{"id":"https://openalex.org/W4318040587","doi":"https://doi.org/10.1093/bjd/ljac140.048","title":"357 The effect of upadacitinib on the genital region in moderate-to-severe atopic dermatitis: an analysis from the Measure Up 1 and Measure Up 2 studies","display_name":"357 The effect of upadacitinib on the genital region in moderate-to-severe atopic dermatitis: an analysis from the Measure Up 1 and Measure Up 2 studies","publication_year":2023,"publication_date":"2023-01-25","ids":{"openalex":"https://openalex.org/W4318040587","doi":"https://doi.org/10.1093/bjd/ljac140.048"},"language":"en","primary_location":{"id":"doi:10.1093/bjd/ljac140.048","doi":"https://doi.org/10.1093/bjd/ljac140.048","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bjd/ljac140.048","pdf_url":null,"source":{"id":"https://openalex.org/S45720283","display_name":"British Journal of Dermatology","issn_l":"0007-0963","issn":["0007-0963","1365-2133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004761425","display_name":"Jennifer Clay Cather","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer Cather","raw_affiliation_strings":["Mindful Dermatology and Modern Research Associates , Dallas, TX , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mindful Dermatology and Modern Research Associates , Dallas, TX , USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043495084","display_name":"Nina Magnolo","orcid":"https://orcid.org/0000-0001-6802-0153","observed_orcids":["https://orcid.org/0000-0001-6802-0153"]},"institutions":[{"id":"https://openalex.org/I4210103666","display_name":"University Hospital M\u00fcnster","ror":"https://ror.org/01856cw59","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210103666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nina Magnolo","raw_affiliation_strings":["Department of Dermatology, University Hospital M\u00fcnster , M\u00fcnster , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University Hospital M\u00fcnster , M\u00fcnster , Germany","institution_ids":["https://openalex.org/I4210103666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041449809","display_name":"Michael D. Cameron","orcid":"https://orcid.org/0000-0003-3154-4775","observed_orcids":["https://orcid.org/0000-0003-3154-4775"]},"institutions":[{"id":"https://openalex.org/I1324220072","display_name":"Mount Sinai Hospital","ror":"https://ror.org/01zkyz108","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I1324220072"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael\u00a0 Cameron","raw_affiliation_strings":["Department of Dermatology, Mount Sinai Hospital , New York, NY , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Mount Sinai Hospital , New York, NY , USA","institution_ids":["https://openalex.org/I1324220072"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032393407","display_name":"Brian Calimlim","orcid":"https://orcid.org/0000-0002-6463-6433","observed_orcids":["https://orcid.org/0000-0002-6463-6433"]},"institutions":[{"id":"https://openalex.org/I2948539688","display_name":"AbbVie (United States)","ror":"https://ror.org/02g5p4n58","country_code":"US","type":"company","lineage":["https://openalex.org/I2948539688"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Calimlim","raw_affiliation_strings":["AbbVie, Inc , North Chicago, IL , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AbbVie, Inc , North Chicago, IL , USA","institution_ids":["https://openalex.org/I2948539688"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael Lane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2948539688","display_name":"AbbVie (United States)","ror":"https://ror.org/02g5p4n58","country_code":"US","type":"company","lineage":["https://openalex.org/I2948539688"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Lane","raw_affiliation_strings":["AbbVie, Inc , North Chicago, IL , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AbbVie, Inc , North Chicago, IL , USA","institution_ids":["https://openalex.org/I2948539688"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Stephanie Hays","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2948539688","display_name":"AbbVie (United States)","ror":"https://ror.org/02g5p4n58","country_code":"US","type":"company","lineage":["https://openalex.org/I2948539688"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie Hays","raw_affiliation_strings":["AbbVie, Inc , North Chicago, IL , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AbbVie, Inc , North Chicago, IL , USA","institution_ids":["https://openalex.org/I2948539688"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012798107","display_name":"Amy Gamelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2948539688","display_name":"AbbVie (United States)","ror":"https://ror.org/02g5p4n58","country_code":"US","type":"company","lineage":["https://openalex.org/I2948539688"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Gamelli","raw_affiliation_strings":["AbbVie, Inc , North Chicago, IL , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AbbVie, Inc , North Chicago, IL , USA","institution_ids":["https://openalex.org/I2948539688"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089346856","display_name":"Yu Ri Woo","orcid":"https://orcid.org/0000-0003-2903-9534","observed_orcids":["https://orcid.org/0000-0003-2903-9534"]},"institutions":[{"id":"https://openalex.org/I4210102816","display_name":"The Catholic University of Korea Incheon St. Mary's Hospital","ror":"https://ror.org/017gxrm85","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210102816","https://openalex.org/I4405260414","https://openalex.org/I87111246"]},{"id":"https://openalex.org/I87111246","display_name":"Catholic University of Korea","ror":"https://ror.org/01fpnj063","country_code":"KR","type":"education","lineage":["https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yu Ri Woo","raw_affiliation_strings":["Department of Dermatology, Incheon St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea , Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Incheon St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea , Seoul, Republic of Korea","institution_ids":["https://openalex.org/I4210102816","https://openalex.org/I87111246"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3416,"currency":"GBP","value_usd":4249},"apc_paid":null,"fwci":0.2562,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.48806177,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"188","issue":"Supplement_2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/upadacitinib","display_name":"upadacitinib","score":0.9470000267028809},{"id":"https://openalex.org/keywords/atopic-dermatitis","display_name":"atopic dermatitis","score":0.9509999752044678},{"id":"https://openalex.org/keywords/jak-inhibitors","display_name":"JAK inhibitors","score":0.8389999866485596},{"id":"https://openalex.org/keywords/scorad","display_name":"SCORAD","score":0.781000018119812},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.6710000038146973},{"id":"https://openalex.org/keywords/pruritus","display_name":"pruritus","score":0.5929999947547913},{"id":"https://openalex.org/keywords/sleep-disturbance","display_name":"sleep disorders","score":0.5059999823570251},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.3240000009536743},{"id":"https://openalex.org/keywords/dose-comparison","display_name":"dose comparison","score":0.6159999966621399},{"id":"https://openalex.org/keywords/placebo-controlled-comparison","display_name":"placebo comparison","score":0.3709999918937683},{"id":"https://openalex.org/keywords/adolescents-and-adults","display_name":"adolescents and adults","score":0.5680000185966492},{"id":"https://openalex.org/keywords/disease-duration","display_name":"disease duration","score":0.42899999022483826},{"id":"https://openalex.org/keywords/dermatology-life-quality-index","display_name":"Dermatology Life Quality Index","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C2780501606","wikidata":"https://www.wikidata.org/wiki/Q7389221","display_name":"SCORAD","level":4,"score":0.8754967451095581},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8085034489631653},{"id":"https://openalex.org/C2778329239","wikidata":"https://www.wikidata.org/wiki/Q268667","display_name":"Atopic dermatitis","level":2,"score":0.7908332347869873},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7794895768165588},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.566279947757721},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5603238344192505},{"id":"https://openalex.org/C183021626","wikidata":"https://www.wikidata.org/wiki/Q4620674","display_name":"Sex organ","level":2,"score":0.4463391602039337},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.4191681742668152},{"id":"https://openalex.org/C2776173921","wikidata":"https://www.wikidata.org/wiki/Q25326609","display_name":"Dermatology Life Quality Index","level":3,"score":0.3902413845062256},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3862245976924896},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.3577728271484375},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1513366997241974},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10298386216163635},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/bjd/ljac140.048","doi":"https://doi.org/10.1093/bjd/ljac140.048","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bjd/ljac140.048","pdf_url":null,"source":{"id":"https://openalex.org/S45720283","display_name":"British Journal of