{"id":"https://openalex.org/W4317523919","doi":"https://doi.org/10.1042/bj3450393","title":"Initial-rate kinetics of the flavin reductase reaction catalysed by human biliverdin-IX\u03b2 reductase (BVR-B)","display_name":"Initial-rate kinetics of the flavin reductase reaction catalysed by human biliverdin-IX\u03b2 reductase (BVR-B)","publication_year":2000,"publication_date":"2000-01-10","ids":{"openalex":"https://openalex.org/W4317523919","doi":"https://doi.org/10.1042/bj3450393","mag":"2041352553","pmid":"https://pubmed.ncbi.nlm.nih.gov/10620517","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1220769"},"language":"en","primary_location":{"id":"doi:10.1042/bj3450393","doi":"https://doi.org/10.1042/bj3450393","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj3450393","pdf_url":"https://portlandpress.com/biochemj/article-pdf/345/2/393/636479/bj3450393.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://portlandpress.com/biochemj/article-pdf/345/2/393/636479/bj3450393.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015817005","display_name":"Orla Cunningham","orcid":"https://orcid.org/0000-0002-3888-9541","observed_orcids":["https://orcid.org/0000-0002-3888-9541"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"Orla CUNNINGHAM","raw_affiliation_strings":["Department of Biochemistry, Trinity College, Dublin 2, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Trinity College, Dublin 2, Ireland","institution_ids":["https://openalex.org/I205274468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113505881","display_name":"Michael G. Gore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael G. GORE","raw_affiliation_strings":["Department of Biochemistry, School of Biological Sciences, University of Southampton, Southampton SO16 7PX, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, School of Biological Sciences, University of Southampton, Southampton SO16 7PX, U.K","institution_ids":["https://openalex.org/I43439940"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112253754","display_name":"Timothy J. Mantle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Timothy J. MANTLE","raw_affiliation_strings":["Department of Biochemistry, Trinity College, Dublin 2, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Trinity College, Dublin 2, Ireland","institution_ids":["https://openalex.org/I205274468"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015817005"],"corresponding_institution_ids":["https://openalex.org/I205274468"],"apc_list":null,"apc_paid":null,"fwci":2.0999,"has_fulltext":true,"cited_by_count":76,"citation_normalized_percentile":{"value":0.87352969,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"345","issue":"2","first_page":"393","last_page":"393"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":0.8384000062942505,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":0.8384000062942505,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12441","display_name":"Porphyrin Metabolism and Disorders","score":0.048500001430511475,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12191","display_name":"Physical Organic Chemistry and Reaction Kinetics","score":0.015300000086426735,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flavin-reductase","display_name":"flavin reductase","score":0.890999972820282},{"id":"https://openalex.org/keywords/initial-rate-kinetics","display_name":"initial rate kinetics","score":0.8019999861717224},{"id":"https://openalex.org/keywords/nadph-binding","display_name":"NADPH binding","score":0.949999988079071},{"id":"https://openalex.org/keywords/fad-reduction","display_name":"FAD reduction","score":0.8700000047683716},{"id":"https://openalex.org/keywords/mixed-inhibition","display_name":"mixed-type inhibition","score":0.6919999718666077},{"id":"https://openalex.org/keywords/heme-degradation","display_name":"heme degradation","score":0.531000018119812},{"id":"https://openalex.org/keywords/heme-oxygenase","display_name":"heme oxygenase","score":0.41499999165534973}],"concepts":[{"id":"https://openalex.org/C33093398","wikidata":"https://www.wikidata.org/wiki/Q174337","display_name":"Flavin group","level":3,"score":0.8270444869995117},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7735368013381958},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.6662145853042603},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.6582188606262207},{"id":"https://openalex.org/C56856141","wikidata":"https://www.wikidata.org/wiki/Q883112","display_name":"Enzyme kinetics","level":4,"score":0.5599976778030396},{"id":"https://openalex.org/C150757390","wikidata":"https://www.wikidata.org/wiki/Q1985205","display_name":"Non-competitive inhibition","level":3,"score":0.5309485793113708},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.521769106388092},{"id":"https://openalex.org/C121745418","wikidata":"https://www.wikidata.org/wiki/Q585536","display_name":"Quenching (fluorescence)","level":3,"score":0.5079885125160217},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.47432300448417664},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4649563729763031},{"id":"https://openalex.org/C71995715","wikidata":"https://www.wikidata.org/wiki/Q78574842","display_name":"Flavoprotein","level":3,"score":0.4419502913951874},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.24769359827041626},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24084627628326416},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.2029203474521637},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07844704389572144},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000332","descriptor_name":"Aerobiosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001664","descriptor_name":"Biliverdine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D001664","descriptor_name":"Biliverdine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005415","descriptor_name":"Flavins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006418","descriptor_name":"Heme","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009247","descriptor_name":"NADH, NADPH Oxidoreductases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D009247","descriptor_name":"NADH, NADPH Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038181","descriptor_name":"FMN Reductase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044925","descriptor_name":"Oxidoreductases Acting on CH-CH Group Donors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1042/bj3450393","doi":"https://doi.org/10.1042/bj3450393","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj3450393","pdf_url":"https://portlandpress.com/biochemj/article-pdf/345/2/393/636479/bj3450393.