{"id":"https://openalex.org/W4317814907","doi":"https://doi.org/10.3389/fendo.2023.1107162","title":"Systematic assessment of streptozotocin-induced diabetic metabolic alterations in rats using metabolomics","display_name":"Systematic assessment of streptozotocin-induced diabetic metabolic alterations in rats using metabolomics","publication_year":2023,"publication_date":"2023-01-24","ids":{"openalex":"https://openalex.org/W4317814907","doi":"https://doi.org/10.3389/fendo.2023.1107162","pmid":"https://pubmed.ncbi.nlm.nih.gov/36761194","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9902650"},"language":"en","primary_location":{"id":"doi:10.3389/fendo.2023.1107162","doi":"https://doi.org/10.3389/fendo.2023.1107162","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2023.1107162","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2023.1107162/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fendo.2023.1107162/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066960329","display_name":"Qingying Si","orcid":"https://orcid.org/0000-0002-2644-4895","observed_orcids":["https://orcid.org/0000-0002-2644-4895"]},"institutions":[{"id":"https://openalex.org/I4210137235","display_name":"Tengzhou Central People's Hospital","ror":"https://ror.org/03b867n98","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137235"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingying Si","raw_affiliation_strings":["Department of Endocrinology, Tengzhou Central People's Hospital, Tengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Tengzhou Central People's Hospital, Tengzhou, China","institution_ids":["https://openalex.org/I4210137235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006259146","display_name":"Jinxiu Guo","orcid":"https://orcid.org/0000-0001-6565-8880","observed_orcids":["https://orcid.org/0000-0001-6565-8880"]},"institutions":[{"id":"https://openalex.org/I4210136826","display_name":"Jining First People's Hospital","ror":"https://ror.org/04gs6v336","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136826"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinxiu Guo","raw_affiliation_strings":["Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, Jining, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, Jining, China","institution_ids":["https://openalex.org/I4210136826","https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068324682","display_name":"Xiumei Yang","orcid":"https://orcid.org/0009-0009-8177-6102","observed_orcids":["https://orcid.org/0009-0009-8177-6102"]},"institutions":[{"id":"https://openalex.org/I4210137235","display_name":"Tengzhou Central People's Hospital","ror":"https://ror.org/03b867n98","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137235"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiumei Yang","raw_affiliation_strings":["Department of Endocrinology, Tengzhou Central People's Hospital, Tengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Tengzhou Central People's Hospital, Tengzhou, China","institution_ids":["https://openalex.org/I4210137235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061465528","display_name":"Yujin Guo","orcid":"https://orcid.org/0000-0001-7454-8595","observed_orcids":["https://orcid.org/0000-0001-7454-8595"]},"institutions":[{"id":"https://openalex.org/I4210136826","display_name":"Jining First People's Hospital","ror":"https://ror.org/04gs6v336","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136826"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yujin Guo","raw_affiliation_strings":["Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, Jining, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, Jining, China","institution_ids":["https://openalex.org/I4210136826","https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025836028","display_name":"Linlin Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137235","display_name":"Tengzhou Central People's Hospital","ror":"https://ror.org/03b867n98","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137235"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linlin Wu","raw_affiliation_strings":["Office of Scientific Research Management, Tengzhou Central People's Hospital, Tengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Office of Scientific Research Management, Tengzhou Central People's Hospital, Tengzhou, China","institution_ids":["https://openalex.org/I4210137235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019925485","display_name":"Dadi Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137235","display_name":"Tengzhou Central People's