{"id":"https://openalex.org/W4317888293","doi":"https://doi.org/10.1080/21678421.2023.2171302","title":"ALSUntangled # 69: astaxanthin","display_name":"ALSUntangled # 69: astaxanthin","publication_year":2023,"publication_date":"2023-01-24","ids":{"openalex":"https://openalex.org/W4317888293","doi":"https://doi.org/10.1080/21678421.2023.2171302","pmid":"https://pubmed.ncbi.nlm.nih.gov/36694292"},"language":"en","primary_location":{"id":"doi:10.1080/21678421.2023.2171302","doi":"https://doi.org/10.1080/21678421.2023.2171302","is_oa":true,"landing_page_url":"https://doi.org/10.1080/21678421.2023.2171302","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/21678421.2023.2171302?needAccess=true&role=button","source":{"id":"https://openalex.org/S4210172367","display_name":"Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration","issn_l":"2167-8421","issn":["2167-8421","2167-9223"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/21678421.2023.2171302?needAccess=true&role=button","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004217512","display_name":"Timothy Fullam","orcid":"https://orcid.org/0000-0001-6708-7559","observed_orcids":["https://orcid.org/0000-0001-6708-7559"]},"institutions":[{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy Fullam","raw_affiliation_strings":["Department of Neurology, UTSA, San Antonio, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, UTSA, San Antonio, TX, USA","institution_ids":["https://openalex.org/I45438204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084638820","display_name":"Carmel Armon","orcid":"https://orcid.org/0000-0003-3881-351X","observed_orcids":["https://orcid.org/0000-0003-3881-351X"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carmel Armon","raw_affiliation_strings":["Department of Neurology, Loma Linda University, Loma Linda, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Loma Linda University, Loma Linda, CA, USA","institution_ids":["https://openalex.org/I26347476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091642579","display_name":"Paul E. Barkhaus","orcid":"https://orcid.org/0000-0001-8268-8643","observed_orcids":["https://orcid.org/0000-0001-8268-8643"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Barkhaus","raw_affiliation_strings":["Department of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Benjamin Barnes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin Barnes","raw_affiliation_strings":["Department of Neurology, Medical College of Georgia, Augusta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Medical College of Georgia, Augusta, GA, USA","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114103980","display_name":"Morgan T Beauchamp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Morgan Beauchamp","raw_affiliation_strings":["Neurosciences Clinical Trials Unit, UNC Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurosciences Clinical Trials Unit, UNC Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031062952","display_name":"Michael G Benatar","orcid":"https://orcid.org/0000-0003-4241-5135","observed_orcids":["https://orcid.org/0000-0003-4241-5135"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Benatar","raw_affiliation_strings":["Department of Neurology, University of Miami, Miami, FL, USA"],"raw_orcid":"https://orcid.org/0000-0003-4241-5135","affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Miami, Miami, FL, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112403925","display_name":"Tulio E. Bertorini","orcid":"https://orcid.org/0000-0002-0028-5929","observed_orcids":["https://orcid.org/0000-0002-0028-5929"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tulio Bertorini","raw_affiliation_strings":["Neurology Department, University of Tennessee Health Science Center, Memphis, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Department, University of Tennessee Health Science Center, Memphis, TN, USA","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057092035","display_name":"Robert P. Bowser","orcid":"https://orcid.org/0000-0001-5404-7259","observed_orcids":["https://orcid.org/0000-0001-5404-7259"]},"institutions":[{"id":"https://openalex.org/I1324766304","display_name":"Barrow Neurological Institute","ror":"https://ror.org/01fwrsq33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324766304","https://openalex.org/I1325481341","https://openalex.org/I2802827176"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Bowser","raw_affiliation_strings":["Department of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA"],"raw_orcid":"https://orcid.org/0000-0001-5404-7259","affiliations":[{"raw_affiliation_string":"Department of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA","institution_ids":["https://openalex.org/I1324766304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110332015","display_name":"Mark B. Bromberg","orcid":"https://orcid.org/0000-0003-3230-7130","observed_orcids":["https://orcid.org/0000-0003-3230-7130"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Bromberg","raw_affiliation_strings":["Department