{"id":"https://openalex.org/W4317907792","doi":"https://doi.org/10.3390/ijms24032250","title":"Immortalized Canine Adipose-Derived Mesenchymal Stem Cells as a Novel Candidate Cell Source for Mesenchymal Stem Cell Therapy","display_name":"Immortalized Canine Adipose-Derived Mesenchymal Stem Cells as a Novel Candidate Cell Source for Mesenchymal Stem Cell Therapy","publication_year":2023,"publication_date":"2023-01-23","ids":{"openalex":"https://openalex.org/W4317907792","doi":"https://doi.org/10.3390/ijms24032250","pmid":"https://pubmed.ncbi.nlm.nih.gov/36768587","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9917102"},"language":"en","primary_location":{"id":"doi:10.3390/ijms24032250","doi":"https://doi.org/10.3390/ijms24032250","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms24032250","pdf_url":"https://www.mdpi.com/1422-0067/24/3/2250/pdf?version=1674477834","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/24/3/2250/pdf?version=1674477834","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049031625","display_name":"Yuyo Yasumura","orcid":"https://orcid.org/0000-0002-3028-779X","observed_orcids":["https://orcid.org/0000-0002-3028-779X"]},"institutions":[{"id":"https://openalex.org/I130126513","display_name":"Nippon Veterinary and Life Science University","ror":"https://ror.org/04wsgqy55","country_code":"JP","type":"education","lineage":["https://openalex.org/I130126513"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuyo Yasumura","raw_affiliation_strings":["Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan"],"raw_orcid":"https://orcid.org/0000-0002-3028-779X","affiliations":[{"raw_affiliation_string":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan","institution_ids":["https://openalex.org/I130126513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059478180","display_name":"Takahiro Teshima","orcid":"https://orcid.org/0000-0001-9646-6785","observed_orcids":["https://orcid.org/0000-0001-9646-6785"]},"institutions":[{"id":"https://openalex.org/I130126513","display_name":"Nippon Veterinary and Life Science University","ror":"https://ror.org/04wsgqy55","country_code":"JP","type":"education","lineage":["https://openalex.org/I130126513"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Takahiro Teshima","raw_affiliation_strings":["Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan","Research Center for Animal Life Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan"],"raw_orcid":"https://orcid.org/0000-0001-9646-6785","affiliations":[{"raw_affiliation_string":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan","institution_ids":["https://openalex.org/I130126513"]},{"raw_affiliation_string":"Research Center for Animal Life Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan","institution_ids":["https://openalex.org/I130126513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000780291","display_name":"Tomokazu Nagashima","orcid":"https://orcid.org/0000-0001-5912-0179","observed_orcids":["https://orcid.org/0000-0001-5912-0179"]},"institutions":[{"id":"https://openalex.org/I130126513","display_name":"Nippon Veterinary and Life Science University","ror":"https://ror.org/04wsgqy55","country_code":"JP","type":"education","lineage":["https://openalex.org/I130126513"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomokazu Nagashima","raw_affiliation_strings":["Laboratory of Veterinary Pathology, Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Veterinary Pathology, Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan","institution_ids":["https://openalex.org/I130126513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025581245","display_name":"Takashi Takano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130126513","display_name":"Nippon Veterinary and Life Science University","ror":"https://ror.org/04wsgqy55","country_code":"JP","type":"education","lineage":["https://openalex.org/I130126513"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Takano","raw_affiliation_strings":["Laboratory of Veterinary Public Health, Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Veterinary Public Health, Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan","institution_ids":["https://openalex.org/I130126513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000750696","display_name":"Masaki Michishita","orcid":"https://orcid.org/0000-0002-0353-3668","observed_orcids":["https://orcid.org/0000-0002-0353-3668"]},"institutions":[{"id":"https://openalex.org/I130126513","display_name":"Nippon Veterinary and Life Science University","ror":"https://ror.org/04wsgqy55","country_code":"JP","type":"education","lineage":["https://openalex.org/I130126513"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaki Michishita","raw_affiliation_strings":["Laboratory of Veterinary Pathology, Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan","Research Center for Animal Life Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Veterinary Pathology, Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan","institution_ids":["https://openalex.org/I130126513"]},{"raw_affiliation_string":"Research Center