Hospital","ror":"https://ror.org/03b867n98","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137235"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dadi Xie","raw_affiliation_strings":["Department of Endocrinology, Tengzhou Central People's Hospital, Tengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Tengzhou Central People's Hospital, Tengzhou, China","institution_ids":["https://openalex.org/I4210137235"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024189982","display_name":"Pei Jiang","orcid":"https://orcid.org/0000-0002-8360-7427","observed_orcids":["https://orcid.org/0000-0002-8360-7427"]},"institutions":[{"id":"https://openalex.org/I4210136826","display_name":"Jining First People's Hospital","ror":"https://ror.org/04gs6v336","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136826"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]},{"id":"https://openalex.org/I51185872","display_name":"Jining Medical University","ror":"https://ror.org/03zn9gq54","country_code":"CN","type":"education","lineage":["https://openalex.org/I51185872"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Pei Jiang","raw_affiliation_strings":["Institute of Translational Pharmacy, Jining Medical Research Academy, Jining, China","Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, Jining, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Translational Pharmacy, Jining Medical Research Academy, Jining, China","institution_ids":["https://openalex.org/I51185872"]},{"raw_affiliation_string":"Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, Jining, China","institution_ids":["https://openalex.org/I4210136826","https://openalex.org/I4210163399"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5024189982","https://openalex.org/A5061465528"],"corresponding_institution_ids":["https://openalex.org/I4210136826","https://openalex.org/I4210163399","https://openalex.org/I51185872"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":0.9821,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.70519873,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"14","issue":null,"first_page":"1107162","last_page":"1107162"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.019899999722838402,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9480000138282776},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.8989999890327454},{"id":"https://openalex.org/keywords/differential-metabolites","display_name":"differential metabolites","score":0.7979999780654907},{"id":"https://openalex.org/keywords/amino-acid-metabolism","display_name":"amino acid metabolism","score":0.9169999957084656},{"id":"https://openalex.org/keywords/b-vitamins","display_name":"B vitamins","score":0.7860000133514404},{"id":"https://openalex.org/keywords/purine-metabolism","display_name":"purine metabolism","score":0.9869999885559082},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.8370000123977661},{"id":"https://openalex.org/keywords/organic-acids","display_name":"organic acids","score":0.6340000033378601},{"id":"https://openalex.org/keywords/pathogenesis-of-diabetes","display_name":"diabetes pathogenesis","score":0.6349999904632568},{"id":"https://openalex.org/keywords/brown-adipose-tissue","display_name":"brown adipose tissue","score":0.5239999890327454},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.878000020980835},{"id":"https://openalex.org/keywords/kidney","display_name":"kidney","score":0.45399999618530273},{"id":"https://openalex.org/keywords/heart","display_name":"heart","score":0.5270000100135803},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.9200000166893005}],"concepts":[{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.8417940139770508},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.7681975364685059},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7130795121192932},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6777162551879883},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.6754502058029175},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5506314039230347},{"id":"https://openalex.org/C2780159080","wikidata":"https://www.wikidata.org/wiki/Q1400536","display_name":"Intraperitoneal injection","level":2,"score":0.5381326079368591},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.5223689675331116},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5086468458175659},{"id":"https://openalex.org/C2778577996","wikidata":"https://www.wikidata.org/wiki/Q2307492","display_name":"Renal