of Neurology, University of Utah, Salt Lake City, UT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090492757","display_name":"Javier Masc\u00edas Cadavid","orcid":"https://orcid.org/0009-0008-1347-1510","observed_orcids":["https://orcid.org/0009-0008-1347-1510"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Javier Mascias Cadavid","raw_affiliation_strings":["ALS Department, Hospital Carlos III-La Paz, Madrid, Spain","10 ALS Department, Hospital Carlos III-La Paz, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ALS Department, Hospital Carlos III-La Paz, Madrid, Spain","institution_ids":[]},{"raw_affiliation_string":"10 ALS Department, Hospital Carlos III-La Paz, Madrid, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030862329","display_name":"Gregory T. Carter","orcid":"https://orcid.org/0000-0001-7617-4750","observed_orcids":["https://orcid.org/0000-0001-7617-4750"]},"institutions":[{"id":"https://openalex.org/I170632171","display_name":"Washington State University Spokane","ror":"https://ror.org/04vfs5h36","country_code":"US","type":"education","lineage":["https://openalex.org/I170632171","https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory T. Carter","raw_affiliation_strings":["Department of Rehabilitation, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA","11 Department of Rehabilitation, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rehabilitation, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA","institution_ids":["https://openalex.org/I170632171"]},{"raw_affiliation_string":"11 Department of Rehabilitation, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA","institution_ids":["https://openalex.org/I170632171"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051045476","display_name":"Mazen M. Dimachkie","orcid":"https://orcid.org/0000-0002-7148-989X","observed_orcids":["https://orcid.org/0000-0002-7148-989X"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mazen Dimachkie","raw_affiliation_strings":["Department of Neurology, University of Kansas, Kansas City, KS, USA","12 Department of Neurology, University of Kansas, Kansas City, KS, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Kansas, Kansas City, KS, USA","institution_ids":["https://openalex.org/I146416000"]},{"raw_affiliation_string":"12 Department of Neurology, University of Kansas, Kansas City, KS, USA","institution_ids":["https://openalex.org/I146416000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087781412","display_name":"Dave Ennist","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405252845","display_name":"FHWien der WKW","ror":"https://ror.org/001gcc176","country_code":"AT","type":"education","lineage":["https://openalex.org/I4405252845"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Dave Ennist","raw_affiliation_strings":["Origent Data Sciences, Inc, Vienna, VA, USA","13 Origent Data Sciences, Inc, Vienna, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Origent Data Sciences, Inc, Vienna, VA, USA","institution_ids":["https://openalex.org/I4405252845"]},{"raw_affiliation_string":"13 Origent Data Sciences, Inc, Vienna, VA, USA","institution_ids":["https://openalex.org/I4405252845"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056304003","display_name":"Eva L. Feldman","orcid":"https://orcid.org/0000-0002-9162-2694","observed_orcids":["https://orcid.org/0000-0002-9162-2694"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eva L. Feldman","raw_affiliation_strings":["Department of Neurology, University of Michigan, Ann Arbor, MI, USA","14 Department of Neurology, University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"14 Department of Neurology, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003112399","display_name":"Terry D Heiman-Patterson","orcid":"https://orcid.org/0000-0002-9910-1041","observed_orcids":["https://orcid.org/0000-0002-9910-1041"]},"institutions":[{"id":"https://openalex.org/I4210117083","display_name":"Temple University Hospital","ror":"https://ror.org/028rvnd71","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210117083","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Terry Heiman-patterson","raw_affiliation_strings":["Department of Neurology, Temple Health, Philadelphia, PA, USA","15 Department of Neurology, Temple Health, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Temple Health, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I4210117083"]},{"raw_affiliation_string":"15 Department of Neurology, Temple Health, Philadelphia, PA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012918500","display_name":"Sartaj Jhooty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sartaj Jhooty","raw_affiliation_strings":["University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","16 University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"16 University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021216158","display_name":"Isaac Lund","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Isaac Lund","raw_affiliation_strings":["Green