for Animal Life Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan","institution_ids":["https://openalex.org/I130126513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005273999","display_name":"Yoshiaki Taira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130126513","display_name":"Nippon Veterinary and Life Science University","ror":"https://ror.org/04wsgqy55","country_code":"JP","type":"education","lineage":["https://openalex.org/I130126513"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiaki Taira","raw_affiliation_strings":["Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan","institution_ids":["https://openalex.org/I130126513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083464734","display_name":"Ryohei H. Suzuki","orcid":"https://orcid.org/0000-0001-9451-5854","observed_orcids":["https://orcid.org/0000-0001-9451-5854"]},"institutions":[{"id":"https://openalex.org/I130126513","display_name":"Nippon Veterinary and Life Science University","ror":"https://ror.org/04wsgqy55","country_code":"JP","type":"education","lineage":["https://openalex.org/I130126513"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryohei Suzuki","raw_affiliation_strings":["Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan"],"raw_orcid":"https://orcid.org/0000-0001-9451-5854","affiliations":[{"raw_affiliation_string":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan","institution_ids":["https://openalex.org/I130126513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032489820","display_name":"Hirotaka Matsumoto","orcid":"https://orcid.org/0000-0002-8832-6341","observed_orcids":["https://orcid.org/0000-0002-8832-6341"]},"institutions":[{"id":"https://openalex.org/I130126513","display_name":"Nippon Veterinary and Life Science University","ror":"https://ror.org/04wsgqy55","country_code":"JP","type":"education","lineage":["https://openalex.org/I130126513"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirotaka Matsumoto","raw_affiliation_strings":["Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan","institution_ids":["https://openalex.org/I130126513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5059478180"],"corresponding_institution_ids":["https://openalex.org/I130126513"],"apc_list":{"value":2500,"currency":"CHF","value_usd":2780},"apc_paid":{"value":2500,"currency":"CHF","value_usd":2780},"fwci":1.0581,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.69431479,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":97},"biblio":{"volume":"24","issue":"3","first_page":"2250","last_page":"2250"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.9440000057220459},{"id":"https://openalex.org/keywords/tert","display_name":"telomerase reverse transcriptase","score":0.8930000066757202},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.8209999799728394},{"id":"https://openalex.org/keywords/trilineage-differentiation","display_name":"trilineage differentiation","score":0.7580000162124634},{"id":"https://openalex.org/keywords/lymphocyte-proliferation-inhibition","display_name":"lymphocyte proliferation inhibition","score":0.8529999852180481},{"id":"https://openalex.org/keywords/cell-heterogeneity","display_name":"cellular heterogeneity","score":0.597000002861023},{"id":"https://openalex.org/keywords/rna-sequencing","display_name":"RNA sequencing","score":0.6259999871253967},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.5350000262260437},{"id":"https://openalex.org/keywords/telomerase","display_name":"telomerase","score":0.8100000023841858},{"id":"https://openalex.org/keywords/stem-cell-therapy","display_name":"stem cell therapy","score":0.5569999814033508}],"concepts":[{"id":"https://openalex.org/C116716535","wikidata":"https://www.wikidata.org/wiki/Q5009851","display_name":"CD90","level":4,"score":0.8632420301437378},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.8154098391532898},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.7262116074562073},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.537094235420227},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42626750469207764},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37274399399757385},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.22980079054832458}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019938","descriptor_name":"Cyclin D1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045164","descriptor_name":"Mesenchymal Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms24032250","doi":"https://doi.org/10.3390/ijms24032250","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms24032250","pdf_url":"https://www.mdpi.com/1422-0067/24/3/2250/pdf?version=1674477834","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9917102","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9917102","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:36768587","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36768587","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/ijms24032250","doi":"https://doi.org/10.3390/ijms24032250","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms24032250","pdf_url":"https://www.mdpi.com/1422-0067/24/3/2250/pdf?version=1674477834","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3806760111","display_name":"Elucidation of the diversity of canine mammary tumors and the foundation of cancer stem cell-targeted therapies","funder_award_id":"22K05996","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7489112976","display_name":"Characteristic analysis of canine mesenchymal stem cells capable of differentiating into insulin-producing cells and establishment of transplantation therapy","funder_award_id":"21H02373","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4317907792.pdf","grobid_xml":"https://content.openalex.org/works/W4317907792.