{"id":"https://openalex.org/W4317890308","doi":"https://doi.org/10.1200/jco.2023.41.4_suppl.444","title":"Serum IL-6 level to predict survival and treatment response in gastric and gastroesophageal junction cancer.","display_name":"Serum IL-6 level to predict survival and treatment response in gastric and gastroesophageal junction cancer.","publication_year":2023,"publication_date":"2023-01-24","ids":{"openalex":"https://openalex.org/W4317890308","doi":"https://doi.org/10.1200/jco.2023.41.4_suppl.444"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2023.41.4_suppl.444","doi":"https://doi.org/10.1200/jco.2023.41.4_suppl.444","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1200/jco.2023.41.4_suppl.444","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2023.41.4_suppl.444","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2023.41.4_suppl.444","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011909438","display_name":"John D. Karalis","orcid":"https://orcid.org/0000-0001-7601-5776","observed_orcids":["https://orcid.org/0000-0001-7601-5776"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John D Karalis","raw_affiliation_strings":["University of Texas Southwestern Medical Center, Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Southwestern Medical Center, Dallas, TX;","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005655365","display_name":"Michelle R. Ju","orcid":"https://orcid.org/0000-0003-0920-7617","observed_orcids":["https://orcid.org/0000-0003-0920-7617"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle R Ju","raw_affiliation_strings":["UT Southwestern Medical Center, Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UT Southwestern Medical Center, Dallas, TX;","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039842436","display_name":"Lynn Y. Yoon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lynn Y Yoon","raw_affiliation_strings":["University of Texas Southwestern Medical Center, Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Southwestern Medical Center, Dallas, TX;","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075042747","display_name":"Esther C. Castro\u2010Dubon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Esther C Castro-Dubon","raw_affiliation_strings":["University of Texas Southwestern Medical Center, Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Southwestern Medical Center, Dallas, TX;","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050345337","display_name":"Suntrea T.G. Hammer","orcid":"https://orcid.org/0000-0002-3384-8257","observed_orcids":["https://orcid.org/0000-0002-3384-8257"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suntrea Hammer","raw_affiliation_strings":["UT Southwestern Medical Center, Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UT Southwestern Medical Center, Dallas, TX;","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031442486","display_name":"Matthew R. Porembka","orcid":"https://orcid.org/0000-0003-1596-0058","observed_orcids":["https://orcid.org/0000-0003-1596-0058"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew R. Porembka","raw_affiliation_strings":["University of Texas Southwestern Medical Center, Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Southwestern Medical Center, Dallas, TX;","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040090483","display_name":"Sam C. Wang","orcid":"https://orcid.org/0000-0003-3626-5273","observed_orcids":["https://orcid.org/0000-0003-3626-5273"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sam C. Wang","raw_affiliation_strings":["University of Texas Southwestern Medical Center, Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Southwestern Medical Center, Dallas, TX;","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":"4_suppl","first_page":"444","last_page":"444"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.7631999850273132,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.7631999850273132,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.20589999854564667,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.01860000006854534,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9160000085830688},{"id":"https://openalex.org/keywords/serum-cytokines","display_name":"serum cytokines","score":0.8539999723434448},{"id":"https://openalex.org/keywords/gastric-adenocarcinoma","display_name":"gastric adenocarcinoma","score":0.9020000100135803},{"id":"https://openalex.org/keywords/gastroesophageal-junction-adenocarcinoma","display_name":"gastroesophageal junction adenocarcinoma","score":0.9670000076293945},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7950000166893005},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8180000185966492},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.6060000061988831},{"id":"https://openalex.org/keywords/tumor-regression-grade","display_name":"tumor regression grade","score":0.8640000224113464},{"id":"https://openalex.org/keywords/neoadjuvant-therapy","display_name":"neoadjuvant therapy","score":0.9169999957084656},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.7480000257492065},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.5690000057220459},{"id":"https://openalex.org/keywords/neoadjuvant-chemoradiotherapy","display_name":"neoadjuvant chemoradiotherapy","score":0.6539999842643738},{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy","display_name":"neoadjuvant chemotherapy","score":0.6869999766349792},{"id":"https://openalex.org/keywords/neoadjuvant-immunotherapy","display_name":"neoadjuvant