Hope High School, Cary, NC, USA","17 Green Hope High School, Cary, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Green Hope High School, Cary, NC, USA","institution_ids":[]},{"raw_affiliation_string":"17 Green Hope High School, Cary, NC, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049896776","display_name":"Christopher J. McDermott","orcid":"https://orcid.org/0000-0002-1269-9053","observed_orcids":["https://orcid.org/0000-0002-1269-9053"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christopher Mcdermott","raw_affiliation_strings":["Department of Neuroscience, University of Sheffield, Sheffield, UK","18 Department of Neuroscience, University of Sheffield, Sheffield, UK"],"raw_orcid":"https://orcid.org/0000-0002-1269-9053","affiliations":[{"raw_affiliation_string":"Department of Neuroscience, University of Sheffield, Sheffield, UK","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"18 Department of Neuroscience, University of Sheffield, Sheffield, UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058244935","display_name":"Gary L. Pattee","orcid":"https://orcid.org/0000-0001-8365-6707","observed_orcids":["https://orcid.org/0000-0001-8365-6707"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary Pattee","raw_affiliation_strings":["Department of Neurology, University of Nebraska Medical Center, Omaha, NE, USA","19 Department of Neurology, University of Nebraska Medical Center, Omaha, NE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Nebraska Medical Center, Omaha, NE, USA","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"19 Department of Neurology, University of Nebraska Medical Center, Omaha, NE, USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058470354","display_name":"Dylan Ratner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dylan Ratner","raw_affiliation_strings":["Tulane University, New Orleans, LA, USA","20 Tulane University, New Orleans, LA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tulane University, New Orleans, LA, USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"20 Tulane University, New Orleans, LA, USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047548456","display_name":"Paul J Wicks","orcid":"https://orcid.org/0000-0002-2293-9284","observed_orcids":["https://orcid.org/0000-0002-2293-9284"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Wicks","raw_affiliation_strings":["Independent Consultant, Lichfield, UK, and","21 Independent Consultant, Lichfield, UK, and"],"raw_orcid":"https://orcid.org/0000-0002-2293-9284","affiliations":[{"raw_affiliation_string":"Independent Consultant, Lichfield, UK, and","institution_ids":[]},{"raw_affiliation_string":"21 Independent Consultant, Lichfield, UK, and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102998448","display_name":"Richard Bedlack","orcid":"https://orcid.org/0000-0003-4666-7495","observed_orcids":["https://orcid.org/0000-0003-4666-7495"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard Bedlack","raw_affiliation_strings":["Department of Neurology, Duke University, Durham, NC, USA","22 Department of Neurology, Duke University, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Duke University, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"22 Department of Neurology, Duke University, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":18,"corresponding_author_ids":["https://openalex.org/A5102998448"],"corresponding_institution_ids":["https://openalex.org/I170897317"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00130847,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"5-6","first_page":"553","last_page":"557"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neurological Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/astaxanthin","display_name":"astaxanthin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":1.0},{"id":"https://openalex.org/keywords/off-label-drug-use","display_name":"off-label drug use","score":0.8029999732971191},{"id":"https://openalex.org/keywords/alternative-medicine","display_name":"complementary and alternative medicine","score":0.8059999942779541},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.8190000057220459},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.996999979019165},{"id":"https://openalex.org/keywords/anti-apoptotic-effects","display_name":"anti-apoptotic effects","score":0.996999979019165},{"id":"https://openalex.org/keywords/carotenoids","display_name":"carotenoids","score":0.6399999856948853},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.4650000035762787}],"concepts":[{"id":"https://openalex.org/C2780962900","wikidata":"https://www.wikidata.org/wiki/Q413740","display_name":"Astaxanthin","level":3,"score":0.9947249889373779},{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.7506002187728882},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.6629106998443604},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5083250403404236},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4246748089790344},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3635846674442291},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2637823820114136},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21251916885375977},{"id":"https://openalex.org/C28781525","wikidata":"https://www.wikidata.org/wiki/Q191907","display_name":"Carotenoid","level":2,"score":0.14354583621025085},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.09433570504188538}],"mesh":[{"descriptor_ui":"D000529","descriptor_name":"Complementary