Dermatology","issn_l":"0007-0963","issn":["0007-0963","1365-2133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Dermatology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4231561986","https://openalex.org/W4381336787","https://openalex.org/W4317952747","https://openalex.org/W7134804515","https://openalex.org/W3164705475","https://openalex.org/W4381383527","https://openalex.org/W2155772286","https://openalex.org/W4378640342","https://openalex.org/W4391610378","https://openalex.org/W4393164331"],"abstract_inverted_index":{"Abstract":[0],"Atopic":[1,80,287],"dermatitis":[2],"(AD)":[3],"is":[4,48,94],"a":[5,49,91],"chronic,":[6],"inflammatory":[7],"skin":[8],"disease":[9,305],"that":[10],"can":[11],"be":[12],"debilitating,":[13],"impacting":[14],"all":[15],"body":[16,92],"areas,":[17],"including":[18],"the":[19,71,85,110,121,153,194,219,226,280,325,337,345,356,366,377,391,477,485],"genital":[20,126,199,205,232,260,298,330,371,413,431,457,481],"region.":[21],"Genital":[22],"AD":[23,127,206,233,331,372,408,414,432,452,458,488],"results":[24],"in":[25,27,41,167,376,390,450,463,467],"impairments":[26],"daily":[28,181,423],"activity":[29],"levels,":[30],"sexual":[31,464],"function":[32],"and":[33,65,87,100,114,143,155,161,169,211,236,276,311,342,382,437,469,499],"sleep,":[34],"contributing":[35],"to":[36,75,89,103,165,178,239,279,425,447,461,489],"impaired":[37],"quality":[38,471],"of":[39,73,109,123,157,196,327,336,344,351,368,411,442,456,472,479,487],"life":[40],"patients":[42,124,171,197,328,369,405,498],"with":[43,56,129,138,172,198,259,297,406,415,427,453],"moderate-to-severe":[44,173,407,451],"AD.":[45,77,104,174],"Upadacitinib":[46],"(UPA)":[47],"selective":[50],"oral":[51,179],"Janus":[52],"kinase":[53,67],"(JAK)":[54],"inhibitor":[55],"greater":[57,304,354,470],"inhibitory":[58],"potency":[59],"for":[60,70,286],"JAK1":[61],"vs.":[62,262,268,274,290,308,320],"JAK2,":[63],"JAK3":[64],"tyrosine":[66],"2,":[68,324],"indicated":[69],"treatment":[72,495],"moderate":[74],"severe":[76,277],"The":[78,190],"SCORing":[79],"Dermatitis":[81,288],"(SCORAD)":[82],"measure":[83],"assesses":[84],"extent":[86],"severity":[88],"which":[90,352,395],"area":[93],"affected,":[95],"as":[96,98],"well":[97],"itch":[99],"sleeplessness":[101,468],"due":[102],"In":[105,445],"this":[106],"post-hoc":[107],"analysis":[108],"Measure":[111,115,140],"Up":[112,116,141],"1":[113,142],"2":[117,144,210,435],"studies,":[118],"we":[119],"evaluated":[120],"proportion":[122,195,326,367],"whose":[125,329,370],"resolved":[128,333,374],"UPA":[130,134,158,162,182,185,240,246,338,346,378,383,416,443],"15":[131,159,183,241,339,379,417],"mg":[132,136,160,164,187,242,248,340,348,380,385,418,421],"or":[133,188,252,419],"30":[135,163,186,247,347,384,420],"compared":[137,424],"placebo.":[139,189],"are":[145],"phase":[146],"3":[147],"multicenter,":[148],"randomized,":[149],"double-blind":[150],"studies":[151],"comparing":[152],"safety":[154],"efficacy":[156],"placebo":[166,253,357,392],"adolescent":[168],"adult":[170],"Patients":[175],"were":[176,237,265,353],"randomized":[177,238],"once":[180],"mg,":[184],"current":[191],"study":[192],"assessed":[193],"involvement":[200,261,299,482],"at":[201,208,234,292,300],"baseline":[202,235,301],"who":[203],"achieved":[204,409],"resolution":[207,410,433,455],"week":[209,212,323,364],"16":[213,440],"based":[214],"on":[215],"data":[216],"collected":[217],"from":[218],"SCORAD.":[220],"Non-responder":[221],"imputation":[222],"was":[223,332,334,373],"used.":[224],"Of":[225],"1679":[227],"participants,":[228],"239":[229],"(14.2%)":[230],"had":[231],"(n":[243,249,254],"=":[244,250,255],"77),":[245],"86)":[251],"76).":[256],"More":[257,404],"participants":[258,296],"those":[263],"without":[264],"male":[266],"(61.1%":[267],"54.1%),":[269],"\u226518":[270],"years":[271],"old":[272],"(92.1%":[273],"85.5%),":[275],"according":[278],"Validated":[281],"Investigator":[282],"Global":[283],"Assessment":[284],"Scale":[285],"(66.9%":[289],"47.2%)":[291],"baseline.":[293],"On":[294],"average,":[295],"also":[302],"reported":[303],"duration":[306],"(25.0":[307],"22.8":[309],"years)":[310],"higher":[312],"Dermatology":[313],"Life":[314],"Quality":[315],"Index":[316],"(DLQI)":[317],"scores":[318],"(19.2":[319],"16.3).":[321],"At":[322,363],"70.1%":[335],"group,":[341,349],"82.6%":[343],"both":[350,399],"than":[355,398],"group":[358,393],"(31.6%;":[359],"P":[360],"<":[361,402],"0.001).":[362,403],"16,":[365],"increased":[375],"(80.5%)":[381],"(83.7%)":[386],"groups,":[387],"but":[388],"not":[389],"(28.9%)":[394],"remained":[396],"lower":[397],"groups":[400],"(P":[401],"their":[412],"monotherapy":[422],"placebo,":[426],">70%":[428],"rapidly":[429],"achieving":[430],"after":[434,439],"weeks":[436,441],">80%":[438],"treatment.":[444],"addition":[446],"overall":[448],"improvements":[449,462],"UPA,":[454],"may":[459],"correspond":[460],"functioning,":[465],"reductions":[466],"life.":[473],"These":[474],"findings":[475],"underscore":[476],"importance":[478],"considering":[480],"when":[483],"assessing":[484],"burden":[486],"comprehensively":[490],"inform":[491],"integrated":[492],"shared":[493],"decision-making":[494],"discussions":[496],"between":[497],"physicians.":[500]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-01-26T00:00:00"}