immunotherapy","score":0.7400000095367432}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9370203018188477},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6933056712150574},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.605433464050293},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5992109775543213},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5747183561325073},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.557537853717804},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.4914025068283081},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.48564139008522034},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.46681568026542664},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.451861709356308},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4288971722126007},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2023.41.4_suppl.444","doi":"https://doi.org/10.1200/jco.2023.41.4_suppl.444","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1200/jco.2023.41.4_suppl.444","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2023.41.4_suppl.444","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1200/jco.2023.41.4_suppl.444","doi":"https://doi.org/10.1200/jco.2023.41.4_suppl.444","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1200/jco.2023.41.4_suppl.444","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2023.41.4_suppl.444","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4317890308.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4384296577","https://openalex.org/W2039766093","https://openalex.org/W4317862720","https://openalex.org/W4391753600","https://openalex.org/W4410905249","https://openalex.org/W2995461228","https://openalex.org/W7149084334","https://openalex.org/W2067264919","https://openalex.org/W100147533","https://openalex.org/W2373111038"],"abstract_inverted_index":{"444":[0],"Background:":[1],"There":[2],"are":[3],"few":[4],"biomarkers":[5],"to":[6,71,102,113,157,284,349],"guide":[7],"treatment":[8],"for":[9,165,172,237,320,341],"gastric":[10],"and":[11,51,175,249,291,316],"gastroesophageal":[12],"junction":[13],"adenocarcinoma":[14],"(G+GEJ).":[15],"The":[16],"systemic":[17],"inflammatory":[18],"response,":[19],"which":[20],"is":[21,31,336],"reflected":[22],"by":[23],"circulating":[24,43,161,185],"serum":[25,44,80,96,209,332],"cytokine":[26,45,118,186],"levels,":[27],"of":[28,42,64,86,117,149,179,222,273,314,318,334],"G+GEJ":[29,58,76],"patients":[30,73,89,123,285,300,342],"associated":[32,139,191,256],"with":[33,47,75,120,140,192,257,343],"survival.":[34],"In":[35,122,167,232],"this":[36],"study,":[37],"we":[38,128],"evaluated":[39],"the":[40,84,115,131,146,176,180,183,208,270,287],"relationship":[41],"levels":[46,148],"overall":[48],"survival":[49],"(OS)":[50],"pathologic":[52,242,325],"tumor":[53,326],"regression":[54,327],"grade":[55],"(TRG)":[56],"in":[57,133,153,212,218,269,286],"patients.":[59,224],"Methods:":[60],"A":[61,105],"retrospective":[62],"review":[63],"a":[65,154,168,219,233,312,337],"prospectively":[66],"maintained":[67],"biobank":[68],"was":[69,81,98,111,138,189,194,254],"performed":[70],"identify":[72],"diagnosed":[74],"from":[77,229],"2016-2022.":[78],"Pre-treatment":[79,331],"collected":[82,99],"at":[83],"time":[85],"diagnosis.":[87],"For":[88],"who":[90,124,301],"received":[91,125,302],"neoadjuvant":[92,126,303,350],"therapy,":[93,127],"an":[94,213],"additional":[95,214],"sample":[97],"immediately":[100],"prior":[101],"surgical":[103],"resection.":[104],"multivariable":[106,169,234],"Cox":[107],"proportional":[108],"hazards":[109],"model":[110],"used":[112],"assess":[114],"association":[116],"concentration":[119],"OS.":[121,166],"assessed":[129],"whether":[130],"change":[132],"IL-6":[134,195,210,226,252,275,335],"(\u0394IL-6)":[135],"after":[136],"therapy":[137,304],"TRG.":[141],"Results:":[142],"We":[143,205],"first":[144],"measured":[145],"pre-treatment":[147,274],"17":[150],"different":[151],"cytokines":[152,162],"67-patient":[155],"cohort":[156,221],"determine":[158],"if":[159],"certain":[160],"were":[163],"prognostic":[164,339],"analysis":[170,235],"adjusted":[171,236],"clinical":[173,240],"stage":[174],"expression":[177],"level":[178,187,211,227,253,276,333],"other":[181],"cytokines,":[182],"only":[184],"that":[188],"independently":[190,255],"OS":[193,258,280],"(HR:":[196,259],"1.06":[197],"per":[198,261],"1":[199,262],"pg/ml":[200,263],"increase,":[201,264],"95%":[202,265],"CI:":[203,266],"1.04-1.08).":[204],"then":[206],"analyzed":[207],"134":[215],"patients,":[216],"resulting":[217],"final":[220],"201":[223],"Serum":[225],"ranged":[228],"0.3-196.7":[230],"pg/ml.":[231],"age,":[238],"sex,":[239],"stage,":[241],"differentiation,":[243],"Lauren":[244],"classification,":[245],"H.":[246],"pylori":[247],"status":[248],"neutrophil-to-lymphocyte":[250],"ratio,":[251],"1.012":[260],"1.006-1.019).":[267],"Patients":[268],"top":[271],"tercile":[272,293],"had":[277,311],"worse":[278],"median":[279],"(10.6":[281],"months)":[282,290],"compared":[283],"intermediate":[288],"(17.4":[289],"bottom":[292],"(35.8":[294],"months,":[295],"p":[296],"<":[297],"0.0001).":[298],"Among":[299],"(n":[305],"=":[306],"50),":[307],"\u0394IL-6":[308,345],"\u2264":[309],"0":[310],"sensitivity":[313],"80%":[315,319],"specificity":[317],"predicting":[321],"complete":[322],"or":[323],"near-complete":[324],"(TRG":[328],"1).":[329],"Conclusions:":[330],"promising":[338],"biomarker":[340],"G+GEJ.":[344],"may":[346],"predict":[347],"response":[348],"therapy.":[351]},"counts_by_year":[],"updated_date":"2026-08-27T14:10:00.468798","created_date":"2023-01-25T00:00:00"}