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"doi:10.1042/0264-6021:3450393","doi":"https://doi.org/10.1042/0264-6021:3450393","is_oa":false,"landing_page_url":"https://doi.org/10.1042/0264-6021:3450393","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1220769","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1220769","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},{"id":"pmid:10620517","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10620517","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"},{"id":"mag:2041352553","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10620517","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"doi:10.1042/bj3450393","doi":"https://doi.org/10.1042/bj3450393","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj3450393","pdf_url":"https://portlandpress.com/biochemj/article-pdf/345/2/393/636479/bj3450393.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4317523919.pdf","grobid_xml":"https://content.openalex.org/works/W4317523919.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W123325334","https://openalex.org/W1575544772","https://openalex.org/W1581256056","https://openalex.org/W1583940462","https://openalex.org/W1595604283","https://openalex.org/W1606031622","https://openalex.org/W1787801016","https://openalex.org/W1862027433","https://openalex.org/W1964729357","https://openalex.org/W1988919519","https://openalex.org/W1993996596","https://openalex.org/W1997661663","https://openalex.org/W1998693229","https://openalex.org/W2006166165","https://openalex.org/W2020128743","https://openalex.org/W2038776471","https://openalex.org/W2041379229","https://openalex.org/W2093057466","https://openalex.org/W2096263026","https://openalex.org/W2415888251","https://openalex.org/W6601641200"],"related_works":["https://openalex.org/W2041352553","https://openalex.org/W2947317995","https://openalex.org/W2036864051","https://openalex.org/W1787801016","https://openalex.org/W2086549127","https://openalex.org/W4236983800","https://openalex.org/W2118652143","https://openalex.org/W2103317372","https://openalex.org/W2041079531","https://openalex.org/W1581256056"],"abstract_inverted_index":{"The":[0,74,170,274],"initial-rate":[1,156,171],"kinetics":[2,172,220,228],"of":[3,43,55,82,90,112,142,267,295,301],"the":[4,23,31,80,119,135,143,160,192,216,271,290],"flavin":[5,136,206,251,306],"reductase":[6,11,137,140,207,253,261,276],"reaction":[7,277],"catalysed":[8],"by":[9,242],"biliverdin-IXbeta":[10],"at":[12,149,176,195],"pH":[13,150,177,196],"7.5":[14],"are":[15,122,179,303],"consistent":[16,180,233],"with":[17,22,87,109,118,181,221,229,234,263],"a":[18,41,53,69,104,110,146,163,182,200,213,235,247],"rapid-equilibrium":[19,183],"ordered":[20,165,184],"mechanism,":[21,185],"pyridine":[24,237],"nucleotide":[25,238],"binding":[26,29],"first.":[27],"NADPH":[28],"to":[30,68,78,102,205,258],"free":[32],"enzyme":[33,75,144,161],"was":[34,46,76,100,131],"characterized":[35],"using":[36],"stopped-flow":[37],"fluorescence":[38,49],"quenching,":[39],"and":[40,85,95,138,226,240,244,280,297],"K(d)":[42,54],"15.8":[44,65],"microM":[45,94,269],"calculated.":[47],"Equilibrium":[48],"quenching":[50],"experiments":[51,129],"indicated":[52,158],"0.55":[56],"microM,":[57,92,97,114],"suggesting":[58],"that":[59,116,133,159,187],"an":[60,264],"enzyme-NADPH":[61],"encounter":[62],"complex":[63],"(K(d)":[64],"microM)":[66,225],"isomerizes":[67],"more":[70],"stable":[71],"'nucleotide-induced'":[72],"conformation.":[73],"shown":[77,101,257],"catalyse":[79],"reduction":[81],"FMN,":[83,108],"FAD":[84],"riboflavin,":[86],"K(m)":[88,266],"values":[89],"52":[91],"125":[93],"53":[96],"respectively.":[98],"Lumichrome":[99],"be":[103],"competitive":[105,219],"inhibitor":[106],"against":[107],"K(i)":[111],"76":[113],"indicating":[115,186],"interactions":[117],"isoalloxazine":[120],"ring":[121],"probably":[123],"sufficient":[124],"for":[125,215,246,270,305],"binding.":[126],"During":[127],"initial":[128],"it":[130],"observed":[132],"both":[134,300],"biliverdin":[139,202,245,296],"activities":[141],"exhibit":[145,259],"sharp":[147],"optimum":[148],"5":[151,178],"in":[152,167,173,289],"citrate":[153,188],"buffer.":[154,169],"An":[155],"study":[157],"obeys":[162],"steady-state":[164],"mechanism":[166],"this":[168],"sodium":[174],"acetate":[175],"may":[189],"directly":[190],"affect":[191],"enzyme's":[193],"behaviour":[194],"5.":[197],"Mesobiliverdin":[198],"XIIIalpha,":[199],"synthetic":[201],"which":[203,302],"binds":[204],"but":[208],"does":[209],"not":[210],"act":[211],"as":[212,286],"substrate":[214],"enzyme,":[217],"exhibits":[218],"FMN":[222,243],"(K(i)":[223],"0.59":[224],"mixed-inhibition":[227],"NADPH.":[230],"This":[231,282],"is":[232,284],"single":[236],"site":[239],"competition":[241],"second":[248],"site.":[249],"Interestingly,":[250],"reductase/biliverdin-IXbeta":[252,307],"has":[254],"also":[255],"been":[256],"ferric":[260,272,275,298],"activity,":[262],"apparent":[265],"2.5":[268],"iron.":[273],"requires":[278],"NAD(P)H":[279],"FMN.":[281],"activity":[283],"intriguing,":[285],"haem":[287],"cleavage":[288],"foetus":[291],"produces":[292],"non-alpha":[293],"isomers":[294],"iron,":[299],"substrates":[304],"reductase.":[308]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2023-01-20T00:00:00"}