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1496192093","https://openalex.org/W1543500873","https://openalex.org/W1581251915","https://openalex.org/W1982323513","https://openalex.org/W1991404626","https://openalex.org/W1992365767","https://openalex.org/W2019414980","https://openalex.org/W2024619097","https://openalex.org/W2025371271","https://openalex.org/W2050742889","https://openalex.org/W2063915006","https://openalex.org/W2129802275","https://openalex.org/W2134395334","https://openalex.org/W2340306432","https://openalex.org/W2506259081","https://openalex.org/W2746710261","https://openalex.org/W2766971919","https://openalex.org/W2780208812","https://openalex.org/W2794398904","https://openalex.org/W2796493184","https://openalex.org/W2804453241","https://openalex.org/W2890594474","https://openalex.org/W2898122766","https://openalex.org/W2903755418","https://openalex.org/W2915757155","https://openalex.org/W2945162057","https://openalex.org/W2950854031","https://openalex.org/W2956415166","https://openalex.org/W2970048739","https://openalex.org/W2981575531","https://openalex.org/W3009434884","https://openalex.org/W3036745223","https://openalex.org/W3043859986","https://openalex.org/W3043861550","https://openalex.org/W3178352573","https://openalex.org/W4200269080","https://openalex.org/W4281382999"],"related_works":["https://openalex.org/W4389788702","https://openalex.org/W2915884595","https://openalex.org/W2772831394","https://openalex.org/W7160178622","https://openalex.org/W2558593042","https://openalex.org/W2924269441","https://openalex.org/W3120947921","https://openalex.org/W7103480822","https://openalex.org/W2023202086","https://openalex.org/W1982342523"],"abstract_inverted_index":{"Mesenchymal":[0],"stem":[1,11,42,247],"cells":[2,36,43,64,152,177,211,238],"are":[3,239],"expected":[4],"to":[5,45,61,123,142,170,201],"be":[6],"a":[7,26,110,165,240],"cell":[8,12,22,128,203,243,248],"source":[9,244],"for":[10,132,245],"therapy":[13],"of":[14,28,53,76,80,134,144],"various":[15],"diseases":[16],"in":[17,113,196,228],"veterinary":[18],"medicine.":[19],"However,":[20],"donor-dependent":[21],"heterogenicity":[23],"has":[24],"been":[25],"cause":[27],"inconsistent":[29],"therapeutic":[30],"efficiency.":[31],"Therefore,":[32],"we":[33],"established":[34,71],"immortalized":[35],"from":[37],"canine":[38,68,86,90],"adipose":[39],"tissue-derived":[40],"mesenchymal":[41,246],"(ADSCs)":[44],"minimize":[46],"cellular":[47,120],"heterogeneity":[48],"by":[49,72,174],"reducing":[50],"the":[51,62,77,124,135,145,175,182,197,202,224],"number":[52],"donors,":[54],"evaluated":[55],"their":[56,154],"properties,":[57],"and":[58,89,99,105,137,150,158,161,185,205,209,236],"compared":[59,122,180],"them":[60],"primary":[63,125,146,183],"with":[65,74,95,103,181,223],"RNA-sequencing.":[66],"Immortalized":[67],"ADSCs":[69,93,184],"were":[70,140,218],"transduction":[73],"combinations":[75],"R24C":[78],"mutation":[79],"human":[81],"cyclin-dependent":[82],"kinase":[83],"4":[84],"(CDKR24C),":[85],"cyclin":[87,97,106],"D1,":[88,98],"TERT.":[91],"The":[92,127,148,168,188,207],"transduced":[94],"CDK4R24C,":[96],"TERT":[100],"(ADSC-K4DT)":[101],"or":[102],"CDK4R24C":[104],"D1":[107],"(ADSC-K4D)":[108],"showed":[109],"dramatic":[111],"increase":[112],"proliferation":[114,173],"(population":[115],"doubling":[116],"level":[117],">100)":[118],"without":[119],"senescence":[121],"ADSCs.":[126,147],"surface":[129],"markers,":[130],"except":[131],"CD90":[133,214,226],"ADSC-K4DT":[136,149,186,208,235],"ADSC-K4D":[138,151,176,210,237],"cells,":[139],"similar":[141],"those":[143],"maintained":[153],"trilineage":[155],"differentiation":[156],"capacity":[157],"chromosome":[159],"condition,":[160],"did":[162],"not":[163],"have":[164],"tumorigenic":[166],"development.":[167],"ability":[169],"inhibit":[171],"lymphocyte":[172],"was":[178],"enhanced":[179],"cells.":[187],"pathway":[189],"analysis":[190],"based":[191],"on":[192],"RNA-sequencing":[193],"revealed":[194],"changes":[195],"pathways":[198],"mainly":[199],"related":[200],"cycle":[204],"telomerase.":[206],"had":[212],"decreased":[213,225],"expression,":[215],"but":[216],"there":[217],"no":[219],"obvious":[220],"defects":[221],"associated":[222],"expression":[227],"this":[229],"study.":[230],"Our":[231],"results":[232],"suggest":[233],"that":[234],"potential":[241],"novel":[242],"therapy.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-01-25T00:00:00"}