Therapies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024341","descriptor_name":"Xanthophylls","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/21678421.2023.2171302","doi":"https://doi.org/10.1080/21678421.2023.2171302","is_oa":true,"landing_page_url":"https://doi.org/10.1080/21678421.2023.2171302","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/21678421.2023.2171302?needAccess=true&role=button","source":{"id":"https://openalex.org/S4210172367","display_name":"Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration","issn_l":"2167-8421","issn":["2167-8421","2167-9223"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration","raw_type":"journal-article"},{"id":"pmid:36694292","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36694292","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Amyotrophic lateral sclerosis & frontotemporal degeneration","raw_type":"Review"}],"best_oa_location":{"id":"doi:10.1080/21678421.2023.2171302","doi":"https://doi.org/10.1080/21678421.2023.2171302","is_oa":true,"landing_page_url":"https://doi.org/10.1080/21678421.2023.2171302","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/21678421.2023.2171302?needAccess=true&role=button","source":{"id":"https://openalex.org/S4210172367","display_name":"Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration","issn_l":"2167-8421","issn":["2167-8421","2167-9223"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4317888293.pdf","grobid_xml":"https://content.openalex.org/works/W4317888293.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W29366428","https://openalex.org/W1565527343","https://openalex.org/W1571973017","https://openalex.org/W1975686505","https://openalex.org/W1988895856","https://openalex.org/W2007602343","https://openalex.org/W2018159197","https://openalex.org/W2026155769","https://openalex.org/W2035924068","https://openalex.org/W2040678584","https://openalex.org/W2041840488","https://openalex.org/W2050172260","https://openalex.org/W2059574388","https://openalex.org/W2079899391","https://openalex.org/W2121647621","https://openalex.org/W2121654587","https://openalex.org/W2146422953","https://openalex.org/W2148283536","https://openalex.org/W2155140532","https://openalex.org/W2221759243","https://openalex.org/W2409752663","https://openalex.org/W2749944343","https://openalex.org/W2758379376","https://openalex.org/W2787429410","https://openalex.org/W2795520497","https://openalex.org/W2888359386","https://openalex.org/W2890592122","https://openalex.org/W2901259512","https://openalex.org/W2945630976","https://openalex.org/W2990363610","https://openalex.org/W3082689073","https://openalex.org/W3100448104","https://openalex.org/W3119933590","https://openalex.org/W3126793131","https://openalex.org/W3150343005","https://openalex.org/W3167341995","https://openalex.org/W4284895677","https://openalex.org/W4290613746","https://openalex.org/W4306765914"],"related_works":["https://openalex.org/W7150898675","https://openalex.org/W4236370556","https://openalex.org/W4309366241","https://openalex.org/W4233219437","https://openalex.org/W4391566185","https://openalex.org/W7196964496","https://openalex.org/W2793144118","https://openalex.org/W3135163060","https://openalex.org/W4389149119","https://openalex.org/W4234056674"],"abstract_inverted_index":{"ALSUntangled":[0],"reviews":[1],"alternative":[2,51],"and":[3,29,74,93],"off-label":[4],"treatments":[5],"for":[6,22],"people":[7,64],"living":[8,65],"with":[9,66],"amyotrophic":[10],"lateral":[11],"sclerosis":[12],"(PALS).":[13],"Here":[14],"we":[15,81],"review":[16],"astaxanthin":[17,62,69,89],"which":[18,53],"has":[19],"plausible":[20],"mechanisms":[21],"slowing":[23],"ALS":[24],"progression":[25],"including":[26],"antioxidant,":[27],"anti-inflammatory,":[28],"anti-apoptotic":[30],"effects.":[31],"While":[32],"there":[33],"are":[34],"no":[35,59],"ALS-specific":[36],"pre-clinical":[37,84],"studies,":[38],"one":[39],"verified":[40],"\"ALS":[41],"reversal\"":[42],"occurred":[43],"in":[44,63,90],"a":[45,48],"person":[46],"using":[47],"combination":[49],"of":[50,61,88],"therapies":[52],"included":[54],"astaxanthin.":[55],"There":[56],"have":[57],"been":[58],"trials":[60,87],"ALS.":[67],"Natural":[68],"appears":[70],"to":[71,96],"be":[72],"safe":[73],"inexpensive.":[75],"Based":[76],"on":[77],"the":[78],"above":[79],"information,":[80],"support":[82],"further":[83,97],"and/or":[85],"clinical":[86],"disease":[91],"models":[92],"PALS,":[94],"respectively,":[95],"elucidate":[98],"efficacy.":[99]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-01-25T00:00:00"}