url":"https://www.scielo.br/j/mioc/a/PqgjsMbfMSJGWHcwTrP9C5c/?lang=en&format=pdf","source":{"id":"https://openalex.org/S165991124","display_name":"Mem\u00f3rias do Instituto Oswaldo Cruz","issn_l":"0074-0276","issn":["0074-0276","1678-8060"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","medline","norway-1","poland-70","russia-white-list-1","scielo"],"host_organization":"https://openalex.org/P4310312016","host_organization_name":"Instituto Oswaldo Cruz, Minist\u00e9rio da Sa\u00fade","host_organization_lineage":["https://openalex.org/P4310312016"],"host_organization_lineage_names":["Instituto Oswaldo Cruz, Minist\u00e9rio da Sa\u00fade"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mem\u00f3rias do Instituto Oswaldo Cruz","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9870257","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9870257","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9870257/pdf/1678-8060-mioc-117-e220072.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mem Inst Oswaldo Cruz","raw_type":"Text"},{"id":"pmid:36700578","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36700578","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Memorias do Instituto Oswaldo Cruz","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1590/0074-02760220072","doi":"https://doi.org/10.1590/0074-02760220072","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1590/0074-02760220072","pdf_url":"https://www.scielo.br/j/mioc/a/PqgjsMbfMSJGWHcwTrP9C5c/?lang=en&format=pdf","source":{"id":"https://openalex.org/S165991124","display_name":"Mem\u00f3rias do Instituto Oswaldo Cruz","issn_l":"0074-0276","issn":["0074-0276","1678-8060"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","medline","norway-1","poland-70","russia-white-list-1","scielo"],"host_organization":"https://openalex.org/P4310312016","host_organization_name":"Instituto Oswaldo Cruz, Minist\u00e9rio da Sa\u00fade","host_organization_lineage":["https://openalex.org/P4310312016"],"host_organization_lineage_names":["Instituto Oswaldo Cruz, Minist\u00e9rio da Sa\u00fade"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mem\u00f3rias do Instituto Oswaldo Cruz","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320321837","display_name":"Ministerio de Econom\u00eda y Competitividad","ror":"https://ror.org/034900433"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320327335","display_name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia, Inova\u00e7\u00f5es e Comunica\u00e7\u00f5es","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4318166199.pdf","grobid_xml":"https://content.openalex.org/works/W4318166199.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1969841753","https://openalex.org/W2102619382","https://openalex.org/W2325881814","https://openalex.org/W2915839491","https://openalex.org/W2989769422","https://openalex.org/W2995449088","https://openalex.org/W3011537081","https://openalex.org/W3014003872","https://openalex.org/W3016126001","https://openalex.org/W3016553966","https://openalex.org/W3019316721","https://openalex.org/W3021544284","https://openalex.org/W3028583791","https://openalex.org/W3030113472","https://openalex.org/W3036512428","https://openalex.org/W3036796082","https://openalex.org/W3036931136","https://openalex.org/W3045525085","https://openalex.org/W3047266728","https://openalex.org/W3049307290","https://openalex.org/W3091820618","https://openalex.org/W3097119905","https://openalex.org/W3113228067","https://openalex.org/W3121286195","https://openalex.org/W3130000845","https://openalex.org/W3138469897","https://openalex.org/W3139099468","https://openalex.org/W3155566633","https://openalex.org/W3159275835","https://openalex.org/W3168693390","https://openalex.org/W3188592837","https://openalex.org/W3194504479","https://openalex.org/W3206533554","https://openalex.org/W4285793206"],"related_works":["https://openalex.org/W6969020686","https://openalex.org/W4404382676","https://openalex.org/W3093516981","https://openalex.org/W4225898602","https://openalex.org/W4399529892","https://openalex.org/W4210945015","https://openalex.org/W3046066086","https://openalex.org/W3024915375","https://openalex.org/W4386954175","https://openalex.org/W4313437809"],"abstract_inverted_index":{"BACKGROUND:":[0],"Patients":[1,114],"with":[2,10,115,122,160],"severe":[3,68,116,191],"coronavirus":[4,195],"disease":[5,117,161],"2019":[6],"(COVID-19)":[7],"often":[8],"present":[9],"coagulopathies":[11],"and":[12,30,76,90,98,151,156,178,201],"have":[13],"high":[14,123,147],"titres":[15],"of":[16,43,55,59,92,103,125,143,149,184,212],"circulating":[17,31,130],"antibodies":[18],"against":[19,34,94,132,153,176,190],"viral":[20,35],"proteins.":[21],"OBJECTIVES:":[22],"Herein,":[23],"we":[24,48,82],"evaluated":[25],"the":[26,56,85,88,95,99,104,133,137,154,164,182,187,210],"association":[27],"between":[28],"D-dimer":[29,126,150],"immunoglobulin":[32],"levels":[33,124,148],"proteins":[36,106],"in":[37,84,166,181,209],"patients":[38,54,165],"at":[39],"different":[40],"clinical":[41],"stages":[42],"COVID-19.":[44,185],"METHODS:":[45],"For":[46],"this,":[47],"performed":[49],"a":[50,119],"cross-sectional":[51],"study":[52],"involving":[53],"first":[57],"wave":[58],"COVID-19":[60],"clinically":[61],"classified":[62],"as":[63,127,129],"oligosymptomatic":[64],"(n":[65,69,73,78],"=":[66,70,74,79],"22),":[67],"30),":[71],"cured":[72],"27)":[75],"non-infected":[77],"9).":[80],"Next,":[81],"measured":[83],"plasma":[86],"samples":[87],"total":[89],"fraction":[91],"immunoglobulins":[93],"nucleoprotein":[96],"(NP)":[97],"receptor-binding":[100],"domain":[101],"(RBD)":[102],"spike":[105],"by":[107],"enzyme-linked":[108],"immunosorbent":[109],"assay":[110],"(ELISA)":[111],"assays.":[112],"FINDINGS:":[113],"had":[118],"coagulation":[120],"disorder":[121],"well":[128],"IgG":[131,152,175],"NP":[134,155,177],"but":[135],"not":[136],"RBD":[138,157,179],"compared":[139],"to":[140,206],"other":[141],"groups":[142],"patients.":[144],"In":[145],"addition,":[146],"were":[158],"associated":[159],"severity":[162],"among":[163],"this":[167,213],"study.":[168],"MAIN":[169],"CONCLUSIONS:":[170],"Our":[171],"data":[172],"suggest":[173],"that":[174],"participates":[180],"worsening":[183],"Although":[186],"humoral":[188],"response":[189],"acute":[192],"respiratory":[193],"syndrome":[194],"2":[196],"(SARS-CoV-2)":[197],"is":[198],"partially":[199],"understood,":[200],"more":[202],"efforts":[203],"are":[204],"needed":[205],"clarify":[207],"gaps":[208],"knowledge":[211],"process.":[214]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-01-27T00:00:00"}