cortex","level":3,"score":0.4882400333881378},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.4535275101661682},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4084528088569641},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21677595376968384},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.1262352168560028}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013311","descriptor_name":"Streptozocin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014803","descriptor_name":"Vitamin B Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3389/fendo.2023.1107162","doi":"https://doi.org/10.3389/fendo.2023.1107162","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2023.1107162","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2023.1107162/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9902650","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9902650","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9902650/pdf/fendo-14-1107162.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Endocrinol (Lausanne)","raw_type":"Text"},{"id":"pmid:36761194","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36761194","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:3830e5a0cc7349cca3113c42a3a19524","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3830e5a0cc7349cca3113c42a3a19524","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Endocrinology, Vol 14 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fendo.2023.1107162","doi":"https://doi.org/10.3389/fendo.2023.1107162","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2023.1107162","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2023.1107162/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1945339604","display_name":null,"funder_award_id":"tsqn201812159","funder_id":"https://openalex.org/F4320328638","funder_display_name":"China International Medical Foundation"},{"id":"https://openalex.org/G2233856085","display_name":null,"funder_award_id":"Z-2018-35-2002","funder_id":"https://openalex.org/F4320328638","funder_display_name":"China International Medical Foundation"},{"id":"https://openalex.org/G2484895283","display_name":null,"funder_award_id":"ZR2021MH145","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2914118499","display_name":null,"funder_award_id":"ZR2021MH145","funder_id":"https://openalex.org/F4320328638","funder_display_name":"China International Medical Foundation"},{"id":"https://openalex.org/G350066863","display_name":null,"funder_award_id":"ZR2021MH145","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"},{"id":"https://openalex.org/G3609425860","display_name":null,"funder_award_id":"81602846","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"},{"id":"https://openalex.org/G381951513","display_name":null,"funder_award_id":"81602846","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4385246540","display_name":null,"funder_award_id":"82272253","funder_id":"https://openalex.org/F4320328638","funder_display_name":"China International Medical Foundation"},{"id":"https://openalex.org/G4842928452","display_name":null,"funder_award_id":"81602846","funder_id":"https://openalex.org/F4320328638","funder_display_name":"China International Medical Foundation"},{"id":"https://openalex.org/G5371148950","display_name":null,"funder_award_id":"B\u201019\u2010H\u201020200622","funder_id":"https://openalex.org/F4320317014","funder_display_name":"Bethune Charitable Foundation"},{"id":"https://openalex.org/G6984318253","display_name":null,"funder_award_id":"tsqn201812159","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"},{"id":"https://openalex.org/G7317780415","display_name":null,"funder_award_id":"82272253","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8064784717","display_name":null,"funder_award_id":"B-19-H-20200622","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8265207734","display_name":null,"funder_award_id":"tsqn201812159","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8880732799","display_name":null,"funder_award_id":"Z-2018-35-2002","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G896762803","display_name":null,"funder_award_id":"[2018] 35","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320317014","display_name":"Bethune Charitable Foundation","ror":"https://ror.org/0430c7a41"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324174","display_name":"Natural Science Foundation of Shandong Province","ror":null},{"id":"https://openalex.org/F4320328638","display_name":"China International Medical Foundation","ror":"https://ror.org/03hy6ga56"},{"id":"https://openalex.org/F4320334012","display_name":"Science and Technology Development Plan of Shandong Province","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4317814907.pdf","grobid_xml":"https://content.openalex.org/works/W4317814907.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1495678345","https://openalex.org/W1591795333","https://openalex.org/W1985842203","https://openalex.org/W1994861768","https://openalex.org/W2011444679","https://openalex.org/W2017771330","https://openalex.org/W2057638850","https://openalex.org/W2090545764","https://openalex.org/W2104522961","https://openalex.org/W2124081028","https://openalex.org/W2124695577","https://openalex.org/W2128850006","https://openalex.org/W2141414207","https://openalex.org/W2158958532","https://openalex.org/W2294856235","https://openalex.org/W2338627428","https://openalex.org/W2346019307","https://openalex.org/W2464094535","https://openalex.org/W2473219541","https://openalex.org/W2512737207","https://openalex.org/W2596280071","https://openalex.org/W2604602590","https://openalex.org/W2744389809","https://openalex.org/W2744498835","https://openalex.org/W2753709051","https://openalex.org/W2786822873","https://openalex.org/W2790532833","https://openalex.org/W2799299786","https://openalex.org/W2807586373","https://openalex.org/W2883669383","https://openalex.org/W2884415415","https://openalex.org/W2897271827","https://openalex.org/W2922680072","https://openalex.org/W2927223903","https://openalex.org/W2985380082","https://openalex.org/W2996701401","https://openalex.org/W3015068940","https://openalex.org/W3042191807","https://openalex.org/W3048300476","https://openalex.org/W3083488236","https://openalex.org/W3090059752","https://openalex.org/W3095899902","https://openalex.org/W3145732841","https://openalex.org/W3155712892","https://openalex.org/W3177139264","https://openalex.org/W3181710594","https://openalex.org/W4220825290","https://openalex.org/W4246561197","https://openalex.org/W4281921165","https://openalex.org/W4283170034","https://openalex.org/W4292089269","https://openalex.org/W4296160957","https://openalex.org/W4296162804","https://openalex.org/W4296931380"],"related_works":["https://openalex.org/W2252293851","https://openalex.org/W2019620907","https://openalex.org/W2334953288","https://openalex.org/W2377903185","https://openalex.org/W2927223903","https://openalex.org/W2058241083","https://openalex.org/W2149606140","https://openalex.org/W2803549960","https://openalex.org/W2562824455","https://openalex.org/W4413584309"],"abstract_inverted_index":{"Purpose:":[0],"Type":[1],"1":[2,66],"diabetes":[3,67,162,201],"is":[4,24],"characterized":[5],"by":[6,171],"elevated":[7],"blood":[8],"glucose":[9],"levels,":[10],"which":[11,194],"negatively":[12],"impacts":[13],"multiple":[14],"organs":[15],"and":[16,21,34,74,90,103,117,145,175],"tissues":[17,120],"throughout":[18],"the":[19,26,32,46,61,87,108,133,139,149,160,190,198],"body,":[20],"its":[22],"prevalence":[23],"on":[25,130,180],"rise.":[27],"Prior":[28],"reports":[29],"primarily":[30,167],"investigated":[31],"serum":[33],"urine":[35],"specimen":[36],"from":[37],"diabetic":[38,51,89,123,192],"patients.":[39,54],"However,":[40],"only":[41],"a":[42],"few":[43],"studies":[44],"examined":[45],"overall":[47],"metabolic":[48,150,156,187],"profile":[49],"of":[50,63,121,200],"animals":[52],"or":[53],"The":[55],"current":[56],"systemic":[57],"investigation":[58],"will":[59],"benefit":[60],"knowledge":[62],"STZ-based":[64],"type":[65],"pathogenesis.":[68,163,202],"Methods:":[69],"gas":[70],"chromatography-mass":[71],"spectrometry":[72],"(GC-MS),":[73],"multivariate":[75],"analysis":[76],"was":[77],"employed":[78],"to":[79,126,159],"screen":[80],"for":[81],"differentially":[82],"expressed":[83],"(DE)":[84],"metabolites":[85,106],"between":[86],"induced":[88],"normal":[91],"rats.":[92,128],"Results:":[93],"We":[94],"identified":[95,185],"18,":[96],"30,":[97],"6,":[98],"24,":[99],"34,":[100],"27,":[101],"27":[102],"12":[104],"DE":[105],"in":[107,138,197],"serum,":[109],"heart,":[110],"liver,":[111],"kidney,":[112],"cortex,":[113],"renal":[114],"lipid,":[115],"hippocampus,":[116],"brown":[118],"fat":[119],"STZ-treated":[122],"rats,":[124,193],"compared":[125],"control":[127],"Based":[129,179],"our":[131,181],"analysis,":[132,152,183],"largest":[134],"differences":[135],"were":[136,166],"observed":[137],"amino":[140],"acids":[141],"(AAs),":[142],"B-group":[143],"vitamin,":[144],"purine":[146],"profiles.":[147],"Using":[148],"pathway":[151],"we":[153,184],"screened":[154],"13":[155],"pathways":[157,165],"related":[158],"STZ-exposed":[161,191],"These":[164],"AA":[168],"metabolism,":[169],"followed":[170],"organic":[172],"acids,":[173],"sugars,":[174],"lipid":[176],"metabolism.":[177],"Conclusion:":[178],"GC-MS":[182],"potential":[186],"alterations":[188],"within":[189],"may":[195],"aid":[196],"understanding":[199]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-01-24T00:00:00"}